Heterocycles : an international journal for reviews and communications in heterocyclic chemistry最新文献

A BIOMIMETIC APPROACH TO THE SYNTHESIS OF TERPENE-AMINO ACID CONJUGATES : THE UGI REACTION IN THE HYPOTHETICAL BIOSYNTHESIS OF MARINE NATURAL PRODUCTS 合成萜烯-氨基酸偶联物的仿生方法:假想的海洋天然产物生物合成中的ugi反应

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-06-01 DOI: 10.3987/COM-16-13442

Y. Ichikawa, Kenta Saito, Rika Mimura, Ayumi Kitamori, Akihito Matsukawa, Akifumi Ikeda, T. Masuda, H. Kotsuki*, Keiji Nakano

引用次数: 4

SYNTHESIS OF NOVEL BENZIMIDAZOLES 2-FUNCTIONALIZED WITH PYRROLIDINONE AND γ-AMINO ACID WITH A HIGH ANTIBACTERIAL ACTIVITY 高抗菌活性吡咯烷酮和γ-氨基酸功能化新型苯并咪唑的合成

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-02-01 DOI: 10.3987/com-15-13343

V. Strelciunaite, K. Anusevičius, I. Tumosienė

引用次数: 8

INHIBITION OF NF-κB AND CELLULAR INVASION BY NOVEL FLAVONOID DISMAL IN OVARIAN CARCINOMA CELLS 新型黄酮类化合物对卵巢癌细胞nf -κb及细胞侵袭的抑制作用

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-02-01 DOI: 10.3987/com-15-13386

K. Umezawa, Liyan Wang, Yinzhi Lin, Kulrawee Sidthipong, Jianqiang Tang, Mengjie Li, T. Koyano, T. Kowithayakorn, K. Sumiyoshi

引用次数: 3

DESIGN, SYNTHESIS AND EVALUATION OF AN L-DOPA-DERIVED MACROCYCLIC HEXAOXAZOLE (6OTD) AS A G-QUADRUPLEX-SELECTIVE LIGAND l -多巴衍生的大环六恶唑(6otd)作为g -四聚体选择性配体的设计、合成和评价

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-02-01 DOI: 10.3987/com-15-13383

Takahiro Nakamura, Yue Ma, Keisuke Iida

引用次数: 1

PREPARATION OF NICOTINOYL AMINO ACID DERIVATIVES BY FMOC-SOLID PHASE SYNTHESIS AND PRELIMINARY STUDIES ON THE DNA-BINDING PROPERTIES OF NICOTINOYL DERIVATIVES fmoc -固相合成法制备烟酰氨基酸衍生物及其与dna结合性能的初步研究

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-02-01 DOI: 10.3987/com-15-13345

Dongxin Zhao, K. Lu

{"title":"PREPARATION OF NICOTINOYL AMINO ACID DERIVATIVES BY FMOC-SOLID PHASE SYNTHESIS AND PRELIMINARY STUDIES ON THE DNA-BINDING PROPERTIES OF NICOTINOYL DERIVATIVES","authors":"Dongxin Zhao, K. Lu","doi":"10.3987/com-15-13345","DOIUrl":"https://doi.org/10.3987/com-15-13345","url":null,"abstract":"Three types of nicotinoyl amino acids, i.e., nicotinoyl leucine (NA-Leu), NA-Leu-His, and NA-Tyr-Tyr, were synthesized by Fmoc solid-phase peptide synthesis, purified by reversed-phase HPLC, and characterized by 1H, 13C NMR and ESI-MS. The interactions of nicotinic acid and nicotinoyl derivatives with ctDNA were investigated by fluorescence spectroscopy. NA-Leu-His and NA-Tyr-Tyr exhibited higher affinity for ctDNA compared with free NA, indicating that the imidazolyl of histidine and the phenol group of tyrosine can enhance the embedding interaction of nicotinoyl derivatives into ctDNA. In addition, leucine in the derivatives helped form a special surrounding and spatial structure to interact with ctDNA. The stronger interaction of NA-Tyr-Tyr and NA-Leu-His with ctDNA suggested that the modified nicotinic acid probably erhaps had significant practical value and should be further studied. INTRODUCTION Nicotinic acid (NA) is one of thirteen necessary vitamins, and also is known as vitamin PP (pellegra preventive factor) because it has been identified as the cause of pellegra disease. Niacinamide cannot be directly converted from NA in the body, but both compounds are important components of the co-factors NAD and NADP.1 At present, NA and niacinamide are mainly used as peripheral vasodilators in the 252 HETEROCYCLES, Vol. 92, No. 2, 2016","PeriodicalId":12850,"journal":{"name":"Heterocycles : an international journal for reviews and communications in heterocyclic chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83373172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPERIMENTAL INVESTIGATION OF TETRACYCLIC COMPOUNDS CONTAINING A NINE-MEMBERED SULTAM VIA COBALT ALKYNE COMPLEXES 含九元磺胺的四环化合物通过钴炔配合物的实验研究

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-02-01 DOI: 10.3987/com-15-13381

Kyosuke Kaneda, Misuzu Fujita, Risa Naruse

引用次数: 0

AN EFFICIENT CONVERSION OF LYSINE TO 2-AMINOCAPROLACTAM 赖氨酸有效转化为2-氨基己内酰胺

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-02-01 DOI: 10.3987/com-15-13358

H. Matsumoto, Kouji Kaiso, A. Kamimura

引用次数: 2

ANTIOXIDANT EFFECTS OF THE HYDROXY GROUPS IN THE SIMPLE PHENOLIC CARBAZOLES 简单酚类咔唑中羟基的抗氧化作用

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-01-01 DOI: 10.3987/com-15-13363

Yuhzo Hieda, N. Hatae, M. Anraku

{"title":"ANTIOXIDANT EFFECTS OF THE HYDROXY GROUPS IN THE SIMPLE PHENOLIC CARBAZOLES","authors":"Yuhzo Hieda, N. Hatae, M. Anraku","doi":"10.3987/com-15-13363","DOIUrl":"https://doi.org/10.3987/com-15-13363","url":null,"abstract":"Antioxidant activities of the simple phenolic carbazoles 5-11 were evaluated by 2,2-diphenyl-1-picrylhydrazyl and 2,2’-azinobis-(3-ethylbenzthiazoline-6-sulfonate) radical scavenging assays. The simple phenolic carbazoles 5-7, 9, and 11 exhibited stronger antioxidant activities than α-tocopherol, and similar antioxidant activities as phenolic carbazole alkaloids carazostatin (1), and carbazomadurins A (3) and B (4). Bond dissociation energies and highest occupied molecule orbital energy levels of a series of phenolic carbazoles including phenolic carbazole alkaloids were calculated. The reducing ability of the phenolic carbazole core could be important role for the antioxidant activity of carbazole alkaloids 1, 3, and 4. Reactive oxygen species (ROS) are highly reactive small substances with an important role in the initiation of various diseases such as carcinogenesis, drug-associated toxicity, inflammation, and atherogenesis as well as aging in aerobic organisms. Natural antioxidants, including ascorbic acid, α-tocopherol (VE), ubiquinol, uric acid, polyphenols and their analogs have been intensive investigation 120 HETEROCYCLES, Vol. 92, No. 1, 2016","PeriodicalId":12850,"journal":{"name":"Heterocycles : an international journal for reviews and communications in heterocyclic chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85521723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

RADICAL SCAVENGING ACTIVITY OF ASCORBIC ACID ANALOGS CONTAINING A CARBONYL CONJUGATED ENE-DIOL STRUCTURE 含有羰基共轭烯-二醇结构的抗坏血酸类似物的自由基清除活性

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-01-01 DOI: 10.3987/com-15-13366

M. Mochizuki, S. Nomura, K. Inami

引用次数: 1

SOLVENT EXTRACTION ABILITY OF NEW DIETHYL PHOSPHATE-MODIFIED THIACALIX[6]ARENE TOWARDS PGM SOLUTION 新型磷酸二乙酯改性噻吩[6]芳烃对PGM溶液的溶剂萃取性能

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry Pub Date : 2016-01-01 DOI: 10.3987/com-15-13346

K. U. M. Rao, T. Kimuro, M. Yamada

引用次数: 4