Headache最新文献

{"title":"Adverse childhood experiences, migraine, and adverse pregnancy outcomes among teenage mothers.","authors":"Yinxian Chen, Mahika Rawat, Maria L Jimenez, B Lee Peterlin, Sixto E Sanchez, Marta B Rondon, Bizu Gelaye","doi":"10.1111/head.70149","DOIUrl":"10.1111/head.70149","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to assess the individual and joint association of adverse childhood experiences (ACEs) and migraine with adverse pregnancy outcomes.</p><p><strong>Purpose: </strong>Teenage pregnancy is prevalent, particularly in low- and middle-income countries. Teenage mothers sustain higher risk of adverse birth outcomes compared to their adult counterparts. ACEs and migraine are prevalent among teenage mothers and may contribute to adverse pregnancy outcomes.</p><p><strong>Methods: </strong>Cross-sectional data were obtained from 819 Peruvian teenage mothers (aged 14 to 18 years) enrolled in the Teen Pregnancy Outcomes, Maternal, and Infant Study from November 2016 to September 2018 in Lima, Peru. Mothers having 4+ ACEs were considered as having high ACEs. Migraine was classified based on ICHD-3 criteria. Adverse pregnancy outcomes included preterm birth (PTB) and low birth weight (LBW).</p><p><strong>Results: </strong>High ACEs were associated with greater odds of PTB (adjusted odds ratio [aOR] = 2.25, 95% confidence interval [CI]: 1.25, 3.95) and LBW (aOR = 2.64, 95% CI: 1.46, 4.67). Participants with migraine also had higher odds of PTB (aOR = 2.15, 95% CI: 1.20, 3.77). When examined jointly, those with only migraine (aOR = 2.79, 95% CI: 1.41, 5.52) or only high ACEs (aOR = 2.94, 95% CI: 1.48, 5.83) showed increased odds of PTB, whereas the combined exposure to both was weaker (aOR = 2.69, 95% CI: 1.04, 6.95), suggestive of a possible negative interaction, although inferences from this are limited by our relatively small sample size as reflected by the wide 95% CI. Similar patterns were observed for LBW.</p><p><strong>Conclusions: </strong>High ACEs and migraine were each independently associated with increased odds of PTB and LBW, but joint exposure did not increase the odds beyond the individual contributions. The suggestion of a possible negative interaction between high ACEs and migraine warrants further investigation to confirm.</p>","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1827-1836"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine in the cradle of civilization: Evaluating ancient Mesopotamian texts through the lens of ICHD-3.","authors":"Bulent Diri, Bilge Piri Cinar, Zeynep Sena Diri, Okan Bolukbasi, Peter J Goadsby, Aynur Ozge","doi":"10.1111/head.70172","DOIUrl":"10.1111/head.70172","url":null,"abstract":"<p><strong>Background: </strong>Migraine is a neurological disorder with well-established diagnostic criteria. In its current formulation, migraine is a modern-day diagnosis, whereas descriptions consistent with migraine may date back to ancient civilizations.</p><p><strong>Objective: </strong>This study aimed to investigate whether symptoms consistent with migraine without aura, as defined by criteria of ICHD-3, are present in cuneiform medical texts from ancient Mesopotamia.</p><p><strong>Methods: </strong>A total of 37 Akkadian-language cuneiform medical texts dated between the second and first millennia bce were analyzed. Texts containing references to secondary headache or aura symptoms were excluded. Each remaining text was examined for descriptions corresponding to ICHD-3 diagnostic criteria (B: duration; C: pain characteristics; D: associated symptoms).</p><p><strong>Results: </strong>Among the 37 texts, 15 included expressions equivalent to continuous or prolonged pain, satisfying criterion B. Criterion C (unilateral, throbbing, and severe pain) was met in 37 texts (26 completely +11 partially). Criterion D (nausea, photophobia, phonophobia) was present in 21 of 37 texts.</p><p><strong>Conclusion: </strong>This study presents compelling evidence that the fundamental features of migraine without aura were described in Mesopotamian medical texts nearly 3000 years ago. These findings suggest that the diagnostic framework of migraine, as captured by ICHD-3, reflects the earliest documented medical traditions.</p>","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1878-1889"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148602257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics, neurovascular compression, and treatment outcomes in SUNCT and SUNA: A contemporary Japanese consecutive case series.","authors":"Shoji Kikui, Daisuke Danno, Masahiro Nawata, Yoshiyasu Iwai, Takao Takeshima","doi":"10.1111/head.70181","DOIUrl":"10.1111/head.70181","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to characterize the contemporary clinical phenotype of short-lasting unilateral neuralgiform headache attacks (SUNHA) in Japan, evaluate the prevalence and clinical relevance of neurovascular compression (NVC), and assess real-world medical and surgical treatment outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;SUNHA, comprising short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and those with cranial autonomic symptoms (SUNA), is a rare trigeminal autonomic cephalalgia disorder. Although several large cohorts have been reported in Western countries, data from Asia, particularly Japan, remain limited. Moreover, the clinical significance of NVC and the role of microvascular decompression (MVD) in medically refractory cases have not been fully established, and no standardized operational definition of refractory SUNHA exists.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a retrospective consecutive case series of 28 patients with SUNHA (14 SUNCT and 14 SUNA) who were evaluated at a tertiary headache center in Japan between 2011 and 2024. Diagnoses were made according to the International Classification of Headache Disorders, 3rd edition. Clinical features, trigger factors, cranial autonomic symptoms, comorbidities, and treatment responses were systematically reviewed and analyzed. High-resolution constructive interference in steady-state (CISS) magnetic resonance imaging was used to assess the NVC. Treatment response was defined as a subjective reduction of ≥50% in the attack burden. Refractory SUNHA was operationally defined as failure of or intolerance to at least two of the three principal preventive drug classes (lamotrigine, gabapentinoids, and topiramate). Surgical outcomes following MVD were evaluated in the refractory cases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;SUNHA accounted for 0.2% of all patients with headache evaluated in this study. The mean age at onset was 53.1 ± 20.9 years, with 17 male and 11 female patients. Right-sided pain (20/28, 71%) and ophthalmic (V1) trigeminal distribution (20/28, 71%) predominated. No statistically significant differences were detected between SUNCT and SUNA with respect to attack duration, frequency, triggers, or treatment responsiveness. NVC was identified in 17 of 27 evaluable patients (17/27, 63%; 95% confidence interval [CI]: 44.3%-78.5%) and was strongly associated with a history of TN-like pain (12/17 vs. 0/10, p &lt; 0.001). Seven of 28 patients (7/28, 25%; 95% CI: 12.7%-43.4%) met criteria for refractory SUNHA, and all refractory cases (7/7, 100%; 95% CI: 64.6%-100%) demonstrated NVC. Five of seven refractory patients (5/7, 71%) underwent MVD and achieved complete and sustained remission.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In this contemporary Japanese SUNHA cohort, no statistically significant clinical differences were detected between SUNCT and SUNA. NVC was relatively common and appeared to be associated w","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1837-1846"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of prodromal symptoms in predicting headache onset: A longitudinal electronic momentary assessment study.","authors":"Megan Lacritz, Richard B Lipton, Christopher Metts, Elizabeth K Seng","doi":"10.1111/head.70146","DOIUrl":"10.1111/head.70146","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This longitudinal observational study investigated the role of prodromal symptoms in predicting headache onset, using electronic headache diaries to assess symptom occurrence and predictive utility in individuals with migraine.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Prodromal symptoms are early indicators of migraine that occur 2-48 h before the headache phase. Whereas commonly reported symptoms include fatigue, stiff neck, and sensitivity to light and sound, few studies have assessed their predictive abilities for headache onset. Understanding the relationship and reliability of these symptoms is important for early migraine intervention strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This is a secondary analysis of a longitudinal observational headache diary study. Participants with episodic migraine (N = 43) were recruited from Einstein College of Medicine between 2017 and 2021 and completed a mobile headache diary three times daily over 3 months. They reported the presence of 11 prodromal symptoms and headache anticipation during headache-free intervals. Associations between prodromal symptoms, anticipation, and subsequent headache onset were examined across multiple time lags. Headache anticipation was evaluated as a moderator of these relationships.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Across 7061 headache-free observations, prodromal symptoms were reported in 52.7% of cases (n = 3721). Phonophobia doubled the odds of head pain onset 6 h before head pain. Nausea, photophobia, and difficulty thinking/concentrating were associated with higher odds of head pain within 24 h of symptom reporting. Blurred vision was associated with higher odds of future head pain at all time points evaluated. Thirst and dizziness were associated with higher odds of head pain 18-36 h before head pain onset. All prodromal symptoms were associated with increased odds of headache anticipation. Headache anticipation itself was associated with higher odds of headache onset within the ~6, 12, and 36 h prior to headache onset (~6 h odds ratio [OR] = 3.35, 95% confidence interval [CI] [2.57, 4.36]). Anticipation weakened the predictive value of several symptoms on headache occurrence, including feeling tired/weary (OR = 0.50, 95% CI [0.37, 0.68]); difficulty thinking/concentrating (0.37, 95% CI [0.24, 0.58]); thirst (OR = 0.42, 95% CI [0.31, 0.58]); blurred vision (OR = 0.63, 95% CI [0.42, 0.93]); photophobia (OR = 0.15, 95% CI [0.07, 0.33]); phonophobia (OR = 0.19, 95% CI [0.12, 0.28]); nausea (OR = 0.33, 95% CI [0.17, 0.65]); and dizziness (OR = 0.17, 95% CI [0.08, 0.35]).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Cardinal (phonophobia, photophobia, and nausea) symptoms of migraine were all associated with higher odds of future head pain 24 h before head pain onset. Other neurologic and homeostatic symptoms also emerged as predictors for head pain. However, predictive performance was modest; therefore, these symptoms should not be considered stand-alone migra","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1767-1778"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A patient-centered conceptual model and measurement framework for migraine experience developed by the Migraine Clinical Outcome Assessment System.","authors":"Rikki Mangrum, Alexandra L Bryant, Carrie R Houts, James S McGinley, Dawn C Buse, Richard B Lipton, R J Wirth","doi":"10.1111/head.70122","DOIUrl":"10.1111/head.70122","url":null,"abstract":"<p><strong>Objective: </strong>To develop a comprehensive, evidence-based, patient-centered conceptual model of migraine and to derive a measurement framework for the development or selection of clinical outcome assessments used in clinical trials of treatments for migraine.</p><p><strong>Background: </strong>Improving ways of assessing the outcomes that matter to people who live with migraine is an important goal for treatment development and evaluation. The Migraine Clinical Outcome Assessment System (MiCOAS) project aimed to gather qualitative data directly from people with migraine and develop a patient-centered core set of outcomes and endpoints for migraine clinical trials. Data gathered by the MiCOAS research team was used to develop a patient-centered conceptual model of migraine and a measurement framework designed to capture outcomes that matter to patients.</p><p><strong>Methods: </strong>A post hoc, pooled secondary interpretive analysis of the results from two MiCOAS qualitative studies (executed in 2020 and 2021 with 71 US adults with migraine) was conducted to develop the conceptual model using iterative diagramming methods to create a visualization. Supporting information exhibits for the visualization were created to record concept definitions and describe their interrelationships. The conceptual model was used to guide development of a measurement framework intended to support the selection or development of patient-reported outcome assessments suitable for regulated clinical trials of both acute and preventive migraine therapies. Input from people with migraine, patient advocates, clinical researchers, and subject matter experts was integrated into the model and the measurement framework.</p><p><strong>Results: </strong>The comprehensive conceptual model diagram organizes patient-reported experiences into domains for symptoms and impacts of migraine and depicts commonly occurring mediating contextual factors (e.g., perceived pain tolerance) that can affect patients' self-reported disease experiences. The measurement framework identifies concepts that are widely experienced or highly disabling to patients with episodic or chronic migraine but also meet the needs of clinical trial endpoint design (e.g., are cross-culturally relevant and amenable to treatment effect within a 3-month trial period) and are capable of capturing experiences during all phases of migraine, including interictal periods.</p><p><strong>Conclusions: </strong>The patient-centered conceptual model of migraine provides a concise but comprehensive framework for describing and measuring patient experiences of migraine disease and its treatment, including symptoms, daily functioning, and distal outcomes that result from the aggregation of migraine experiences over time. The measurement framework was developed to support comprehensive endpoint design for migraine clinical trials and has been used to guide the development of the MiCOAS measurement instruments.</p>","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1753-1766"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148294706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal hormone therapy, migraine history, and headache severity: Results from the Women's Health Initiative Hormone Therapy clinical trials.","authors":"Holly M Crowe, Tracy E Madsen, Janet W Rich-Edwards, Aladdin H Shadyab, Longjian Liu, Leslie V Farland, Peter F Schnatz, JoAnn E Manson, Kathryn M Rexrode, Marcia L Stefanick","doi":"10.1111/head.70168","DOIUrl":"10.1111/head.70168","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the association of oral menopausal hormone therapy (estrogen only [E-only] or estrogen and progestin [E+P]), as compared to placebo on postmenopausal headache severity among females with and without a history of migraine in the Women's Health Initiative Hormone Therapy (WHI-HT) trials.</p><p><strong>Background: </strong>Migraine is three times more common among females than males and is a major source of pain and disability among women throughout the life course. Previous observational research found a positive association between menopausal hormone therapy (MHT) use and migraine prevalence, but the longitudinal association of MHT with postmenopausal migraine severity is unclear.</p><p><strong>Methods: </strong>We examined changes in self-reported headache severity between baseline and year 1 in 22,876 females (average age 64 years) across the United States enrolled in the WHI-HT trials between 1993 and 1998. We conducted a secondary, stratified analysis of data of two parallel, randomized, placebo-controlled clinical trials to estimate the association of MHT and headache severity overall and stratified by history of migraine at baseline. Additionally, we assessed the association between MHT and headache trajectory, based on whether headaches worsened over the follow-up period.</p><p><strong>Results: </strong>At baseline, the prevalence of a lifetime migraine diagnosis was 10%. Among participants with a history of migraine, randomization to E-only MHT was not associated with more severe headache at 1 year (adjusted odds ratio [aOR] = 1.14, 95% confidence interval [CI]: 0.90-1.44), or worsening headache trajectory (adjusted risk ratio [aRR] = 0.98, 95% CI: 0.71-1.34) after 1 year. Randomization to E+P MHT was modestly associated with more severe headache, although estimates did not reach statistical significance (aOR = 1.21, 95% CI: 0.98-1.50). E+P MHT was significantly associated with worsening headache trajectory (aRR= 1.53, 95% CI: 1.14-2.03). Among those without a migraine history, E-only MHT was not strongly associated with moderate-to-severe headache severity (aOR: 1.11, 95% CI: 1.01-1.21) or worsening headache trajectory (aRR = 1.08 95% CI: 0.96-1.22) after 1 year. However, E+P MHT was associated with modestly increased odds of moderate-to-severe headache severity (aOR = 1.14, 95% CI: 1.06-1.23) and a higher likelihood of worsening headache trajectory (aRR = 1.18, 95% CI: 1.07-1.30) after 1 year.</p><p><strong>Conclusions: </strong>In this study of MHT in the WHI hormone therapy trial participants, E-only MHT was not associated with increased odds of more severe postmenopausal headache severity. Among those with a history of migraine, E+P MHT was associated with more severe and worsening postmenopausal headache. Further research on the effect of newer MHT formulations on postmenopausal headache is warranted.</p>","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1741-1752"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 2026 Headache Editorial Board conflict of interest declarations.","authors":"Jenn Vallimont","doi":"10.1111/head.70204","DOIUrl":"https://doi.org/10.1111/head.70204","url":null,"abstract":"","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three decades of research on the association between temporomandibular disorders and headache: A bibliometric analysis.","authors":"Tatiana P da Fonte, Maria L M Mesquita, Matheus Herreira-Ferreira, Livia M S P Fiamengui, Leonardo R Bonjardim, Juliana Stuginski-Barbosa, Paulo C R Conti","doi":"10.1111/head.70169","DOIUrl":"https://doi.org/10.1111/head.70169","url":null,"abstract":"<p><strong>Objectives: </strong>To perform a bibliometric analysis of the scientific literature published over the past 3 decades on the relationship between temporomandibular disorders (TMDs) and headache, examining scientific production, citation impact, and the conceptual structure and temporal evolution of research topics in this field.</p><p><strong>Background: </strong>TMDs are the most common chronic orofacial pain condition, whereas migraine and tension-type headache are among the leading causes of pain and disability worldwide. These conditions frequently co-occur and share underlying pain-related mechanisms, contributing to increased symptom burden and challenges in clinical management. Understanding how this relationship has been investigated over time is essential for identifying gaps in the literature and supporting more integrated approaches to diagnosis and management.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted using the Web of Science Core Collection, including original articles and reviews published between 1995 and 2025. Performance analysis, citation metrics, and keyword-based approaches were applied to evaluate scientific production, collaboration patterns, and the conceptual and temporal evolution of research topics.</p><p><strong>Results: </strong>A total of 177 publications from 86 sources were analyzed, involving 641 authors and 5738 references, with a mean of 5.19 coauthors per document. Annual scientific production increased over time, with an annual growth rate of 10%. Research output was concentrated in a limited set of countries, led by the United States (n = 179 coauthorship occurrences) and Brazil (n = 106), followed by Finland, Italy, Poland, and Denmark. The most globally cited study was Ohrbach et al. (2011; 289 citations), with other highly cited works focusing on epidemiology, symptom characterization, and comorbidity patterns (e.g., LeResche et al. 2005; Ballegaard et al. 2008; Gonçalves et al. 2010, 2011). Keyword frequency and co-occurrence analyses showed a structured organization centered on clinical and epidemiological domains, with migraine and diagnostic criteria acting as bridging elements across clusters. Trend analyses indicated a shift from broader descriptors (e.g., gender, general population) toward standardized diagnostic frameworks and methodological refinement (e.g., diagnostic criteria, management), and, more recently, the incorporation of chronic pain, psychosocial factors, and mechanisms (e.g., chronic pain, depression, mechanisms).</p><p><strong>Conclusion: </strong>Research on the relationship between TMD and headache has evolved into a structured and expanding field, with increasing thematic diversification. Recent developments indicate a shift toward more complex and multidimensional research frameworks, reflecting broader approaches to understanding these conditions.</p>","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between parental migraine, infantile colic, and later migraine in childhood: A scoping review of current evidence.","authors":"Bella Poutanen, Ilari Kuitunen","doi":"10.1111/head.70185","DOIUrl":"https://doi.org/10.1111/head.70185","url":null,"abstract":"<p><strong>Background: </strong>Evidence suggests that infantile colic, a common condition in early infancy, shares pathophysiological features with migraine.</p><p><strong>Objective: </strong>Aim was to examine the current evidence on the association between infantile colic and migraine, focusing on both maternal migraine as a risk factor for infantile colic and infantile colic as a predictor of later childhood migraine.</p><p><strong>Design: </strong>We performed a scoping review.</p><p><strong>Methods: </strong>We performed a scoping review and searched the PubMed, Scopus, and Web of Science databases from inception to 30 September 2025. Observational studies examining either maternal migraine and infantile colic or infantile colic and subsequent childhood migraine were included. Data were extracted on study design, population characteristics, and effect estimates. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were extracted where available, and crude ORs were calculated when necessary.</p><p><strong>Results: </strong>Twelve observational studies published from 1997 through 2025 were included. Estimates varied widely across six studies focusing on maternal migraine and infant colic, with ORs ranging from 0.97 to 37.71, reflecting substantial heterogeneity in study design, populations, and definitions. Another six studies showed that infantile colic was associated with later migraine, with ORs ranging from 0.50 to 107.14, although estimates varied substantially and some CIs were wide.</p><p><strong>Conclusion: </strong>Available observational evidence suggests a consistent association between migraine and infantile colic. Infantile colic may represent an early-life marker of migraine susceptibility, but causality cannot be established. Further prospective studies are needed to clarify underlying mechanisms and clinical implications.</p>","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of migraine on fertility and family planning in the Nationwide Swedish Health Care Registry.","authors":"Leon S Moskatel, Liza Smirnoff, Hanna Muhlrad, Jane Yan, Nina Bohm-Starke","doi":"10.1111/head.70158","DOIUrl":"https://doi.org/10.1111/head.70158","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives/background: &lt;/strong&gt;Our objective was to determine the impact of migraine on women's fertility and birth planning. Migraine preferentially affects women of childbearing age, and previous studies have suggested that migraine negatively affects a woman's decision to have children. We used the Swedish National Registry to determine the impact of migraine on women's fertility patterns including overall likelihood of childbirth, number of children, age at first birth, and birthing outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Our study used a retrospective matched cohort design including all women born in Sweden between 1973 and 1996 who were registered in the Swedish Medical Birth Register and resided in Sweden as of 2018. Cases comprised women in the National Patient Register diagnosed with migraine between 2001 and 2018. Each case was matched by birth year to two controls without a recorded migraine diagnosis. We first assessed partum outcomes including number of children, age at first birth, length of gestation, and interval between first and second pregnancy. We then analyzed postpartum outcomes including birth weight less than 2500 g, preterm delivery before 37 weeks, Apgar score less than 7 at 5 min, postpartum depression, and preeclampsia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Our inclusion criteria yielded a cohort of 49,318 women with migraine and 98,636 women without, of whom 37,455 had data in the birth register: 7198 with a diagnosis of migraine before pregnancy (MBP), 6575 with migraine after pregnancy (MAP), and 23,682 with no diagnosis of migraine. Overall, women with any diagnosis of migraine in the study window had an increased likelihood of having any births relative to women without migraine (adjusted odds ratio = 1.21, 95% confidence interval [CI] = 1.18-1.24; p &lt; 0.001) and had 0.072 more children (95% CI = 0.063-0.081; p &lt; 0.001). However, when stratified by whether the diagnosis of migraine occurred before or after pregnancy, women with MBP had 0.23 fewer children (95% CI = -0.24 to -0.21; p &lt; 0.001), whereas those with MAP had 0.33 more children (95% CI = +0.30 to +0.35; p &lt; 0.001). Similarly, women with MBP were older than controls (+0.52 years, 95% CI = +0.40 to +0.63; p &lt; 0.001), whereas those with MAP were younger by 1.65 years (95% CI = -1.77 to -1.53; p &lt; 0.001). Women with MBP waited less time between pregnancies (-0.69 years, 95% CI = -0.74 to -0.64; p &lt; 0.001), whereas those with MAP waited longer (+0.82, 95% CI = +0.74 to +0.90; p &lt; 0.001). Preterm deliveries were increased only in MBP with aura. Vaginal deliveries only decreased in those with MAP, whereas postpartum depression was increased in those with both MBP and MAP. Preeclampsia was increased in those with MBP only.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our study suggests that women in Sweden with MBP delay having children, have fewer children, and are at an older age than women without migraine, but may wait less time between pregnancies. Our study ","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}