Heteroatom Chemistry最新文献_第8页

Synthesis of novel 2-acetamidothiazoles tethered with 1,2,3-triazole and pyridine pharmacophores 以1,2,3-三唑和吡啶为药效载体的新型2-乙酰氨基噻唑的合成

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-11-01 DOI: 10.1002/hc.21447

Reena Kaushik, Mahesh Chand, Mohd. Rashid, Subhash C. Jain

{"title":"Synthesis of novel 2-acetamidothiazoles tethered with 1,2,3-triazole and pyridine pharmacophores","authors":"Reena Kaushik, Mahesh Chand, Mohd. Rashid, Subhash C. Jain","doi":"10.1002/hc.21447","DOIUrl":"10.1002/hc.21447","url":null,"abstract":"A novel series of 2-acetamidothiazoles bearing 1,2,3-triazole and pyridine moieties were designed and synthesized using simple chemical methodology. 3-Amino pyridine was converted into a potent intermediate 2-chloro-N-(4-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4-yl)thiazol-2-yl)acetamide (5) in four steps using molecular modification approach. Heterocyclic amine(s)/ heterocyclic and aromatic thiol(s) were then introduced in 5 to obtain target compounds 6a-6i. In all, we have synthesized eleven novel molecules which have the flavor of each of these heterocyclic moieties, viz. pyridine, 1,2,3-triazole, 2-acetamido-thiazole, heterocyclic amine(s)/ heterocyclic and aromatic thiol(s). The presence of each of these bioactive moieties in a single molecular frame could be beneficial to the development of new drug candidate because these moieties together contribute to the overall resultant biological activity of the target hybrid molecule. Structure elucidation of all the newly synthesized compounds was established using IR, 1H, 13C NMR, mass spectrometry along with their elemental analyses.","PeriodicalId":12816,"journal":{"name":"Heteroatom Chemistry","volume":"29 4","pages":""},"PeriodicalIF":0.3,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hc.21447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43973597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[FeFe]-hydrogenase H-cluster mimics mediated by mixed (S, Se) and (S, Te) bridging moieties: Insight into molecular structures and electrochemical characteristics 混合（S，Se）和（S，Te）桥接部分介导的[FeFe]-氢化酶H-簇模拟物：对分子结构和电化学特性的洞察

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-10-30 DOI: 10.1002/hc.21446

Hassan Abul-Futouh, Mohammad El-khateeb, Helmar Görls, Wolfgang Weigand

{"title":"[FeFe]-hydrogenase H-cluster mimics mediated by mixed (S, Se) and (S, Te) bridging moieties: Insight into molecular structures and electrochemical characteristics","authors":"Hassan Abul-Futouh, Mohammad El-khateeb, Helmar Görls, Wolfgang Weigand","doi":"10.1002/hc.21446","DOIUrl":"10.1002/hc.21446","url":null,"abstract":"Two synthetic models of the active site of [FeFe]-hydrogenase containing mixed (S, Se) and (S, Te) bridges have been synthesized and characterized. These complexes [Fe2(CO)6{μ-S(CH2)4E-μ)}] (E = Se (1), Te (2)) are obtained in moderate yields from the reaction of Fe3(CO)12 with 1,2-thiaselenane or 1,2-thiatellurane. They have been characterized by spectroscopic techniques (IR, 1H-, 13C{1H}-, 77Se{1H}-, 125Te{1H}-NMR, and MS) and elemental analysis. The structures of [Fe2(CO)6{μ-S(CH2)4Se-μ)}] and [Fe2(CO)6{μ-S(CH2)4Te-μ)}] are determined by X-ray structure determination and show the expected butterfly geometry. Moreover, the influence of the mixed chalcogen atoms on the redox properties and the catalytic behavior of 1 and 2 are studied using cyclic voltammetry.","PeriodicalId":12816,"journal":{"name":"Heteroatom Chemistry","volume":"29 5-6","pages":""},"PeriodicalIF":0.3,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hc.21446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43959379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Tri(1-naphthyl)phosphine as a ligand in palladium-free Sonogashira cross-coupling of arylhalogenides with acetylenes 三（1-萘基）膦作为配体参与芳基卤代物与乙炔的无钯Sonogashira交叉偶联

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-10-27 DOI: 10.1002/hc.21443

Anastasiya I. Govdi, Sergey F. Vasilevsky, Svetlana F. Malysheva, Olga N. Kazheva, Oleg A. Dyachenko, Vladimir A. Kuimov

引用次数: 5

A tribute to Professor Naomichi Furukawa on the occasion of his 82nd birthday 在古川直一教授82岁生日之际向他致敬

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-10-25 DOI: 10.1002/hc.21442

Satoshi Ogawa, Akihiko Ishii, Derek P. Gates

引用次数: 0

A theoretical study of the properties of ninety-two “aromatic” six-membered rings including benzene, azines, phosphinines and azaphosphinines 苯、叠氮、磷化物和氮杂磷化物等92个“芳香”六元环性质的理论研究

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-10-23 DOI: 10.1002/hc.21441

Eric Elguero, Ibon Alkorta, José Elguero

引用次数: 6

Synthesis of 2,2-diarylvinyl phenyl selenides by dehydration of 2-hydroxyalkyl phenyl selenides 2-羟基烷基苯基硒化物脱水合成2,2-二芳基苯基硒化物

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-10-12 DOI: 10.1002/hc.21438

Nicolai Stuhr-Hansen

引用次数: 0

Oxime derivative unsymmetrical azine, its Ni(II), Cu(II) and Zn(II) complexes: Synthesis, spectroscopy and catecholase activity 肟衍生物不对称嗪及其Ni（II）、Cu（II）和Zn（II）配合物的合成、光谱和邻苯二酚酶活性

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-10-08 DOI: 10.1002/hc.21439

Kerim Serbest, Özge Göktekin, Kaan Karaoğlu, Ali Zengin, Ufuk Çoruh

{"title":"Oxime derivative unsymmetrical azine, its Ni(II), Cu(II) and Zn(II) complexes: Synthesis, spectroscopy and catecholase activity","authors":"Kerim Serbest, Özge Göktekin, Kaan Karaoğlu, Ali Zengin, Ufuk Çoruh","doi":"10.1002/hc.21439","DOIUrl":"10.1002/hc.21439","url":null,"abstract":"1-[(Z)-{(2E)-[(3E)-3-(hydroxyimino)butan-lidene]hydrazinylidene}methyl]naphthalen -2-ol, H2L (3) was synthesized by the agents of 2-hydroxy-1-naphtaldehyde, 2,3-butanedione monoxime and hydrazine in two steps. The structures of the compounds have been proposed by elemental analyses, spectroscopic data, that is, IR, 1H NMR, UV-vis, X-ray, mass spectra (ESI or TOF), molar conductivities and magnetic susceptibility measurements. The ligand has potentially three nitrogens and an oxygen donor to be able to bind a metal center. In the light of analytical and physical results, it was suggested that the ligand may coordinate to by N,O/N2/N2O donor set to form square planar, octahedral, distorted square planar and tetrahedral complexes. Proton NMR evidence indicating that the ligand coordinates the metal ion through the phenolic oxygen and nitrogen of imine in the nickel and zinc complexes. Molar conductivity measurements reveal that all the complexes are non-electrolytes. In addition, catecholase activities of the complexes were studied. However, the only one of the complexes, 1b, behaves as an effective catalyst toward oxidation of 3,5-di-tert-butylcatechol (3,5-DTBC) to its corresponding quinone derivative in MeOH saturated with O2. The reaction follows Michaelis-Menten enzymatic reaction kinetics with turnover numbers (kcat) 1.19 × 103/hour.","PeriodicalId":12816,"journal":{"name":"Heteroatom Chemistry","volume":"29 4","pages":""},"PeriodicalIF":0.3,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hc.21439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42842926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Efficient chemical fixation of CO2 into cyclic carbonates using poly(4-vinylpyridine) supported iodine as an eco-friendly and reusable heterogeneous catalyst 聚(4-乙烯基吡啶)负载碘作为一种环保、可重复使用的多相催化剂，将二氧化碳高效地化学固定成环碳酸盐

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-10-07 DOI: 10.1002/hc.21440

Nader Ghaffari Khaligh, Taraneh Mihankhah, Mohd Rafie Johan

引用次数: 7

Sulfur and phosphorus heteroatom-containing compounds as corrosion inhibitors: An overview 含硫磷杂原子化合物作为缓蚀剂:综述

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-09-19 DOI: 10.1002/hc.21437

Chandrabhan Verma, Dakeshwar K. Verma, Eno E. Ebenso, Mumtaz A. Quraishi

{"title":"Sulfur and phosphorus heteroatom-containing compounds as corrosion inhibitors: An overview","authors":"Chandrabhan Verma, Dakeshwar K. Verma, Eno E. Ebenso, Mumtaz A. Quraishi","doi":"10.1002/hc.21437","DOIUrl":"10.1002/hc.21437","url":null,"abstract":"Use of organic compounds containing nitrogen (N), oxygen (O), sulfur (S), and phosphorus (P) heteroatoms in their molecular structures is one of the most effective, economic, and practical corrosion inhibitors. The effectiveness of the heteroatoms toward metallic corrosion inhibition follows the order: P > S > N > O. The metal-inhibitor interactions involve the charge sharing between the heteroatoms and empty d-orbitals of the surface metallic atoms; therefore, a heteroatom with lower electronegativity value is more potent to form strong bonding (charge sharing) with metallic surface as compared to more electronegative heteroatom. Literature study reveals that almost all corrosion inhibitors have either one or more heteroatoms in their molecular structures particularly in the form of polar functional groups, which enhance their adsorption tendency on metallic surface. Present review paper features the collection of some major works that have been published on metallic corrosion inhibition containing these P, S, O, and N heteroatoms. Since now, several review articles have been published describing the application of N and O atoms; however, the reviews on use of P and S heteroatoms are scare. Therefore, aim of the present article was to mainly describe the collection of corrosion inhibitors containing S and P heteroatoms.","PeriodicalId":12816,"journal":{"name":"Heteroatom Chemistry","volume":"29 4","pages":""},"PeriodicalIF":0.3,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/hc.21437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47553898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 96

Green synthesis and cytotoxic activity of dibenzyl α-hydroxyphosphonates and α-hydroxyphosphonic acids α-羟基膦酸二苄基酯和α-羟基磷酸的绿色合成及其细胞毒性

IF 0.3 4区化学

Heteroatom Chemistry Pub Date : 2018-09-19 DOI: 10.1002/hc.21436

Zita Rádai, Petra Szeles, Nóra Zsuzsa Kiss, László Hegedűs, Tímea Windt, Veronika Nagy, György Keglevich

引用次数: 13