GSC Biological and Pharmaceutical Sciences最新文献_第9页

Niosomes: A targeted drug delivery system Niosomes：定向给药系统

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0536

Shrikrushna M. Khambalkar, Aishwarya D. Ghuge, Swati P. Deshmukh, Krushna P. Jadhav, Roshan V. Jaiswal, Amit A. Khune

{"title":"Niosomes: A targeted drug delivery system","authors":"Shrikrushna M. Khambalkar, Aishwarya D. Ghuge, Swati P. Deshmukh, Krushna P. Jadhav, Roshan V. Jaiswal, Amit A. Khune","doi":"10.30574/gscbps.2024.26.1.0536","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.1.0536","url":null,"abstract":"Niosomes are the multilamellar vesicles structure of non-ionic surfactant. Niosomes act as a drug carrier in drug delivery system. Niosomes improved the therapeutic performance of encapsulated drug molecules by protecting the drug from host biological environments resulting in their delayed clearance. In this present review article, we concentrate on the drug Niosomes which is a normal approach for drug delivery system. The niosomes have become the area of interest in the drug delivery system their advantage one liposomes in the field of drug delivery system for being non-toxic makes them more suitable for drug delivery system. Their ability to encapsulate both hydrophilic, lipophilic drugs simultaneously has increased its demand in the present scenario. Niosomes are vesicles made up of non-ionic surfactant, which are biodegradable, nontoxic, more stable and inexpensive and have ability to substitute liposomes but they also flexibility in the route of administration Thus, in the present articles more focus is made on the development method of niosomes which is used as a novel approach in present scenario So, Niosomes as a drug carrier is of greater Importance in the pharmaceutical field","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"10 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspirin and meloxicam co-administration with leaf extract of Terminalia catappa; prevention of red blood cell related cardiovascular complications in alloxan induced diabetic rats 阿司匹林和美洛昔康与鸡冠花叶提取物联合用药；预防阿脲诱导的糖尿病大鼠红细胞相关的心血管并发症

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0543

Ezekiel E. Ben, Asuquo E. Asuquo, Okon, I. Asuquo, Titilope H. Olatunbosun

{"title":"Aspirin and meloxicam co-administration with leaf extract of Terminalia catappa; prevention of red blood cell related cardiovascular complications in alloxan induced diabetic rats","authors":"Ezekiel E. Ben, Asuquo E. Asuquo, Okon, I. Asuquo, Titilope H. Olatunbosun","doi":"10.30574/gscbps.2024.26.1.0543","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.1.0543","url":null,"abstract":"Hyperglycemia induced alterations in red blood cell parameters are associated with cardiovascular complications in diabetes mellitus. This study was designed to investigate abnormalities in red blood cell parameters and changes due to aspirin and meloxicam administrations in diabetic rats. Thirty-six (36) healthy male Wistar rats weighting 150-200g were used for the study. The animals were randomly distributed into six groups of six rats each. Group 1 and 2 respectively served as control and diabetic groups administered with 5 ml/kg body weight of distilled water orally. Groups 3 and 4 were diabetic rats treated with aspirin and meloxicam at 30 mg/kg and 2 mg/kg body weight respectively. A combined administration of aspirin and meloxicam at their respective doses with 130mg/kg body weight of Terminalia catappa extract was in groups 5 and 6. The results showed that RBC count, PCV, HGB and MCV were reduced significantly (p<0.05) in diabetic group but significantly (p<0.05) increased in aspirin, meloxicam and in combined extract treated groups of diabetic rats. Therefore, diabetic induced alterations in red blood cell parameters which maybe attributed to inflammation were reversed by aspirin and meloxicam. Co-administration of these NSAID with T. catappa leaf extract would enhance their safety use in prevention of cardiovascular complications in diabetes mellitus.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"9 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the anticancer potential of Boswellia serrata: A comprehensive review 探索乳香的抗癌潜力：全面综述

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0027

Olabode Martins Olabintan, Yusuf Adekola Wahab, Nurain Kehinde Ahmed

{"title":"Exploring the anticancer potential of Boswellia serrata: A comprehensive review","authors":"Olabode Martins Olabintan, Yusuf Adekola Wahab, Nurain Kehinde Ahmed","doi":"10.30574/gscbps.2024.26.1.0027","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.1.0027","url":null,"abstract":"Plants are endowed with numerous phytochemicals and bioactive compounds which have been explored and reported to possess therapeutic potential against different diseases. The aim of this review paper is to explore the anticancer potential of Boswellia serrata. Cancer is known to be a burden on the global healthcare system while Boswellia serrata has been reported to possess numerous bioactive compounds with anticancer effects. Therefore, there is a need to further assess the applicability of Boswellia serrata as an anticancer. The included studies for review were accessed via online databases such as Scopus, PubMed, and Google scholar with specified inclusion and exclusion criteria to guide the study selection process. Following a critical content analysis, it was found that Boswellia serrata possesses numerous bioactive compounds with anti-proliferative, cell cycle inhibitory, apoptosis, anti-metastatic, and anti-tumor effect. In conclusion, Boswellia serrata holds a great potential in the treatment of cancer and can be a potent tool in the ongoing fight against cancer; however, further studies are essential to understand the mechanism of actions of specific bioactive compounds identified in Boswellia serrata.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"173 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the binding affinities and stabilities of ivermectin and moxidectin against Sars-CoV-2 receptors using molecular docking and molecular dynamics simulation 利用分子对接和分子动力学模拟验证伊维菌素和莫西菌素与 Sars-CoV-2 受体的结合亲和力和稳定性

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0030

Emmanuel Chuks Oranu, Esther Oluchukwu Eze, Adanna Ijeawele, Chisom George Obidimma, Belinda Chinecherem Umeh, Perpetua Chinonyelum Ejezie, IC Uzochukwu

{"title":"Validation of the binding affinities and stabilities of ivermectin and moxidectin against Sars-CoV-2 receptors using molecular docking and molecular dynamics simulation","authors":"Emmanuel Chuks Oranu, Esther Oluchukwu Eze, Adanna Ijeawele, Chisom George Obidimma, Belinda Chinecherem Umeh, Perpetua Chinonyelum Ejezie, IC Uzochukwu","doi":"10.30574/gscbps.2024.26.1.0030","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.1.0030","url":null,"abstract":"Corona-viruses (CoVs), a large family of single-stranded RNA viruses, can infect animals and also humans, causing respiratory, gastrointestinal, hepatic, and neurologic disease. As the largest known RNA viruses, they are further divided into four genera: alpha-coronavirus, beta- corona- virus, gamma-corona virus and delta-coronavirus. SARS-CoV-2 belong to genus betacoronavirus. The viral genome of SARS-CoV-2 codes 4 major structural proteins: the nucleocapsid (N) protein, the transmembrane (M) protein, the envelope (E) protein, and the spike (S) protein. It also encodes 16 nonstructural proteins (NSPs) and 9 accessory proteins required for replication and pathogenesis. The Molecular docking simulations was used to determine the binding affinities of Ivermectin, Moxidectin and Molnupiravir against NSP13 receptor of SARS-CoV-2. The experimental crystal structures of the receptor was obtained from the protein data bank (PDB). The receptor was prepared using Chimera-1.10.1 and AutoDock tools-1.5.6. The 3D structure of the selected approved drugs and the reference ligand was obtained from PDB and Drugbank and prepared using AutoDock tools-1.5.6. Validation of docking protocol was done by reproducing the PDB crystal structures insilico. Molecular docking simulations were performed using AutoDockVina-4.2.6 on the Linux operating system (ubuntu) 20.04. Then the docking results were analysed and visualized using Pymol-2.3.0. Molecular dynamics of the frontrunners with the reference ligand and protein was done in 10000 ps. Moxidectin, molnupiravir and Ivermectin showed high binding affinities to the receptors. Moxidectin and Ivermectin showed stability after molecular dynamics simulation to further validate the claim. These drugs are predicted as possible antivirals in the treatment of Covid-19.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"233 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140483906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender discrepancies in sources of information and COVID-19 pandemic knowledge: Insight from some districts and municipalities in Ghana 信息来源和 COVID-19 大流行病知识中的性别差异：加纳一些地区和城市的启示

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0022

Emmanuel Owusu, Edward Debrah-Wiafe, Emmanuel Appaw Larbi, Nicholas Apreh-Siaw, Faustina Ahwireng, Christopher Amoah, Bernice Amoah

{"title":"Gender discrepancies in sources of information and COVID-19 pandemic knowledge: Insight from some districts and municipalities in Ghana","authors":"Emmanuel Owusu, Edward Debrah-Wiafe, Emmanuel Appaw Larbi, Nicholas Apreh-Siaw, Faustina Ahwireng, Christopher Amoah, Bernice Amoah","doi":"10.30574/gscbps.2024.26.1.0022","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.1.0022","url":null,"abstract":"The aim of the study was to investigate gender variations in the sources of information and knowledge about COVID-19. The study took place in Okere District, Akuapem South District, and Akuapem North Municipal Assemblies in the Eastern Region of Ghana. A convenient sampling method was employed to select 800 participants, who were given a self-designed questionnaire on COVID-19 knowledge (SMQKC). The hypothesis posited that there would be no significant difference in information sources, knowledge of causes and transmission, symptoms, prevention and control, and other management protocols of COVID-19 between males and females in the urban areas of the studied Municipal and District Assemblies (MDAs). The results revealed that social media and radio were the two main sources of information on COVID-19, and the difference in information sources between males and females was statistically significant. An independent t-test indicated a significant difference in knowledge of causes and transmission, symptoms, prevention and control, and other management measures between males and females regarding COVID-19 at a 95% confidence interval. The study suggests, among other things, a targeted effort to disseminate information on diseases, particularly COVID-19, to females, considering their gender roles that bring them closer to risks associated with infectious diseases compared to their male counterparts.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"207 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140483943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting health: Introducing an eco-friendly herbal mosquito repellent extracted from local sweet orange peels 促进健康：介绍一种从当地甜橙皮中提取的环保草药驱蚊剂

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0014

Mu’awiya Baba Aminu, Yisa Adeniyi Abolade, A. Adegoke, Samuel Mensah Noi, Chisom Maureen Nwoye, Omolade Ajayi, Onah Kyrian, Berther Onyenachi Akagbue, Tasha Siame, Adeyemi Adeesan Bamidele

{"title":"Promoting health: Introducing an eco-friendly herbal mosquito repellent extracted from local sweet orange peels","authors":"Mu’awiya Baba Aminu, Yisa Adeniyi Abolade, A. Adegoke, Samuel Mensah Noi, Chisom Maureen Nwoye, Omolade Ajayi, Onah Kyrian, Berther Onyenachi Akagbue, Tasha Siame, Adeyemi Adeesan Bamidele","doi":"10.30574/gscbps.2024.26.1.0014","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.1.0014","url":null,"abstract":"With time, mosquitoes have grown to pose a severe threat to human health. Thus, the necessity to provide a sustainable solution to the mosquito problem in our environment emerges. Using mosquito coils and other locally produced ones has been documented in previous research. There is a health danger from mosquito coil smoke. Severe headaches, nausea, vomiting, respiratory issues, and exacerbation of asthmatic patients' respiratory symptoms have been reported as a consequence. Although numerous methods of mosquito control exist, an affordable, long-term solution still has to be created. The research goal was to use locally available plant materials in distant places to create a safe, economical, and environmentally friendly herbal insect repellent. Orange sweet peels are used to extract oil, which is then followed by material shrinkage and distillation. The two most common chemical components found in orange peels are limonene and linalool molecules. These findings suggest that the essential oil extracted from sweet orange peel may possess antibacterial and antioxidant properties, making it a highly efficient spray-on mosquito repellant for a variety of mosquito species.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"90 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the protective effects of co-administered Zingiber officinale and Allium sativum ethanol extracts on hepatic and renal functions using female Wister rat modelsDaniel Ikechukwu Oraekei *, Peter Chibueze Ihekwereme, Chukwuka Benjamin Uzodinma, 利用雌性威斯特大鼠模型评估联合服用的细辛和薤白乙醇提取物对肝肾功能的保护作用丹尼尔-伊基丘克乌-奥雷凯 *、彼得-奇布埃兹-伊赫克韦雷梅、楚库卡-本杰明-乌佐丁玛

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0021

Daniel Ikechukwu Oraekei, Peter Chibueze Ihekwereme, Chukwuka Benjamin Uzodinma, Onyeka Chinwuba Obidiegwu, Marcellus Ejike Nnamani, Nnamdi Markben Adione

{"title":"Evaluation of the protective effects of co-administered Zingiber officinale and Allium sativum ethanol extracts on hepatic and renal functions using female Wister rat modelsDaniel Ikechukwu Oraekei *, Peter Chibueze Ihekwereme, Chukwuka Benjamin Uzodinma,","authors":"Daniel Ikechukwu Oraekei, Peter Chibueze Ihekwereme, Chukwuka Benjamin Uzodinma, Onyeka Chinwuba Obidiegwu, Marcellus Ejike Nnamani, Nnamdi Markben Adione","doi":"10.30574/gscbps.2024.26.1.0021","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.1.0021","url":null,"abstract":"Hepatic and renal function tests are done to indicate how well the liver and kidneys are working. Parameters been tested include serum concentration of alanine transferase, aspartate transferase, alkaline phosphatase, blood urea nitrogen and creatinine among others. This study was aimed at evaluating the effect of singly and combined administration of Zingiber officinale and Allium sativum on hepatic and renal functions. The herbs were extracted with ethanol. A total of 40 female Wister rats were grouped into eight (n=5). Group 1 was treated with distilled water and served as control; group 2 was treated with 530 mg/kg body weight of Zingiber officinale and group 3 treated with the same dose of Alliun sativum. Groups 4-8 were treated with different ratios of Z;A (Zingiber officinale: Allium sativum). On the 91st day of treatment, blood samples were collected from all the rats and analyzed for the parameters. Zingiber officinale decreased all the tested parameters significantly (P ˂ 0.05) when compared with group 1. Allium sativum on the contrary increased the parameters except for creatinine where it showed no activity. The combination of the two herbs reduced the concentration of the parameters but the reduction was only significant (P ˂ 0.05) when the proportion of Zingiber officinale was greater. In conclusion, only monotherapy of Zingiber officinale protected the liver and kidneys from damage; and if these herbs must be used together for enhanced liver and kidney health, the ration Z:A = 8:2 in which the proportion of Zingiber officinale is more should be recommended.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"177 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140485237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-rabies in the serum of laying hens after single dose rabies vaccination: An initial observation 单剂狂犬病疫苗接种后蛋鸡血清中的抗狂犬病抗体：初步观察

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0554

Sulaiman N Depamede, Made Sriasih, Nurul Azizah

引用次数: 0

Overview on telmisartan therapy 替米沙坦治疗概述

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0498

Feryal Hashim Rada

引用次数: 0

Response of off-season strawberries (Fragaria sp.) production under the effects of paclobutrazol and drought stress 反季节草莓（Fragaria sp.）在五氯硝基苯唑和干旱胁迫作用下的产量反应

GSC Biological and Pharmaceutical Sciences Pub Date : 2024-01-30 DOI: 10.30574/gscbps.2024.26.1.0471

Komang Sandiasa, I Nyoman Rai, Ida Ayu Putri Darmawati, I Gusti Ngurah Santosa

{"title":"Response of off-season strawberries (Fragaria sp.) production under the effects of paclobutrazol and drought stress","authors":"Komang Sandiasa, I Nyoman Rai, Ida Ayu Putri Darmawati, I Gusti Ngurah Santosa","doi":"10.30574/gscbps.2024.26.1.0471","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.1.0471","url":null,"abstract":"Strawberry (Fragaria sp.) is a fruit crop harvested seasonally with the peak season from August to November while the off-season harvest is January to June with limited harvest. The purpose of this study was to find the concentration of paclobutrazol and the level of drought stress for off-season strawberry production. This research conducted on April to July 2023. The experiment used a factorial Randomized Block Design consisting of 2 factors and 3 replications with 16 treatment combinations. The first factor was paclobutrazol consisting of four levels, namely P0 = control, P1 = 10,000 ppm, P2 = 20,000 ppm and P3 = 30,000 ppm and the second factor was the level of drought stress consisting of four levels i.e. C0 = 100% field capacity, C1 = 80% field capacity, C2 = 60% field capacity and C3 = 40% field capacity. The results showed that paclobutrazol accelerated flowering time, increased fruit set, leaf relative water content, root length, chlorophyll content, but decreased the number of fruits formed, harvested fruits, fruit diameter, harvested fruit weight, weight per fruit, root oven dry weight, percentage of fallen fruits and total soluble solids. Drought stress level increased leaf relative water content, root length, root oven dry weight, percentage of fallen fruit, percentage of fruit set, but decreased number of flowers formed, fruits harvested, weight of fruits harvested, weight per fruit, fruit diameter, total soluble solids, chlorophyll content and delayed flowering time.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"13 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0