Graefe's Archive for Clinical and Experimental Ophthalmology最新文献

{"title":"Changing indications for keratoplasty: monocentric analysis of the past two decades","authors":"Jan Vincent Hoffmann, Paola Kammrath Betancor, Philip Maier, Thabo Lapp, Sonja Heinzelmann, Daniel Böhringer, Stefan Lang, Thomas Reinhard","doi":"10.1007/s00417-024-06639-y","DOIUrl":"https://doi.org/10.1007/s00417-024-06639-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Over the past two decades, lamellar keratoplasty procedures, such as Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) and Descemet's Membrane Endothelial Keratoplasty (DMEK) as well as Deep Anterior Lamellar Keratoplasty (DALK), have become an integral part of clinical practice. With advances in contact lens fitting for keratoconus management and the implementation of UVA-Riboflavin Crosslinking (CXL), the landscape of keratoplasty indications is undergoing changes. Procedures and indications in a single tertiary care center over the past two decades are reviewed in this retrospective analysis. Methods: Retrospective analysis utilized anonymized electronic data from the LIONS cornea bank Baden-Württemberg, Eye Center Freiburg, spanning from beginning of 2004 to end of 2023. The primary focus was on surgical procedures and indications for keratoplasty.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The study encompassed a comprehensive analysis of 7130 corneal transplants. Penetrating keratoplasty (PK) exhibited a significant decline from 95% (<i>n</i> = 206, 2004) to 11% (<i>n</i> = 46, 2023), while DMEK increased from 48% (<i>n</i> = 157, 2012) to 82% (<i>n</i> = 347, 2023). Fuchs endothelial dystrophy (FED) emerged as the dominant indication, witnessing a significant increase from 24% (2004, <i>n</i> = 39) to 72% (2023, <i>n</i> = 288). Conversely, keratoconus (KC) showed a reciprocal change from 25% (2004, <i>n</i> = 40) to 4% (2023, <i>n</i> = 17). PK demonstrated a noteworthy indication shift in descending order from Bullous Keratopathy (BK), FED, and KC in 2004 to KC, graft failure, corneal scars, and ulcers in 2023. Repeat keratoplasty following DMEK remained rare, but a discernible upward trend was observed for PK.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>This retrospective analysis highlights significant changes in both keratoplasty indications and techniques over the past two decades. DMEK has emerged as a successful intervention for treating endothelial diseases, while PK retains its qualitative indispensability for a wide range of indications. Modern corneal banks are urged to maintain a robust supply of grafts for all surgical techniques in anticipation of potential increased demand in the future, particularly for repeat keratoplasties.</p><h3 data-test=\"abstract-sub-heading\">Key messages</h3><p><b><i>What is known</i></b></p><p>• Over the past two decades, lamellar keratoplasty procedures such as DSAEK and DMEK have increasingly replaced penetrating keratoplasty (PK) in clinical practice due to their improved outcomes and reduced complications for certain indications.</p><p><b><i>New Findings</i></b></p><p>• Our study reveals a significant shift in keratoplasty indications, with Fuchs endothelial dystrophy (FED) emerging as the predominant indication, increasing from 24% in 2004 to 72% in 2023, while keratoconus (KC) declined from 25 to 4% du","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"186 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compliance with rigid gas-permeable contact lens use in children younger than 6 years in China: a 6-year retrospective study","authors":"Xiao-Di Yang, Yong Lyu, Guang-Ming Wan","doi":"10.1007/s00417-024-06637-0","DOIUrl":"https://doi.org/10.1007/s00417-024-06637-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To explore the abandonment rate and factors influencing the use of rigid gas-permeable contact lenses (RGPCL) among children aged &lt; 6 years.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This retrospective case series study included 70 children aged &lt; 6 years who were fitted with RGPCL for visual rehabilitation between January 2016 and December 2021. We collected data on indications, discontinuation rates, and reasons for discontinuation from medical records and via telephone calls and investigated the factors influencing contact lens abandonment.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The median age of the 70 participants was 5.0 (interquartile range: 4.0–5.9) years. Further, 36 (51.4%) children stopped wearing contact lenses; among them, 17 (47.2%) stopped within 3 months, and the median duration of lens wearing was 4.0 (interquartile range: 1.0–11.5) months. Additionally, there was a correlation between the duration of lens wearing and lens abandonment (<i>r</i> = -0.698, <i>P</i> &lt; 0.001). A high parental education level (hazard ratio [HR] = 0.425; 95% confidence interval [CI] 0.198, 0.913; <i>P</i> = 0.028) was a protective factor against lens abandonment, while parental assessment indicating harder than expected practicality (HR = 4.062; 95% CI 1.204, 13.707; <i>P</i> = 0.024) was a risk factor for abandonment.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Children aged &lt; 6 years are susceptible to early discontinuation of RGPCL use. Since parents perform daily lens manipulation, they are crucial to the continuity of lens use in these children. To improve RGPCL use continuity, communication and supervision should be strengthened before and after RGPCL fittings.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypseudophakia: from “Piggyback” to supplementary sulcus-fixated IOLs","authors":"Ramin Khoramnia, Guenal Kahraman, Michael Amon, Grzegorz Łabuz, Isabella D. Baur, Gerd U. Auffarth","doi":"10.1007/s00417-024-06618-3","DOIUrl":"https://doi.org/10.1007/s00417-024-06618-3","url":null,"abstract":"&lt;h3 data-test=\"abstract-sub-heading\"&gt;Abstract&lt;/h3&gt;&lt;p&gt;Polypseudophakia, the concept of using a second intraocular lens (IOL) to supplement an IOL that has already been placed in the capsular bag, was first used as a corrective measure where the power requirement was higher than that of available single IOLs. Subsequently, the technique was modified to compensate for post-operative residual refractive errors. In these early cases, an IOL designed for the capsular bag would be implanted in the sulcus. Although these approaches were less than ideal, alternative means of correcting residual refractive errors were not without their limitations: IOL exchange can be traumatic to the eye and is not easily carried out once fibrosis has occurred, while corneal refractive surgical techniques are not suitable for all patients. Piggyback implantation was the term first coined to describe the use of two IOLs, placed together in the capsular bag. The term was later extended to include the procedure where an IOL designed for the capsular bag was placed in the sulcus. Unfortunately, the term piggyback has persisted even though these two approaches have been largely discredited. Intraocular lenses are now available which have been specifically designed for placement in the ciliary sulcus. As these newer IOLs avoid the many unacceptable complications brought about by both types of earlier piggyback implantation, it is time to employ a new terminology, such as supplementary IOL or secondary enhancement to distinguish between the placement of an unsuitable capsular bag IOL in the sulcus and the implantation of an IOL specifically designed for ciliary sulcus implantation. In addition to minimising possible complications, supplementary IOLs designed for the sulcus have expanded the options available to the ophthalmic surgeon. With these new IOLs it is possible to correct presbyopia and residual astigmatism, and to provide temporary correction of refractive errors in growing, or unstable, eyes. This article aims to review the literature available on supplementary IOL implantation in the ciliary sulcus and to summarise the evidence for the efficacy and safety of this intervention.&lt;/p&gt;&lt;h3 data-test=\"abstract-sub-heading\"&gt;Key messages&lt;/h3&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;What is known&lt;/i&gt;&lt;/b&gt;&lt;/p&gt;&lt;ul&gt;\u0000&lt;li&gt;\u0000&lt;p&gt;Polypseudophakia has been used for over 30 years to correct hyperopia or residual refractive error, but early techniques were associated with significant complications.&lt;/p&gt;\u0000&lt;/li&gt;\u0000&lt;/ul&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;What is new&lt;/i&gt;&lt;/b&gt;&lt;/p&gt;&lt;ul&gt;\u0000&lt;li&gt;\u0000&lt;p&gt;The development of specially designed sulcus-fixated supplementary IOLs significantly reduces the risks associated with these procedures, and has also opened up new opportunities in patient care.&lt;/p&gt;\u0000&lt;/li&gt;\u0000&lt;li&gt;\u0000&lt;p&gt;The reversibility of the procedure allows patients to experience multifocality, and to provide temporary and adjustable correction in unstable or growing eyes.&lt;/p&gt;\u0000&lt;/li&gt;\u0000&lt;li&gt;\u0000&lt;p&gt;The terms “secondary enhancement” or “DUET” to describe supplementary IOL implant","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for early and late retinal detachment after boston type I keratoprosthesis surgery","authors":"Eva Calpe, Jorge Fernández-Engroba, Gemma Julio, Josip Pavan, Clara Bonel, Rafael I. Barraquer","doi":"10.1007/s00417-024-06613-8","DOIUrl":"https://doi.org/10.1007/s00417-024-06613-8","url":null,"abstract":"&lt;h3 data-test=\"abstract-sub-heading\"&gt;Purpose&lt;/h3&gt;&lt;p&gt;To determine the differential risk factors for retinal detachment (RD) after Boston Type 1 Keratoprosthesis (B1KPro) during the first year after surgery (early RD; ERD) and afterwards (late RD; LRD).&lt;/p&gt;&lt;h3 data-test=\"abstract-sub-heading\"&gt;Methods&lt;/h3&gt;&lt;p&gt;Retrospective cohort study of 94 eyes (90 patients) undergoing B1KPro implantation at Centro de Oftalmología Barraquer from June 2006 to July 2022 with a minimum follow-up of one year.&lt;/p&gt;&lt;h3 data-test=\"abstract-sub-heading\"&gt;Results&lt;/h3&gt;&lt;p&gt;The incidence of RD in the whole sample after B1KPro implantation was 29% (27/94), occurring in 21% of eyes (ERD; 20/94) the first year, and in 7% afterwards (LRD; 7/94). Hypotony was revealed as a significant risk factor for ERD (16/19 = 84%; OR = 14.5, &lt;i&gt;P&lt;/i&gt; &lt; 0.0001), together with aphakia (16/20 = 80%; OR = 5.9, &lt;i&gt;P&lt;/i&gt; = 0.004), intraocular lens (IOL) removal (4/8 = 50%; OR = 6.2, &lt;i&gt;P&lt;/i&gt; = 0.03), previous choroidal detachment (CD; 7/20 = 35%; OR = 35.5, &lt;i&gt;P&lt;/i&gt; = 0.001) and previous pars plana vitrectomy (PPV; 15/20 = 75%; OR = 6.6, &lt;i&gt;P&lt;/i&gt; = 0.006). Multivariate analysis included hypotony and PPV &lt;i&gt;at any time&lt;/i&gt; as variables significantly associated with ERD occurrence. The occurrence of LRD was significantly related to peripheral retinal changes, detected few days before (4/6 = 66%; OR = 65, &lt;i&gt;P&lt;/i&gt; &lt; 0.0001).&lt;/p&gt;&lt;h3 data-test=\"abstract-sub-heading\"&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Hypotony emerged as one of the main factors influencing ERD occurrence after B1KPro implantation. Additionally, previous CD, PPV, aphakia, and IOL removal should be considered to estimate the risk of postoperative retinal detachment. In contrast, peripheral retinal changes after B1KPro seem to be significantly related to LRD occurrence. This study reinforces the need for frequent intraocular pressure evaluation, and comprehensive periodic retinal assessment over time.&lt;/p&gt;&lt;h3 data-test=\"abstract-sub-heading\"&gt;Key messages&lt;/h3&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;What is known&lt;/i&gt;&lt;/b&gt;&lt;/p&gt;\u0000&lt;ul&gt;\u0000&lt;li&gt;\u0000&lt;p&gt;Retinal detachment (RD) is a severe complication after Boston Type 1 Keratoprosthesis (B1KPro) implantation, resulting in a permanent reduction of visual acuity in a clinically relevant percentage of eyes.&lt;/p&gt;\u0000&lt;/li&gt;\u0000&lt;li&gt;\u0000&lt;p&gt;The time of RD occurrence after B1KPro implantation differs in the literature but is reported to be more common within the first year. Previous aphakia, choroidal detachment, or RD repair, intraocular lens removal, vitritis, or history of Nd-YAG laser have been described as risk factors for RD after B1KPro surgery in samples with varying follow-ups.&lt;/p&gt;\u0000&lt;/li&gt;\u0000&lt;/ul&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;What is new:&lt;/i&gt;&lt;/b&gt;&lt;/p&gt;\u0000&lt;ul&gt;\u0000&lt;li&gt;\u0000&lt;p&gt;Multivariate analysis in the first year after B1KPro surgery showed hypotony and pars plana vitrectomy &lt;i&gt;at any time&lt;/i&gt; as significant risk factors for early RD.&lt;/p&gt;\u0000&lt;/li&gt;\u0000&lt;li&gt;\u0000&lt;p&gt;Late RD cases, occurring after one year following the B1KPro surgery, seem to be significantly related to peripheral retinal changes suffered a few da","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: 170 years of data-mining: history and future.","authors":"Bernd Kirchhof","doi":"10.1007/s00417-024-06640-5","DOIUrl":"https://doi.org/10.1007/s00417-024-06640-5","url":null,"abstract":"","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between indocyanine green angiography and optical coherence tomography angiography for the detection of nonexudative macular neovascularization","authors":"Stefan Kickinger, Martin Stattin, Anna-Maria Haas, Daniel Ahmed-Balestra, Michael Jacob, Claus Zehetner, Katharina Krepler, Siamak Ansari-Shahrezaei","doi":"10.1007/s00417-024-06597-5","DOIUrl":"https://doi.org/10.1007/s00417-024-06597-5","url":null,"abstract":"<p>\u0000<b><i>What is known</i></b></p>\u0000<p> •The prevalence of nonexudative MNV (neMNV) in the opposite eyes of patients with unilateral exudative neovascular AMD (nAMD) ranges from 6 to 27%. The importance of screening and in consequence close monitoring of a detected neMNV is underlined by the 14 to 23-fold risk of conversion to exudative disease, which they carry within the first two years of follow up.</p>\u0000<p> •In the only study designed to compare the sensitivity of OCTA vs. ICGA, 3/41 eyes exhibited neMNV in both modalities and were therefore equally effective.</p>\u0000<p>\u0000<b><i>What is new</i></b></p>\u0000<p> •This study showed that in a larger study population of 241 patients the sensitivity of ICGA and OCTA were equal with 80% (32/40) and 83% (33/40), although some neMNV would be missed by solely employing one imaging method.</p>\u0000<p> •Accurate detection of neMNV using multimodal imaging should result in better monitoring of patients who are at high risk of conversion to exudative nAMD.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invivo generated autologous plasmin enzyme assisted vitrectomy, partial circumferential-oral retinotomy, silicone oil injection in patients with chronic retinal detachment without posterior vitreous detachment","authors":"Cengiz Aras, Fevzi Senturk, Sevil Karaman Erdur, Mahmut Dogramaci, Mehmet Selim Kocabora, Ali Demircan, Yunus Emre Budak","doi":"10.1007/s00417-024-06466-1","DOIUrl":"https://doi.org/10.1007/s00417-024-06466-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To report the results of invivo generated autologous plasmin enzyme(IVAP) assisted vitrectomy, partial circumferential-oral retinotomy and silicone oil injection for surgical treatment of patients with chronic retinal detachment without posterior vitreous detachment(PVD).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Study was performed in retrospective, comparative manner. A total of 16 consecutive eyes with chronic retinal detachment who had intravitreal injection of 50 µgr of t-PA and 0.1 ml of autologous whole blood, 3 days before surgery, underwent lens extraction with phacoemulsification, IVAP assisted vitrectomy, partial circumferential-oral retinotomy, and silicone oil injection(Study Group) were compared to a similar group of 15 eyes who had undergone vitrectomy, with or without lens extraction and silicone oil injection(Control Group) for the treatment of chronic retinal detachment. Primary outcome measures were initial retinal reattachment and number of operations at postoperative 6 months.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Mean age of 16 patients of whom 7 were female, was 39.31 ± 17.76 years in study group and 15 patients of whom 4 were female, was 35.40 ± 11.92 years (<i>p</i> = 0.607). Mean follow-up time was 10.68 ± 7.15 months in study group and 29.13 ± 18.83 months in control group (<i>p</i> = 0.001). Initial retinal reattachment was achieved in 87.50% (14 out of 16 patients) in the study group, whereas it was 46.66% (7 out of 15 patients) in the control group (<i>p</i> = 0.017). The mean number of operations for reattachment in the study group was 1.12 ± 0.34, whereas it was 1.46 ± 0.51 in the control group (<i>p</i> = 0.039) at postoperative 6 months While the preoperative LogMAR visual acuity was 1.25 ± 0.64, it was 0.53 ± 0.37 at postoperative 6 months in study group (<i>p</i> = 0.001). Conversely, in the control group, the preoperative LogMAR visual acuity was 1.22 ± 0.33, it was 1.20 ± 0.89 at postoperative 6 months (<i>p</i> = 0.780). At postoperative 6 months,, epiretinal membrane developed in 2 eyes of the study group, 1 eye in the control group, and phthisis bulbi occurred in 1 eye of control group.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>IVAP assisted vitrectomy, partial circumferential-oral retinotomy and silicone oil injection is effective and safe for the surgical treatment of chronic retinal detachment without PVD.</p>\u0000","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140610138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological findings of failed blebs after microinvasive bleb surgery with the XEN Gel Stent and Preserflo MicroShunt","authors":"Jonas Neubauer, Daniela Suesskind, Caroline J. Gassel, Emil Nasyrov, Bogomil Voykov","doi":"10.1007/s00417-024-06479-w","DOIUrl":"https://doi.org/10.1007/s00417-024-06479-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The success of XEN Gel Stent (XEN) and Preserflo MicroShunt (Preserflo) implantation depends mainly on the development of bleb fibrosis. This study aimed to describe the histological findings of bleb fibrosis after XEN and Preserflo surgery.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This retrospective study included patients with different types of glaucoma who underwent revision surgery after XEN or Preserflo implantation. The available clinical information and histological samples of removed fibrotic tissue were analyzed.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Thirty-six patients were included. Revision surgery was performed at a median of 195 (range = 31–1264) days after primary surgery. The mean intraocular pressure changed from 29.1 (± 10.3) mmHg at baseline to 18.3 (± 8.7) mmHg (− 37%; <i>p</i> &lt; 0.0001) and 16.2 (± 4.2) mmHg (− 45%; <i>p</i> &lt; 0.0001) after 6 and 12 months, respectively. Histological analysis revealed an increase in activated fibroblasts and macrophages in all specimens and a parallel orientation of fibroblasts in a minor part of the probe in 60% of the specimens. No pronounced inflammatory reaction in the form of lymphocytic or granulocytic infiltration was observed. The comparison of specimens from uveitic glaucoma and primary open-angle glaucoma patients revealed no significant differences.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The histological analysis of fibrotic blebs from the XEN and Preserflo implants did not show any pronounced immune or foreign-body reaction and revealed a similar histological pattern of failed blebs after trabeculectomy.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cycloplegia on crystalline lens morphology and location in acute acquired concomitant esotropia","authors":"Weibin Chen, Jiawen Liu, Wei Dai, Jie Hao, Jiayu Chen, Jing Fu","doi":"10.1007/s00417-024-06484-z","DOIUrl":"https://doi.org/10.1007/s00417-024-06484-z","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The study aims to compare morphology and location of crystalline lens between acute acquired concomitant esotropia (AACE) patients and control subjects, both before and after cycloplegia.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This is a prospective and observational clinical study. Morphological and locational parameters of the crystalline lens in 53 AACE patients and 32 control subjects were assessed before and after cycloplegia using CASIA2 system, which represents the latest swept-source anterior segment optical coherence tomography. Cycloplegic refraction was recorded by administering 1% atropine in patients younger than 12 years and 1% cyclopentolate in those &gt; 12 years old. Morphological parameters included anterior radius of curvature (ARC), posterior radius of curvature (PRC), lens thickness (LTH), and equivalent diameter of lens (LED). Locational parameters comprised lens decentration (LD) and lens tilt (LT). Comparison of these parameters before and after cycloplegia were conducted between AACE and controls. Additionally, the study analyzed and compared the changes in these parameter post-cycloplegia.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Our findings suggest no significant difference in morphological parameters including ARC, PRC, LTH and LED between AACE patients and controls before or after cycloplegia. However, 2D-modeling data in the 0° meridian revealed that variation post-cycloplegia of LD (lens shift) in right eyes was different in AACE patients, measuring − 0.03(0.08) [median(interquartile range)] which was significantly distinct from the control group, exhibiting a measurement of 0.01(0.06) (z = − 2.373, <i>p</i> = 0.018). In left eyes, a similar trend was observed with lens shift in the 0° meridian being 0.02(0.06) in AACE, significantly differing from control group's measurement of − 0.02(0.08) (z = − 2.809, <i>p</i> = 0.005). Further, correlation analysis revealed that larger temporal shift of lens was associated with greater changes in ARC (r = 0.294, <i>p</i> = 0.006) and LTH (r = − 0.230, <i>p</i> = 0.031).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The morphological features of the crystalline lens were similar in AACE patients and controls; however, the change of lens location by cycloplegia was observed only in AACE patients, suggesting an association with excessive accommodation.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of submacular hemorrhage at baseline on the long-term outcomes of aflibercept treatment for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy","authors":"Mio Morizane Hosokawa, Chihiro Ouchi, Yusuke Shiode, Shuhei Kimura, Ryo Matoba, Tetsuro Morita, Yuki Morizane","doi":"10.1007/s00417-024-06453-6","DOIUrl":"https://doi.org/10.1007/s00417-024-06453-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To investigate the influence of submacular hemorrhage (SMH) at baseline on long-term visual outcomes of patients with typical age-related macular degeneration (tAMD) and polypoidal choroidal vasculopathy (PCV) treated with intravitreal aflibercept (IVA).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>In this retrospective study, eyes of treatment-naïve patients with tAMD and PCV who initiated IVA under a treat-and-extend regimen and were followed up for ≥ 5 years were classified into the tAMD-SMH ( +), tAMD-SMH (-), PCV-SMH ( +), and PCV-SMH (-) groups based on the presence of SMH at baseline. Best-corrected visual acuity (BCVA) changes and macular fibrosis and atrophy incidences were assessed.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>This study included 127 eyes (127 patients), including 51 with tAMD and 76 with PCV; 18 eyes had SMH at baseline. In the tAMD-SMH ( +) group (<i>n</i> = 6), the mean logMAR BCVA significantly deteriorated from 0.59 ± 0.45 at baseline to 0.88 ± 0.47 at the final visit (<i>P</i> = 0.024). No significant BCVA changes were observed in the tAMD-SMH (-) (<i>n</i> = 45), PCV-SMH ( +) (<i>n</i> = 12), or PCV-SMH (-) (<i>n</i> = 64) groups (all <i>P</i> &gt; 0.05). The tAMD-SMH ( +) group showed a significantly higher incidence of macular fibrosis at the final visit than did the tAMD-SMH (-) group (<i>P</i> = 0.042). There was no influence of baseline SMH on the macular fibrosis incidence in eyes with PCV and the macular atrophy incidence in eyes with tAMD and PCV.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The presence of SMH at baseline resulted in poorer long-term visual acuity in eyes with tAMD, even with aflibercept treatment. However, no such influence was observed in eyes with PCV.</p>\u0000","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}