GOUT AND NUCLEIC ACID METABOLISM最新文献

{"title":"ガイドライン作成委員一覧","authors":"","doi":"10.6032/gnam.42.suppl-5","DOIUrl":"https://doi.org/10.6032/gnam.42.suppl-5","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87925538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of“ Clinical Practice Guideline for Renal Hypouricemia” (1st edition)","authors":"A. Nakayama, H. Matsuo, A. Ohtahara, K. Ogino, M. Hakoda, T. Hamada, M. Hosoyamada, Satoshi Yamaguchi, I. Hisatome, K. Ichida, N. Shinomiya","doi":"10.6032/GNAM.42.1","DOIUrl":"https://doi.org/10.6032/GNAM.42.1","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87495293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPRT1欠損症9例の遺伝子解析","authors":"Hikota Osawa, Atsuo Taniguchi, C. Sekita, H. Kaneko, Naomi Ichikawa, Y. Seto, H. Yamanaka, Yasukazu Yamada","doi":"10.6032/gnam.42.123","DOIUrl":"https://doi.org/10.6032/gnam.42.123","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87633673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"職域健診受診者約5万人における低尿酸血症−年齢, レベル別頻度−","authors":"Hiroshi Shio","doi":"10.6032/GNAM.42.139","DOIUrl":"https://doi.org/10.6032/GNAM.42.139","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84251065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"エネルギー代謝から見たXOR（XDH/XO）の臓器間局在性とプリンサルベージ回路の重要性についての仮説","authors":"Takeshi Nishino, M. Hosoyamada, N. Kamatani","doi":"10.6032/GNAM.42.99","DOIUrl":"https://doi.org/10.6032/GNAM.42.99","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83944474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"初回痛風発作を起こした母趾MTP関節における単純X線撮影と関節超音波検査所見の検討","authors":"T. Morito","doi":"10.6032/gnam.42.68","DOIUrl":"https://doi.org/10.6032/gnam.42.68","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82946880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"第52回日本痛風・核酸代謝学会総会ご案内","authors":"","doi":"10.6032/gnam.42.info_1_1","DOIUrl":"https://doi.org/10.6032/gnam.42.info_1_1","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89216888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"小児ウイルス腸炎における高尿酸血症―尿酸排泄動態からの検討―","authors":"Atsushi Hayashi, A. Ohtahara, E. Mizuta","doi":"10.6032/gnam.42.127","DOIUrl":"https://doi.org/10.6032/gnam.42.127","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85419727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"腎性低尿酸血症の合併症（尿路結石症）","authors":"","doi":"10.6032/gnam.42.suppl-39","DOIUrl":"https://doi.org/10.6032/gnam.42.suppl-39","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"289 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79542537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yogurt containing Lactobacillus gasseri PA-3 alleviates increases in serum uric acid concentration induced by purine ingestion: a randomized, double-blind, placebo-controlled study","authors":"Masafumi Kurajoh, Y. Moriwaki, H. Koyama, H. Tsuboi, H. Matsuda, Yamada Naruomi, C. Saito, H. Kano, Y. Asami, Tetsuya Yamamoto","doi":"10.6032/GNAM.42.31","DOIUrl":"https://doi.org/10.6032/GNAM.42.31","url":null,"abstract":"Objective: Ingestion of yogurt containing Lactobacillus gasseri PA-3(PA-3, Accession No : NITE BP-224) (PA-3Y)has been shown to reduce serum uric acid(SUA)levels by interfering with the intestinal absorption of food-derived purines in animal studies. To confirm this mechanism in humans, the ability of PA-3 intake to alleviate purine ingestion-induced increases in SUA levels was analyzed. Research Methods and Procedures: In this randomized, double-blind, placebo-controlled crossover study, 16 healthy adults were randomized to groups ingesting of 112 g of PA-3Y or yogurt without PA-3(control yogurt)in addition to standardized meals for 3 days. Purine-loading tests, in which subjects ingested 112 g of PA-3Y or control yogurt followed immediately by 498 mg of a mixture of purine nucleotides, were performed on the fourth day of each test period. Blood and urine samples were collected before and after the purine-loading tests. Results : The increase in the SUA concentration from the baseline was significantly lower following the ingestion of PA-3Y than of control yogurt alone, especially at 30(P=0.033)and 60(P=0.028)minutes. In addition, the area under the curve for the increase in the SUA concentration from the baseline to 150 minutes was also significantly lower (P=0.041)in the PA-3Y than in the control yogurt group. However, urinary and fractional excretions of uric acid were not different between the two groups. Conclusion : The ingestion of PA-3 before purine intake alleviates the increase in SUA levels, probably by reducing purine absorption in the intestine, and not by enhancing urinary excretion of uric acid. Introduction Hyperuricemia is defined as a serum uric acid (SUA)concentration over 7.0 mg dL1. Persistent hyperuricemia can lead to the deposition of urate crystals in the joints and kidneys, resulting in acute arthritis or kidney injury such as nephrolithiasis and nephropathy13). Hyperuricemia has also been associated Masafumi Kurajoh1, 2) Yuji Moriwaki1) Hidenori Koyama1) Hiroshi Tsuboi3) Hirotaka Matsuda3) Naruomi Yamada3) Chizuru Saito3) Hiroshi Kano3) Yukio Asami3) Tetsuya Yamamoto1) Yogurt containing Lactobacillus gasseri PA-3 alleviates increases in serum uric acid concentration induced by purine ingestion: a randomized, double-blind, placebo-controlled study 受付:2017年11月10日,受理:2018年3月2日 1) Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine 2) Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine 3) Food Science Research Laboratories, Meiji Co., LTD.","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89534491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}