发布求助
文献互助 智能选刊 最新文献

Gastrointestinal cancer research : GCR最新文献

筛选
英文 中文
A Possible Role for TNF-α in Coordinating Inflammation and Angiogenesis in Chronic Liver Disease and Hepatocellular Carcinoma. TNF-α 在慢性肝病和肝细胞癌中协调炎症和血管生成的可能作用
Gastrointestinal cancer research : GCR Pub Date : 2013-07-01
Olfat Hammam, Ola Mahmoud, Manal Zahran, Azza Sayed, Rabab Salama, Karim Hosny, Ahmed Farghly
{"title":"A Possible Role for TNF-α in Coordinating Inflammation and Angiogenesis in Chronic Liver Disease and Hepatocellular Carcinoma.","authors":"Olfat Hammam, Ola Mahmoud, Manal Zahran, Azza Sayed, Rabab Salama, Karim Hosny, Ahmed Farghly","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Increasing evidence supports the hypothesis that chronic and persistent inflammation contributes to cancer development. However, the molecular mechanisms that lead to cancer in chronic inflammation and the role of angiogenesis in inflammation-associated cancer remain poorly understood.</p><p><strong>Methods: </strong>NINETY PATIENTS WERE ENROLLED: 30 cases of CHC without cirrhosis, 28 cases of CHC with liver cirrhosis, and 32 cases of HCC and hepatitis C virus infection. Ten wedge liver biopsies, taken during laparoscopic cholecystectomy, served as normal controls. Serum TNF-α levels were measured using the ELISA technique; in situ hybridization and immunohistochemical studies were used to detect hepatic levels of messenger RNA (mRNA) transcripts and mature protein, respectively, for both TNF-α and VEGF.</p><p><strong>Results: </strong>The highest hepatic expression of TNF-α was noticed in liver cirrhosis specimens compared to noncirrhotic CHC and HCC. Hepatic expression of VEGF and serum level of TNF-α revealed significant increases in the progression of the disease. Moreover, cases with higher grades of inflammation or stages of fibrosis showed significant increases in serum TNF-α and expression of TNF-α and VEGF. Expression of mRNA of both TNF-α and VEGF shows increasing expression with positive correlation to progression of viral hepatitis to cirrhosis with more positivity in cases developed HCC.</p><p><strong>Conclusions: </strong>VEGF signaling could be one of the molecular signaling pathways involved in TNF-α induced angiogenesis which might pose an important link between inflammation and fibrosis in CHC and HCC development and progression. Moreover, serum inflammatory biomarkers can be used to monitor the disease progression.</p>","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 4","pages":"107-14"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782877/pdf/gcr107.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40256909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upcoming articles. 即将到来的文章。
Gastrointestinal cancer research : GCR Pub Date : 2013-07-01
{"title":"Upcoming articles.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 4","pages":"128"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782875/pdf/gcr128.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40256912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful retreatment with chemoradiotherapy for local recurrence of pancreatic adenocarcinoma after neoadjuvant therapy and pancreaticoduodenectomy. 胰腺癌新辅助治疗及胰十二指肠切除术后局部复发的放化疗成功。
Gastrointestinal cancer research : GCR Pub Date : 2013-07-01
Minda A Gowarty, Bassem I Zaki, Michael J Tsapakos, Stuart R Gordon, Arief A Suriawinata, Gregory J Tsongalis, John E Sutton, J Marc Pipas
{"title":"Successful retreatment with chemoradiotherapy for local recurrence of pancreatic adenocarcinoma after neoadjuvant therapy and pancreaticoduodenectomy.","authors":"Minda A Gowarty,&nbsp;Bassem I Zaki,&nbsp;Michael J Tsapakos,&nbsp;Stuart R Gordon,&nbsp;Arief A Suriawinata,&nbsp;Gregory J Tsongalis,&nbsp;John E Sutton,&nbsp;J Marc Pipas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 4","pages":"118-9"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782873/pdf/gcr118.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40256911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and outcomes of adenosquamous carcinoma of the pancreas. 胰腺腺鳞癌的特点和预后。
Gastrointestinal cancer research : GCR Pub Date : 2013-05-01
Christine G Simone, Tania Zuluaga Toro, Ellie Chan, Michael M Feely, Jose G Trevino, Thomas J George
{"title":"Characteristics and outcomes of adenosquamous carcinoma of the pancreas.","authors":"Christine G Simone,&nbsp;Tania Zuluaga Toro,&nbsp;Ellie Chan,&nbsp;Michael M Feely,&nbsp;Jose G Trevino,&nbsp;Thomas J George","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Adenosquamous carcinoma of the pancreas (ASCAP) is a rare histologic type of pancreatic carcinoma that constitutes 1% to 4% of all pancreatic exocrine malignancies. It has a clinical presentation similar to that of adenocarcinoma of the pancreas (ACP), but may have a worse overall prognosis, with most patients surviving for less than 2 years.</p><p><strong>Methods: </strong>This was an institutional, retrospective, cohort analysis of 237 patients who underwent resection of pancreatic cancer with curative intent.</p><p><strong>Results: </strong>Of the 237 cases examined, we identified 7 (2.9%) with histologically confirmed ASCAP. Demographics, comorbidities, risk factors, presenting symptoms, survival data, tumor characteristics, and types of treatment for each patient were included in the analysis. Risk factors for development of ASCAP were not conclusive. Although human papilloma virus (HPV) has been implicated in other squamous cell cancers, in our cohort, its involvement in ASCAP was 0%. Presurgical fine-needle aspiration failed to identify the invasive squamous cell component in all cases. In this cohort analysis, overall survival ranged from 3 to 25 months, with 2 patients surviving more than 20 months after surgical resection. With a median follow-up of 2.9 years, our data demonstrate a trend to worse median overall survival for ASCAP than for ACP (8.2 vs. 20.4 months; P = .23), with a limited number of long-term survivors.</p><p><strong>Conclusions: </strong>Although recommended, adjuvant treatment was inconsistently provided for patients in this ASCAP cohort. Published data show variability in overall survival, but our findings support that surgical resection is one of the few options for control of this rare, poorly understood pancreatic malignancy. Further research is necessary to define risk factors and adjuvant and neoadjuvant treatments, to help improve patient outcomes.</p>","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 3","pages":"75-9"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737509/pdf/gcr75.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 40-year-old woman with locally advanced rectal cancer and a solitary liver metastasis. 一名40岁女性患有局部晚期直肠癌和单发肝转移。
Gastrointestinal cancer research : GCR Pub Date : 2013-05-01
Carla Hajj, Karyn Goodman, David Kelsen, Jinru Shia, Ali Shamseddine, Mohamed Naghy, Mustafa Sidani, Mohamed Eloubeidi, Fady Merhi, Fady Geara, Celina Ang, Leonard Saltz, Ghassan K Abou-Alfa
{"title":"A 40-year-old woman with locally advanced rectal cancer and a solitary liver metastasis.","authors":"Carla Hajj,&nbsp;Karyn Goodman,&nbsp;David Kelsen,&nbsp;Jinru Shia,&nbsp;Ali Shamseddine,&nbsp;Mohamed Naghy,&nbsp;Mustafa Sidani,&nbsp;Mohamed Eloubeidi,&nbsp;Fady Merhi,&nbsp;Fady Geara,&nbsp;Celina Ang,&nbsp;Leonard Saltz,&nbsp;Ghassan K Abou-Alfa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 3","pages":"87-9"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737511/pdf/gcr87.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An extremely rare case of pancreatic cancer presenting with leptomeningeal carcinomatosis and synchronous intraparenchymal brain metastasis. 摘要一例极为罕见的胰脏癌，表现为脑膜轻脑膜癌及脑实质内同步转移。
Gastrointestinal cancer research : GCR Pub Date : 2013-05-01
Rohit Rao, Santhosh K Sadashiv, Swapna Goday, Dulabh Monga
{"title":"An extremely rare case of pancreatic cancer presenting with leptomeningeal carcinomatosis and synchronous intraparenchymal brain metastasis.","authors":"Rohit Rao,&nbsp;Santhosh K Sadashiv,&nbsp;Swapna Goday,&nbsp;Dulabh Monga","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 3","pages":"90-2"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737512/pdf/gcr90.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent racial disparities in survival among u.s. Adults with hepatocellular carcinoma after liver transplantation: the paradox of all-cause and cause-specific mortality. 美国成年肝细胞癌患者肝移植后生存的持续种族差异:全因死亡率和病因特异性死亡率的悖论。
Gastrointestinal cancer research : GCR Pub Date : 2013-05-01
Basile Njei, Ivo Ditah, Joseph K Lim
{"title":"Persistent racial disparities in survival among u.s. Adults with hepatocellular carcinoma after liver transplantation: the paradox of all-cause and cause-specific mortality.","authors":"Basile Njei,&nbsp;Ivo Ditah,&nbsp;Joseph K Lim","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 3","pages":"73-4"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737508/pdf/gcr73.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Above-Label Doses of Octreotide-LAR in Patients With Metastatic Small Intestinal Carcinoid Tumors. 奥曲肽- lar在转移性小肠类癌患者中的应用
Gastrointestinal cancer research : GCR Pub Date : 2013-05-01
Jonathan Strosberg, Jill Weber, Max Feldman, Jamie Goldman, Khaldoun Almhanna, Larry Kvols
{"title":"Above-Label Doses of Octreotide-LAR in Patients With Metastatic Small Intestinal Carcinoid Tumors.","authors":"Jonathan Strosberg,&nbsp;Jill Weber,&nbsp;Max Feldman,&nbsp;Jamie Goldman,&nbsp;Khaldoun Almhanna,&nbsp;Larry Kvols","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Octreotide LAR is indicated for treatment of malignant carcinoid syndrome and has been studied at doses of 10 to 30 mg intramuscularly every 4 weeks. In clinical practice, higher doses are often prescribed for patients who experience refractory carcinoid syndrome (flushing and/or diarrhea) or tumor growth while on the maximum label-recommended dose.</p><p><strong>Methods: </strong>We performed a retrospective, longitudinal review of octreotide LAR administration at a tertiary institution to determine the frequency of above-label dosing and outcomes.</p><p><strong>Results: </strong>Three hundred thirty-eight patients were considered evaluable, among whom 100 (30%) underwent at least 1 increase in dose or frequency of octreotide-LAR above the standard label dose. The most common maximum doses were 40 mg every 4 weeks (n = 37 patients), 60 mg every 4 weeks (n = 34), and 30 mg every 3 weeks (n = 18). The indications for dose increase were worsening carcinoid syndrome (n = 60), radiographic progression (n = 33), and rising urine 5-HIAA (n = 6). Of the patients whose doses were increased for refractory carcinoid syndrome, 62% (n = 34) experienced improvement in diarrhea, and 56% (n = 28) experienced improvement in flushing.</p><p><strong>Conclusions: </strong>In conclusion, octreotide LAR is commonly prescribed in doses or schedules above the recommended dose and frequency. Patients with refractory carcinoid syndrome appear to experience a clinical benefit from this change. Prospective data may be used to further evaluate this strategy.</p>","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 3","pages":"81-5"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737510/pdf/gcr81.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upcoming articles. 即将到来的文章。
Gastrointestinal cancer research : GCR Pub Date : 2013-05-01
{"title":"Upcoming articles.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 3","pages":"100"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737507/pdf/gcr100.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal chemotherapy dosing in a bilateral lower extremities amputee with metastatic pancreatic adenocarcinoma. 转移性胰腺腺癌双侧下肢截肢患者的最佳化疗剂量。
Gastrointestinal cancer research : GCR Pub Date : 2013-05-01
Dwight Owen, Eileen M O'Reilly, Celina Ang, Jennifer Ma, Richard K G Do, Ghassan K Abou-Alfa
{"title":"Optimal chemotherapy dosing in a bilateral lower extremities amputee with metastatic pancreatic adenocarcinoma.","authors":"Dwight Owen,&nbsp;Eileen M O'Reilly,&nbsp;Celina Ang,&nbsp;Jennifer Ma,&nbsp;Richard K G Do,&nbsp;Ghassan K Abou-Alfa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12695,"journal":{"name":"Gastrointestinal cancer research : GCR","volume":"6 3","pages":"93-4"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737513/pdf/gcr93.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信