Future Journal of Pharmaceuticals and Health Sciences最新文献_第2页

Unveiling the Secrets of Bougainvillea: A Review of Phytochemical and Pharmacological Properties 揭开九重葛的秘密：植物化学和药理特性综述

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-03-07 DOI: 10.26452/fjphs.v4i1.586

Nagashubha Bobbarjang, Uma Maheshwara Rao V, Iswarya S, Karishma Pn, Mythri G, Tariq Ahmad Khari, M. Gs, Charitha B, Kiran Sai Maccha

{"title":"Unveiling the Secrets of Bougainvillea: A Review of Phytochemical and Pharmacological Properties","authors":"Nagashubha Bobbarjang, Uma Maheshwara Rao V, Iswarya S, Karishma Pn, Mythri G, Tariq Ahmad Khari, M. Gs, Charitha B, Kiran Sai Maccha","doi":"10.26452/fjphs.v4i1.586","DOIUrl":"https://doi.org/10.26452/fjphs.v4i1.586","url":null,"abstract":"This review dives into the fascinating world of Bougainvillea, exploring its chemical makeup and potential health benefits. While research encompasses 18 species, most studies (phytochemical, pharmacological, and toxicological) have focused on just four species and their cultivars, along with one hybrid. Interestingly, some Bougainvillea species already have a history of use in traditional medicine. Scientific investigations have confirmed the presence of diverse chemical compounds within Bougainvillea, including aliphatic hydrocarbons, fatty acids, volatile oils, phenolics, flavonoids, and terpenes. These studies suggest that not only the extracts but also isolated active components from Bougainvillea exhibit a wide range of pharmacological activities. This exciting potential pave the way for further exploration of Bougainvillea as a source of valuable therapeutic compounds. To unlock the full potential of Bougainvillea, future research should delve deeper into the phytochemical, pharmacological, and toxicological properties of all species, cultivars, and hybrids. Understanding mechanisms of action, safety, and efficacy is crucial for responsible development of any potential medications derived from this beautiful and promising genus.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin hydrochloride: The most prescribed treatment for type II diabetes -gets banned 盐酸二甲双胍：二甲双胍：治疗 II 型糖尿病的最常用处方药 - 被禁用

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-03-07 DOI: 10.26452/fjphs.v4i1.585

Joan Vijetha R, Kaviyarasan K, Annie Bhuvana Mary A, Gopinath N, Sam Daniel J, Vasanth B

引用次数: 0

Screening of important factors using factorial design to predict simvastatin loaded solid lipid nanoparticles 利用因子设计筛选重要因素，预测辛伐他汀负载固体脂质纳米粒

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-02-09 DOI: 10.26452/fjphs.v4i1.581

Bhaskar Reddy Kesavan, Audinarayana Nelavala, Soujanya G S

{"title":"Screening of important factors using factorial design to predict simvastatin loaded solid lipid nanoparticles","authors":"Bhaskar Reddy Kesavan, Audinarayana Nelavala, Soujanya G S","doi":"10.26452/fjphs.v4i1.581","DOIUrl":"https://doi.org/10.26452/fjphs.v4i1.581","url":null,"abstract":"This study aims to optimize Simvastatin-loaded Solid Lipid Nanoparticles (SLNs) using a 2^k factorial design approach. Simvastatin, a widely used cholesterol-lowering drug, faces bioavailability challenges, prompting the use of nanotechnology for drug delivery. The study focuses on lipid concentration, surfactant concentration, and homogenization speed as critical factors influencing SLN characteristics. These factors were chosen based on their potential impact on SLN physicochemical properties like particle size, polydispersity index, and drug entrapment efficiency. Through systematic variation of factor levels, a matrix of experiments will be created, measuring responses (particle size, polydispersity index, and drug entrapment efficiency) for each run. Statistical analysis, including ANOVA, will assess factor significance and interactions. The study aims to reveal critical parameters affecting Simvastatin-loaded SLN formulation. The optimized formulation targets uniform and stable nanoparticles with enhanced drug entrapment, enhancing Simvastatin bioavailability. The factorial design method offers a systematic, resource-efficient approach for simultaneously screening and optimizing multiple factors, streamlining the experimental process.Top of Form","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"392 7-8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening of important factors using factorial design to predict simvastatin loaded solid lipid nanoparticles 利用因子设计筛选重要因素，预测辛伐他汀负载固体脂质纳米粒

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-02-09 DOI: 10.26452/fjphs.v4i1.581

Bhaskar Reddy Kesavan, Audinarayana Nelavala, Soujanya G S

{"title":"Screening of important factors using factorial design to predict simvastatin loaded solid lipid nanoparticles","authors":"Bhaskar Reddy Kesavan, Audinarayana Nelavala, Soujanya G S","doi":"10.26452/fjphs.v4i1.581","DOIUrl":"https://doi.org/10.26452/fjphs.v4i1.581","url":null,"abstract":"This study aims to optimize Simvastatin-loaded Solid Lipid Nanoparticles (SLNs) using a 2^k factorial design approach. Simvastatin, a widely used cholesterol-lowering drug, faces bioavailability challenges, prompting the use of nanotechnology for drug delivery. The study focuses on lipid concentration, surfactant concentration, and homogenization speed as critical factors influencing SLN characteristics. These factors were chosen based on their potential impact on SLN physicochemical properties like particle size, polydispersity index, and drug entrapment efficiency. Through systematic variation of factor levels, a matrix of experiments will be created, measuring responses (particle size, polydispersity index, and drug entrapment efficiency) for each run. Statistical analysis, including ANOVA, will assess factor significance and interactions. The study aims to reveal critical parameters affecting Simvastatin-loaded SLN formulation. The optimized formulation targets uniform and stable nanoparticles with enhanced drug entrapment, enhancing Simvastatin bioavailability. The factorial design method offers a systematic, resource-efficient approach for simultaneously screening and optimizing multiple factors, streamlining the experimental process.Top of Form","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":" 55","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139788218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation, Evaluation and Characterization of Hydrochlorothiazide Niosomes 氢氯噻嗪 Niosomes 的配制、评估和表征

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-02-01 DOI: 10.26452/fjphs.v4i1.566

Ameer Pasha Shaik, Vinod Naidu

{"title":"Formulation, Evaluation and Characterization of Hydrochlorothiazide Niosomes","authors":"Ameer Pasha Shaik, Vinod Naidu","doi":"10.26452/fjphs.v4i1.566","DOIUrl":"https://doi.org/10.26452/fjphs.v4i1.566","url":null,"abstract":"One of the many different carriers for getting a drug molecule to its site of action is a niosome, also known as a nonionic surfactant vesicle. Hydrophilic and hydrophobic medicines can both be trapped by them. The primary purpose of the medication hydrochlorothiazide, an angiotensin II type 1 receptor (AT1) antagonist, is to treat high blood pressure. Using cholesterol and nonionic surfactants (span 60) at varying concentrations, niosomes containing hydrochlorothiazide were created by the thin film hydration method. FTIR investigations, in vitro release studies, vesicular diameter, drug content, repeatability, shape and size distribution microphotography, and entrapment efficiency were all assessed for each niosome formulation.According to the findings, entrapment efficiency rises with surfactant concentration in all developed niosomal formulations. Low SD was found for the drug content, which ranged from 90.060.57 to 96.150.42. It was discovered that niosomes ranged in size from 0.280±0.098µm to 0.299±0.044µm and had a spherical shape. The medicine and formulation additives did not interact, according to the IR spectral analysis. Membrane diffusion cells were used to study the in vitro dissolution parameters. The findings indicate that formulation F6 exhibits a more controlled release action compared to the other formulation, with a 'n' value of 0.917, indicating that zero order kinetics were used to release the medication.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"248 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139819219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation, Evaluation and Characterization of Hydrochlorothiazide Niosomes 氢氯噻嗪 Niosomes 的配制、评估和表征

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-02-01 DOI: 10.26452/fjphs.v4i1.566

Ameer Pasha Shaik, Vinod Naidu

{"title":"Formulation, Evaluation and Characterization of Hydrochlorothiazide Niosomes","authors":"Ameer Pasha Shaik, Vinod Naidu","doi":"10.26452/fjphs.v4i1.566","DOIUrl":"https://doi.org/10.26452/fjphs.v4i1.566","url":null,"abstract":"One of the many different carriers for getting a drug molecule to its site of action is a niosome, also known as a nonionic surfactant vesicle. Hydrophilic and hydrophobic medicines can both be trapped by them. The primary purpose of the medication hydrochlorothiazide, an angiotensin II type 1 receptor (AT1) antagonist, is to treat high blood pressure. Using cholesterol and nonionic surfactants (span 60) at varying concentrations, niosomes containing hydrochlorothiazide were created by the thin film hydration method. FTIR investigations, in vitro release studies, vesicular diameter, drug content, repeatability, shape and size distribution microphotography, and entrapment efficiency were all assessed for each niosome formulation.According to the findings, entrapment efficiency rises with surfactant concentration in all developed niosomal formulations. Low SD was found for the drug content, which ranged from 90.060.57 to 96.150.42. It was discovered that niosomes ranged in size from 0.280±0.098µm to 0.299±0.044µm and had a spherical shape. The medicine and formulation additives did not interact, according to the IR spectral analysis. Membrane diffusion cells were used to study the in vitro dissolution parameters. The findings indicate that formulation F6 exhibits a more controlled release action compared to the other formulation, with a 'n' value of 0.917, indicating that zero order kinetics were used to release the medication.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139879364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An expatiate review on adjuvant chemotherapy of colorectal cancer 大肠癌辅助化疗综述

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-02-01 DOI: 10.26452/fjphs.v4i1.567

Shahireen Shahireen, Vipplavi Eka, Kavya Rachamsetty, Dhachinamoorthi Duraiswamy, Rama Chandra Reddy L

引用次数: 0

Formulation and characterization: Metoprolol succinate controlled release matrix tablets 配方和特征：琥珀酸美托洛尔控释基质片剂

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-02-01 DOI: 10.26452/fjphs.v4i1.568

Alagusundaram M, Priyanka Keshri, Pratibha Sharma, Nem Kumar Jain, China Babu Dara

引用次数: 0

Formulation and characterization: Metoprolol succinate controlled release matrix tablets 配方和特征：琥珀酸美托洛尔控释基质片剂

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-02-01 DOI: 10.26452/fjphs.v4i1.568

Alagusundaram M, Priyanka Keshri, Pratibha Sharma, Nem Kumar Jain, China Babu Dara

引用次数: 0

An expatiate review on adjuvant chemotherapy of colorectal cancer 大肠癌辅助化疗综述

Future Journal of Pharmaceuticals and Health Sciences Pub Date : 2024-02-01 DOI: 10.26452/fjphs.v4i1.567

Shahireen Shahireen, Vipplavi Eka, Kavya Rachamsetty, Dhachinamoorthi Duraiswamy, Rama Chandra Reddy L

引用次数: 0