Frontiers in Medical Technology最新文献

{"title":"Recent technologies in cardiac imaging.","authors":"Quinn Counseller, Yasser Aboelkassem","doi":"10.3389/fmedt.2022.984492","DOIUrl":"10.3389/fmedt.2022.984492","url":null,"abstract":"<p><p>Cardiac imaging allows physicians to view the structure and function of the heart to detect various heart abnormalities, ranging from inefficiencies in contraction, regulation of volumetric input and output of blood, deficits in valve function and structure, accumulation of plaque in arteries, and more. Commonly used cardiovascular imaging techniques include x-ray, computed tomography (CT), magnetic resonance imaging (MRI), echocardiogram, and positron emission tomography (PET)/single-photon emission computed tomography (SPECT). More recently, even more tools are at our disposal for investigating the heart's physiology, performance, structure, and function due to technological advancements. This review study summarizes cardiac imaging techniques with a particular interest in MRI and CT, noting each tool's origin, benefits, downfalls, clinical application, and advancement of cardiac imaging in the near future.</p>","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"4 ","pages":"984492"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10632840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative survey study of the use of a low cost exoscope vs. microscope for anterior cervical discectomy and fusion (ACDF).","authors":"Manuel Encarnacion Ramirez, Ismael Peralta Baez, Renat Nurmukhametov, Efgeni Goncharov, Ibrahim E Efe, Albert Sufianov, Issael Ramirez Pena","doi":"10.3389/fmedt.2022.1055189","DOIUrl":"10.3389/fmedt.2022.1055189","url":null,"abstract":"<p><strong>Background: </strong>Anterior cervical discectomy and fusion (ACDF) is an often performed procedure in spine neurosurgery. These are often performed using an operating microscope (OM) for better illumination and visualization. But its use is limited to the surgeon and the assistant. There is difficulty in maneuvering long surgical instruments due to the limited space available. Exoscope (EX) has been used as an alternative to microscopes and endoscopes. We used an EX in patients undergoing ACDF for cervical spondylotic myelopathy.</p><p><strong>Methods: </strong>A prospective comparative trial was conducted to test the safety and usability of a low-cost EX compared to a conventional surgical binocular OM in ACDF. Twenty-six patients with degenerative cervical myelopathy symptoms were operated by ACDF assisted by the EX and OM between December 2021 and June 2022. The authors collected and compared data on operative time, intraoperative hemorrhage, hospital admission, and complications in the two groups.</p><p><strong>Results: </strong>There were no statistically significant differences between the two groups in mean operative time, hospital stay, or postoperative complications. The average intraoperative blood loss was significantly more in the OM group. There were no surgical complications related to the use of the EX or OM. The comfort level, preoperative setup and intraoperative adjustment of position and angle of the EX were rated higher than the OM group. The image quality, depth perception, and illumination were rated as inferior to that of the OM. The low-cost EX was rated to be superior to that of the OM with regard to education and training purposes.</p><p><strong>Conclusion: </strong>Our study showed that the low-cost EX appears to be a safe and effective alternative for OM-assisted ACDF with great comfort and ergonomics and serves as an essential tool for education and training purposes. However, some limitations of our EX included slightly inferior image quality and illumination when compared with the OM.</p>","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"4 ","pages":"1055189"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9158954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the radio electric asymmetric conveyer (REAC) on motor disorders: An integrative review.","authors":"Vinícius Gomes Machado,&nbsp;Ana Beatriz Sorgenfrei Brun,&nbsp;Elisangela Ferretti Manffra","doi":"10.3389/fmedt.2023.1122245","DOIUrl":"https://doi.org/10.3389/fmedt.2023.1122245","url":null,"abstract":"<p><strong>Introduction: </strong>The radio electric asymmetric conveyer (REAC) is a technology that has the purpose of restoring the cellular polarity triggering the rebalancing of the endogenous bioelectric field, which considering the neurological dysfunctions, affects the neural communication mechanisms. The studies published so far show that the REAC neuromodulation technology has positive effects in treating these dysfunctions, with the principles of endogenous bioelectricity as a basis to achieve these effects.</p><p><strong>Objectives: </strong>This study aims to review the literature that explored the effects of REAC protocols on motor control and to identify which mechanisms would be involved.</p><p><strong>Materials and methods: </strong>This integrative review considered studies that used REAC as a therapeutic intervention directed at human motor control and experimental research with animals that applied REAC to obtain effects related to motor behavior.</p><p><strong>Results: </strong>Ten articles were included, eight clinical and two experimental studies. The clinical studies used the neuro postural optimization (NPO) protocol in 473 patients, of which 53 were healthy subjects, 91 were Alzheimer's disease patients, 128 were patients with atypical swallowing, 12 subjects with neurological diseases, and 189 were without the specification of disease. The experimental studies used the antalgic neuromodulation and neurodegeneration protocols in animal models.</p><p><strong>Conclusion: </strong>The information integrated in this review made it possible to consider REAC technology a promising resource for treating motor control dysfunctions. It is possible to infer that the technology promotes functional optimization of neuronal circuits that may be related to more efficient strategies to perform motor tasks.</p>","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"5 ","pages":"1122245"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9122051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Where to from here: Advancing patient and public involvement in health technology assessment (HTA) following the COVID-19 pandemic.","authors":"Janet L Wale,&nbsp;Marie-Pascale Pomey","doi":"10.3389/fmedt.2023.1168278","DOIUrl":"https://doi.org/10.3389/fmedt.2023.1168278","url":null,"abstract":"COPYRIGHT © 2023 Wale and Pomey. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"5 ","pages":"1168278"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9197253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: New trends in biomimetic tissue and organ modelling.","authors":"Camilla Luni,&nbsp;Anna Urciuolo,&nbsp;Jeremy Micah Crook,&nbsp;Carmine Gentile","doi":"10.3389/fmedt.2023.1182828","DOIUrl":"https://doi.org/10.3389/fmedt.2023.1182828","url":null,"abstract":"COPYRIGHT © 2023 Luni, Urciuolo, Crook and Gentile. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"5 ","pages":"1182828"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9406361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Highlights in diagnostic and therapeutic devices 2021/22.","authors":"Yangzhi Zhu,&nbsp;Mohammod Abdul Motin,&nbsp;Qingyu Cui","doi":"10.3389/fmedt.2023.1119558","DOIUrl":"https://doi.org/10.3389/fmedt.2023.1119558","url":null,"abstract":"COPYRIGHT © 2023 Zhu, Motin and Cui. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"5 ","pages":"1119558"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9469525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A descriptive study of the clinical impacts on COVID-19 survivors using telemonitoring (The TeleCOVID Study).","authors":"Josephine Sau Fan Chow,&nbsp;Annamarie D'Souza,&nbsp;Megan Ford,&nbsp;Sonia Marshall,&nbsp;Susana San Miguel,&nbsp;Ahilan Parameswaran,&nbsp;Mark Parsons,&nbsp;Jacqueline Ramirez,&nbsp;Rumbidzai Teramayi,&nbsp;Nutan Maurya","doi":"10.3389/fmedt.2023.1126258","DOIUrl":"https://doi.org/10.3389/fmedt.2023.1126258","url":null,"abstract":"<p><strong>Background: </strong>There is increasing evidence that COVID-19 survivors are at increased risk of experiencing a wide range of cardiovascular complications post infection; however, there are no validated models or clear guidelines for remotely monitoring the cardiac health of COVID-19 survivors.</p><p><strong>Objective: </strong>This study aims to test a virtual, in-home healthcare monitoring model of care for detection of clinical symptoms and impacts on COVID-19 survivors. It also aims to demonstrate system usability and feasibility.</p><p><strong>Methods: </strong>This open label, prospective, descriptive study was conducted in South Western Sydney. Included in the study were patients admitted to the hospital with the diagnosis of COVID-19 between June 2021 and November 2021. Eligible participants after consent were provided with a pulse oximeter to measure oxygen saturation and a S-Patch EX to monitor their electrocardiogram (ECG) for a duration of 3 months. Data was transmitted in real-time to a mobile phone <i>via</i> Bluetooth technology and results were sent to the study team <i>via</i> a cloud-based platform. All the data was reviewed in a timely manner by the investigator team, for post COVID-19 related symptoms, such as reduction in oxygen saturation and arrhythmia.</p><p><strong>Outcome measure: </strong>This study was designed for feasibility in real clinical setting implementation, enabling the study team to develop and utilise a virtual, in-home healthcare monitoring model of care to detect post COVID-19 clinical symptoms and impacts on COVID-19 survivors.</p><p><strong>Results: </strong>During the study period, 23 patients provided consent for participation. Out of which 19 patients commenced monitoring. Sixteen patients with 81 (73.6%) valid tests were included in the analysis and amongst them seven patients were detected by artificial intelligence to have cardiac arrhythmias but not clinically symptomatic. The patients with arrhythmias had a higher occurrence of supraventricular ectopy, and most of them took at least 2 tests before detection. Notably, patients with arrhythmia had significantly more tests than those without [<i>t</i>-test, <i>t</i> (13) = 2.29, <i>p </i>< 0.05].</p><p><strong>Conclusions: </strong>Preliminary observations have identified cardiac arrhythmias on prolonged cardiac monitoring in 7 out of the first 16 participants who completed their 3 months follow-up. This has allowed early escalation to their treating doctors for further investigations and early interventions.</p>","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"5 ","pages":"1126258"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9311400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital technologies and healthcare architects' wellbeing in the National Health Service Estate of England during the pandemic.","authors":"Evangelia Chrysikou,&nbsp;Eleni Papadonikolaki,&nbsp;Eleftheria Savvopoulou,&nbsp;Eleni Tsiantou,&nbsp;Christian Alexander Klinke","doi":"10.3389/fmedt.2023.1212734","DOIUrl":"https://doi.org/10.3389/fmedt.2023.1212734","url":null,"abstract":"<p><strong>Introduction: </strong>UK Built Environment is currently undergoing a digital transformation, as is happening in the National Health Service (NHS) of England. In this paper, the focus was on the intersection of the two sectors and specifically the potential digital transformation of the NHS Estate. The NHS has developed a strategy for its workforce, to improve staff health and wellbeing, and support equality, diversity, inclusion and the development of existing staff. Digital technologies (DTs) can relate to all Estates and Facilities Management priorities, as it cross-cuts all proposed actions. As opposed to most studies on the wellbeing of blue-collar workers, this article focuses on white-collar workers, specifically architects working in the NHS, especially since NHS at this stage is developing two important policies: the New Hospital Programme and the Workforce Action Plan. Therefore, it is important for the NHS to look at the digital transformation strategy in the prism of the other two. As architecture traditionally has low job satisfaction, it negatively impacts wellbeing. This study argues that this might have been accentuated during the pandemic for the architects working in the NHS and dealing with the added pressure from three new major tasks: adjusting the infrastructure capacity to fight Covid-19; and creating the infrastructure for the testing and vaccination programs. DTs in architecture potentially affect job satisfaction in terms of creativity, autonomy, time pressure, organisational commitment, and so on.</p><p><strong>Methodology: </strong>The methodology comprises a literature review and a pilot of interviews with healthcare architects/designers working in the NHS or on NHS-related projects. The research context is informed by the COVID-19 crisis that brought healthcare architecture to the frontline of the pandemic, with NHS architects creating new wards and vaccination centers, while private healthcare architects designed new hospitals.</p><p><strong>Results: </strong>In the niche area of healthcare architecture, architects were in their busiest year. Yet, the DTs available to them then could only support limited tasks and did not link well to operational data.</p><p><strong>Discussion: </strong>To explore how DTs transform the wellbeing of healthcare architects, understanding wellbeing in healthcare architecture in light of digital transformation is crucial for creating the necessary leadership for the sector to grow.</p>","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"5 ","pages":"1212734"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10049399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel and efficient method for the reconstruction of adenoviruses through isothermal assembly and its potential applications.","authors":"Ke Wen,&nbsp;Matthew D Resch,&nbsp;Ryan Mazboudi,&nbsp;Hannah Mulhall Maasz,&nbsp;Jose M Galarza","doi":"10.3389/fmedt.2023.1095198","DOIUrl":"https://doi.org/10.3389/fmedt.2023.1095198","url":null,"abstract":"<p><p>Adenovirus based vectors are useful tools for vaccine development, gene therapy, and oncolytic virotherapy. Here we describe a novel approach for the genetic engineering of any portion of the adenovirus genome and the reconstruction of either fully replication competent or defective virions. This innovative strategy is rapid, effective and suitable for the manipulation of the entire genome broadening the spectrum of potential applications for the adenovirus system. Our strategy involved insertion of restriction enzyme recognition sequences absent in the native virus into the termini of the adenovirus genome in order to facilitate recovery. These restriction enzyme sites, together with the two inverted terminal repeats and packaging sequences, were synthesized and then subcloned into the pBR322 vector. The remaining internal portion of the adenovirus genome was separated and amplified <i>via</i> PCR into six segments, of which groups of two were joined together by PCR and then subcloned into pBR322 plasmids. During the PCR reaction, an overlap of 30-40 bp was added to the termini of the adjacent fragments, allowing for the subsequent isothermal assembly and correct orientation of all fragments. This approach allows for the genetic modification of each genomic fragment according to the specific research goals, (e.g., deletion, substitution, addition, etc.) To recreate the entire viral genome, the four engineered fragments (each comprised of two adenovirus genomic sections) as well as the pBR322 backbone, were reassembled into a single construct utilizing an isothermal assembly reaction. Finally, the reassembled plasmid containing the entire genome was linearized and transfected into HEK293 cells to recover the complete reconstructed adenoviral vector. Using this approach, we have successfully generated two recombinant reporter adenoviruses, one of human adenovirus serotype 14 and another of serotype 55. The E3 region was replaced by the reporter genes (GFP and Luciferase) to visualize and track the recovery process. Subsequent infection of A549 cells with these reconstructed adenovirus vectors demonstrated that they were replication competent. This method shortens the viral reconstruction process because the one-step isothermal assembly requires less than 4 days, and recombinant adenovirus recovery occurs within 10 days. This new method allows for single or multiple genetic modifications within any portion of the viral genome and can be used to construct or manipulate any adenovirus whose complete genome sequence is known.</p>","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"5 ","pages":"1095198"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Data-driven technologies for future healthcare systems.","authors":"Md Anisur Rahman,&nbsp;Alireza Moayedikia,&nbsp;Uffe Kock Wiil","doi":"10.3389/fmedt.2023.1183687","DOIUrl":"https://doi.org/10.3389/fmedt.2023.1183687","url":null,"abstract":"COPYRIGHT © 2023 Rahman, Moayedikia and Wiil. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","PeriodicalId":12599,"journal":{"name":"Frontiers in Medical Technology","volume":"5 ","pages":"1183687"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9965045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}