Medical Informatics Europe最新文献_第2页

Medical Informatic Research Management in Academia - the Danish Setting 医学信息学研究管理在学术界-丹麦设置

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.3233/978-1-60750-806-9-977

S. K. Andersen

引用次数: 0

Linking Medical Data Standards, Knowledge-Based Systems and the technique of Partial Evaluation 链接医疗数据标准、基于知识的系统和部分评价技术

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.1007/978-3-642-93503-9_157

P. Hammond, L. Aye, J. Kay

引用次数: 0

Computerized cephalometry on orthodontic radiographs: towards flexible and easily customized systems 正畸x线片上的计算机头测术:走向灵活和易于定制的系统

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.1007/978-3-642-93503-9_87

F. Veiga, M. J. M. D. Barbosa

引用次数: 0

Clinical specimen receipt system using a mobile smart device 临床标本接收系统采用移动智能设备

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.3233/978-1-61499-512-8-951

K. Lee, Deok Whan Kim, H. J. Kim, Nam Sik Cho, B. Lee

引用次数: 0

Using gene expression and systems biology to interrogate auditory hallucinations in schizophrenic patients 利用基因表达和系统生物学研究精神分裂症患者的幻听

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.3233/978-1-61499-512-8-950

G. López-Campos, J. Gilabert-Juan, N. Sebastia-Ortega, Rocío González-Martínez, J. Nácher, J. Sanjuán, M. Moltó

{"title":"Using gene expression and systems biology to interrogate auditory hallucinations in schizophrenic patients","authors":"G. López-Campos, J. Gilabert-Juan, N. Sebastia-Ortega, Rocío González-Martínez, J. Nácher, J. Sanjuán, M. Moltó","doi":"10.3233/978-1-61499-512-8-950","DOIUrl":"https://doi.org/10.3233/978-1-61499-512-8-950","url":null,"abstract":"Schizophrenia is a severe mental disorder affecting around 1% of the population. This disease presents a complex aetiology that has not been completely unveiled yet. Auditory hallucinations are a very significant and disruptive symptom of schizophrenia affecting between 60% and 80% of schizophrenic patients. In this paper we have used a network-based transcriptomic analysis aiming to identify differences in gene expression between schizophrenic patients with and without auditory hallucinations. Gene expression data from blood samples drained from 30 schizophrenia patients were generated using Affymetrix Human Gene 2.0 ST Genechips. Affymetrix Expression console was used for normalization and quality control purposes. The RMA normalization method was applied for gene summarization and then a filter applied to keep only the most variably expressed probesets (4,508). These dataset was analysed using the weighted gene co-expression network analysis (WGCNA) package in R. The gene co-expression network analyses allowed us to identify eleven different gene modules based on their topological overlap. These modules were related to the relevant phenotypic information and allowing us to identify modules related with different phenotypic traits of interest. Gene co-expression network analysis is a useful tool for the analysis of gene expression analysis. Its application in the analysis of schizophrenia gene expression provides an insight on the molecular mechanisms related with this disease and the differences at the molecular level between patients presenting auditory hallucinations and those that do not. In our analysis we have been able to identify different gene modules containing genes expression profiles that can be related with clinically relevant phenotypes. These gene modules could be functionally annotated and related with different pathways and gene ontology terms that are relevant in the context of this analysis.","PeriodicalId":125683,"journal":{"name":"Medical Informatics Europe","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129757826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a mobile EPR system for a new Healthcare Professional in Germany 对德国新医疗保健专业人员的移动EPR系统进行评估

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.3233/978-1-61499-432-9-1270

Sebastian Ahrndt, A. Rieger, E. Eryilmaz, S. Albayrak

引用次数: 0

Development of ISO 13606 archetypes for the standardisation of data registration in the Primary Care environment 开发ISO 13606原型，用于初级保健环境中数据注册的标准化

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.3233/978-1-61499-512-8-877

J. B. Castro, Alejandro Lamelo Alfonsín, J. P. Cebreiro, Dolores Rimada Mora, L. C. García, G. González

{"title":"Development of ISO 13606 archetypes for the standardisation of data registration in the Primary Care environment","authors":"J. B. Castro, Alejandro Lamelo Alfonsín, J. P. Cebreiro, Dolores Rimada Mora, L. C. García, G. González","doi":"10.3233/978-1-61499-512-8-877","DOIUrl":"https://doi.org/10.3233/978-1-61499-512-8-877","url":null,"abstract":"On daily procedures, companies and organizations produce a wide quantity of data. Medical information doubles every five years approximately, and most of this information has no structure and cannot be utilised. Information obtained during Primary Health Care (PC) consultations is expected to be standardized and organised following instructions made by archetype 13606 of the International Organization for Standardization (ISO) in order to guarantee the Continuity of Care as well as the potential use of these data for secondary purposes, such as investigation or statistics. This study was designed to investigate the feasibility of representing the information collected in Primary Care consultations in a structured and normalized way. A key difference to other approaches is that the intended solution is, to the best of our knowledge, the first one to register all the information collected in this area. The participation of the Primary Health Care service (PC) from Complejo Hospitalario Universitario de A Coruna (CHUAC) has been of vital importance in this project as it has provided the necessary clinical knowledge and it has allowed us to verify the effectiveness obtained in actual environments. The archetypes developed can be reused in a wide range of projects. As an example of use, we have used these archetypes to create an intelligent system that generates organised reports based on the information dictated on a medical consultation which, afterwards, can be analysed from an analytical point of view.","PeriodicalId":125683,"journal":{"name":"Medical Informatics Europe","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128738128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Declarative and operational in knowledge based systems 在基于知识的系统中具有声明性和可操作性

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.1007/978-3-642-93503-9_53

M. Popper, M. Hauskrecht

引用次数: 2

Generic Case Extractor: Extended Export of Clinical Facts from i2b2 通用病例提取器:从i2b2扩展的临床事实输出

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.3233/978-1-61499-512-8-937

Daniel Firnkorn, M. Gietzelt, C. Karmen, Matthias Ganzinger, P. Knaup-Gregori

引用次数: 0

The FEBE Project: Designing a Clinical Information System FEBE项目:设计一个临床信息系统

Medical Informatics Europe Pub Date : 1900-01-01 DOI: 10.1007/978-3-642-93503-9_15

Romilly C. Gregory, M. Leaning, J. Summerfield, Jonathon Browne, D. Wilkinson, A. McGrath

引用次数: 0