Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia最新文献_第9页

[ADPKD and IPMN: Mere Coincidence or Double Trouble?] [ADPKD 和 IPMN：巧合还是双重麻烦？］

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-05

Kristiana Kola, Liliana Italia De Rosa, Martina Catania, Matteo Brambilla Pisoni, Francesca Tunesi, Sara Farinone, Micaela Petrone, Paolo Manunta, Giuseppe Vezzoli, Maria Teresa Sciarrone Alibrandi

引用次数: 0

[Lactobacillemia: A Rare Entity in Immunocompromised Patients. Description of a Clinical Case and Literature Review]. [乳酸菌血症：免疫力低下患者中的罕见病例。临床病例描述与文献综述]。

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-08

Marina Cornacchiari, Anna Mudoni, Amelia Liccardo, Bianca Visciano, Maria Antonietta Rizzo, Paola Cuoccio, Luca Francesco Di Toma

{"title":"[Lactobacillemia: A Rare Entity in Immunocompromised Patients. Description of a Clinical Case and Literature Review].","authors":"Marina Cornacchiari, Anna Mudoni, Amelia Liccardo, Bianca Visciano, Maria Antonietta Rizzo, Paola Cuoccio, Luca Francesco Di Toma","doi":"10.69097/41-04-2024-08","DOIUrl":"https://doi.org/10.69097/41-04-2024-08","url":null,"abstract":"Bacteremia caused by Lactobacillus is rare, data on its clinical significance are based only on case reports and a limited number of studies, often difficult to interpret. Lactobacillus species is a commensal colonizer of the mouth, gastrointestinal and genitourinary tract. Its significance as a pathogen is overlooked frequently. The diagnosis of these infections requires a mutual relationship between the physician and the microbiologist to rule out contamination risk. Most patients with Lactobacillus bacteremia are immunosuppressed or patients at increased risk of symptomatic bacteremia with comorbidities, treated with broad-spectrum antibiotics and have indwelling venous catheters. Risk factors related to Lactobacillus bacteremia include impaired host defenses and severe underlying diseases, as well as prior surgery and prolonged antibiotic therapy ineffective for lactobacilli. We describe an unusual case of a woman, on chronic hemodialysis treatment, with a sepsis due to Lactobacillus casei and review the literature.","PeriodicalId":12553,"journal":{"name":"Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Stenotic FAV: Success of the Collaboration Between Spoke and HUB]. [Stenotic FAV：Spoke 和 HUB 之间的成功合作]。

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-09

Ramona Nicotera, Armando Pingitore, Pietro Prunestì, Salvatore Chiarella, Cinzia Donato, Giovanni Mazzitello, Margherita Bovino, Pierpaolo Cannistrà

引用次数: 0

[Familial Hypocalciuric Hypercalcemia Type 1 Likely Secondary to a New Inactivating Mutation of CASR]. [家族性高钙尿酸性高钙血症 1 型可能继发于 CASR 的一个新的非活化突变】。］

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-06

Fulvia Zanchelli, Antonio Giudicissi, L Neri, V Sgarlato, P F Bruno, M Ruggeri, S Signorotti, D Apuzzo, E Notaro, A Buscaroli

{"title":"[Familial Hypocalciuric Hypercalcemia Type 1 Likely Secondary to a New Inactivating Mutation of CASR].","authors":"Fulvia Zanchelli, Antonio Giudicissi, L Neri, V Sgarlato, P F Bruno, M Ruggeri, S Signorotti, D Apuzzo, E Notaro, A Buscaroli","doi":"10.69097/41-04-2024-06","DOIUrl":"10.69097/41-04-2024-06","url":null,"abstract":"Familial Hypocalciuria Hypercalcemia (FHH) is an inherited disease with autosomal dominant transmission characterized by the presence of usually mild-to-moderate hypercalcemia, hypophosphatemia, hypocalciuria, and normal or moderately increased PTH values. Generally, FFH is asymptomatic although symptoms related to elevated plasma calcium values such as asthenia, intense thirst, polyuria, polydipsia or confusional state may occur. Three types of FHH, which differ in the genetic alterations underlying the condition, are described. The majority of FHH cases are classified as type 1 (about 65 percent of cases), due to mutation in the gene for the calcium-sensitive receptor CASR, expressed on chromosome (Chr) 3q13.3-21, which encodes for a calcium-sensitive receptor G-protein-coupled protein of the plasma membrane. FHH types 2 and 3 are due to GNA11 and AP2S1 mutations, respectively, and other genes involved in the pathogenesis of the disease have likely yet to be identified. Rarely, familial hypocalciuric hypercalcemia may not recognize a genetic cause but be caused by autoantibodies directed against CASR. The frequency of the disease is not known and is estimated, probably by default, because of paucisymptomatic presentation of the disease, to be around 1:80000 cases. Recognition of FHH is especially important for differential diagnosis with primary hyperparathyroidism, which has a much higher incidence, about 1:1000 cases. This allows for the identification of patients at risk for chondrocalcinosis and/or pancreatitis. Clinical suspicion must be raised in cases of hypercalcaemia associated with hypocalciuria, and genetic analysis is fundamental in the differential diagnosis toward forms of primary hyperparathyroidism that might result in unnecessary surgical interventions. We describe a clinical case in which a novel inactivating mutation of CASR leading to FHH type 1 was found.","PeriodicalId":12553,"journal":{"name":"Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effect of Plasmafiltration and Adsorption in Cocaine Abuse: A Case Report]. [血浆过滤和吸附对可卡因滥用的影响：病例报告]。

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-07

N Coviello, A Carella, G Loizzo, C Prisciandaro, G Tarantino, M V Bonfantino, F D'Elia

{"title":"[Effect of Plasmafiltration and Adsorption in Cocaine Abuse: A Case Report].","authors":"N Coviello, A Carella, G Loizzo, C Prisciandaro, G Tarantino, M V Bonfantino, F D'Elia","doi":"10.69097/41-04-2024-07","DOIUrl":"https://doi.org/10.69097/41-04-2024-07","url":null,"abstract":"Rhabdomyolysis is one of the principal causes of acute kidney disease. Multiple endogenous and exogenous causes could start this process: cocaine addiction, a social phenomenon present in our Country among young adults, is one exogenous causes. Natural stimulating alkaloid cocaine has toxic action on multiple systems, principally central nervous system and cardiovascular system. Etiopathogenesis is related either to changes in local and systemic hemodynamics, or to direct damage caused by myofibril accumulation, or to immunological events leading to vasculitis or thrombotic microangiopathies. Scientific evidences describe different therapeutic approaches: supportive therapy, extracorporeal treatments and possible removal of the pathogenic noxa, and the therapeutic apheresis plays a role yet to be confirmed in this field. We describe the case of a 52-year-old man, hospitalized in the Cardiological Intensive Care Unit of our hospital, due to serious alterations in the indices of myocardiocytonecrosis and liver function, following cocaine abuse. During hospitalization, renal function indices worsened associated to diuresis contraction and onset of metabolic acidosis, not responsive to medical therapy. Also in consideration of myoglobin high circulating levels, related to rhabdomyolysis, the patient went under a cycle of selective apheresis using adsorption with a TR350 cartridge associated to hemodialysis: after two adsorption sessions, the patient resumed spontaneous diuresis with progressive normalization of the blood indices.","PeriodicalId":12553,"journal":{"name":"Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to Assess the Glomerular Filtration Rate, and Which Method is Deemed Most Reliable? 如何评估肾小球滤过率，哪种方法最可靠？

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-02

Fabrizio Cristiano, Cosima Posari, Benito d'Angelo, Alessandra Schiazza, Anna Gigante, Ludovico Caravelli, Alessandra Piano, Stefania Fulle, Jenny Cristiano, Ginevra di Matteo, Guillermo Rosa Diez, Vittore Verratti

{"title":"How to Assess the Glomerular Filtration Rate, and Which Method is Deemed Most Reliable?","authors":"Fabrizio Cristiano, Cosima Posari, Benito d'Angelo, Alessandra Schiazza, Anna Gigante, Ludovico Caravelli, Alessandra Piano, Stefania Fulle, Jenny Cristiano, Ginevra di Matteo, Guillermo Rosa Diez, Vittore Verratti","doi":"10.69097/41-04-2024-02","DOIUrl":"https://doi.org/10.69097/41-04-2024-02","url":null,"abstract":"The prevalence of chronic kidney disease (CKD) continues to rise globally, paralleled by an increase in associated morbidity and mortality, as well as significant implications for patient quality of life and national economies. Chronic kidney disease often progresses unrecognized by patients and physicians, despite diagnosis relying on two simple laboratory measures: estimated glomerular filtration rate (eGFR) and urine analysis. GFR measurement has been grounded in renal physiology, specifically the concept of clearance, with creatinine identified as a suitable endogenous marker for estimating creatinine clearance (CrCl). On this foundation, various equations have been developed to calculate CrCl or estimated GFR (eGFR) using four variables that incorporate creatinine and certain demographic information, such as sex and age. However, creatinine measurement requires standardization to minimize assay variability across laboratories. Moreover, the accuracy of these equations remains contentious in certain patient subgroups. For these reasons, additional mathematical models have been devised to enhance CrCl estimation, for example, when urine collection is impractical, in elderly or debilitated patients, and in individuals with trauma, diabetes, or obesity. Presently, eGFR in adults can be immediately measured and reported using creatinine-based equations traceable through isotope dilution mass spectrometry. In conclusion, leveraging insights from renal physiology, eGFR can be employed clinically for early diagnosis and treatment of CKD, as well as a public health tool to estimate its prevalence.","PeriodicalId":12553,"journal":{"name":"Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Idiopathic Nephrotic Syndrome Relapse in Pediatric Age. 小儿特发性肾病综合征复发的风险因素。

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-04

Luca Pecoraro, Germana Longo, Mattia Parolin, Enrico Vidal, Nadia Antonucci, Valeria Silecchia, Maria Sangermano, Elisa Benetti

{"title":"Risk Factors for Idiopathic Nephrotic Syndrome Relapse in Pediatric Age.","authors":"Luca Pecoraro, Germana Longo, Mattia Parolin, Enrico Vidal, Nadia Antonucci, Valeria Silecchia, Maria Sangermano, Elisa Benetti","doi":"10.69097/41-04-2024-04","DOIUrl":"10.69097/41-04-2024-04","url":null,"abstract":"Introduction. Eighty percent of children with primitive nephrotic syndrome (NS) will have at least one relapse in their life. Specific risk factors could be associated with a higher incidence of relapses and a worse prognosis. This study aims to deepen the demographic and onset-related risk factors in children with known diagnosis of primitive NS attending the Pediatric Nephrology Unit of the University Hospital of Padua. Methods. Observational, descriptive study of all children (1-11 years old) with a known diagnosis of Primitive NS who attended our Pediatric Nephrology Unit between 1 January 2002 and 31 March 2023. Results. 49 patients were involved. 79.5% had at least one episode of NS relapse during their lifetime. 69.4% were classified as frequently relapsing or steroid-dependent NS. The relapse risk factor \"non-Western ethnicity\" was related to a worse prognosis and steroid-dependent NS classification (p = 0.041). The onset-related risk factor \"thrombocytosis\" appears to be related to a better prognosis (p = 0.03). Conclusion. The relapse risk factors \"non-Western ethnicity\" and \"thrombocytosis\" are characterized by worse and better prognosis, respectively. This evidence could support the follow-up of primitive NS in pediatric age.","PeriodicalId":12553,"journal":{"name":"Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

["Quality" Peritoneal Dialysis]. ["优质 "腹膜透析]。

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-01

Antonino Previti, Giorgio Laudadio, Paolo Luca Lentini

引用次数: 0

Renal Functional Reserve in Naïve HIV Patients. 新艾滋病病毒感染者的肾功能储备

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-11

Carlos G Musso, Rossina Juarez, W Belloso, Henry Gonzalez-Torres, Mercedes Capotondo, Terrasa Sergio, Fabrizio Cristiano, Gustavo Aroca Martinez

{"title":"Renal Functional Reserve in Naïve HIV Patients.","authors":"Carlos G Musso, Rossina Juarez, W Belloso, Henry Gonzalez-Torres, Mercedes Capotondo, Terrasa Sergio, Fabrizio Cristiano, Gustavo Aroca Martinez","doi":"10.69097/41-04-2024-11","DOIUrl":"https://doi.org/10.69097/41-04-2024-11","url":null,"abstract":"Introduction. Renal functional reserve (RFR) is the kidney capability of increasing its basal glomerular filtration rate (GFR) at least 20% after an adequate stimulus. Renal disorders have been reported in seropositive HIV patients, particularly the decrease in glomerular filtration rate (eGFR), nephrotic syndrome, and proximal tubular deficiency associated with the disease itself or the use of some anti-retroviral treatments. Thus, it was decided to carry out a prospective study in order to evaluate if RFR test was preserved in naive HIV patients. Material and Method. GFR was measured by using cimetidine-aided creatinine clearance (CACC), and RFR as described Hellerstein et al. in seropositive naive HIV patients and healthy volunteers. Results. RFR was evaluated in 12 naïve HIV patients who showed positive RFR (24.8±2%), but significantly lower compared to RFR in 9 control individuals (90.3 ± 5%). Conclusion. In this study was found that renal functional reserve was positive in naïve HIV patients, but significantly lower compared to renal functional reserve achieved by seronegative healthy individuals.","PeriodicalId":12553,"journal":{"name":"Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical Thermography for the Management of Hemodialysis Vascular Access]. [血液透析血管通路管理的临床热成像]。

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2024-08-26 DOI: 10.69097/41-04-2024-10

Giuseppe Gatta, Antonio Scarlatella, Francesco Aucella, Maria Nardella, David Perpetuini, Michele Tritto, Daniela Cardone, Carlo Lomonte, Arcangelo Merla, Filippo Aucella

{"title":"[Clinical Thermography for the Management of Hemodialysis Vascular Access].","authors":"Giuseppe Gatta, Antonio Scarlatella, Francesco Aucella, Maria Nardella, David Perpetuini, Michele Tritto, Daniela Cardone, Carlo Lomonte, Arcangelo Merla, Filippo Aucella","doi":"10.69097/41-04-2024-10","DOIUrl":"https://doi.org/10.69097/41-04-2024-10","url":null,"abstract":"The arteriovenous fistula (AVF) represents the favorite vascular access in individuals with chronic kidney disease (CKD). Because AVF is a guarantee of survival for these patients, proper surgical packing and a timely follow-up program is crucial. Although a good objective examination of the limb site of FAV provides useful information both in planning the fistula surgery and in its surveillance and monitoring, it is now well established that the advent of instrumental diagnostics (ultrasonography, digital angiography, Angio-TC, MRI) has contributed significantly to improving primary and secondary patency of FAV and early diagnosis of vascular access complications. In this area, clinical thermography, a noninvasive and nondestructive diagnostic technique for assessing minute surface temperature differences, has shown good potential for the assessment of AVF. In fact, thermographic analysis of a limb site of AVF shows an increase in temperature at the site of the anastomosis and along the course of the arterialized vein. In this article we report our experience on the use of thermography in preoperative evaluation and postoperative surgical packing of an AVF. Further studies could validate the use of clinical thermography as a diagnostic technique to be used in the field of hemodialysis vascular accesses.","PeriodicalId":12553,"journal":{"name":"Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0