Genetics and Molecular Research最新文献_第10页

Research Article A comparison of regression methods based on dimensional reduction for genomic prediction 研究论文基于降维的基因组预测回归方法的比较

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/GMR18877

J. A. D. Costa, Carolina Azevedo, M. Nascimento, F. F. Silva, M. Resende, A. C. Nascimento

{"title":"Research Article A comparison of regression methods based on dimensional reduction for genomic prediction","authors":"J. A. D. Costa, Carolina Azevedo, M. Nascimento, F. F. Silva, M. Resende, A. C. Nascimento","doi":"10.4238/GMR18877","DOIUrl":"https://doi.org/10.4238/GMR18877","url":null,"abstract":". The quality of fit of a multiple linear regression model often encounters multicollinearity and high dimensionality problems, making it impossible to obtain stable estimates through the traditional method of estimation based on ordinary least squares. To overcome such challenges, dimensionality reduction methods have been proposed, because of their simple theory and easy application. We compared three dimensionality reduction methods: Principal Components Regression (PCR), Partial Least Squares (PLS), and Independent Components Regression (ICR). An important step for dimensionality reduction and prediction is selecting the number of components, as it affects the linear combinations of the explanatory variables. The linear combinations are inserted into the model to predict the response based on a reduced number of parameters. We examined the criteria for the selection of the number of components. The dimensionality reduction methods were applied to genomic and phenotype data. We evaluated 370 accessions of Asian rice, Oryza sativa , which were genotyped for 36,901 SNPs markers considered to predict the genomic values for the number of panicles per plant trait. This data set presented multicollinearity and high dimensionality. The computational time for each method was also recorded. Among the methods, PCR and ICR gave the highest accuracy values, with ICR standing out for presenting estimates of the least biased genomic values. However, ICR required more computational time than the other methodologies.","PeriodicalId":12518,"journal":{"name":"Genetics and Molecular Research","volume":"56 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70933271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Article Simulation of wheat yield by nitrogen and ear components in harvest prediction analysis 研究文章利用氮素和穗部成分模拟小麦产量在收获预测分析中的应用

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/gmr18943

O. Alessi, J. Da Silva, V. Pansera, J.A. da Rosa, I. Carvalho, F. Lautenchleger, M. S. Jung, de F. Colet, C. Teixeira, N. Basso, J. V. Tisott, C. M. Babeski

引用次数: 1

Research Article Virulence genes in Staphylococcus aureus isolated from cell phone screens of dentistry students in Cuenca-Ecuador 从厄瓜多尔昆卡牙科学生手机屏幕中分离的金黄色葡萄球菌的毒力基因

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/gmr18928

M. Pacheco, P. P. Orellana, C. Andrade, J.E. Torracchi

{"title":"Research Article Virulence genes in Staphylococcus aureus isolated from cell phone screens of dentistry students in Cuenca-Ecuador","authors":"M. Pacheco, P. P. Orellana, C. Andrade, J.E. Torracchi","doi":"10.4238/gmr18928","DOIUrl":"https://doi.org/10.4238/gmr18928","url":null,"abstract":"Staphylococcus aureus is one of the main pathogens of importance in health care. Distributed worldwide, it has considerable impact on community and nosocomial infections. This bacteria has the tst and lukS-F PV genes that code for the TSST-1 toxin and leucocidin. These pathogenic microorganisms have the ability to survive for long periods on inert surfaces such as mobile phone screens. Senior dentistry students work in clinics and use their cell phones often, which could potentially spread this pathogen. We looked for the tst and lukS-F PV genes in S. aureus isolated from mobile phone screens of final year dentistry students. This was a descriptive cross-sectional observational study using 92 samples from the mobile phone screens of dental students, among which 16 were positive for S. aureus. They were identified by means of culture methods and detection of the nuc, nucA and femB genes. The DNA was extracted using the alkaline lysis method; PCR was used in the molecular identification of the tst and lukS-F PV genes. Nine of the 16 S. aureus isolates had the tst gene, and 1/16 the lukS-F PV gene. This study shows the high frequency of virulent S. aureus on the","PeriodicalId":12518,"journal":{"name":"Genetics and Molecular Research","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70934277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Article Strategies for cervical cancer screening in the scope of the Brazilian Unified National Health System 研究文章在巴西统一国家卫生系统范围内的宫颈癌筛查策略

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/GMR18719

A. Reis, C. Araujo, E. Silva, Thales Biffe Alves, Y.M.F. Ternes, R. Santos

引用次数: 1

Research Article Standard and immunohistochemical staining methods for diagnosis of cervical lymph node metastasis in nasopharyngeal carcinoma 研究:鼻咽癌颈部淋巴结转移的标准及免疫组织化学染色诊断方法

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/GMR18735

N. D. Phúc, L. Ky, N. Binh, N. T. Tuan, N. Van, T. X. Hai, V. Thuc

引用次数: 0

Research Article Thrombolysis and thrombectomy as an effective treatment for ischemic cerebral circulation disorders 溶栓和取栓是缺血性脑循环疾病的有效治疗方法

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/GMR18740

N. H. Ngoc, N. V. Thống, N. An

引用次数: 0

Research Article Anticancer and antimicrobial activities of diosmin 研究文章薯蓣皂苷的抗癌和抗菌活性

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/GMR18752

A. Kilit, O. Köse, Gülmen Imi, E. Aydemir

引用次数: 7

Research Article Common bean (Phaseolus vulgaris) mulatinho type accessions conserved ex situ in Brazil 巴西非原生境保存的多品种豆(Phaseolus vulgaris)

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/GMR18770

Adriza Silva, A. T. Machado, P. P. Torga, C. Silva-Neto, P. G. Bustamante, P. Bianchini, R. P. Soratto, J. P. Oliveira

引用次数: 0

Research Article Exogenous pyruvate mitigates the detrimental effects of water stress in contrasting peanut genotypes 外源丙酮酸减轻水分胁迫对花生基因型的不利影响

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/gmr18907

D. D. Barbosa, P. Fernandes, A. Marcelino, F. A. Silva, M. S. Dias, C.R.C. Silva, R. C. Santos

{"title":"Research Article Exogenous pyruvate mitigates the detrimental effects of water stress in contrasting peanut genotypes","authors":"D. D. Barbosa, P. Fernandes, A. Marcelino, F. A. Silva, M. S. Dias, C.R.C. Silva, R. C. Santos","doi":"10.4238/gmr18907","DOIUrl":"https://doi.org/10.4238/gmr18907","url":null,"abstract":"Water stress triggers various cellular responses in plants, altering normal metabolic flow. Pyruvate, an important component of the glycolysis pathway, is directly involved in cell processes, triggering genes that influence drought tolerance. Research with Arabidopsis has shown that synthetic pyruvate relieves drought damage. We evaluated the effects of exogenous pyruvate at 100 and 50,000 μM on mitigation of drought stress in two peanut cultivars submitted to water restriction. The evaluations were based on growth, gas exchange, and photosynthesis rate analyses. In addition, superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX) enzymes, and free proline were also assayed. In general, exogenous application of pyruvate contributed to mitigate the effects of water stress in the cultivar IAC Caiapó (sensitive to drought), based on gas exchange and instantaneous efficiency of water use. Exogenous pyruvate contributed to restore the action of antioxidative enzymes in BR 1 (tolerant to drought), based on measures of SOD (45%), CAT (129%) and APX (60%) in stressed plants, and full recovery at 50,000 μM. When treated with proline, stress attenuation was found only at 100 μM in both cultivars; the excess seemed to have a negative effect on stressed plants, probably affecting the cell","PeriodicalId":12518,"journal":{"name":"Genetics and Molecular Research","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70933603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Research Article Molecular diagnosis and clinicopathological characteristics of canine distemper neurologic disease 研究文章犬瘟热神经疾病的分子诊断及临床病理特征

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Genetics and Molecular Research Pub Date : 2021-01-01 DOI: 10.4238/gmr18884

I. S. Jesus, A. C. Cruz, C. Santos, Elem Cristina Macedo Barra, J. H. Costa, T. Monteiro, Camila de Cássia dos Santos, Keila Feitosa Valente, Barbara Wilka Leal Silva, É. D. L. Rodrigues, J. C. F. Almeida, E. S. Filho, M. Figueiredo, Sinerey Karla Salim Aragão de Sousa, S. P. Silva, L. M. Casseb, A. Negrão, A. Casseb

引用次数: 0