{"title":"Synthesis, structural elucidation and bioassay of morpholine/thiomorpholine and piperidine containing oxazoles","authors":"G. Sravya, N. B. Reddy, G. Zyryanov","doi":"10.1063/5.0018089","DOIUrl":"https://doi.org/10.1063/5.0018089","url":null,"abstract":"The ubiquity of azoles in a wide variety of naturally occurring and synthetic molecules and their pivotal role as synthetic intermediates has attracted the attention of both industrial and academic communities. Oxazoles are widely distributed in natural products including phenoxan,hennoxazoles and many of them possess significant biological activities such as antifungal, cytotoxic, anthelmintic etc., Methods for the synthesis of substituted oxazoles include Robinson – Gabriel synthesis of cyclodehydration of α-acylaminocarbonyl compounds, Morpholine is a heterocyclic organic compound, has both features of amine due to the presence of nitrogen atom that it considered as a secondary amine and also ether functional group due to the presence of oxygen atom. Moreover, thiomorpholines analogs are associated with a variety of pharmacological activities including anti mycobacterial, antibacterial, analgesic and anti-inflammatory. Similarly, the piperazine moiety is existing in numerous biologically active compounds as well as the antimicrobial and the antidepressants. In continuation of our studies and also to establish structureactivity relationship of the compounds, the present work synthesis and antimicrobial activity of sulfonyl methyl linked mono and bis-heterocycles having different heterocyclic moieties has been taken up. References 1. Shaw A. Y. Ugi/Robinson-Gabriel reactions directed toward the synthesis of 2,4,5-trisubstituted oxazoles / Z. Xu, C. Hulme // Tetrahedron Letters.– 2012. – Vol.53. Iss. 15. – P.1998–2000. 2. Williams D. R. Studies of mild dehydrogenations in heterocyclic systems / P. D. Lowder, Y. G. Gu. D. A. Brooks // Tetrahedron Letters. – 1997. – Vol.38, Iss. 3. – P. 331–334. 3. Baran, Y. Spectroscopic and structural properties of N-(acetamide)morpholinium bromide. H. Ozay, H. Esener, M. Turkyilmaz // Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. – 2011 – Vol.81. Iss. – 1. P.99-103.","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126797558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. A. Brusnitsina, E. I. Stepanovskih, T. Alekseeva
{"title":"Kinetic laws of the process of chemical deposition of copper from trilonate solutions","authors":"L. A. Brusnitsina, E. I. Stepanovskih, T. Alekseeva","doi":"10.1063/5.0018474","DOIUrl":"https://doi.org/10.1063/5.0018474","url":null,"abstract":"","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"239 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122917177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design, synthesis, characterization of geminal bisphosphonates and bioactivity evaluation","authors":"C. B. Reddy, N. B. Reddy, C. N. Raju","doi":"10.1063/5.0018372","DOIUrl":"https://doi.org/10.1063/5.0018372","url":null,"abstract":". Cancer is a deadly disease evading all human efforts to understand its etiology, prevention and cure. In the cancer, chronicmyelogenous leukemia is one type. It is also known as chronic myeloid leukemia. It is a malignant cancer of the myeloid line of cells in the bone marrow that results in the uncontrolled growth of white blood cells in the bone marrow, bloodstream, and body tissues. The colorectal cancer is another type of cancer that occurs in the colon or rectum. Sometimes it is called colon cancer. Management of these cancers is highly difficult. In persuation of our goal to synthesise cancer active compounds, the author accomplished synthesis of substituted amino methylene bisphosphonates (3a-j) and studied their antitumor activity.","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131462981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Krishnan, N. Mani, S. Anand, R. Guruvendhan, S. Vishal
{"title":"Mechanical and microstructural analysis of Al-W-Sn metal matrix composites","authors":"V. Krishnan, N. Mani, S. Anand, R. Guruvendhan, S. Vishal","doi":"10.1063/5.0024902","DOIUrl":"https://doi.org/10.1063/5.0024902","url":null,"abstract":"In the current scenario, composite materials are given preference. For this study, Al 7075 is reinforced with varying mass fractions of W and Sn. It is to be fabricated by stir casting technique to improve the ultimate strength and micro structural studies have been carried out to understand the nature of structure. Al-7075 has been selected as the metal matrix for this current study as it has balanced properties required in automobile and aerospace applications. Also, it is good heat treatable and age hardenable as compared to 6 series aluminium alloys. It is generally termed as aluminium-zinc alloy as it has zinc as major composition. The results indicated that the new composition of metal matrix composite was quite successful to obtain uniform dispersion of particles reinforcement in the matrix of the alloy.","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130268112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of natural fibre mat and fibre hybrid composites","authors":"K. Balasubramanian, N. Rajeswari, M. shankar","doi":"10.1063/5.0025500","DOIUrl":"https://doi.org/10.1063/5.0025500","url":null,"abstract":"","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"166 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120937648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Voinkov, R. Drokin, D. V. Tufyakov, E. Ulomsky, V. Rusinov
{"title":"Nucleophilic substitution of nitro group in dihydroazole[5,1-c][1,2,4]triazines","authors":"E. Voinkov, R. Drokin, D. V. Tufyakov, E. Ulomsky, V. Rusinov","doi":"10.1063/5.0018191","DOIUrl":"https://doi.org/10.1063/5.0018191","url":null,"abstract":". Previously, nucleophilic substitution of a nitro group in a series of azoloazines by O, S, Nnucleophiles was studied [1-3], but works describing the substitution of a nitro group in dihydroazolo [5,1-c][1,2,4]triazines by primary aromatic amines are absent due to the lack of nucleophilicity of the latter. We managed to carry out the nucleophilic substitution of the nitro group into fragments methoxyaniline by boiling in acetonitrile. The reactions of dihydroazolo[5,1-c][1,2,4]triazines with hydrazine hydrate were previously studied. The authors suggested that heating nitroazolotriazine in ethanol with hydrazine hydrate leads to the reductive decomposition of the triazine ring to form 3-methyl-5-(N-methylamino)-1,2,4-triazole [3]. We found that nitrodihydroazolo[5,1-c][1,2,4]triazines react with dimethylmethylenehydrazine to produce the nucleophilic substitution product at low temperatures.","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"188 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116639164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Size optimization of shoulder filleted shafts with relief grooves for improving their fatigue life","authors":"S. Prajwal, V. Dhinakaran, T. Jagadeesha","doi":"10.1063/5.0024911","DOIUrl":"https://doi.org/10.1063/5.0024911","url":null,"abstract":"","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130806553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Sathish, D. Subramanian, R. Saravanan, V. Dhinakaran
{"title":"Experimental study about flash and fire point comparison on three combinations of waste tyre oil with diesel for alternate fuel properties identification","authors":"T. Sathish, D. Subramanian, R. Saravanan, V. Dhinakaran","doi":"10.1063/5.0024958","DOIUrl":"https://doi.org/10.1063/5.0024958","url":null,"abstract":"The current study investigates about flash and fire point comparison of three different combinations of waste tyre oil with diesel for alternate fuel prosperities identification in compression ignition engines. Waste tyre oil is gained through esterification process. 500 ml of diesel and tyre oil with three combinations taken for the experiment. These samples tested before and after esterification process. Then the corresponding flash and fire point values noted for this investigation.","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131526000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Mothilal, G. Ragothaman, D. Manuel, S. Socrates, S. Mathavan
{"title":"Analysis on mechanical properties of wood plastic composite","authors":"T. Mothilal, G. Ragothaman, D. Manuel, S. Socrates, S. Mathavan","doi":"10.1063/5.0024893","DOIUrl":"https://doi.org/10.1063/5.0024893","url":null,"abstract":"","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129276205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Sravya, G. Zyryanov, M. Reddy, V. Ratnakaram, N. B. Reddy
{"title":"Meglumine sulphate: An efficient catalyst for the synthesis of bis(indolyl)methanes","authors":"G. Sravya, G. Zyryanov, M. Reddy, V. Ratnakaram, N. B. Reddy","doi":"10.1063/5.0018097","DOIUrl":"https://doi.org/10.1063/5.0018097","url":null,"abstract":"The reaction of indoles with carbonyl compounds in the presence of 5 mol% Meglumine Sulphate in acetonitrile was executed to synthesize bis(indolyl)methane derivatives using conventional and ultrasonication methods. The reaction proceeded in shorter reaction time in ultrasonication methodology leading to high yield of the products.","PeriodicalId":124111,"journal":{"name":"PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121082757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}