Formosan Journal of Surgery最新文献

Lycopene exerts cytotoxic effects by mitochondrial reactive oxygen species–induced apoptosis in glioblastoma multiforme 番茄红素通过线粒体活性氧诱导多形性胶质母细胞瘤细胞凋亡发挥细胞毒性作用

Formosan Journal of Surgery Pub Date : 2024-03-06 DOI: 10.1097/fs9.0000000000000123

Huey-Jiun Ko, Yu‐Feng Su, Joon‐Khim Loh, Cheng Yu Tsai

{"title":"Lycopene exerts cytotoxic effects by mitochondrial reactive oxygen species–induced apoptosis in glioblastoma multiforme","authors":"Huey-Jiun Ko, Yu‐Feng Su, Joon‐Khim Loh, Cheng Yu Tsai","doi":"10.1097/fs9.0000000000000123","DOIUrl":"https://doi.org/10.1097/fs9.0000000000000123","url":null,"abstract":"Abstract Background Glioblastoma multiforme (GBM) faces challenges with standard treatments, prompting exploration into alternative approaches. Reactive oxygen species (ROS) are implicated in cancer development, making antioxidants from natural sources, such as lycopene in tomatoes, promising candidates. This study aimed to assess the effectiveness of lycopene in GBM. Materials and Methods The PAMPA-BBB assay predicted lycopene penetration. After treating GBM8401 and T98G GBM cells with lycopene, flow cytometry assessed cell cycle and apoptosis, while the CCK-8 assay measured antiproliferative efficacy. Colony formation assay examined cell growth, and intracellular and mitochondrial ROS levels were quantified. Western blot analyzed protein levels of p-ERK/ERK, p53, and cyclin-related proteins. Results Our results demonstrated lycopene penetration across the blood-brain barrier and its induction of apoptosis, inhibiting proliferation in GBM8401 and T98G GBM cells. In addition, lycopene promoted p53 upregulation and suppressed cyclins B and cyclin D, leading to cell cycle arrest through ROS-activated ERK pathways. Conclusions In conclusion, our study focused on lycopene’s potential in GBM treatment, revealing its ability to induce apoptosis, inhibit proliferation, and regulate the cell cycle through ROS-activated ERK pathways. These findings suggest lycopene as a promising candidate for preventing and treating GBM by targeting ROS-induced cell proliferation, paving the way for future research.","PeriodicalId":12390,"journal":{"name":"Formosan Journal of Surgery","volume":"57 5","pages":"181-188"},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147888626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analgesic Effects of Ibuprofen Soft and Flexible Absorbent Foam Dressing After Colorectal Surgery: A Single-Center Comparative Study 结肠直肠手术后布洛芬软敷料和弹性吸收泡沫敷料的镇痛效果：单中心比较研究

IF 0.4

Formosan Journal of Surgery Pub Date : 2024-01-11 DOI: 10.1097/fs9.0000000000000116

Tzu-Yen Cheng, Kee-Thai Kiu, Min-Hsuan Yen, Ka-Wai Tam, Tung-Cheng Chang

{"title":"Analgesic Effects of Ibuprofen Soft and Flexible Absorbent Foam Dressing After Colorectal Surgery: A Single-Center Comparative Study","authors":"Tzu-Yen Cheng, Kee-Thai Kiu, Min-Hsuan Yen, Ka-Wai Tam, Tung-Cheng Chang","doi":"10.1097/fs9.0000000000000116","DOIUrl":"https://doi.org/10.1097/fs9.0000000000000116","url":null,"abstract":"\u0000 \u0000 \u0000 Postoperative wound care and pain management are crucial components of the postoperative recovery process. This study aims to evaluate whether the analgesic effects of the ibuprofen soft and flexible absorbent foam dressing are superior to those of traditional gauze following colorectal surgery.\u0000 \u0000 \u0000 \u0000 Data pertaining to patients who underwent colorectal surgery between May 2021 and January 2022 were extracted from the electronic medical records database archive of a single institution. The ibuprofen soft and flexible absorbent foam dressing was applied to 62 patients for postoperative wound care, while gauze was used for 78 patients. Primary outcome measurements included the count of dressings, visual analog scale pain scores, analgesic dosage, complications, and length of hospitalization.\u0000 \u0000 \u0000 \u0000 The mean pain score on the 5th day postoperation was significantly lower for the ibuprofen group (2.03 ± 1.55) than for the control group (2.63 ± 1.72, p = 0.035). The mean dosage (mg) of parecoxib on the 3rd day postoperation was significantly lower for the ibuprofen group (2.58 ± 12.27) than for the control group (10.26 ± 21.80, p = 0.01). The cumulative number of dressing changes during the 1st week postoperation was significantly lower for the ibuprofen group (mean ± standard deviation; 3.00 ± 0.98) than for the control group (7.55 ± 2.68, p < 0.001). No significant differences were observed in the complication rate or length of hospitalization between the groups.\u0000 \u0000 \u0000 \u0000 The ibuprofen soft and flexible absorbent foam dressing can either enhance the analgesic effect during postoperative recovery or reduce the cost and dressing time associated with postoperative wound care.\u0000","PeriodicalId":12390,"journal":{"name":"Formosan Journal of Surgery","volume":"6 2","pages":""},"PeriodicalIF":0.4,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139438458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Many publications, salami publication and issues to be recognize in clinical surgery 许多出版物、腊肠出版物和临床手术中应认识到的问题

IF 0.4

Formosan Journal of Surgery Pub Date : 2024-01-08 DOI: 10.1097/fs9.0000000000000111

H. Daungsupawong, V. Wiwanitkit

引用次数: 0

Constructive commentary, not individual attack, a way for proper criticism in clinical surgery 建设性评论，而非个人攻击，是临床外科手术中正确批评的一种方式

IF 0.4

Formosan Journal of Surgery Pub Date : 2024-01-08 DOI: 10.1097/fs9.0000000000000110

H. Daungsupawong, V. Wiwanitkit

引用次数: 0

Bilateral Thoracic Sympathectomy for Refractory Coronary Artery Spasm - A Case Report 双侧胸交感神经切除术治疗难治性冠状动脉痉挛--病例报告

IF 0.4

Formosan Journal of Surgery Pub Date : 2024-01-08 DOI: 10.1097/fs9.0000000000000105

Lee Han-Hung, Chao-Kun Chen, Su Ying-Chieh, Wei-Ting Chang, Fong Yao

引用次数: 0

Unaddressed Health Risks among Foreign Volunteer Rescue Teams: Insights from the Turkish Earthquake Crisis in 2023 - A Case Study of the Indochina Team 外国志愿救援队中尚未解决的健康风险：2023 年土耳其地震危机的启示--印度支那救援队案例研究

IF 0.4

Formosan Journal of Surgery Pub Date : 2024-01-08 DOI: 10.1097/fs9.0000000000000107

R. Mungmunpuntipantip, V. Wiwanitkit

引用次数: 0

Ukraine/Russia conflict to Israel/Palestine conflict: concern on the role of clinical surgery and practice during war state 从乌克兰/俄罗斯冲突到以色列/巴勒斯坦冲突：关注战争状态下临床外科手术和实践的作用

IF 0.4

Formosan Journal of Surgery Pub Date : 2024-01-08 DOI: 10.1097/fs9.0000000000000108

Somsri Wiwanitmkit, V. Wiwanitkit

引用次数: 0

Surgical management of a giant kidney tumor weighing 9.2 kg 重达 9.2 千克的巨大肾肿瘤的手术治疗

IF 0.4

Formosan Journal of Surgery Pub Date : 2023-11-22 DOI: 10.1097/fs9.0000000000000101

Naveen Kumar, Vipin Chandra, Parvez Ahmad, Kashif Rizwi

引用次数: 0

AI uses in clinical surgery research and publication: an emerging ethical issue 人工智能在临床外科研究和出版中的应用：一个新出现的伦理问题

IF 0.4

Formosan Journal of Surgery Pub Date : 2023-11-16 DOI: 10.1097/fs9.0000000000000102

Rujittika Mungmunpuntipantip, V. Wiwanitkit

引用次数: 0

Using Three-Dimensional versus Two–Dimensional Laparoscopy in Sleeve Gastrectomy: A case matched comparison 三维与二维腹腔镜在袖式胃切除术中的应用:一例匹配比较

Formosan Journal of Surgery Pub Date : 2023-10-30 DOI: 10.1097/fs9.0000000000000100

Lung-Yun Kang, Wei-Jei Lee, Sheng-Shih Chen

{"title":"Using Three-Dimensional versus Two–Dimensional Laparoscopy in Sleeve Gastrectomy: A case matched comparison","authors":"Lung-Yun Kang, Wei-Jei Lee, Sheng-Shih Chen","doi":"10.1097/fs9.0000000000000100","DOIUrl":"https://doi.org/10.1097/fs9.0000000000000100","url":null,"abstract":"ABSTRACT Background Laparoscopic sleeve gastrectomy using two-dimensional (2-D) systems has been proven to be a safe and effective treatment for obesity. Three-dimensional (3-D) systems have recently been introduced in the general field. We hypothesized that using a 3-D system offers more benefits than using 2-D laparoscopy in sleeve gastrectomy. Methods Patients who underwent laparoscopic sleeve gastrectomy (LSG) without any other surgeries between January 1st, 2017, and February 28th, 2019, were included. Characteristic factors and outcomes were reviewed and compared between the groups using the 2-D system and the 3-D system, including sex, age, length of stay (LOS), body mass index (BMI), operative time, blood loss, morbidity, total body weight loss, and excess weight loss. Results Seventy-five patients underwent LSG and were included in the study. Among them, forty-two patients used the 3-D system, while thirty-three patients used the 2-D system. There were no significant differences between the two groups in terms of basic characteristics, including age, sex, and BMI. The morbidity rate did not differ, but the 3-D group experienced less blood loss (25.12 ml vs. 47.27 ml; p = 0.001) and shorter operative times (105.93 ± 30.645 mins vs. 128.94 ± 28.566 mins; p = 0.001) compared to the 2-D group (25.12 ml vs. 47.27 ml; p = 0.001). Weight loss at 6 months was similar between the two groups. Conclusion In conclusion, 3-D LSG shows promise in reducing both blood loss and operative time. Nevertheless, further prospective trials are essential to definitively establish its efficacy.","PeriodicalId":12390,"journal":{"name":"Formosan Journal of Surgery","volume":"226 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136103452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0