Pharmaceutical Communications最新文献

{"title":"Formulation and Evaluation of Metronidazole Loaded Nanosponges for Topical Delivery","authors":"Rashid A Khan, Dr. Anum Saif, Humaira Naureen, Atif Sarwar, Muhammad Ali Shahbaz, Muhammad Nouman Arif","doi":"10.55627/pharma.001.001.0185","DOIUrl":"https://doi.org/10.55627/pharma.001.001.0185","url":null,"abstract":"Formulations of metronidazole M1, M2, M3, M4, and M5 with the polymer ethyl cellulose and M1*, M2*, M3*, M4* and M5* with the polymer Eudragit RS100 at varying concentrations were prepared and characterized by Zeta sizer, SEM, DSC, FTIR and XRD. The gel was evaluated for its spreadability, skin irritancy, entrapment efficiency and drug release. Size in M5* was 292.2 nm with PDI of 1.00 and in M2, 371.8 nm with PDI of 0.809 was observed. The entrapment efficiency and production yield with M5* was observed to be 68.40 % and 66.9 % respectively. While the EE and PY with M2 were 66.70 % and 58 % respectively. FTIR did not reveal any incompatibility between the polymer and the drugs and by SEM results, the shape of nanosponges appeared to be spherical and porous. 10% of the drug was released from nanosponges in Ist hour and almost 70 % in 8 hours.","PeriodicalId":123783,"journal":{"name":"Pharmaceutical Communications","volume":"35 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120943024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-formulation Study of Tamoxifen and Excipients in Formulation of Nanoparticle Drug Delivery System","authors":"Muzna Ali Khattak, Z. Iqbal, Sadia Pervez, Taleya Hidayatullah, Shazma Gohar, Tahir Ali Arbab","doi":"10.55627/pharma.001.001.0197","DOIUrl":"https://doi.org/10.55627/pharma.001.001.0197","url":null,"abstract":"The inactive ingredients (excipients) are integral to the pharmaceutical drug delivery system. If not selected intelligently and added without a proper scientific approach can lead to the instability of the active pharmaceutical ingredient (API), low therapeutic outcome, or untoward effects.  In this investigation, pre-formulation studies were carried out to confirm that the excipients used in the preparation of the nanoparticles were compatible with tamoxifen. The high-performance liquid chromatography-ultra-violet assay, Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA) of the stored preparation showed that the nanoparticles were stable, indicating that the ingredients were not reactive and compatible with each other. The tamoxifen drug content was above 98%. Also, the FTIR spectrum of the optimized and physical mixture showed that the API retained its major (1357.89 cm-1, 1589.34 cm-1, 1739.79 cm-, 12870.08 cm-1, and 3402.43 cm-1) characteristic peaks. The XRD confirmed that the drug is very well dispersed in amorphous form with no extraneous peaks. The TGA isotherm indicated that the melting point of the optimized formulation was 400 oC which is significantly higher than the pure tamoxifen, which is 150 oC. the TGA results indicated that the formulation is heat stable.","PeriodicalId":123783,"journal":{"name":"Pharmaceutical Communications","volume":"86 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131371185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Transdermal Drug Delivery: Design, Evaluation and Approach towards Painless Drug Delivery System","authors":"Muhammad Shahid Latif, A. Nawaz, Muhammad Khursheed Alam Shah, A. Iqbal","doi":"10.55627/pharma.001.001.0196","DOIUrl":"https://doi.org/10.55627/pharma.001.001.0196","url":null,"abstract":"Transdermal drug delivery systems were developed in order to overcome the difficulties associated with oral drug delivery. Through an adhesive patch affixed to the skin, transdermal patches deliver medications into the bloodstream. This treatment may benefit damaged areas of the body. Unlike oral, topical, intramuscular, and intravenous drug delivery methods, transdermal drug delivery enables controlled drug release into the body. Body heat is used to melt thin layers of medication embedded in the adhesive through the transdermal patch's porous membrane. As a barrier against foreign invaders, the skin serves as a protective layer. A medication with a molecular weight less than 500 Da can penetrate the stratum corneum through the outermost layer of the skin. An overview of transdermal patches is provided in this review article, including matrix patches, reservoir patches, membrane patches, micro reservoir patches, and patches that contain drugs in adhesive forms. These dosage forms have also been evaluated using various methods.","PeriodicalId":123783,"journal":{"name":"Pharmaceutical Communications","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130789499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Applications of Magnetic Nanoparticles; A Review","authors":"Shahana Khattak, Gul Rehman Elmi, Farah Azhar, Hina Ahsan, Kalsoom Saleem, Faryal Jahan","doi":"10.55627/pharma.001.001.0200","DOIUrl":"https://doi.org/10.55627/pharma.001.001.0200","url":null,"abstract":"In nanotechnology field, iron oxide magnetic nanoparticles (IONPs) have gained much interest. The magnetic nanoparticles have been widely explored for applications due to ease of manufacturing and functionalization with polymers and other materials which makes them highly sensitive for many biological and biomedical applications. They transform electromagnetic energy into heat when exposed to magnetic field, and, hence, prove themselves as potent anti-cancer agent. The most advanced application of nanoscale materials towards human health is application as contrast agents in imaging modalities. MNPs proved safer as imaging contrast agents than conventional methods. MNPs have also been used in overcoming bacterial resistance and as anti-viral agent. They provide further evidences as emerging means in treatment and diagnosis of CVD and chronic inflammatory diseases like Rheumatoid arthritis. They also have employed in gene therapy to treat chronic diseases now a day.","PeriodicalId":123783,"journal":{"name":"Pharmaceutical Communications","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128292201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Hydrotropic Phenomenon on Solubility Enhancement of Ebastine; Formulation and Characterization","authors":"Anum Saif, Rashid Ali, Khan, S. Zaman, Muhammad Ali Shahbaz, Atif Sarwar, Muhammad Nouman Arif","doi":"10.55627/pharma.001.001.0180","DOIUrl":"https://doi.org/10.55627/pharma.001.001.0180","url":null,"abstract":"Hydrotropes are the nontoxic small organic molecules that at certain concentrations result in solubility enhancement of poorly water-soluble compounds. In this study various hydrotropes including nicotinamide, sodium acetate and trisodium citrate were used at varying ratios to observe the effect on solubility enhancement of Ebastine. Various combinations of drug-hydrotrope complexes were prepared with each above mentioned hydrotropes using solvent evaporation technique. The resultant residues were subjected to various analytical and characterization techniques for verification of complexation and solubility enhancement. These techniques included Powder X-ray diffraction studies, FTIR and UV spectroscopy. Three different formulations were prepared using various hydrotrop-drug complexes and their stability studies along with in-vitro release were carried out using simulated environment in dissolution apparatus and then later UV spectrophotometric studies were conducted.Standard curve was constructed for UV Spectroscopic analysis and the UV analysis of %age drug release from final suspension dosage form revealed 67.56%, 55.04 % and 66.76 % for the complex containing drug-nicotinamide at ratio of 3:1, drug- sodium acetate at 2:2and drug-trisodium citrate at 2:2 respectively. This release profile clearly indicated the increment in water solubility of the said insoluble drug in the prepared suspension formulated from the drug-hydrotrope complex","PeriodicalId":123783,"journal":{"name":"Pharmaceutical Communications","volume":"63 39","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114005596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome to Pharmaceutical Communications","authors":"F. Nasir","doi":"10.55627/pharma.001.001.0203","DOIUrl":"https://doi.org/10.55627/pharma.001.001.0203","url":null,"abstract":"Welcome to the inaugural issue of Pharmaceutical Communications-a biannual, open access, and peer-reviewed journal aiming to publish high-quality research articles in the field of basic & advanced pharmaceutics and pharmaceutical technology. Pharmaceutical Communications is a biannual, peer-reviewed journal published online and in print that primarily publishes research articles and reviews that focus on basic and advanced pharmaceutics. The journal accepts manuscripts related to but not limited to, the processing of pharmaceuticals, such as crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, pharmaceutical technology, targeted drug delivery. Other topics include pharmaceutical marketing, pharmaceutical promotion, patient-provider communication, healthcare communication, patient safety, and innovations in the pharmaceutical industry.\u0000Pharmaceutical Communications primarily accepts original research articles and reviews. However, invited editorial summaries and letters to the editor are also occasionally published.\u0000The journal provides a platform for scientists, practitioners, and healthcare professionals to share their knowledge and experiences in the field of pharmaceutics. The journal also serves as a forum for discussing and debating current issues and trends in the pharmaceutical industry. The journal welcomes submissions from academics, practitioners, and industry professionals who wish to share their research and perspectives on topics related to pharmaceutics.\u0000In the last two decades, rapid technological advances have enabled researchers to investigate arcane technological phenomena and ask more profound questions. Several pharmaceutical processes involved in the manufacturing of various dosage forms are being unraveled at a rapid pace, high resolution, and with unprecedented details. Authors carrying out investigations leveraging these technologies dealing with the composition, formulation, preparation, or manufacturing and quality control of extemporaneously compounded or commercially manufactured drugs are encouraged to submit their findings to Pharmaceutical Communications.\u0000The purpose of this journal is to provide a platform to the scientific fraternity, especially regional and national academics, where they could get their studies published after a rapid, transparent, and high-quality peer review. All the articles published in Pharmaceutical Communications will be freely available to readers immediately after publication. The open-access policy of our journal is likely to increase the readership of articles and enhance their visibility and citation potential. The journal also welcomes submissions from authors from any country. Therefore, I invite you to submit your work to Pharmaceutical Communications. We look forward to receiving your submissions!\u0000Professor Dr. Fazli Nasir\u0000Editor-In-Chief\u0000Rehabilitatio","PeriodicalId":123783,"journal":{"name":"Pharmaceutical Communications","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123482359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}