European Spine JournalPub Date : 2025-10-01Epub Date: 2025-07-03DOI: 10.1007/s00586-025-09108-0
Ali Reza Nazari
{"title":"A structural description for severe degeneration of intervertebral discs to computationally interpret experimental results obtained by stress profilometry.","authors":"Ali Reza Nazari","doi":"10.1007/s00586-025-09108-0","DOIUrl":"10.1007/s00586-025-09108-0","url":null,"abstract":"<p><p>In this paper, reduction of load carrying capacity in severely degenerated intervertebral discs (IVDs) was attributed to structural damage to the tissues involved with IVDs. Damage to the collagen fibers was blamed for degradation of the annulus fibrosus (AF) and dehydration of nucleus pulposus (NP) was adopted for losing its incompressibility and unstable migration in a degenerated condition. The change of the mechanical properties in the tissues due to degeneration was referred to various experimental reports that were used to simulate a computational model from a lumbar vertebral segment for a patient with degenerated IVDs. In the first phase of the study, the most accurate mechanical properties, suggested for the tissues by the various references, were selected for simulation of the stress diagrams, obtained by stress profilometry. Then in the second phase, reliability of some damage scenarios according to the pathophysiological descriptions for the tissues in a severely degenerated condition was examined. The results of the model showed that the incompressible response of NP which was taking 79% of a compression load for a normal condition of IVD, took just 40% of the load in a degenerated condition. The models postulated the residual stiffness of a severely degenerated IVD equal to 13% of its original value.</p>","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":"4619-4630"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Distinctive features of upright CT myelography in patients with lumbar spine degenerative diseases.","authors":"Soya Kawabata, Yuki Akaike, Sota Nagai, Takaya Imai, Hiroki Takeda, Kei Ito, Shinjiro Kaneko, Kota Watanabe, Takeo Nagura, Morio Matsumoto, Masaya Nakamura, Yoshitake Yamada, Masahiro Jinzaki, Yoshiharu Ohno, Masanori Inoue, Nobuyuki Fujita","doi":"10.1007/s00586-025-09237-6","DOIUrl":"10.1007/s00586-025-09237-6","url":null,"abstract":"<p><strong>Purpose: </strong>Recently, a full-body upright computed tomography (CT) scanner has been developed, which when combined with myelography, is expected to provide valuable insights into the pathology of lumbar spine degenerative diseases (LSDD). This study aims to elucidate the distinctive features of upright CT myelography (CTM) in LSDD by comparing it with supine magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>This study included 110 patients who underwent both supine MRI and upright CTM for LSDD. The anteroposterior diameter (APD), transverse diameter (TD), and area of the dural sac were measured from L1/2 to L5/S1. Lumbar lordosis (LL) was also measured in both modalities.</p><p><strong>Results: </strong>The APD of the dural sac was significantly smaller at L2/3 and L4/5, while the TD was significantly larger at L1/2 and L2/3 on upright CTM compared to supine MRI. The dural sac area was significantly larger at L1/2 and smaller at L4/5 on upright CTM. Subgroup analysis divided patients into Group I (LL greater in upright CTM, n = 56) and Group D (LL smaller in upright CTM, n = 54). The dural sac area was significantly smaller at L3/4 and L4/5 in Group I and larger at L1/2 in Group D on upright CTM.</p><p><strong>Conclusions: </strong>Changes in the APD, TD and area of the dural sac during the transition from supine to standing were markedly dependent on the intervertebral level. These parameters were also influenced by patterns of change in LL between the two positions. Upright CTM revealed diverse position-related morphological changes in the lumbar dural sac in LSDD patients.</p>","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":"4496-4504"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European Spine JournalPub Date : 2025-10-01Epub Date: 2025-08-23DOI: 10.1007/s00586-025-09185-1
Yang Xiao, Xi Yang
{"title":"Letter to the editor concerning \"Anterior cervical tunnectomy and fusion (ACTF): a novel technique for cervical canal decompression\" by Cheng Qiu, et al. (Eur Spine J [2023]: doi: 10.1007/s00586-023-07691-8).","authors":"Yang Xiao, Xi Yang","doi":"10.1007/s00586-025-09185-1","DOIUrl":"10.1007/s00586-025-09185-1","url":null,"abstract":"","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":"4857-4858"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The influence of sarcopenia on clinical and radiological features in patients with single-segment degenerative lumbar spondylolisthesis at L4/5 level.","authors":"Tianshu Feng, Congyu Wang, Xinyu Yang, Jinghang Li, Jinbo Zhao, Shuo Wang, Xinyu Liu, Lianlei Wang","doi":"10.1007/s00586-025-09050-1","DOIUrl":"10.1007/s00586-025-09050-1","url":null,"abstract":"<p><strong>Purpose: </strong>Sarcopenia may be related to more severe clinical and radiological features; however, its influence on the patients with single-segment DLS at L4/5 level remains unclear. In the study, the impact of sarcopenia on clinical and radiological factors were investigated in patients with L4/5 degenerative lumbar spondylolisthesis (DLS).</p><p><strong>Materials and methods: </strong>Patients diagnosed with single-segment DLS at L4/5 level were enrolled in the retrospective analysis based on a prospective, nonrandomized cohort dataset. According to our diagnostic process of sarcopenia, patients were classified into sarcopenia and non-sarcopenia groups. Clinical features including demographic characteristics, patient-reported outcome measures (PROMs) and clinician- reported outcome measures (ClinROMs) were collected. The radiological features included slip segment, percentage of slip (Slip%), translational motion, angular motion, dural sac cross-sectional area (DSA), ligamentum flavum thickness (LFT), paraspinal muscle parameters, and the use of grading systems to evaluate intervertebral discs, facet joints, and ligament degeneration.</p><p><strong>Results: </strong>A total of 161 individuals were included, with 44 in the sarcopenia group and 117 in the non-sarcopenia group. Statistical analysis indicated that patients with sarcopenia exhibited significantly lower height, weight, body mass index (BMI), pain duration of back and leg, DSA, Japanese Orthopaedic Association scores (JOA), relative functional cross-sectional area (rfCSA) of psoas (PS) and erector spinae (ES) (P < 0.05). Additionally, the proportion of female, Oswestry Disability Index (ODI), LFT, Pfirrmann grading, percentage of fat infiltration (FI%) of ES in the sarcopenia group were significantly higher (P < 0.05). Multivariate logistic regression analysis showed a significant association between sarcopenia and ODI (OR 0.934, 95% CI 0.899-0.972), Slip% (OR 0.874, 95% CI 0.776-0.986), LFT (OR 0.501, 95% CI 0.288-0.872), and rfCSA of ES (OR 1.571, 95% CI 1.128-2.187).</p><p><strong>Conclusion: </strong>Single-segment DLS patients at L4/5 level with sarcopenia suffered from greater pain and function impairment. In addition, more severe vertebral slippage and spinal stenosis were found, which may be linked to the degeneration of paraspinal muscles, intervertebral discs, and ligamentum flavum.</p>","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":"4607-4618"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European Spine JournalPub Date : 2025-10-01Epub Date: 2025-07-24DOI: 10.1007/s00586-025-09182-4
Vishal Kumar, Vikash Raj, Sitanshu Barik
{"title":"Letter to the editor concerning \"Pain improvement and reoperation rate after full-endoscopic decompression for lateral recess stenosis: a 10-year follow-up\" by W. Kesornsak et al. (Eur spine J [2023]: doi:10.1007/s00586-023-07801-6).","authors":"Vishal Kumar, Vikash Raj, Sitanshu Barik","doi":"10.1007/s00586-025-09182-4","DOIUrl":"10.1007/s00586-025-09182-4","url":null,"abstract":"","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":"4852"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European Spine JournalPub Date : 2025-10-01Epub Date: 2025-07-29DOI: 10.1007/s00586-025-09188-y
Yicheng Zhu, Jintao Liu, Guanyi Gong
{"title":"Letter to the editor concerning \"Percutaneous pedicle screw placement with a mini-open decompression versus open surgery in the treatment of lumbar spondylolisthesis: one-year results of a randomised controlled trial\" by Broekema A, et al. (Eur spine J [2025]: doi: 10.1007/s00586-025-08855-4).","authors":"Yicheng Zhu, Jintao Liu, Guanyi Gong","doi":"10.1007/s00586-025-09188-y","DOIUrl":"10.1007/s00586-025-09188-y","url":null,"abstract":"","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":"4789-4790"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characteristics of endplate changes in patients with lumbar disc herniation treated by discectomy and their effects on clinical symptoms during one-year postoperative follow-up.","authors":"Kenichi Kawaguchi, Hirokazu Saiwai, Kazu Kobayakawa, Kiyoshi Tarukado, Kazuya Yokota, Katsumi Harimaya, Go Kato, Yasuharu Nakashima","doi":"10.1007/s00586-025-09171-7","DOIUrl":"10.1007/s00586-025-09171-7","url":null,"abstract":"<p><strong>Purpose: </strong>The impact of endplate changes, such as Modic changes (MCs), on symptoms following discectomy remains uncertain. This study aimed to investigate the postoperative progression of MCs and bony endplate defects after discectomy for lumbar disc herniation (LDH) and to elucidate its association with clinical outcomes.</p><p><strong>Methods: </strong>A total of 247 patients who underwent microscopic discectomy were included. The natural progression of MCs and bony endplate defects at the operated level were assessed using magnetic resonance imaging. Clinical outcomes were evaluated using a visual analog scale (VAS) and the Roland-Morris Disability Questionnaire. The study examined the progression of endplate changes and their impact on clinical outcomes, with a focus on the type of postoperative MC.</p><p><strong>Results: </strong>The natural progression of postoperative MCs was varied, with MCs coexisting with bony endplate defects (p < 0.001). Persistent or converted type 1-related MCs were more likely to exacerbate pre-existing signal changes at one year and were associated with higher VAS scores for low back pain (LBP) compared to type 2 MCs (p < 0.001). Patients with type 1-related MCs (β: 0.429, p < 0.001) and preoperative LBP (β: 0.215, p = 0.025) were closely associated with residual LBP at one year or more.</p><p><strong>Conclusion: </strong>In patients with baseline signal changes in subchondral bone marrow, the presence of type 1 MCs was more likely to promote the increase of MCs than type 2. Furthermore, the presence of type 1 MCs may predict residual postoperative LBP, suggesting that bone marrow signal changes are more strongly associated with clinical symptoms than morphological changes in bony endplates in patients with LDH.</p>","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":"4445-4454"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European Spine JournalPub Date : 2025-10-01Epub Date: 2025-08-09DOI: 10.1007/s00586-025-09261-6
Tharun Teja Aduri, Sharath Raj
{"title":"Letter to the editor concerning \"CALM1 polymorphism in degenerative cervical myelopathy of the Indian cohort\" by Maheshwari S et al. (Eur spine J [2025]: doi.org/10.1007/s00586-025-09090-7).","authors":"Tharun Teja Aduri, Sharath Raj","doi":"10.1007/s00586-025-09261-6","DOIUrl":"10.1007/s00586-025-09261-6","url":null,"abstract":"<p><p>We appreciate the efforts of Maheshwari et al. in exploring CALM1 polymorphisms in degenerative cervical myelopathy (DCM) within an Indian cohort. While the study offers valuable insights, we respectfully highlight certain methodological concerns-particularly regarding statistical interpretation, control group heterogeneity, and age differences between groups. Furthermore, interpretations suggesting pathogenicity for a computationally benign variant may benefit from additional functional validation. We believe that addressing these aspects in future studies will enhance the robustness and translational relevance of genetic research in DCM.</p>","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":"4803-4804"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}