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Knockdown of FOXO4 protects against OGD/R‑induced cerebral microvascular endothelial cell injury and regulates the AMPK/Nrf2/HO‑1 pathway through transcriptional activation of CTRP6 敲除 FOXO4 可防止 OGD/R 诱导的脑微血管内皮细胞损伤，并通过 CTRP6 的转录激活调节 AMPK/Nrf2/HO-1 通路
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-09 DOI: 10.3892/etm.2024.12382
Xiangting Cui, Zhili Li, Yuhua Yuan
{"title":"Knockdown of FOXO4 protects against OGD/R‑induced cerebral microvascular endothelial cell injury and regulates the AMPK/Nrf2/HO‑1 pathway through transcriptional activation of CTRP6","authors":"Xiangting Cui, Zhili Li, Yuhua Yuan","doi":"10.3892/etm.2024.12382","DOIUrl":"https://doi.org/10.3892/etm.2024.12382","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"23 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of the circular RNA regulatory network in the pathogenesis of biliary atresia 环状 RNA 调控网络在胆道闭锁发病机制中的作用
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-09 DOI: 10.3892/etm.2024.12383
Dong Liu, Yinghui Dong, Jiahui Gao, Zhouguang Wu, Lihui Zhang, Bin Wang
{"title":"Role of the circular RNA regulatory network in the pathogenesis of biliary atresia","authors":"Dong Liu, Yinghui Dong, Jiahui Gao, Zhouguang Wu, Lihui Zhang, Bin Wang","doi":"10.3892/etm.2024.12383","DOIUrl":"https://doi.org/10.3892/etm.2024.12383","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"60 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Sildenafil on healthy humans in high‑altitude hypoxia at rest and during exercise: A meta‑analysis 西地那非对高海拔缺氧状态下的健康人在休息和运动时的疗效：荟萃分析
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-08 DOI: 10.3892/etm.2024.12376
Zhan-Cui Dang, Zhiquan Yang, Shou Liu, Guo-Mei Du, Linde Jin, Zhong-Zhi Zhao
{"title":"Efficacy of Sildenafil on healthy humans in high‑altitude hypoxia at rest and during exercise: A meta‑analysis","authors":"Zhan-Cui Dang, Zhiquan Yang, Shou Liu, Guo-Mei Du, Linde Jin, Zhong-Zhi Zhao","doi":"10.3892/etm.2024.12376","DOIUrl":"https://doi.org/10.3892/etm.2024.12376","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"16 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatic GATA4 mutation contributes to tetralogy of Fallot 体细胞 GATA4 基因突变导致法洛氏四联症
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-08 DOI: 10.3892/etm.2024.12379
P. Abhinav, Yanjie Li, Ri-tai Huang, Xing-yuan Liu, Jianing Gu, Chen-Xi Yang, Ying-Jia Xu, Juan Wang, Yi-Qing Yang
{"title":"Somatic GATA4 mutation contributes to tetralogy of Fallot","authors":"P. Abhinav, Yanjie Li, Ri-tai Huang, Xing-yuan Liu, Jianing Gu, Chen-Xi Yang, Ying-Jia Xu, Juan Wang, Yi-Qing Yang","doi":"10.3892/etm.2024.12379","DOIUrl":"https://doi.org/10.3892/etm.2024.12379","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"58 18","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIF‑1 and macrophage activation signalling pathways are potential biomarkers of invasive aspergillosis HIF-1 和巨噬细胞活化信号通路是侵袭性曲霉病的潜在生物标志物
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-08 DOI: 10.3892/etm.2024.12375
Min Wang, Yuling Hu, Feng Cai, Jiayong Qiu, Yimin Mao, Yingmin Zhang
{"title":"HIF‑1 and macrophage activation signalling pathways are potential biomarkers of invasive aspergillosis","authors":"Min Wang, Yuling Hu, Feng Cai, Jiayong Qiu, Yimin Mao, Yingmin Zhang","doi":"10.3892/etm.2024.12375","DOIUrl":"https://doi.org/10.3892/etm.2024.12375","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"27 15","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chondromyxoid fibroma of the lumbar facet joint: A case report 腰椎面关节软骨样纤维瘤：病例报告
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-08 DOI: 10.3892/etm.2024.12381
Bing Kang, Chengwei Yang, Songkai Li, Haoyue Wu, Weiduo Yang, Xusheng Li, Qiang Dou, Gang Chen
{"title":"Chondromyxoid fibroma of the lumbar facet joint: A case report","authors":"Bing Kang, Chengwei Yang, Songkai Li, Haoyue Wu, Weiduo Yang, Xusheng Li, Qiang Dou, Gang Chen","doi":"10.3892/etm.2024.12381","DOIUrl":"https://doi.org/10.3892/etm.2024.12381","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"20 21","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive cardiac lipoma at the left ventricular intermuscular region: A case report 左心室肌间区侵入性心脏脂肪瘤：病例报告
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-08 DOI: 10.3892/etm.2024.12373
Juan Xia, Jian-Ping Liu, Wei Hong, Jing Ge, Yong-Heng Zhang, Lin Cao, Xian-Zheng Zhang, Xiao-Hong Chen, Qin Zhou
{"title":"Invasive cardiac lipoma at the left ventricular intermuscular region: A case report","authors":"Juan Xia, Jian-Ping Liu, Wei Hong, Jing Ge, Yong-Heng Zhang, Lin Cao, Xian-Zheng Zhang, Xiao-Hong Chen, Qin Zhou","doi":"10.3892/etm.2024.12373","DOIUrl":"https://doi.org/10.3892/etm.2024.12373","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"55 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gingival overgrowth approached using recent mechanical and laser technologies: A case report 利用最新的机械和激光技术治疗牙龈增生：病例报告
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-08 DOI: 10.3892/etm.2024.12374
Laurenta Lelia Mihai, I. Parlatescu, Anca Calin, Alexandru Burcea
{"title":"Gingival overgrowth approached using recent mechanical and laser technologies: A case report","authors":"Laurenta Lelia Mihai, I. Parlatescu, Anca Calin, Alexandru Burcea","doi":"10.3892/etm.2024.12374","DOIUrl":"https://doi.org/10.3892/etm.2024.12374","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"50 22","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of enzyme‑induced collagen crosslinking on porcine cornea 酶诱导胶原交联对猪角膜的功效
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-08 DOI: 10.3892/etm.2024.12377
Shijie Zhang, Wenbo Zhang, Shiyu Xiao, Yanzhen Zhang, Duo Chen, Xiaoyu Liu, Yuan Wu
{"title":"Efficacy of enzyme‑induced collagen crosslinking on porcine cornea","authors":"Shijie Zhang, Wenbo Zhang, Shiyu Xiao, Yanzhen Zhang, Duo Chen, Xiaoyu Liu, Yuan Wu","doi":"10.3892/etm.2024.12377","DOIUrl":"https://doi.org/10.3892/etm.2024.12377","url":null,"abstract":"The purpose of the present study was to investigate the effect of a new crosslinking (CXL) method, induced by enzymes, on porcine corneas. Corneal strip (10x3 mm) pairs obtained from 60 fresh porcine eyes were harvested and divided into four groups, Groups A-D. Each pair of corneal strips was incised from the central part of the same cornea; one was incubated in transglutaminase (Tgase) solution (microbial Tgase 2 produced by tissue engineering) and the other remained untreated as a control. CXL strips of Groups A-D were incubated with 2, 1, 0.5 and 0.25 U/ml Tgase solution, respectively at 37˚C for 30 min. After that, tensile strain measurements were performed for all strips. One cornea from each group was chosen randomly for hematoxylin and eosin, and Masson staining to identify histological morphology changes. The elastic modulus of treated corneas of Groups A-D were 6.56±2.93, 4.72±1.29, 5.24±2.13 and 3.48±1.60 MPa (mean ± SD), respectively at a strain of 20%, and had a 66, 43, 36 and -6% increase compared with those of their control strips. Compared with the control strips, the elastic modulus of the treated strips significantly increased in Groups A-C. The central corneal thickness of the treated corneas in Groups A-D were 1.54±0.14, 1.41±0.15, 1.47±0.11 and 1.43±0.13 µm, respectively; however, there was not a statistically significant difference compared with the control group. No reduction in corneal transparency was observed, and no obvious abnormalities were found in corneal morphology. CXL mediated by enzymes can lead to a notable enhancement in the biomechanical characteristics of the cornea while maintaining its structural integrity. Enzyme-induced CXL could be a new generation CXL method for strengthening the cornea.","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"2 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Retracted] 14‑3‑3β exerts glioma‑promoting effects and is associated with malignant progression and poor prognosis in patients with glioma [撤稿】14-3-3β 具有胶质瘤促进作用，与胶质瘤患者的恶性进展和预后不良有关
IF 2.7 4区 医学
Experimental and therapeutic medicine Pub Date : 2024-01-03 DOI: 10.3892/etm.2024.12368
Liang Liu, Zhixiong Liu, Hao Wang, Long Chen, Fuqiang Ruan, Jihui Zhang, Yi Hu, Hengshan Luo, Shuai Wen
{"title":"[Retracted] 14‑3‑3β exerts glioma‑promoting effects and is associated with malignant progression and poor prognosis in patients with glioma","authors":"Liang Liu, Zhixiong Liu, Hao Wang, Long Chen, Fuqiang Ruan, Jihui Zhang, Yi Hu, Hengshan Luo, Shuai Wen","doi":"10.3892/etm.2024.12368","DOIUrl":"https://doi.org/10.3892/etm.2024.12368","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"50 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139452030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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