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[The role of the monoaminergic component in realizing the effect of sydnocarb on the differentiation of visual stimuli]. [单胺能成分在实现辛诺卡威对视觉刺激分化的作用中的作用]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
A I Machula, V A Kozhevnikov
{"title":"[The role of the monoaminergic component in realizing the effect of sydnocarb on the differentiation of visual stimuli].","authors":"A I Machula,&nbsp;V A Kozhevnikov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the experiments on cats by the method of conditioned defensive reflexes there was studied the effect of a psychostimulant sydnocarb on differentiation of short-term and long-term visual stimuli, latencies of the responses to differentiated and single visual stimuli, the number of interstimulus responses, the time of taking a decision. The serotoninergic, dopaminergic and adrenergic substances were used to analyse the influences on the mediator systems. Syndocarb action was found to be mediated by the noradrenergic and serotoninergic systems.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The clinico-pharmacological analysis of the neurotropic action of psychostimulants and preparations with a metabolic type of action]. [精神兴奋剂和具有代谢作用的制剂的促神经作用的临床药理学分析]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
B I Ben'kovich
{"title":"[The clinico-pharmacological analysis of the neurotropic action of psychostimulants and preparations with a metabolic type of action].","authors":"B I Ben'kovich","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The plants of Siberia and the Far East--sources in the search for drug preparations for oncological practice]. [西伯利亚和远东的植物——寻找肿瘤药物制剂的来源]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
E N Amosova, E P Zueva, E D Gol'dberg
{"title":"[The plants of Siberia and the Far East--sources in the search for drug preparations for oncological practice].","authors":"E N Amosova,&nbsp;E P Zueva,&nbsp;E D Gol'dberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of the experimental selection of the agents modifiers of the biological reactions derived from plants of the Siberia and Far East were generalized. On the models of transplanted tumours of mice and rats there was shown the possibility of increasing the antitumour resistance of the organism during the use of the plant-derived agents under conditions of chemotherapeutic and surgical treatment.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The action of bemitil on the self-regulation systems during short-term immobilization]. [贝米特对短期固定过程中自我调节系统的作用]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
L T Kirichek, Iu G Bobkov
{"title":"[The action of bemitil on the self-regulation systems during short-term immobilization].","authors":"L T Kirichek,&nbsp;Iu G Bobkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the immobilized rats bemithyl (50 mg/kg in a single dose) was shown to normalize the state of the musculomotor and cardiovascular systems exerting the positive influence on the key links of the process of autoregulation in the form of the sedative (the central nervous system), stress-protective (hormonal regulation) and antihypoxic (metabolism) effects that characterizes it as the drug with the distinct antistress activity.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A neurochemical analysis of the interaction of afferent signals at the spinal cord level]. [脊髓水平传入信号相互作用的神经化学分析]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
M B Bogdanov
{"title":"[A neurochemical analysis of the interaction of afferent signals at the spinal cord level].","authors":"M B Bogdanov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antinociceptive effect of electrical nerve stimulation with low (2-4 V, 100 Hz, 5 min) and high (45 V, 1 Hz, 1 min) intensity in the unanesthetized rats with the transsected spinal cord was determined by microelectrode recording in the ventrolateral tracts. The action of low intensity stimulation was reduced by yohimbine or during antinociceptive effect of clonidine. It was potentiated by baclofen and physostigmine. Prazosin, bicuculline, methysergid, strychnin, atropine, muscimole, THIP did not influence the effect of low-intensity stimulation. Metysergide partially reduced the effect of high-intensity stimulation. The data suggest that 2-adrenoreceptors are involved in the action of low-intensity stimulation and 5-HT-receptors are involved in the action of high-intensity one. For potentiating the effect of low-intensity stimulation on the segmental level it is possible to use baclofen and physostigmine.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The history of the Department of Pharmacology of the Kiev Medical Institute]. [基辅医学院药学系的历史]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
I S Chekman
{"title":"[The history of the Department of Pharmacology of the Kiev Medical Institute].","authors":"I S Chekman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock]. [吲哚美辛对过敏性休克时血流动力学及冠状血管阻力变化的影响]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
A A Moĭbenko, V N Bulakh, L A Grabovskiĭ, L N Bakumenko
{"title":"[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock].","authors":"A A Moĭbenko,&nbsp;V N Bulakh,&nbsp;L A Grabovskiĭ,&nbsp;L N Bakumenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The preliminary inhibition of prostanoid biosynthesis by indomethacin (10 mg/kg, intravenously) strongly changes the typical anaphylactic shock reaction produced by the intracoronary injection of the challenging dose of the antigen in the dogs sensitized with normal horse serum. A rapid fall of blood pressure and cardiac output at the first stage of the anaphylactic reaction is sharply diminished, the reaction of the coronary vessels is inversed. Instead of dilatation, vasoconstriction occurred increasing with the repeated administration of the antigen. The data obtained suggest that the initial hypotension under anaphylactic shock is due to prostanoid production while the coronary spasm is the result of lipoxygenase activation.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The action of teturam and acetaldehyde on the tissue catecholamines of rats]. [teturam和乙醛对大鼠组织儿茶酚胺的作用]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
G Kh Bozhko, T P Boĭko, P V Voloshin
{"title":"[The action of teturam and acetaldehyde on the tissue catecholamines of rats].","authors":"G Kh Bozhko,&nbsp;T P Boĭko,&nbsp;P V Voloshin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of the isolated and combined effects of teturam and acetaldehyde indicate that a decrease of noradrenaline levels in the brain and heart is induced by teturam. An increase of adrenaline content in the hypothalamus is determined by acetaldehyde. In the adrenals the agents produce the oppositely directed changes in catecholamine content. Against the background of chronic administration of acetaldehyde teturam potentiates its influence on changes in noradrenaline levels in all tissues except the adrenals and adrenaline levels in the hypothalamus and brain stem.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The use of the modelling of the component structure of myocardial contraction for evaluating the mechanisms of action of cardiotropic substances]. [利用心肌收缩的组成结构建模来评估亲心物质的作用机制]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
S A Bogomaz, V F Tarasenko, B I Laptev
{"title":"[The use of the modelling of the component structure of myocardial contraction for evaluating the mechanisms of action of cardiotropic substances].","authors":"S A Bogomaz,&nbsp;V F Tarasenko,&nbsp;B I Laptev","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The antiarrhythmic action of the synthetic acetylcholine analog EDIHYP in calcium chloride- and strophanthin-induced heart rhythm disorders]. [合成乙酰胆碱类似物EDIHYP在氯化钙和strophthin诱导的心律失常中的抗心律失常作用]。
Farmakologiia i toksikologiia Pub Date : 1991-11-01
N A Abdikaliev, I Ia Kalvin'sh, F Z Meerson
{"title":"[The antiarrhythmic action of the synthetic acetylcholine analog EDIHYP in calcium chloride- and strophanthin-induced heart rhythm disorders].","authors":"N A Abdikaliev,&nbsp;I Ia Kalvin'sh,&nbsp;F Z Meerson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The experiments on Wistar rats and chinchilla rabbits showed that EDIHYP (5 mg/kg intravenously) completely prevented cardiac fibrillation and mortality in rats with calcium-chloride-induced arrhythmias, (CaCl2-200 mg/kg intravenously). Administration of atropine (0.1 mg/kg, if administered subcutaneously, 30 minutes before the acute experiment) exerts no influence on the drug's antiarrhythmic activity but eliminates its cholinergic component--salivation and lacrimation. When administered in the same dose EDIHYP to a great extent prevents oubaine (strophanthin)-induced arrhythmias in rabbits but fails to influence aconitine-induced arrhythmias. This suggests that EDIHYP's ability of direct or indirect blockade of slow Ca-channels underlies the mechanism of its antiarrhythmic action.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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