Proceedings of the 17th Southern Biomedical Engineering Conference最新文献

{"title":"An Injectable, Biodegradable PEG Copolyester As A Carrier For Endothelial Cells","authors":"L. Suggs, C. Garcia, A. Mikos","doi":"10.1109/SBEC.1998.666672","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666672","url":null,"abstract":"INTRODUCTION We have developed a block copolymer of poly(propy1ene fumarate-co-ethylene glycol), P(PFCO-EG)’, in order to adprobIems with currcntIy used cardiovascular stenting materials. P(PF-co-EG) is crosslinkable through the fumarate double bonds forming a mechanicaUy stable hydrogel which degrades into fumaric acid, propylene glycol, and PEG. Because of these properties, P(F‘F-co-EG) has potential for use as an injectable, biodegradable implant. We propose to embed endotheIial cells during the crosslinking process and have assessed the feasibility of using this material as a carrier for endothelial cells. The cytotoxicity of preformed copolymer disks was examined as well as cell viabiLity upon embedding.","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"121 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120940624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite Element Based Design Of Prosthetic Socket And Socket/Artificial Limb Connection","authors":"Y. P. Singh","doi":"10.1109/SBEC.1998.666698","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666698","url":null,"abstract":"The paper presents the progress made on the development of finite element based design of prosthetic socket and socket/artificial limb connection. The data made available to author from the UTHSCSA-Rehabilitation Engineering Laboratory (REL) in the native GEO file format was converted to DXF file format by using a FORTRAN 77 computer program developed at the UTSA Division of Engineering. The DXF file conversion allowed the surface profile to be viewed and manipulated within AutoCAD software. Preliminary design drawing for socket, socketlartificial limb connection was developed and converted to IGES file format for use within the ANSYS finite element analysis program. A Finite element model was created within ANSYS, pertinent loads and pressure were applied to the model, and stresses and deflections were determined in the socket.","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125371695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling The Growth Of Endothelium With Celluar Automata","authors":"A. Ambani, K. Zygourakis, P. Markenscoff","doi":"10.1109/SBEC.1998.666752","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666752","url":null,"abstract":"","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114570838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Regeneration Using Controlled Release of rhBMP-2 From Bioabsorbable Scaffolds","authors":"K. Whang, D. Tsai, E. K. Nam, M. Aitken, P. Patel, K. Healy","doi":"10.1109/SBEC.1998.666750","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666750","url":null,"abstract":"","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129245505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Gyro Totally Implantable Centrifugal Pump - Long-Term Implantation and Biocompatibility of Titanium Alloy Model","authors":"G. Ohtsuka, S. Yamane, A. Sueoka, Y. Takami, K. Nakata, M. Yoshikawa, J. Mueller, J. Glueck, H. Schima, E. Wolner, J. Baldwin, Y. Nosé","doi":"10.1109/SBEC.1998.666755","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666755","url":null,"abstract":"","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"8 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129925414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isothermal Microcalorimetry: A Versatile New Tool for Biomaterials Research","authors":"A. U. Daniels, S.J. Chadebois, R. A. Smith, W. Watson","doi":"10.1109/SBEC.1998.666684","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666684","url":null,"abstract":"U 2 -15 2 -30 E ;i 4 5 = 2 do--7s -Introduction. Some of the earliest scientific measurements were of heat produced or absorbed during physical changes of state and chemical reactions, including metabolic activity. Crude calorimeters for this purpose were among the earliest scientific instruments. For example, Bunsen (181 1-1899) placed smdl animals on blocks of ice, and used differences in the amount of melt water produced as a measure of relative metabolic activity. Calorimetry has, of course, progressed steadily. However, not many biomaterials scientists are aware of the sensitivity and power of isothermal microcalorimetry (IMC) as a tool for detecting either the rate of material degradation processes or the magnitude of cellular metabolic responses to materials, nor is there awareness of the predictive power of such data. This paper presents the principles of JMC and the results of some initial studies.","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129123805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion Model Of Dapsone Release Through A Controlled Drug Delivery Device","authors":"C. Anderson, A. Lasserre, P. K. Bajpai, S. Gir","doi":"10.1109/SBEC.1998.666633","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666633","url":null,"abstract":"A diffusion model has been developed to investigate previous$ obtained experimend data relating to the release of Dapsone Pis(4-amino pheny1)sulfone using a controlled drug delivery device (1). The results from the modeling indicated that diffusion coefficient of dapsone in the above system was 1.14 x lo5 cm2/sec. IMlRODUCTXON","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123686128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical Stimulation Of Neurite Outgrowth And Nerve Regeneration","authors":"C. Schmidt, V. R. Shastri, E.J. Furnish, R. Langer","doi":"10.1109/SBEC.1998.666724","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666724","url":null,"abstract":"","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116289896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Angle Light Scattering for Dermal Wound Collagen Structural Analysis","authors":"M. S. Sacks, L. Bowes, E. D. Hiester, J. Brahmatewari, P. Mertz, W. Eaglstein","doi":"10.1109/SBEC.1998.666678","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666678","url":null,"abstract":"MTRODUCTION. The process of demal wound heaiing is a very complex one, taking place in several consecutive stages. Cytokines, in particular growth factors, are important in rhe regulation of these stages. Transforming Growth Factor p (TGFP) is known to play a crucial role during inflammation and extracellular ma^ deposition. Chronic exposure to large amounts of TGFP may promote excessive fibrosis. Attempts to prevent fibrosis and scarring have been aimed at lowering the levels of TGFP in the wound site. Local application of neutralizing antibodies to TGFP (Ab-TGFP) has been shown to signpiticantly decrease the amount of scarring during wound h e a h g . Small angle light scattering (SALS) offers a means to quantitatively determine differences in collagen fiber orientation and directional uniformity during the would healing process in the presence of TGFP or Ab-TGFP. In this study, we demonstrate that SALS can be used to quantify differences in the collagen fiber architecture of histological sections taken from dermal wounds that exposed to TGFP and Ab-TGFP. METHODS. Recombinant human TGFP2 and Ab-TGFP;, of the IgG subtype were utilized with a methylcellulose 2% gel as the delivery vehicle. Two white specific pathogen pigs (15-20Kg) were wounded according to established procedures following AAALAC standards. Biopsies were performed on days 7, 14, and 46 post-wounding, with normal unwounded s!un also taken as the conuol. Tissue specimens were fixed and standard histological sections prepared using H&E staining. A detailed description of the SALS device and its accuracy in tissue structural analysis has been previously presented (Sacks, et al. 1997). Briefly, a 4 mW HeNe (X = 632.8 nm) continuous unpolarized wave laser is passed Wough the tlssue specimen, which scatters light according to the internal fiber structure within the light beam envelope (Fig. 1). The information obtainable from thc scattered light distribution I (0) includes the preferred fiber . drrection, defined as the cennoid of I(O), and the degree of orientation defined as the angle containmg half of the total area under the I(cD), representing 50% of the fibers (Sacks, et al. 1997). After SALS scanning, the data was analyzed and the degree of orientation and collagen preferred directions mapped (Fig. 2). SALS data from the wounded section was extracted and the means for degree of orientation computed. RESULTS A N D DISCUSSION. Normal skin revealed the lowest degree of orientation (54.6\"), while the TGFP treated wounds had a significantly greater (p < 0.0001) degree of orientation at days 7 and 14. The greater degree of orientation is consistent the presence of fibrosis in the wound site. Specimens treated with Ab-TGFPL3 displayed a degree of orientation intermediate between normal and TGFP treated wounds. By day 46, wound architectures were indistinguishable. These results suggest that SALS can be used to detect a d quanti@ the differences in collagen fiber onentation in normal eal","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116340839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Big-H3 As A Potential Protein Coating To Engineer Directed Nerve Extension","authors":"J. W. Ferguson, V. Hernandez, R. LeBaron","doi":"10.1109/SBEC.1998.666704","DOIUrl":"https://doi.org/10.1109/SBEC.1998.666704","url":null,"abstract":"","PeriodicalId":122159,"journal":{"name":"Proceedings of the 17th Southern Biomedical Engineering Conference","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124499971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}