Expert Review of Anti-infective Therapy最新文献_第9页

Assessment of potentially unnecessary antibiotic use for suspected urinary tract infections in nursing homes using a simplified algorithm. 使用简化算法评估养老院疑似尿路感染可能不必要的抗生素使用。

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-02-01 Epub Date: 2025-01-26 DOI: 10.1080/14787210.2025.2456860

Carl Llor, Jonas Olsen, Jesper Lykkegaard, Marilena Anastasaki, Jette Nygaard Jensen, Jens Søndergaard, Valeria Antsupova, Davorina Petek, Malene Plejdrup Hansen, Marie Theut, Christos Lions, Lina Jaruseviciene, Ruta Radzeviciene, András Bálint, Helena Glasova, Jozef Glasa, Nina Sodja, Ana Moragas, Ramon Monfà, Ana García-Sangenís, Anna Kowalczyk, Georg Ruppe, Laura Vallejo-Torres, Marina Elistratova, Beatriz González López-Valcárcel, Greta Tsoulchai

{"title":"Assessment of potentially unnecessary antibiotic use for suspected urinary tract infections in nursing homes using a simplified algorithm.","authors":"Carl Llor, Jonas Olsen, Jesper Lykkegaard, Marilena Anastasaki, Jette Nygaard Jensen, Jens Søndergaard, Valeria Antsupova, Davorina Petek, Malene Plejdrup Hansen, Marie Theut, Christos Lions, Lina Jaruseviciene, Ruta Radzeviciene, András Bálint, Helena Glasova, Jozef Glasa, Nina Sodja, Ana Moragas, Ramon Monfà, Ana García-Sangenís, Anna Kowalczyk, Georg Ruppe, Laura Vallejo-Torres, Marina Elistratova, Beatriz González López-Valcárcel, Greta Tsoulchai","doi":"10.1080/14787210.2025.2456860","DOIUrl":"10.1080/14787210.2025.2456860","url":null,"abstract":"Background: Nursing home (NH) residents are frequently treated with antibiotics for urinary tract infections (UTIs), often due to overdiagnosis. The aim of this study was to evaluate the proportion of potentially unnecessary antibiotic use for suspected UTIs in NHs across eight European countries.Research design and methods: Over a three-month period (February to April 2024), NH professionals recorded information on all antibiotic treatments for UTIs using a specific registration chart. Based on medical literature and the expertise of the project consortium members, the authors developed and endorsed by consensus a simplified algorithm to assess unnecessary antibiotic use in residents without indwelling catheters.Results: The study, conducted across 110 NHs, included 2773 antibiotic-treated infections. Of these, 1158 (41.8%) were treated for UTIs. Among 975 UTI cases without catheters, 54.1% may have been unnecessarily treated. Over one-third involved nonspecific symptoms including poor general condition and changes in urine appearance, while specific urinary symptoms, such as incontinence (21.3%) and dysuria (20.8%), were less common. A trend toward greater, potentially unnecessary antibiotic use was observed when urine dipsticks were performed.Conclusions: The findings reveal potentially unnecessary antibiotic use. Further algorithm validation is needed to enhance diagnostic criteria, reduce overuse, and improve UTI management in NHs.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"235-241"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling sulbactam-durlobactam: insights into its role in combating infections caused by Acinetobacter baumannii. 解开舒巴坦-杜罗巴坦：洞察其在对抗鲍曼不动杆菌引起的感染中的作用。

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-01-01 Epub Date: 2024-12-19 DOI: 10.1080/14787210.2024.2440018

Yakun Fu, Tomefa E Asempa, Joseph L Kuti

{"title":"Unraveling sulbactam-durlobactam: insights into its role in combating infections caused by Acinetobacter baumannii.","authors":"Yakun Fu, Tomefa E Asempa, Joseph L Kuti","doi":"10.1080/14787210.2024.2440018","DOIUrl":"10.1080/14787210.2024.2440018","url":null,"abstract":"Introduction: Carbapenem-resistant Acinetobacter baumannii (CRAB) is a critical priority pathogen posing a substantial threat to our public health due to its virulence and resistance to broad-spectrum antimicrobials. Sulbactam-durlobactam (Xacduro) is a newly approved β-lactam-β-lactamase inhibitor combination agent with potent in vitro and in vivo activity against CRAB. The phase III randomized trial (ATTACK) demonstrated the safety and efficacy of sulbactam-durlobactam in combination with imipenem-cilastatin as background therapy in treating adult patients with hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia caused by CRAB.Areas covered: This review will discuss pharmacology, antimicrobial activity, pharmacokinetics/pharmacodynamics, clinical efficacy, safety, and therapeutic role of sulbactam-durlobactam. To gather relevant information, a literature search was performed using PubMed and Google Scholar electronic databases. Search terms used include sulbactam, sulbactam-durlobactam, ETX2514, Acinetobacter baumannii, Acinetobacter baumannii-calcoaceticus complex, CRAB, OXA-24, and OmpA. Additional information was obtained from the sulbactam-durlobactam FDA package insert and infectious diseases conference abstracts.Expert opinion: Sulbactam-durlobactam is a well-tolerated β-lactam-β-lactamase inhibitor combination agent with efficacy against CRAB. Given the limitations of alternative treatment options, sulbactam-durlobactam may also be considered as a treatment option for non-respiratory infections caused by CRAB, however further clinical studies are warranted.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"67-78"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting H3N2 influenza: advancements in treatment and vaccine strategies. 针对 H3N2 流感：治疗和疫苗策略的进展。

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-01-01 Epub Date: 2025-01-03 DOI: 10.1080/14787210.2024.2443920

Shriyansh Srivastava, Nandani Jayaswal, Sachin Kumar, G S N Koteswara Rao, Roja Rani Budha, Aroop Mohanty, Rachana Mehta, Vasso Apostolopoulos, Sanjit Sah, D Katterine Bonilla-Aldana, Ricardo Ulloque-Badaracco, Alfonso J Rodriguez-Morales

{"title":"Targeting H3N2 influenza: advancements in treatment and vaccine strategies.","authors":"Shriyansh Srivastava, Nandani Jayaswal, Sachin Kumar, G S N Koteswara Rao, Roja Rani Budha, Aroop Mohanty, Rachana Mehta, Vasso Apostolopoulos, Sanjit Sah, D Katterine Bonilla-Aldana, Ricardo Ulloque-Badaracco, Alfonso J Rodriguez-Morales","doi":"10.1080/14787210.2024.2443920","DOIUrl":"10.1080/14787210.2024.2443920","url":null,"abstract":"Introduction: The emergence of the H3N2 influenza virus in 1968 marked a significant event as it crossed the species barrier. This shift led to a pandemic, resulting in the deaths of one million people globally and highlighting the virus's severe impact on older individuals due to antigenic drift.Area covered: This review comprehensively examines the virological characteristics, evolutionary trends, and global epidemiology of the Influenza A (H3N2) virus. It delves into vaccination strategies, antiviral interventions, and emerging diagnostic approaches. The impact of antigenic variation on vaccine design and effectiveness, seasonal outbreak patterns, and pandemic potential are explored. Additionally, the interplay between viral factors and host immune responses is assessed. Researchers are actively investigating innovative strategies to enhance vaccine efficacy against H3N2 mutations, such as precise antigenic material administration, controlled release patterns, understanding immune system mechanisms, and glycan engineering.Expert opinion: The ongoing mutational dynamics of the H3N2 virus necessitate regular vaccine updates, as advocated by the WHO. Research in the Western Pacific region underscores the need for heightened awareness and effective control strategies. Evaluating antiviral therapies and addressing drug resistance requires multidisciplinary approaches involving researchers, healthcare professionals, and policymakers. This comprehensive understanding of H3N2 is vital for improving public health interventions and preparing for future influenza challenges.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"5-18"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of resistance to cell wall and plasma membrane targeting antifungal drugs in Candida species isolated in Africa. 非洲念珠菌对细胞壁和质膜靶向抗真菌药物的耐药性机制。

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-01-01 Epub Date: 2025-01-06 DOI: 10.1080/14787210.2024.2448844

Chibuike Ibe, Akaninyene Otu, Carolina Henritta Pohl

{"title":"Mechanisms of resistance to cell wall and plasma membrane targeting antifungal drugs in Candida species isolated in Africa.","authors":"Chibuike Ibe, Akaninyene Otu, Carolina Henritta Pohl","doi":"10.1080/14787210.2024.2448844","DOIUrl":"10.1080/14787210.2024.2448844","url":null,"abstract":"Introduction: There is a rise in the emergence of multidrug resistant fungal pathogens worldwide, including in Africa.Method: This systematic review summarized the published data on the mechanisms and epidemiology of antifungal resistance in Candida species in Africa between 2000 and early 2024.Result: Seventeen reports from seven African countries were analyzed but due to the paucity of data, the prevalence of antifungal resistant Candida isolates in Africa could not be estimated. However, a total of 1376 (out of 2812) resistant isolates were documented with South Africa reporting the most. Candida auris was the most reported species with multidrug and pandrug resistant strains documented in South Africa. Generally, azoles but not posaconazole or isavuconazole, resistance was reported. Fluconazole resistant isolates harbored Erg11 Y132F, VF125LA and K177A/R/N335S/E343D substitutions, MRR1 gain of function mutations or efflux pump protein over expression. Resistance to members of the echinocandin family was also reported and Fks1 S639P substitution was observed.Conclusion: The data highlight that the increasing Candida species resistance to cell wall and cell membrane active antifungals is a cause for serious concern in Africa. There is need to increase antifungal research capacity and mount epidemiological surveillance to determine the true scale of the problem.Prospero registration number: CRD42024550231.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"91-104"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoalbuminemia as a predictor of severe dengue: a systematic review and meta-analysis. 低白蛋白血症作为严重登革热的预测因子：一项系统回顾和荟萃分析。

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-01-01 Epub Date: 2025-01-04 DOI: 10.1080/14787210.2024.2448721

Muhammed Shabil, Ganesh Bushi, Vasso Apostolopoulos, Tahani Alrahbeni, Khalid Al-Mugheed, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Neelima Kukreti, Sarvesh Rustagi, Yousef N Alhashem, Jawaher Alotaibi, Nawal A Al Kaabi, Tarek Sulaiman, Hussain R Alturaifi, Faryal Khamis, Ali A Rabaan, Prakasini Satapathy

{"title":"Hypoalbuminemia as a predictor of severe dengue: a systematic review and meta-analysis.","authors":"Muhammed Shabil, Ganesh Bushi, Vasso Apostolopoulos, Tahani Alrahbeni, Khalid Al-Mugheed, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Neelima Kukreti, Sarvesh Rustagi, Yousef N Alhashem, Jawaher Alotaibi, Nawal A Al Kaabi, Tarek Sulaiman, Hussain R Alturaifi, Faryal Khamis, Ali A Rabaan, Prakasini Satapathy","doi":"10.1080/14787210.2024.2448721","DOIUrl":"10.1080/14787210.2024.2448721","url":null,"abstract":"Introduction: Dengue fever is a significant health concern globally, especially in tropical regions. Identifying reliable markers for severe dengue, such as hypoalbuminemia, is crucial for early diagnosis and treatment.Methods: This review systematically explores the association between hypoalbuminemia and severe dengue. We searched databases including PubMed, Embase, Scopus, Cochrane, and Web of Science until 28 December 2023, focusing on studies that reported albumin levels in dengue patients. Our selection criteria aimed at observational studies, from which data extraction and quality assessment were performed using Nested- Knowledge and the Newcastle-Ottawa Scale.Results: A meta-analysis of 17 studies involving 974 severe and 18,496 non-severe dengue patients identified a standardized mean difference (SMD) in albumin levels of -1.625 g/dL (95% CI: -3.618 to -0.369). Subgroup analysis indicated more pronounced hypoalbuminemia in pediatric patients, with a pooled SMD of -1.08 g/dL (95% CI: -1.71 to -0.45). Our analysis demonstrated the link between hypoalbuminemia and severe dengue, indicating a significant pooled relative risk of 2.286, within 95% CI 1.308 to 3.996.Conclusions: The study confirms hypoalbuminemia as a significant predictor of severe dengue. Recognizing hypoalbuminemia in dengue patients can aid clinicians in forecasting the severity, potentially improving patient outcomes through targeted therapeutic strategies.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"105-118"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of adjuvants to improve antibiotic efficacy and reduce the burden of antimicrobial resistance. 使用佐剂提高抗生素疗效，减轻抗菌素耐药性负担。

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1080/14787210.2024.2441891

Teresa Gil-Gil, Pablo Laborda, José Luis Martínez, Sara Hernando-Amado

{"title":"Use of adjuvants to improve antibiotic efficacy and reduce the burden of antimicrobial resistance.","authors":"Teresa Gil-Gil, Pablo Laborda, José Luis Martínez, Sara Hernando-Amado","doi":"10.1080/14787210.2024.2441891","DOIUrl":"10.1080/14787210.2024.2441891","url":null,"abstract":"Introduction: The increase in antibiotic resistance, together with the absence of novel antibiotics, makes mandatory the introduction of novel strategies to optimize the use of existing antibiotics. Among these strategies, the use of molecules that increase their activity looks promising.Areas covered: Different categories of adjuvants have been reviewed. Anti-resistance adjuvants increase the activity of antibiotics by inhibiting antibiotic resistance determinants. Anti-virulence approaches focus on the infection process itself; reducing virulence in combination with an antibiotic can improve therapeutic efficacy. Combination of phages with antibiotics can also be useful, since they present different mechanisms of action and targets. Finally, combining antibiotics with adjuvants in the same molecule may serve to improve antibiotics' efficacy and to overcome potential problems of differential pharmacokinetics/pharmacodynamics.Expert opinion: The successful combination of inhibitors of β-lactamases with β-lactams has shown that adjuvants can improve the efficacy of current antibiotics. In this sense, novel anti-resistance adjuvants able to inhibit efflux pumps are still needed, as well as anti-virulence compounds that improve the efficacy of antibiotics by interfering with the infection process. Although adjuvants may present different pharmacodynamics/pharmacokinetics than antibiotics, conjugates containing both compounds can solve this problem. Finally, already approved drugs can be a promising source of antibiotic adjuvants.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"31-47"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on actinomycetoma treatment: linezolid in the treatment of actinomycetomas due to Nocardia spp and Actinomadura madurae resistant to conventional treatments. 放线菌瘤治疗的最新进展：利奈唑胺用于治疗诺卡菌和硬膜放线菌引起的放线菌瘤，这些放线菌瘤对常规治疗具有耐药性。

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-01-01 Epub Date: 2025-01-06 DOI: 10.1080/14787210.2024.2448723

Alexandro Bonifaz, Roxana S García-Sotelo, Fabiola Lumbán-Ramirez, Denisse Vázquez-González, José Iván Inclán-Reyes, Mario Eduardo Sierra-Garduño, Javier Araiza, David Chandler

{"title":"Update on actinomycetoma treatment: linezolid in the treatment of actinomycetomas due to Nocardia spp and Actinomadura madurae resistant to conventional treatments.","authors":"Alexandro Bonifaz, Roxana S García-Sotelo, Fabiola Lumbán-Ramirez, Denisse Vázquez-González, José Iván Inclán-Reyes, Mario Eduardo Sierra-Garduño, Javier Araiza, David Chandler","doi":"10.1080/14787210.2024.2448723","DOIUrl":"10.1080/14787210.2024.2448723","url":null,"abstract":"Introduction: Mycetoma is a chronic granulomatous infection, common throughout tropical regions, and is considered a neglected disease that mostly affects impoverished populations. Mycetoma is divided into eumycetoma, caused by fungi, and actinomycetoma, caused by filamentous bacteria. Clinical presentation is distinctive, and making the diagnosis is usually not difficult; however, access to safe and effective treatments is a major challenge. There is not a single best treatment, with the choice of treatment depending on etiology, severity and extent of disease, and patient comorbidities.Areas covered: The following topics regarding actinomycetoma are discussed. I) Background information on actinomycetoma, and etiology. II) Differences between actinomycetoma caused by Nocardia, and cutaneous nocardiosis. III) Review of the treatment options for actinomycetoma, caused by three species - Nocardia, Actinomadura, and Streptomyces. IV) Experience using linezolid in the treatment of mycetoma caused by Nocardia spp. and Actinomadura madurae.Expert opinion: Multiple treatment regimens for actinomycetoma were discussed according to the causative agent. Experience in using linezolid in combined therapy for actinomycetoma caused by Nocardia in which conventional treatment options failed was also presented. The first case report of treatment with linezolid for mycetoma caused by Actinomadura madurae is presented in this article.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"79-89"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could the next disease X be pandemic of virus-induced encephalitis? what should be our first medical response? 下一个 "X 病 "会是由病毒引起的脑炎大流行吗？我们的第一医疗反应应该是什么？

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-01-01 Epub Date: 2025-01-03 DOI: 10.1080/14787210.2024.2432277

Mina T Kelleni

引用次数: 0

Optic and peripheral neuropathy associated with short and prolonged administration of tedizolid: a review. 视神经和周围神经病变与短期和长期施用泰德唑胺有关：综述。

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI: 10.1080/14787210.2024.2448143

Angeliki Katsarou, Maria Tzikopoulou, Dimitrios Papadopoulos, Sotiria Palioura, Matthew E Falagas

{"title":"Optic and peripheral neuropathy associated with short and prolonged administration of tedizolid: a review.","authors":"Angeliki Katsarou, Maria Tzikopoulou, Dimitrios Papadopoulos, Sotiria Palioura, Matthew E Falagas","doi":"10.1080/14787210.2024.2448143","DOIUrl":"10.1080/14787210.2024.2448143","url":null,"abstract":"Introduction: Tedizolid is a novel antibiotic of the class of oxazolidinones. This review evaluates the published literature on the optic and peripheral neuropathy associated with short and prolonged administration of tedizolid.Areas covered: A review of published data from 4 databases was conducted, regarding the development of optic and peripheral neuropathy in patients who received tedizolid for short or prolonged duration. A total of 1,212 records were screened; 33 were included in this review. No peripheral or optic neuropathy cases were reported in 6 randomized controlled trials that studied tedizolid use for a short course. In contrast, 2 cases with optic neuropathy (1 not supported by objective findings) in 87 patients of the prospective studies were identified. Additionally, in a total of 277 patients who participated in the 6 retrospective studies, 9 adverse events related to optic or peripheral neuropathy and 1 case with foot drop in 22 patients of the relevant cases reports were recorded.Expert opinion: The available data suggests that the safety profile of tedizolid is favorable, especially when given for a short time. However, more clinical studies are needed regarding its long-term use, given that the neurotoxicity induced by oxazolidinones may be time and dose-dependent.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"49-65"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evolving scenario of HCV-related mixed cryoglobulinemia and B-cell lymphoma in the era of direct-acting antivirals. 在直接作用抗病毒药物时代，hcv相关的混合冷球蛋白血症和b细胞淋巴瘤的演变情况。

IF 4.2 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-01-01 Epub Date: 2025-01-03 DOI: 10.1080/14787210.2024.2442475

Antonio Tonutti, Davide Polverini, Stella De Nicola, Angela Ceribelli, Matteo Soleri, Maria De Santis, Alessio Aghemo, Carlo Selmi, Nicola Pugliese

{"title":"The evolving scenario of HCV-related mixed cryoglobulinemia and B-cell lymphoma in the era of direct-acting antivirals.","authors":"Antonio Tonutti, Davide Polverini, Stella De Nicola, Angela Ceribelli, Matteo Soleri, Maria De Santis, Alessio Aghemo, Carlo Selmi, Nicola Pugliese","doi":"10.1080/14787210.2024.2442475","DOIUrl":"10.1080/14787210.2024.2442475","url":null,"abstract":"Introduction: Hepatitis C virus (HCV) infection represents a significant global health burden, particularly due to its extrahepatic immune-mediated manifestations, such as mixed cryoglobulinemia, associated vasculitis (CryoVas), and non-Hodgkin B-cell lymphoma (B-NHL), which pose significant challenges. The advent of direct-acting antiviral (DAA) has changed the therapeutic landscape for HCV-related complications.Areas covered: This review explores the evolving epidemiology and management of HCV extrahepatic manifestation and lymphoproliferative disorders in the era of DAAs. It examines the efficacy of DAAs in controlling CryoVas and their complex role in HCV-related B-cell lymphoma. The literature search included studies on the immunological dynamics between HCV, CryoVas, and lymphoma, focusing on the impact of sustained virological response (SVR) on immune dysregulation, relapse risk, refractory disease, and patient stratification based on risk profiles.Expert opinion: DAAs have significantly improved the management of HCV-related CryoVas and autoimmune manifestations, but remain a challenge in refractory cases and the risk of lymphoma. Future strategies should focus on refining risk stratification and integrating new therapeutic approaches to better address immune dysregulation and associated complications.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"19-30"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0