Folia Pharmacologica Japonica最新文献_第7页

Folia Pharmacologica Japonica Pub Date : 2024-07-01 DOI: 10.1254/fpj.24028

Motokazu Koga

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[Canine inherited retinal degeneration as model to study disease mechanisms and therapy for ciliopathies]. [以犬遗传性视网膜变性为模型，研究纤毛疾病的发病机制和治疗方法］

Folia Pharmacologica Japonica Pub Date : 2024-07-01 Epub Date: 2024-04-26 DOI: 10.1254/fpj.23071

Kei Takahashi, Keiko Miyadera

{"title":"[Canine inherited retinal degeneration as model to study disease mechanisms and therapy for ciliopathies].","authors":"Kei Takahashi, Keiko Miyadera","doi":"10.1254/fpj.23071","DOIUrl":"10.1254/fpj.23071","url":null,"abstract":"Humans have a highly developed retina and obtain approximately 80% of their external information from vision. Photoreceptor cells, which are located in the outermost layer of the neuroretina and recognize light signals, are highly specialized sensory cilia that share structural and functional features with primary cilia. Genetic disorders of the retina or photoreceptor cells are termed inherited retinal diseases (IRDs) and are caused by variants in one of more than 280 genes identified to date. Among the genes responsible for IRDs, many are shared with those responsible for ciliopathies. In studies of inherited diseases, mouse models are commonly used due to their advantages in breeding, handling, and relative feasibility in creating pathological models. On the other hand, structural, functional, and genetic differences in the retina between mice and humans can be a barrier in IRD research. To overcome the limitations of mouse models, larger vertebrate models of IRDs can be a useful research subject. In particular, canines have retinas that are structurally and functionally similar and eyes that are anatomically comparable to those of humans. In addition, due to their unique veterinary clinical surveillance and genetic background, naturally occurring canine IRDs are more likely to be identified than in other large animals. To date, pathogenic mutations related to canine IRDs have been identified in more than 30 genes, contributing to the understanding of pathogeneses and to the development of new therapies. This review provides an overview of the roles of the canine IRD models in ciliopathy research.","PeriodicalId":12208,"journal":{"name":"Folia Pharmacologica Japonica","volume":" ","pages":"192-197"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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研究者が論文を書くということ研究人员撰写论文的意义。

Folia Pharmacologica Japonica Pub Date : 2024-07-01 DOI: 10.1254/fpj.24020

Atsushi Sugiyama

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[Regulation of adipose progenitors and fibro-adipogenic progenitors through primary cilia]. [通过初级纤毛调节脂肪祖细胞和纤维-脂肪生成祖细胞]。

Folia Pharmacologica Japonica Pub Date : 2024-07-01 Epub Date: 2024-04-26 DOI: 10.1254/fpj.23108

Yuhei Nishimura

{"title":"[Regulation of adipose progenitors and fibro-adipogenic progenitors through primary cilia].","authors":"Yuhei Nishimura","doi":"10.1254/fpj.23108","DOIUrl":"10.1254/fpj.23108","url":null,"abstract":"The primary cilium, an antenna-like structure of cell membrane, detects various signals and regulates cellular functions such as proliferation and differentiation. The impairment of primary cilium is associated with the etiologies of diseases including cancer, obesity, and congenital anomalies. In this review, novel functions of trichoplein, a suppressor of ciliogenesis, on the regulation of adipose progenitors and fibro-adipogenic progenitors are focused. Trichoplein-knockout mice show resistance to high-fat diet-induced obesity and accelerated regeneration after skeletal muscle injury. The primary cilia of adipose progenitors from trichoplein-knockout mice are elongated, leading to the inhibitions of the accumulation of lipid raft to the base of primary cilia and the phosphorylation of AKT. The primary cilia of fibro-adipogenic progenitors from trichoplein-knockout mice are also elongated, causing the increased expression of IL-13 through IL-33 receptor signaling. These mechanisms are involved in the resistance to diet-induced obesity and improved regeneration. These findings suggest that targeting the primary cilia of specific cells may be a novel therapeutic approach through modulating cellular functions.","PeriodicalId":12208,"journal":{"name":"Folia Pharmacologica Japonica","volume":" ","pages":"188-191"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Role of endosomal pathway in the ciliary transport and the membrane organization of outer segment disc membrane in photoreceptors]. [内体途径在光感受器睫状体运输和外节盘膜组织中的作用]。

Folia Pharmacologica Japonica Pub Date : 2024-07-01 Epub Date: 2024-04-26 DOI: 10.1254/fpj.23077

Wataru Otsu

{"title":"[Role of endosomal pathway in the ciliary transport and the membrane organization of outer segment disc membrane in photoreceptors].","authors":"Wataru Otsu","doi":"10.1254/fpj.23077","DOIUrl":"10.1254/fpj.23077","url":null,"abstract":"A photoreceptor is a specialized neuron that is responsible for the conversion of light into an electrical signal. Photoreceptors are classified into rods and cones, and both photoreceptors possess light-sensing ciliary organelles called outer segments (OSs), anchored in the cells by a microtubule-based axoneme. The OS consists of a stack of disc membranes, which are abundant for the retinal phototransduction proteins such as rhodopsin. Recently, modern protein synchronization techniques using in vivo transfection in rodents revealed that rhodopsin transits through Rab11-positive recycling endosomes, preferentially entering the OS in the dark. Moreover, Peripherin-2 (PRPH2, also called retinal degeneration slow, RDS), a photoreceptor-specific tetraspanin protein essential for the morphogenesis of disc membranes, is delivered to the OS following complementary to that of rhodopsin. Various PRPH2 disease-causing mutations have been found in humans, and most of the mutations in the cytosolic C-terminus of PRPH2 are linked to cone-dominant macular dystrophies. It has been shown that the late endosome is the waystation that sorts newly synthesized PRPH2 into the cilium. The multiple C-terminal motifs of PRPH2 regulate its late endosome and ciliary targeting through ubiquitination and binding to an Endosomal Sorting Complexes Required for Transport (ESCRT) component, Hrs. These findings suggest that the late endosomes play an important role in the biosynthetic pathway of ciliary proteins and can be a new therapeutic target for the diseases caused by ciliary defects.","PeriodicalId":12208,"journal":{"name":"Folia Pharmacologica Japonica","volume":" ","pages":"203-208"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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序文序文

Folia Pharmacologica Japonica Pub Date : 2024-07-01 DOI: 10.1254/fpj.24034

Akiyoshi Saitoh

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第144回日本薬理学会近畿部会／大阪医科薬科大学薬学部薬品作用解析学研究室第144回日本薬理学会近畿部会／大阪医科薬科大学薬学部薬品作用解析学研究室

Folia Pharmacologica Japonica Pub Date : 2024-07-01 DOI: 10.1254/fpj.24024

Yukihiro Ohno

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[Mechanisms of bone formation by primary cilia]. [初级纤毛形成骨的机制]。

Folia Pharmacologica Japonica Pub Date : 2024-07-01 Epub Date: 2024-04-26 DOI: 10.1254/fpj.23113

Masaki Saito, Gen-Ichi Atsumi

{"title":"[Mechanisms of bone formation by primary cilia].","authors":"Masaki Saito, Gen-Ichi Atsumi","doi":"10.1254/fpj.23113","DOIUrl":"10.1254/fpj.23113","url":null,"abstract":"Primary cilia are immotile cilia assembled from the centriole-derived basal body, and they protrude on the cell surface in almost all cell types during the cell cycle G0 phase. Due to the diffusion barrier at the ciliary base, cilia harbor selective G protein-coupled receptors, growth factor receptors, and ion channels on their membrane. Thus, cilia act as sensory organelles, regulating the proliferation and differentiation of the cells and promoting the formation and maturation of various organs including bone, brain, and kidney. It has been unveiled that malformation and dysregulation of cilia cause organ dysplasia, so-called ciliopathy, thus research on primary cilia has become active during the past 20 years. Research on the roles of cilia in bone formation and its regulatory mechanisms have also progressed. It is widely recognized that cilia of preosteoblasts receive hedgehog and promote differentiation of the cells to osteoblasts, resulting in the formation of skulls and long bones. Recently, it has been shown that a membrane-associated protein 4.1G is important in ciliogenesis, hedgehog signaling, and osteoblast differentiation in neonatal bone formation. In this review, we would like to summarize the roles of primary cilia in bone formation and their regulatory mechanisms including the contribution of 4.1G.","PeriodicalId":12208,"journal":{"name":"Folia Pharmacologica Japonica","volume":" ","pages":"198-202"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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序文序文

Folia Pharmacologica Japonica Pub Date : 2024-07-01 DOI: 10.1254/fpj.24003

Wataru Otsu, Masaki Saito

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新教授紹介新教授介绍

Folia Pharmacologica Japonica Pub Date : 2024-07-01 DOI: 10.1254/fpj.24021

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