Evidence-Based Medicine最新文献_第10页

Reflections on using non-inferiority randomised placebo controlled trials in assessing cardiovascular safety of new agents for treatment of type 2 diabetes. 使用非劣效性随机安慰剂对照试验评估治疗2型糖尿病新药心血管安全性的思考

Evidence-Based Medicine Pub Date : 2017-04-01 Epub Date: 2017-03-08 DOI: 10.1136/ebmed-2017-110685

Denise Campbell-Scherer

{"title":"Reflections on using non-inferiority randomised placebo controlled trials in assessing cardiovascular safety of new agents for treatment of type 2 diabetes.","authors":"Denise Campbell-Scherer","doi":"10.1136/ebmed-2017-110685","DOIUrl":"https://doi.org/10.1136/ebmed-2017-110685","url":null,"abstract":"<p><p>The 2008 Food and Drug Administration (FDA) guidance to industry requires experimental evidence that new agents to treat type 2 diabetes do not have an unacceptable increase in cardiovascular risk. They specify this unacceptable increase to be a risk ratio of 1.3 in non-inferiority trials which may use placebo control. Clinically, this means that if a new agent achieves this threshold of not being 30% worse than placebo it is declared 'non-inferior'. This guidance was in response to safety concerns raised about medications approved on their basis of reducing glycated haemoglobin alone. There was concern that this FDA guidance would stifle new drugs coming to market. On the contrary, there have been a number of exciting new classes of agents approved with improved confidence that they reduce glycated haemoglobin, and that they also do not excessively increase cardiovascular risk. Cardiovascular safety trials have been conducted for a number of novel medications using a non-inferiority approach. However, clinicians need to recognise that the results of non-inferiority trials are not as credible as superiority trials. It is important to closely review the trials before accepting claims of 'non-inferiority' or 'cardiac neutrality' especially when these studies are often compared with placebo, and may be accepting estimates of effect which span potentially clinically meaningful harm. There are compelling reasons to further investigate agents showing promise in non-inferiority trials with superiority trials, which include prespecified subgroups, and with sufficient power and duration to provide robust estimates of harms and benefits to inform clinical decision-making.</p>","PeriodicalId":12182,"journal":{"name":"Evidence-Based Medicine","volume":" ","pages":"54-56"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmed-2017-110685","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34795968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome. 与院内心脏骤停的传统CPR相比，体外心肺复苏术可提高出院存活率和更有利的神经预后。

Evidence-Based Medicine Pub Date : 2016-12-01 Epub Date: 2016-09-01 DOI: 10.1136/ebmed-2016-110467

Lindsay Ryerson, Gonzalo Garcia Guerra, Laurance Lequier

{"title":"Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome.","authors":"Lindsay Ryerson, Gonzalo Garcia Guerra, Laurance Lequier","doi":"10.1136/ebmed-2016-110467","DOIUrl":"https://doi.org/10.1136/ebmed-2016-110467","url":null,"abstract":"Commentary on: Lasa JJ, Rogers RS, Localio R, et al. Extracorporeal Cardiopulmonary Resuscitation (E-CPR) During pediatric in-hospital cardiopulmonary arrest is associated with improved survival to discharge: a report from the American Heart Association's Get With The Guidelines-Resuscitation (GWTG-R) registry. Circulation 2016;133:165–76[OpenUrl][1][Abstract/FREE Full Text][2].\u0000\u0000Data from national and international paediatric databases indicate that the use of extracorporeal cardiopulmonary resuscitation (E-CPR) is increasing.1 Considering the significant resources and cost involved in the use of E-CPR, its use needs to be critically examined to optimise outcomes. This large, multicentre study compared conventional cardiopulmonary resuscitation (C-CPR) and (E-CPR) in paediatric in-hospital cardiac arrest (IHCA).\u0000\u0000This is a retrospective multicentre cohort study that used data from the American Heart Association Get with the Guidelines Registry. The study included all children (<18 years of age) who had an IHCA and received CPR for ≥10 min between 1 January 2000 and 31 December, 2011. Patients from hospitals with no E-CPR cases, obstetric and trauma diagnosis, missing E-CPR or survival information and …\u0000\u0000 [1]: {openurl}?query=rft.jtitle%253DCirculation%26rft_id%253Dinfo%253Adoi%252F10.1161%252FCIRCULATIONAHA.115.016082%26rft_id%253Dinfo%253Apmid%252F26635402%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0000 [2]: /lookup/ijlink?linkType=ABST&journalCode=circulationaha&resid=133/2/165&atom=%2Febmed%2F21%2F6%2F227.atom","PeriodicalId":12182,"journal":{"name":"Evidence-Based Medicine","volume":"21 6","pages":"227-228"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmed-2016-110467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34356299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditionally taught clinical variables and risk factors perform poorly in the prediction of acute coronary syndromes in the emergency department. 传统的临床变量和危险因素在急诊科预测急性冠状动脉综合征方面表现不佳。

Evidence-Based Medicine Pub Date : 2016-12-01 Epub Date: 2016-09-06 DOI: 10.1136/ebmed-2015-110361

Martin Than

{"title":"Traditionally taught clinical variables and risk factors perform poorly in the prediction of acute coronary syndromes in the emergency department.","authors":"Martin Than","doi":"10.1136/ebmed-2015-110361","DOIUrl":"https://doi.org/10.1136/ebmed-2015-110361","url":null,"abstract":"Commentary on: Fanaroff AC, Rymer JA, Goldstein SA, et al. Does this patient with chest pain have acute coronary syndrome? The rational clinical examination systematic review. JAMA 2015;314:1955–65[OpenUrl][1][CrossRef][2][PubMed][3].\u0000\u0000Up to 5–10% of annual presentations to emergency departments (EDs) and 25% of hospital admissions are patients with symptoms suggestive of acute coronary syndromes (ACS). Estimating the pretest probability of ACS is important. Traditionally, this has been determined using clinical acumen, primarily involving historical variables and risk factors learnt during early training and reinforced in clinical practice. This systematic review assessed diagnostic utility of the history, physical examination and ECG to increase or decrease the estimated likelihood of ACS. It also assessed the accuracy of decision aids (risk scores) in combination with the initial ECG and troponin level.\u0000\u0000Studies included in this systematic review had to (1) involve patients presenting to an ED with suspected …\u0000\u0000 [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.volume%253D314%26rft.spage%253D1955%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.2015.12735%26rft_id%253Dinfo%253Apmid%252F26547467%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0000 [2]: /lookup/external-ref?access_num=10.1001/jama.2015.12735&link_type=DOI\u0000 [3]: /lookup/external-ref?access_num=26547467&link_type=MED&atom=%2Febmed%2F21%2F6%2F236.atom","PeriodicalId":12182,"journal":{"name":"Evidence-Based Medicine","volume":"21 6","pages":"236"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmed-2015-110361","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34421241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Physical activity reduces cardiovascular disease risk in older adults. 体力活动可降低老年人患心血管疾病的风险。

Evidence-Based Medicine Pub Date : 2016-10-01 Epub Date: 2016-08-31 DOI: 10.1136/ebmed-2016-110496

Simon Endes

{"title":"Physical activity reduces cardiovascular disease risk in older adults.","authors":"Simon Endes","doi":"10.1136/ebmed-2016-110496","DOIUrl":"https://doi.org/10.1136/ebmed-2016-110496","url":null,"abstract":"Commentary on: Soares-Miranda L, Siscovick DS, Psaty BM, et al. Physical activity and risk of coronary heart disease and stroke in older adults: the cardiovascular health study. Circulation 2016;133:147–55[OpenUrl][1][Abstract/FREE Full Text][2].\u0000\u0000Currently, at least 150 min per week of moderate-to-vigorous physical activity is recommended for adults of all ages to beneficially influence individual and population health and cardiovascular mortality.1 Adhering to current physical activity guidelines has been shown to be associated with a 20% lower mortality risk compared to physically inactive persons.2 A physically active lifestyle is linked with decreased risk of cardiovascular disease (CVD) and CVD events, such as myocardial infarction or stroke, at all ages, and in some improvements in atherosclerotic processes and stiffening of the arteries.3–6 Walking is a low-risk activity and …\u0000\u0000 [1]: {openurl}?query=rft.jtitle%253DCirculation%26rft_id%253Dinfo%253Adoi%252F10.1161%252FCIRCULATIONAHA.115.018323%26rft_id%253Dinfo%253Apmid%252F26538582%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0000 [2]: /lookup/ijlink?linkType=ABST&journalCode=circulationaha&resid=133/2/147&atom=%2Febmed%2F21%2F5%2F191.atom","PeriodicalId":12182,"journal":{"name":"Evidence-Based Medicine","volume":"21 5","pages":"191"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmed-2016-110496","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34351771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Risk score developed from routinely collected data by primary healthcare practitioners is useful to rule out dementia in 60-79 year-olds. 初级保健从业人员从常规收集的数据中开发的风险评分有助于排除60-79岁人群中的痴呆症。

Evidence-Based Medicine Pub Date : 2016-10-01 Epub Date: 2016-08-12 DOI: 10.1136/ebmed-2016-110419

Jean François Dartigues, Catherine Helmer

{"title":"Risk score developed from routinely collected data by primary healthcare practitioners is useful to rule out dementia in 60-79 year-olds.","authors":"Jean François Dartigues, Catherine Helmer","doi":"10.1136/ebmed-2016-110419","DOIUrl":"https://doi.org/10.1136/ebmed-2016-110419","url":null,"abstract":"Commentary on: Walters K, Hardoon S, Petersen I, et al. Predicting dementia risk in primary care: development and validation of the Dementia Risk Score using routinely collected data. BMC Medicine 2016;14:6[OpenUrl][1][CrossRef][2][PubMed][3].\u0000\u0000In spite of major repercussions on the life of patients and caregivers, dementia remains a neglected domain in primary care setting. Previous studies have shown that only a third of new dementia cases occurring in the general population were referred to a specialist1 and that too at a severe stage of the disease, 25% of cases were ignored.2 A great proportion of primary care practitioners (PCPs) consider dementia to be an irreversible consequence of brain ageing. However, PCPs are pragmatic, and if a simple predicting score based on …\u0000\u0000 [1]: {openurl}?query=rft.jtitle%253DBMC%2BMedicine%26rft.volume%253D14%26rft.spage%253D6%26rft_id%253Dinfo%253Adoi%252F10.1186%252Fs12916-016-0549-y%26rft_id%253Dinfo%253Apmid%252F26797096%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0000 [2]: /lookup/external-ref?access_num=10.1186/s12916-016-0549-y&link_type=DOI\u0000 [3]: /lookup/external-ref?access_num=26797096&link_type=MED&atom=%2Febmed%2F21%2F5%2F198.atom","PeriodicalId":12182,"journal":{"name":"Evidence-Based Medicine","volume":"21 5","pages":"198"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmed-2016-110419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34659522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Smokers with respiratory symptoms but no airflow limitation, often have activity limitation, exacerbations and evidence of airway disease. 有呼吸道症状但没有气流限制的吸烟者，通常有活动限制、加重和气道疾病的证据。

Evidence-Based Medicine Pub Date : 2016-10-01 Epub Date: 2016-08-23 DOI: 10.1136/ebmed-2016-110501

Charlotte Suppli Ulrik

{"title":"Smokers with respiratory symptoms but no airflow limitation, often have activity limitation, exacerbations and evidence of airway disease.","authors":"Charlotte Suppli Ulrik","doi":"10.1136/ebmed-2016-110501","DOIUrl":"https://doi.org/10.1136/ebmed-2016-110501","url":null,"abstract":"Commentary on : Woodruff PG, Barr RG, Bleecker E, et al. Clinical significance of symptoms in smokers with preserved pulmonary function. N Engl J Med 2016;374:1811–21.[OpenUrl][1][CrossRef][2][PubMed][3]\u0000\u0000COPD is, according to the Global Initiative for Chronic Obstructive Lung Disease, defined as persistent airflow limitation, that is, the key diagnostic criterion is a postbronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio <0.70.1 However, this definition has clear limitations in clinical practice, as it does not take symptoms into account and only applies to individuals in whom fixed airflow limitation has developed.2 Furthermore, this diagnostic criterion, that is, FEV1/FVC ratio <0.70, is likely to be insensitive for recognition of early COPD.3 ,4 Some current or …\u0000\u0000 [1]: {openurl}?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D374%26rft.spage%253D1811%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1505971%26rft_id%253Dinfo%253Apmid%252F27168432%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0000 [2]: /lookup/external-ref?access_num=10.1056/NEJMoa1505971&link_type=DOI\u0000 [3]: /lookup/external-ref?access_num=27168432&link_type=MED&atom=%2Febmed%2Fearly%2F2016%2F08%2F23%2Febmed-2016-110501.atom","PeriodicalId":12182,"journal":{"name":"Evidence-Based Medicine","volume":"21 5","pages":"189"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmed-2016-110501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34689436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Transfemoral transcatheter aortic-valve replacement should be preferred over surgery in most intermediate-risk patients. 在大多数中等风险患者中，经股动脉导管主动脉瓣置换术应优于手术。

Evidence-Based Medicine Pub Date : 2016-10-01 Epub Date: 2016-08-08 DOI: 10.1136/ebmed-2016-110484

Corrado Tamburino, Piera Capranzano

{"title":"Transfemoral transcatheter aortic-valve replacement should be preferred over surgery in most intermediate-risk patients.","authors":"Corrado Tamburino, Piera Capranzano","doi":"10.1136/ebmed-2016-110484","DOIUrl":"https://doi.org/10.1136/ebmed-2016-110484","url":null,"abstract":"Commentary on: Leon MB, Smith CR, Mack MJ, et al., PARTNER 2 Investigators. Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med 2016;374:1609–20[OpenUrl][1][CrossRef][2][PubMed][3].\u0000\u0000Evidence derived from randomised clinical trials support transcatheter aortic valve replacement (TAVR) as a choice for patients with aortic stenosis with a prohibitive surgical risk and as a valid alternative therapy for those at high-risk of surgical mortality. Owing to increases in operator experience as well as improvements with transcatheter techniques and devices associated with reduction in procedural complications, TAVR has been progressively extended to less risky patients,1 despite the lack of rigorous clinical-trial assessment of this expansion. In the Placement of Aortic Transcatheter Valves 2 (PARTNER-2) Cohort A randomised trial, safety and effectiveness of TAVR with a lower-profile second-generation valve system were compared with conventional surgical aortic valve replacement (SAVR) in patients with intermediate-risk clinical …\u0000\u0000 [1]: {openurl}?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D374%26rft.spage%253D1609%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1514616%26rft_id%253Dinfo%253Apmid%252F27040324%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0000 [2]: /lookup/external-ref?access_num=10.1056/NEJMoa1514616&link_type=DOI\u0000 [3]: /lookup/external-ref?access_num=27040324&link_type=MED&atom=%2Febmed%2F21%2F5%2F173.atom","PeriodicalId":12182,"journal":{"name":"Evidence-Based Medicine","volume":"21 5","pages":"173"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmed-2016-110484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34739529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of a significant relationship between energy intake in pregnancy and gestational weight gain underlines the need for further evaluations of energy metabolism during this time. 缺乏孕期能量摄入与妊娠期体重增加之间的显著关系，强调了对这段时间内能量代谢的进一步评估的必要性。

Evidence-Based Medicine Pub Date : 2016-10-01 Epub Date: 2016-08-26 DOI: 10.1136/ebmed-2016-110471

Rhonda Bell, Paula Robson

{"title":"Lack of a significant relationship between energy intake in pregnancy and gestational weight gain underlines the need for further evaluations of energy metabolism during this time.","authors":"Rhonda Bell, Paula Robson","doi":"10.1136/ebmed-2016-110471","DOIUrl":"https://doi.org/10.1136/ebmed-2016-110471","url":null,"abstract":"Commentary on: Jebeile H, Mijatovic J, Louie JC, et al. A systematic review and meta-analysis of energy intake and weight gain in pregnancy. Am J Obstet Gynecol 2016;214(4):465–83[OpenUrl][1][CrossRef][2][PubMed][3].\u0000\u0000Recent updates to gestational weight gain (GWG) guidelines recommend women gain weight within a specific range, based on pre-pregnancy body mass index (BMI), to support the best pregnancy outcomes. While many women exceed the GWG guidelines, the extent to which this reflects inappropriate increases in energy intake is unclear. This study set out to determine whether a greater increment in reported energy intake between early and late pregnancy was associated with greater or excessive GWG.\u0000\u0000The authors conducted a systematic review of studies of women with a full-term singleton pregnancy that included measurement of …\u0000\u0000 [1]: {openurl}?query=rft.jtitle%253DAm%2BJ%2BObstet%2BGynecol%26rft.volume%253D214%26rft.spage%253D465%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.ajog.2015.12.049%26rft_id%253Dinfo%253Apmid%252F26739796%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0000 [2]: /lookup/external-ref?access_num=10.1016/j.ajog.2015.12.049&link_type=DOI\u0000 [3]: /lookup/external-ref?access_num=26739796&link_type=MED&atom=%2Febmed%2F21%2F5%2F192.atom","PeriodicalId":12182,"journal":{"name":"Evidence-Based Medicine","volume":"21 5","pages":"192"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmed-2016-110471","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34340533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Ultrasound-based IOTA simple rules allow accurate malignancy risk estimation for adnexal masses. 基于超声的IOTA简单规则可以准确估计附件肿块的恶性风险。

Evidence-Based Medicine Pub Date : 2016-10-01 Epub Date: 2016-08-09 DOI: 10.1136/ebmed-2016-110459

Juan Luis Alcázar

引用次数: 7

Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries. 局部非甾体抗炎药显著减轻成人急性肌肉骨骼损伤的疼痛。

Evidence-Based Medicine Pub Date : 2016-10-01 Epub Date: 2016-08-12 DOI: 10.1136/ebmed-2016-110406

Gwendolyn Vuurberg, Gino M M J Kerkhoffs

引用次数: 1