European urology focus最新文献

{"title":"Reply to Francesco Montorsi, Edoardo Pozzi, Marco Bianchi, et al's Letter to the Editor re: Gautier Müllhaupt, Lukas Hechelhammer, Nicole Graf, et al. Prostatic Artery Embolisation Versus Transurethral Resection of the Prostate for Benign Prostatic Obstruction: 5-year Outcomes of a Randomised, Open-label, Noninferiority Trial. Eur Urol Focus 2024;10:788-95.","authors":"Gautier Müllhaupt, Lukas Hechelhammer, Nicole Graf, Livio Mordasini, Hans-Peter Schmid, Daniel S Engeler, Dominik Abt","doi":"10.1016/j.euf.2025.06.017","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.017","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Behnam Shakiba and Vahid Vahedi's Letter to the Editor re: David Chung, Gregory Hosier. Clinical Protocol for Same-day-discharge Percutaneous Nephrolithotomy. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2025.04.005.","authors":"David Chung, Gregory Hosier","doi":"10.1016/j.euf.2025.06.019","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.019","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Guidelines for the Management of Benign Prostatic Obstruction: Practical Tips for Patient Selection to Achieve Optimal Outcomes.","authors":"Michael Baboudjian, Cosimo De Nunzio, Jean-Nicolas Cornu","doi":"10.1016/j.euf.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.006","url":null,"abstract":"<p><p>A variety of treatment options are available for benign prostate obstruction (BPO) causing lower urinary tract symptoms. A shared decision-making approach with the patient is crucial before proceeding with BPO surgery. Patient characteristics, preferences, and expectations should be taken into account when weighing up the risks and benefits of each option for individual cases. PATIENT SUMMARY: Our guideline describes factors to consider when doctors and their patients make shared decisions on which treatment options are best for a benign enlarged prostate causing urinary symptoms.</p>","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Piet Ost, Shankar Siva, Sigmund Brabrabd, et al. Salvage Metastasis-directed Therapy Versus Elective Nodal Radiotherapy for Oligorecurrent Nodal Prostate Cancer Metastases (PEACE V-STORM): A Phase 2, Open-label, Randomised Controlled Trial. Lancet Oncol 2025;26:695-706.","authors":"André N Vis, Roderick C N van den Bergh","doi":"10.1016/j.euf.2025.06.020","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.020","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed Thulium:YAG Laser for Lithotripsy.","authors":"Cristian Axel Hernandez-Gaytan, Silvia Proietti, Federico De Leonardis, Luca Mongelli, Franco Gaboardi, Guido Giusti","doi":"10.1016/j.euf.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.002","url":null,"abstract":"<p><p>Pulsed thulium:YAG (p-Tm:YAG) laser is a novel technology for lithotripsy that seems to be positioned favorably in the middle ground between Ho:YAG laser and thulium fiber laser. This mini review summarizes current evidence regarding p-Tm:YAG physical properties, laboratory results, and clinical outcomes. p-Tm:YAG laser features high peak power, efficient energy use, and a stable pulse profile. In vitro studies have demonstrated effective ablation, minimal retropulsion, and the ability to produce fine stone dust regardless of stone composition. Clinically, flexible ureteroscopy and mini-percutaneous nephrolithotomy using p-Tm:YAG may achieve high stone-free rates and low complication rates. Moreover, comparisons with the other lasers show similar or even better performance in terms of ablation efficiency and operative time. Although these preliminary results are very promising, robust data are needed to validate the versatility of p-Tm:YAG laser for routine use in clinical practice. PATIENT SUMMARY: We summarize current evidence on the new pulsed thulium:YAG laser for the treatment of urinary stones. High stone-free rates and low complication rates have been reported for patients treated for kidney stone disease. Further studies with more patients are needed to establish the superiority of this laser over others.</p>","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Patients with Muscle-invasive Bladder Cancer Undergoing Radical Cystectomy, Dynamics of Circulating Tumor DNA Following Cystectomy: Association with Patient Outcomes.","authors":"Angelos Tasios, Ursula Amstutz, Roland Seiler, Frederike Fuhlbrück, Natasha Oza, Nicolas Arnold, George N Thalmann, Beat Roth, Tobias Grob, Bernhard Kiss","doi":"10.1016/j.euf.2025.06.018","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.018","url":null,"abstract":"<p><strong>Background and objective: </strong>Despite various novel therapeutic possibilities for patients with muscle-invasive bladder cancer (MIBC), therapy response varies highly. Circulating tumor DNA (ctDNA) represents a fraction of cell-free DNA released into the bloodstream by apoptotic cell turnover or cell death in the tumor. We investigated whether ctDNA measurements before and after radical cystectomy are associated with disease recurrence.</p><p><strong>Methods: </strong>We prospectively collected plasma, tumor tissue, and germline samples before and after radical cystectomy. Seventy patients had complete data for both pre- and postsurgery analyses. Commonly mutated genes in plasma and tissue, particularly TERT and TP53, were assessed using the AVENIO ctDNA platform (research use only; Roche, Branchburg, NJ, USA) and then evaluated for a potential association with patient outcome measures, including survival and disease recurrence.</p><p><strong>Key findings and limitations: </strong>In the overall study population, patients with negative ctDNA status in postsurgery plasma had significantly longer recurrence-free survival than those with positive ctDNA status (p = 0.01). The ctDNA positivity fell from 46% before surgery to 23% after surgery, and a positive postoperative result predicted recurrence independently. Patients who were ctDNA positive before surgery and converted to ctDNA negative after surgery showed longer survival than those remaining ctDNA positive (median survival 36 vs 18 mo).</p><p><strong>Conclusions and clinical implications: </strong>Our results highlight that perioperative ctDNA status is associated with patient prognosis in MIBC.</p>","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Guru P. Sonpavde. Role of Adjuvant Therapy in Current Perioperative Immunotherapy-based Trials in Bladder Cancer: A Justified Standard. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2025.05.008.","authors":"Lingyu Guo, Tian An","doi":"10.1016/j.euf.2025.06.021","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.021","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Impacted Ureteral Stones.","authors":"Jeffrey Johnson, Srinath-Reddi Pingle, Ojas Shah","doi":"10.1016/j.euf.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.010","url":null,"abstract":"<p><p>Impacted ureteral stones are a challenge because of the inherent nature of the condition and the complexities of intervention. Imaging studies and measurement of ureteral wall thickness can aid in preparing for intervention and preoperative patient counseling. Diligent management and appropriate knowledge of lasers, scopes, and disposable equipment can help in optimizing success rates and preservation of renal function.</p>","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Crisis to Innovation: The Impact of COVID-19 on Outpatient Procedures in Robotic Urological Surgery.","authors":"Simone Crivellaro, Flavia Tamborino","doi":"10.1016/j.euf.2025.06.015","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.015","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost and Effectiveness of Flexible Ureteroscopy Versus Shockwave Lithotripsy for Urolithiasis: A Systematic Review and Meta-analysis by the European Association of Urology Endourology Section.","authors":"Carlotta Nedbal, Robert Geraghty, Pietro Tramanzoli, Dario Sessa, Vineet Gauhar, Andrea Benedetto Galosi, Andrea Gregori, Bhaskar K Somani","doi":"10.1016/j.euf.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.euf.2025.06.004","url":null,"abstract":"<p><strong>Background and objective: </strong>We conducted a systematic review and meta-analysis to compare the cost and effectiveness of flexible ureteroscopy (URS) and shockwave lithotripsy (SWL) in the management of urolithiasis. Given the widespread use of both modalities, comparison of their stone-free rates (SFRs), retreatment rates, complications, costs, and hospital length of stay (LOS) can provide valuable insights for optimizing treatment strategies.</p><p><strong>Methods: </strong>A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, with searches of the PubMed, Cochrane, and Google Scholar databases for relevant studies. The inclusion criteria were comparative studies analysing costs and clinical outcomes of SWL and URS for urolithiasis management. The meta-analysis included 22 studies involving 146 845 patients, of whom 81 772 (55.7%) underwent SWL and 65 073 (44.3%) underwent URS. Statistical analyses were performed using R. Random-effects or fixed-effect models were applied, depending on study heterogeneity. Subgroup analyses by stone size and location were also conducted.</p><p><strong>Key findings and limitations: </strong>URS had a significantly higher SFR (82.2% vs 64.4%; p < 0.001) and a significantly lower retreatment rate (10.6% vs 29.4%; p < 0.001) in comparison to SWL. There were no significant differences between URS and SWL in the overall complication rate (22.6% vs 22.5%), the mean procedural cost ($2546.20 ± $1297.30 vs $2830.40 ± $1652.10), or mean LOS (2.8 d for both). Subgroup analyses confirmed similar trends across stone size and location categories.</p><p><strong>Conclusions and clinical implications: </strong>While direct procedural costs were only slightly lower for URS, this modality had superior efficacy, with higher SFR and lower retreatment rates, suggesting it is a more cost-effective option in the long term. These findings support preference for URS for urolithiasis treatment when considering both clinical and economic outcomes.</p>","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}