Expert Review of Molecular Diagnostics最新文献_第8页

Transforming breast cancer care: the critical role of digital pathology and artificial intelligence in biomarker testing and risk stratification. 改变乳腺癌护理：数字病理学和人工智能在生物标志物检测和风险分层中的关键作用。

IF 3.6 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2026-01-01 Epub Date: 2026-01-07 DOI: 10.1080/14737159.2026.2613253

Maryam Tahir, Yan Hu, Anil Parwani, Zaibo Li

引用次数: 0

Importance of extracellular vesicles in the pathogenesis, diagnosis and treatment of infections caused by Leishmania species: a state of art review and future prospects. 细胞外囊泡在利什曼原虫感染的发病机制、诊断和治疗中的重要性：现状综述和未来展望。

IF 4.3 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2026-01-01 Epub Date: 2026-01-11 DOI: 10.1080/14737159.2026.2613252

Reza Saberi, Bahareh Basirpour, Vera Lucia Pereira-Chioccola, Masoud Keighobadi, Farzane Jafarian, Javad Akhtari, Fakhar Mahdi

{"title":"Importance of extracellular vesicles in the pathogenesis, diagnosis and treatment of infections caused by Leishmania species: a state of art review and future prospects.","authors":"Reza Saberi, Bahareh Basirpour, Vera Lucia Pereira-Chioccola, Masoud Keighobadi, Farzane Jafarian, Javad Akhtari, Fakhar Mahdi","doi":"10.1080/14737159.2026.2613252","DOIUrl":"10.1080/14737159.2026.2613252","url":null,"abstract":"Introduction: Infections caused by different Leishmania species are considered as neglected diseases and are prevalent in many tropical and temperate regions worldwide. Extracellular vehicles (EVs) transport different nanoparticles for extracellular medium as enzymes, proteins, lipids, nucleic acids and others for cellular metabolic activities. However, the precise role of EVs in infections caused by Leishmania species is not totally established. This article revised the significance of EVs in pathogenesis, diagnosis and treatment strategies for the different forms of leishmaniasis.Areas covered: EVs of Leishmania spp. may be considered as potential drug targets in treatment, as they can encapsulate small molecules or drugs for more effective delivery to specific cells or tissues. The perspectives on EVs research in Leishmania facilitate the understanding of the role of these nanoparticles in parasite-host interactions and the development of diagnostic and therapeutic strategies, as vaccine development, and enhancing drug delivery systems.Expert opinion: The knowledge of the participation of EVs in Leishmania species offers opportunities to further our understanding in pathogenesis and in the development of innovative diagnostic tools and treatments and to explore new approaches to disease.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"45-60"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the potential of long non-coding RNAs in bladder cancer. 揭示长链非编码rna在膀胱癌中的潜力。

IF 4.3 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2026-01-01 Epub Date: 2025-12-13 DOI: 10.1080/14737159.2025.2603407

Yoran L Tomassen, Ewan A Gibb, Yair Lotan, Joep J de Jong

{"title":"Unlocking the potential of long non-coding RNAs in bladder cancer.","authors":"Yoran L Tomassen, Ewan A Gibb, Yair Lotan, Joep J de Jong","doi":"10.1080/14737159.2025.2603407","DOIUrl":"10.1080/14737159.2025.2603407","url":null,"abstract":"Introduction: Bladder cancer (BC) is a prevalent urinary tract malignancy, characterized by high recurrence rates and heterogeneous disease progression. Non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) present distinct clinical challenges, and conventional clinicopathological parameters are often insufficient to predict recurrence or progression accurately. Long non-coding RNAs (lncRNAs) have emerged as key regulators of tumor biology, influencing proliferation, migration, epithelial-mesenchymal transition, and therapy resistance, with potential in risk stratification, prognostic prediction and guidance of therapy de-escalation or intensification.Areas covered: This narrative review examines the role of lncRNAs in BC, focusing on their biological functions, prognostic significance, and potential to guide personalized treatment strategies. We discuss lncRNA involvement in NMIBC and MIBC, highlight molecular profiling studies enabling risk stratification and molecular subtyping for guiding treatment de-escalation or intensification. Finally, we address the challenges and future directions for integrating lncRNA profiling into routine clinical practice.Expert opinion: LncRNAs offer a promising approach for precision oncology in bladder cancer, providing insights beyond traditional clinical parameters. Integrating lncRNA profiling into routine practice could optimize risk stratification, guide therapy intensity, and reduce overtreatment. Although current evidence is encouraging, large-scale prospective trials are needed to validate lncRNA signatures and fully realize their potential in personalized bladder cancer management.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"9-12"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145721864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in ovarian cancer screening and early detection: from biomarkers to multivariate index assays. 卵巢癌筛查和早期检测的进展：从生物标志物到多变量指数分析。

IF 4.3 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2026-01-01 Epub Date: 2026-01-27 DOI: 10.1080/14737159.2025.2608820

Carlos Salomon, Melissa Razo-Azamar, Aleksandra Gentry-Maharaj, Gregory E Rice, Usha Menon

{"title":"Advances in ovarian cancer screening and early detection: from biomarkers to multivariate index assays.","authors":"Carlos Salomon, Melissa Razo-Azamar, Aleksandra Gentry-Maharaj, Gregory E Rice, Usha Menon","doi":"10.1080/14737159.2025.2608820","DOIUrl":"10.1080/14737159.2025.2608820","url":null,"abstract":"Introduction: Ovarian cancer is a leading cause of cancer-related death in women, primarily due to nonspecific symptoms and diagnosis at an advanced stage. Improving outcomes through earlier diagnosis and effective population screening remains a global priority.Context: Existing modalities ,including CA125 and transvaginal ultrasound (TVUS), lack sufficient specificity and sensitivity, and no screening strategy has demonstrated a reduction in mortality. Multivariate Index Assays (MIAs), that combine multiple biomarker results into a single risk score, have emerged as a promising approach for differential diagnosis of adnexal masses, early detection, and screening.Areas covered: This review summarizes current literature and clinical trial data on MIAs in ovarian cancer, describing their advantages over single biomarkers, their potential to improve patient outcomes, and their role in personalized medicin. Successful clinical adoption of MIAs will depend on well-designed prospective studies that robustly validate their clinical utility.Expert opinion/commentary: It is also critical to clearly distinguish between diagnostic and screening applications, as each requires different performance characteristics, regulatory pathways, and target populations, and no ovarian cancer screening test is currently approved for routine use.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"25-43"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on the diagnostic and prognostic value of MUC4 expression in gastric cancers. 黏液蛋白4在胃癌诊断和预后价值的研究进展。

IF 4.3 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2026-01-01 Epub Date: 2026-01-11 DOI: 10.1080/14737159.2026.2613251

Abhijit Aithal, Blackberrie Eddins, Michael Bouvet, Valerie P O'Brien, Maneesh Jain, Surinder K Batra

{"title":"An update on the diagnostic and prognostic value of MUC4 expression in gastric cancers.","authors":"Abhijit Aithal, Blackberrie Eddins, Michael Bouvet, Valerie P O'Brien, Maneesh Jain, Surinder K Batra","doi":"10.1080/14737159.2026.2613251","DOIUrl":"10.1080/14737159.2026.2613251","url":null,"abstract":"Introduction: MUC4 is overexpressed in gastric cancer and its precursor lesions and plays an essential role in disease progression.Area covered: In this review, we describe the diagnostic and prognostic value of MUC4 expression in gastric cancer. First, we provide a summary of gastric cancer pathogenesis and its intricate relationship with mucin expression. We will then provide an extensive description of MUC4 expression in gastric cancer and its diagnostic and therapeutic significance.Expert opinion: Apart from its protective role in normal physiology, MUC4 contributes to disease progression and metastasis in several malignancies, including gastric cancer. MUC4 is expressed at negligible levels in normal gastric mucosa. However, some patients with intestinal metaplasia and gastric cancer have high levels of MUC4 expression, particularly in the pit cell compartment. The expression of MUC4 in metaplastic pit cells is associated with increased proliferation, inflammation, and epithelial-to-mesenchymal transition. Hence, evaluating MUC4 expression in precursor lesions may help stratify disease and identify cases in which curative surgery should be performed. MUC4 expression in gastric cancer is associated with disease aggressiveness, lymphatic invasion, and nodal metastasis. Due to its role in disease pathobiology, it is a promising target for the diagnosis and therapy of gastric cancer.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"13-23"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive understanding of HDL-associated apolipoproteins: future potential biomarker in sepsis. 全面了解高密度脂蛋白相关载脂蛋白：败血症的未来潜在生物标志物。

IF 4.3 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2026-01-01 Epub Date: 2026-01-16 DOI: 10.1080/14737159.2026.2616759

Jingjing Ning, Tiantian Liu, Yilin Zhao, Chunxia Wang

{"title":"A comprehensive understanding of HDL-associated apolipoproteins: future potential biomarker in sepsis.","authors":"Jingjing Ning, Tiantian Liu, Yilin Zhao, Chunxia Wang","doi":"10.1080/14737159.2026.2616759","DOIUrl":"10.1080/14737159.2026.2616759","url":null,"abstract":"Introduction: Sepsis, a life-threatening condition characterized by dysregulated host immune and metabolic responses to infection, is associated with high mortality, making accurate diagnosis and targeted treatment crucial. Sepsis often induces a notable reduction in serum high-density lipoprotein (HDL) levels. As the fundamental structural and functional components of HDL, apolipoproteins play pivotal roles in mediating the function of HDL. Therefore, these apolipoproteins can serve as potential biomarkers in sepsis.Areas covered: This review systematically synthesizes current evidence on the dynamic expression profiles of these apolipoproteins in sepsis, highlighting the relation of their single nucleotide polymorphisms (SNPs) with sepsis and clinical relevance in diagnosis and prognosis. Furthermore, it also summarizes the underlying mechanisms by which these apolipoproteins are involved in the progression of sepsis.Expert opinion: The changes in the levels of HDL-associated apolipoproteins can characterize the progression of sepsis and the type of infecting bacteria, and provide therapeutic targets for the treatment of sepsis. Therefore, the comprehensive understanding of their integrated effects holds promise for developing precision interventions to improve clinical outcomes of sepsis.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"61-70"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying sex-specific biomarkers for intrinsic capacity decline in the aging population. 识别老龄化人口内在能力下降的性别特异性生物标志物。

IF 4.3 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2026-01-01 Epub Date: 2025-12-28 DOI: 10.1080/14737159.2025.2606411

Lv-Tao Zeng, Ya-Qing Ma, Hong-Lei Liu, Jian-Ping Cai

{"title":"Identifying sex-specific biomarkers for intrinsic capacity decline in the aging population.","authors":"Lv-Tao Zeng, Ya-Qing Ma, Hong-Lei Liu, Jian-Ping Cai","doi":"10.1080/14737159.2025.2606411","DOIUrl":"10.1080/14737159.2025.2606411","url":null,"abstract":"Background: Intrinsic capacity (IC) decline is a key marker of aging-related functional loss, yet sex-specific biomarkers remain poorly characterized. This cross-sectional study of 1014 community-dwelling older adults investigated the associative strength and potential statistical intermediaries of insulin-like growth factor binding protein 2 (IGFBP2) and growth differentiation factor 15 (GDF-15) in IC impairment, with sex-stratified analyses.Research design and methods: Dose-response relationships were assessed using restricted cubic splines. Multivariable logistic regression evaluated independent associations after adjusting for covariates. Mediation analysis explored roles of renal, muscular, metabolic, and oxidative stress indicators.Results: IC impairment was associated with higher IGFBP2 and GDF-15 (all p < 0.001). In males, IGFBP2 showed a reverse L-shaped association (inflection at 310 ng/mL; AUC = 0.75), partially explained by renal function (β2-MG), muscle damage (CK, LDH), oxidative stress (SOD), and nutrition (ALB), with 11.02% mediation. In females, GDF-15 had a nonlinear relationship (inflection at 1.99 ng/mL; AUC = 0.76), attributable in part to glucose (FBG), lipids (FFA), and renal function (BUN), accounting for 19.8% of the effect. Fully adjusted ORs were 2.41 (IGFBP2 in males) and 4.27 (GDF-15 in females), both p < 0.001.Conclusion: IGFBP2 and GDF-15 are sex-specific biomarkers for IC decline, operating through distinct pathways, and may aid early screening and targeted interventions.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"71-83"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of C-reactive protein triglyceride glucose index versus triglyceride glucose index in critically ill patients: a machine learning-driven cohort analysis. 危重患者c反应蛋白甘油三酯葡萄糖指数与甘油三酯葡萄糖指数的预后价值：机器学习驱动的队列分析

IF 4.3 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2026-01-01 Epub Date: 2025-12-22 DOI: 10.1080/14737159.2025.2607497

Wen-Liang Shuai, Jie Liu, Tao Zhou, Ju-Xiang Li, Xia Tao, Bing Zou

{"title":"Prognostic value of C-reactive protein triglyceride glucose index versus triglyceride glucose index in critically ill patients: a machine learning-driven cohort analysis.","authors":"Wen-Liang Shuai, Jie Liu, Tao Zhou, Ju-Xiang Li, Xia Tao, Bing Zou","doi":"10.1080/14737159.2025.2607497","DOIUrl":"10.1080/14737159.2025.2607497","url":null,"abstract":"Background: Critically ill patients have high mortality influenced by insulin resistance (IR)and inflammation.The C-reactive protein-triglyceride-glucose index (CTI), integrating IR and inflammation, has unclear prognostic value in this population compared to the traditional triglyceride-glucose index (TyG).Methods: This cohort study analyzed 1963 critically ill patients from MIMIC-IV. Outcomes included in-hospital mortality, acute kidney injury (AKI), and length of stay. Analyses employed multivariable regression, mediation, and machine learning.Results: Elevated CTI showed a graded association with mortality. Per unit increase conferred 22% higher risk (OR 1.22, 95% CI 1.08-1.38); the top quartile had double the risk (OR 2.07, 1.36-3.13) and a mortality rate of 26.48% vs. 9.98% in the lowest quartile. CTI also independently predicted higher AKI risk (OR 1.28, 1.13-1.45; incidence 91.24% vs. 73.32% in Q4 vs. Q1) and prolonged ICU/hospital stay (β 1.99 and 3.71 days, p < 0.05). AKI mediated 5.53% of the CTI-mortality relationship. CTI's discriminative power surpassed TyG (DeLong p = 0.001). In prognostic modeling, CTI was a key feature, with the Gradient Boosting Machine model achieving optimal performance (AUC 0.789).Conclusion: CTI is strongly associated with adverse outcomes and may outperform TyG in critically ill patients, supporting its utility for risk stratification.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"85-95"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep proteomics in cancer diagnostics: barriers and breakthroughs. 深层蛋白质组学在癌症诊断中的应用：障碍与突破。

IF 3.6 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2026-01-01 Epub Date: 2025-12-25 DOI: 10.1080/14737159.2025.2607503

Justin M Drake, Harrison Ball, Forest M White, Emmanuel S Antonarakis

引用次数: 0

Molecular insights into the gut-thyroid axis: microbiota-driven biomarkers and diagnostic applications. 分子洞察肠-甲状腺轴：微生物驱动的生物标志物和诊断应用。

IF 4.3 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-12-01 Epub Date: 2025-12-09 DOI: 10.1080/14737159.2025.2599225

Zoran Gluvić, Sonja Zafirović, Emina Sudar-Milovanović, Julijana Stanimirović, Sanja Soskić, Danimir Jevremović, Esma R Isenović

{"title":"Molecular insights into the gut-thyroid axis: microbiota-driven biomarkers and diagnostic applications.","authors":"Zoran Gluvić, Sonja Zafirović, Emina Sudar-Milovanović, Julijana Stanimirović, Sanja Soskić, Danimir Jevremović, Esma R Isenović","doi":"10.1080/14737159.2025.2599225","DOIUrl":"10.1080/14737159.2025.2599225","url":null,"abstract":"Introduction: New research has shown an intriguing link between the gut bacteria and the thyroid. A gut-thyroid relationship affects energy production, immunological function, and inflammation. As a result, disrupted gut flora harmony is associated with an increased/altered risk of thyroid dysfunction, autoimmune disorders, and metabolic imbalance. In addition to current diagnostic technology, understanding the gut flora-thyroid relationship could assist in the detection of thyroid-related conditions and modify patient treatment.Areas covered: This review explores state-of-the-art molecular techniques, e.g. metagenomics profiling and metabolomics, to uncover clinically relevant microbiota-driven biomarkers related to thyroid disorders.Expert opinion: Revealing potential microbiota-driven biomarker candidates is pivotal in enhancing our understanding of the mechanisms of thyroid disorders more precisely and identifying diagnostic and prognostic markers with clinical potential. Precisely, the individualization in the approach to patients with thyroid disorder, inevitably considering the harmonization of the gut microbiota-thyroid hormone relationship, is the basis of rational pharmacotherapy.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"915-928"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0