European Neuropsychopharmacology最新文献

{"title":"Contrasting genetic burden for bipolar disorder: Early onset versus late onset in an older adult bipolar disorder sample","authors":"Laura Montejo ,&nbsp;Brisa Sole ,&nbsp;Giovanna Fico ,&nbsp;Janos L. Kalman ,&nbsp;Monika Budde ,&nbsp;Urs Heilbronner ,&nbsp;Vincenzo Oliva ,&nbsp;Michele De Prisco ,&nbsp;Sara Martin-Parra ,&nbsp;Andrea Ruiz ,&nbsp;Anabel Martinez-Aran ,&nbsp;Kristina Adorjan ,&nbsp;Peter Falkai ,&nbsp;Maria Heilbronner ,&nbsp;Mojtaba Oraki Kohshour ,&nbsp;Daniela Reich-Erkelenz ,&nbsp;Sabrina K. Schaupp ,&nbsp;Eva C. Schulte ,&nbsp;Fanny Senner ,&nbsp;Thomas Vogl ,&nbsp;Carla Torrent","doi":"10.1016/j.euroneuro.2024.12.001","DOIUrl":"10.1016/j.euroneuro.2024.12.001","url":null,"abstract":"<div><div>Older Adults with Bipolar Disorder (OABD) represent a heterogeneous group, including those with early and late onset of the disorder. Recent evidence shows both groups have distinct clinical, cognitive, and medical features, tied to different neurobiological profiles. This study explored the link between polygenic risk scores (PRS) for bipolar disorder (PRS-BD), schizophrenia (PRS-SCZ), and major depressive disorder (PRS-MDD) with age of onset in OABD. PRS-SCZ, PRS-BD, and PRS-MDD among early vs late onset were calculated. PRS was used to infer posterior SNP effect sizes using a fully Bayesian approach. Demographic, clinical, and cognitive variables were also analyzed. Logistic regression analysis was used to estimate the amount of variation of each group explained by standardized PRS-SCZ, PRS-MDD, and PRS-BD. A total of 207 OABD subjects were included (144 EOBD; 63 LOBD). EOBD showed higher PRS-BD compared to LOBD (<em>p</em> = 0.005), while no association was found between age of onset and PRS-SCZ or PRS-MDD. Compared to LOBD, EOBD individuals also showed a higher likelihood for suicide attempts (<em>p</em> = 0.01), higher presence of psychotic symptoms (<em>p</em> = 0.003), higher prevalence of BD-I (<em>p</em> = 0.002), higher rates of familiarity for any psychiatric disorder (<em>p</em> = 0.004), and lower processing speed measured with Trail-Making Test part A (<em>p</em> = 0.03). OABD subjects with an early onset showed a greater genetic burden for BD compared to subjects with a late onset. These findings contribute to the notion that EOBD and LOBD may represent different forms of OABD, particularly regarding the genetic predisposition to BD.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 29-37"},"PeriodicalIF":6.1,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal structure and its relationship with premorbid, clinical, and cognitive variables in young Spanish patients with early course schizophrenia spectrum disorders","authors":"Jairo M. González-Díaz ,&nbsp;Bernardo Sánchez Dalmau ,&nbsp;Anna Camós-Carreras ,&nbsp;Salut Alba-Arbalat ,&nbsp;Silvia Amoretti ,&nbsp;Maria Florencia Forte ,&nbsp;Maria Serra-Navarro ,&nbsp;Sergi Salmerón ,&nbsp;Anaid Pérez-Ramos ,&nbsp;Eduard Vieta ,&nbsp;Carla Torrent ,&nbsp;Miquel Bernardo","doi":"10.1016/j.euroneuro.2024.12.006","DOIUrl":"10.1016/j.euroneuro.2024.12.006","url":null,"abstract":"<div><div>Emerging evidence suggests that retinal structural alterations are present in schizophrenia spectrum disorders (SSD), potentially reflecting broader neurodevelopmental and neurodegenerative processes. This cross-sectional study investigates retinal thickness and its clinical correlations in a sample of early-course SSD patients compared to healthy controls (HCs). One hundred-two eyes from 26 SSD cases and 25 age- and sex-matched HCs were included. Retinal structure was evaluated using Spectral-Domain Optical Coherence Tomography (SD-OCT), focusing on the peripapillary retinal nerve fiber layer (pRNFL), macular volume/thickness, and ganglion cell-inner plexiform layer (GCL+IPL) thickness. Although SSD cases showed increased peripapillary retinal nerve fiber layer (pRNFL) thickness in specific quadrants, most retinal parameters did not differ significantly between groups. Preliminary associations were observed between retinal measures, premorbid adjustment, DUP, and cognitive performance. These findings, while suggesting the potential of retinal imaging as a tool for early detection and monitoring of psychotic disorders, must be interpreted with caution. Further longitudinal and multimodal research is warranted to explore the association between these retinal changes and neuroinflammation, neurodegeneration, and overall brain health in SSD patients.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 38-47"},"PeriodicalIF":6.1,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the past: The risks and rewards of post-hoc findings","authors":"Vincenzo Oliva ,&nbsp;Eduard Vieta","doi":"10.1016/j.euroneuro.2024.12.005","DOIUrl":"10.1016/j.euroneuro.2024.12.005","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 21-22"},"PeriodicalIF":6.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining schizophrenia treatment with muscarinic modulation—A perspective","authors":"Muhammad Furqan","doi":"10.1016/j.euroneuro.2024.11.014","DOIUrl":"10.1016/j.euroneuro.2024.11.014","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 19-20"},"PeriodicalIF":6.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of mortality and complications in people with depressive disorder and diabetes mellitus: A 20-year population-based propensity score-matched cohort study","authors":"Matthew Tsz Ho Ho ,&nbsp;Joe Kwun Nam Chan ,&nbsp;Heidi Ka Ying Lo ,&nbsp;Catherine Zhiqian Fang ,&nbsp;Corine Sau Man Wong ,&nbsp;Krystal Chi Kei Lee ,&nbsp;Francisco Tsz Tsun Lai ,&nbsp;Amy Pui Pui Ng ,&nbsp;Ken Qingqi Chen ,&nbsp;William Chi Wai Wong ,&nbsp;Wing Chung Chang","doi":"10.1016/j.euroneuro.2024.11.011","DOIUrl":"10.1016/j.euroneuro.2024.11.011","url":null,"abstract":"<div><div>People with depression have increased premature mortality and elevated prevalence of diabetes-mellitus compared to general population. However, risk of mortality and diabetes-related complications among patients with depression and co-occurring diabetes is under-studied. This population-based propensity score-matched (1:10) cohort study identified 12,175 patients with pre-existing depression and incident-diabetes (depression-diabetes group) and 117,958 patients with incident-diabetes only (diabetes-only group) between 2002 and 2021 in Hong-Kong, using territory-wide medical-record database of public-healthcare services, to investigate whether depression increased the risk of overall mortality, complications and post-complication mortality in people with diabetes. Associations of depression with all-cause mortality, complication and post-complication all-cause mortality rates were examined by Cox proportional-hazards model. Complications were assessed by Diabetes-Complications-Severity-Index (DCSI). Associations of complications, in terms of DCSI scores (complication burden), specific types and two-way combinations of complications (complication patterns) with all-cause mortality rate in depression were also examined. Our results showed that depression-diabetes group exhibited increased all-cause mortality risk (adjusted hazards-ratio: 1.06 [95 %CI: 1.02–1.10]) relative to diabetes-only group, particularly among men and older age group, with significantly higher rate of experiencing neuropathy (1.44 [1.27–1.62]) and metabolic complications (1.30 [1.09–1.56]) and lower likelihood of peripheral-vascular complications, retinopathy and nephropathy, albeit comparable macrovascular and microvascular complication rates. The mortality-rate-ratio for patients with depression and diabetes was significantly higher than patients with diabetes-only at a low level of complication burden. In conclusion, depression patients with co-occurring diabetes are at increased risk of excess mortality. Further research is warranted to improve diabetes-related outcomes and reduce mortality gap in this vulnerable population.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 10-18"},"PeriodicalIF":6.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amphiphysin and GAD65 IgG antibodies in patients with obsessive-compulsive syndromes","authors":"Katharina von Zedtwitz ,&nbsp;Bernd Feige ,&nbsp;Alexander Maier ,&nbsp;Sarah L. Schaefer ,&nbsp;Kathrin Nickel ,&nbsp;Marco Reisert ,&nbsp;Kai Spiegelhalder ,&nbsp;Nils Venhoff ,&nbsp;Joachim Brumberg ,&nbsp;Horst Urbach ,&nbsp;Rick Dersch ,&nbsp;Miriam A. Schiele ,&nbsp;Katharina Domschke ,&nbsp;Ludger Tebartz van Elst ,&nbsp;Volker A. Coenen ,&nbsp;Luciana Hannibal ,&nbsp;Harald Prüss ,&nbsp;Simon J. Maier ,&nbsp;Dominique Endres","doi":"10.1016/j.euroneuro.2024.10.005","DOIUrl":"10.1016/j.euroneuro.2024.10.005","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"90 ","pages":"Pages 80-82"},"PeriodicalIF":6.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between genetic risk of attention deficit hyperactivity disorder and trajectories of daily gaming time in children","authors":"Nagahide Takahashi ,&nbsp;Akemi Okumura ,&nbsp;Tomoko Nishimura ,&nbsp;Taeko Harada ,&nbsp;Toshiki Iwabuchi ,&nbsp;Md Shafiur Rahman ,&nbsp;Kenji J. Tsuchiya","doi":"10.1016/j.euroneuro.2024.11.012","DOIUrl":"10.1016/j.euroneuro.2024.11.012","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"91 ","pages":"Pages 54-55"},"PeriodicalIF":6.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of mortality and complications in patients with severe mental illness and co-occurring diabetes mellitus: A systematic review and meta-analysis","authors":"Matthew Tsz Ho Ho ,&nbsp;Joe Kwun Nam Chan ,&nbsp;Will Chi Yuen Chiu ,&nbsp;Lucy Lo Wah Tsang ,&nbsp;Kenneth Shut Wah Chan ,&nbsp;Mimi Mei Cheung Wong ,&nbsp;Ho Hon Wong ,&nbsp;Pui Fai Pang ,&nbsp;Wing Chung Chang","doi":"10.1016/j.euroneuro.2024.11.002","DOIUrl":"10.1016/j.euroneuro.2024.11.002","url":null,"abstract":"<div><div>People with severe-mental-illness (SMI), often defined as “schizophrenia-spectrum disorders and bipolar disorder”, have increased premature mortality and elevated prevalence of diabetes compared with general population. Evidence indicated that one-third of their premature death was from cardiovascular diseases (CVD), with risk conferred by diabetes. Although earlier studies have examined SMI-associated diabetes-related outcomes, findings were inconsistent and not systematically evaluated. We systematically reviewed and quantitatively synthesized diabetes-related outcomes in patients with SMI (schizophrenia-spectrum disorders and bipolar disorder) by searching Embase, MEDLINE, PsycInfo, and Web-of-Science from inception to 31-March-2024, and included studies examining mortality and complication outcomes in SMI patients with co-occurring diabetes relative to patients with diabetes-only. Results were synthesized by random-effects models, with stratified-analyses by study-level characteristics. The study was registered with PROSPERO (CRD42023448490). Twenty-one studies involving 161,156 SMI patients with co-occurring diabetes were identified from ten regions. Regarding mortality risk, SMI-diabetes group exhibited increased risks of all-cause mortality (RR=1.77[95 % CI: 1.46–2.14]) and CVD-specific mortality (1.88[1.73–2.04]) relative to diabetes-only group. All-cause mortality risk was present in distinct regions and has persisted over time. Regarding complication risk, SMI-diabetes group showed higher risk of any complications (1.23[1.06–1.43]) than comparison, with stratified-analyses showing higher risk of metabolic-complications (1.84[1.58–2.15]), and lower likelihood of peripheral-vascular complications (0.91[0.84–0.99]), neuropathy (0.85[0.78–0.93]), and retinopathy (0.70[0.60–0.82]), albeit comparable cardiovascular-complications (1.04[0.89–1.22]), cerebrovascular-complications (1.07[0.86–1.33]), and nephropathy (0.92[0.72–1.17]). High heterogeneity was noted and could not be fully-explained by subgroup-analyses. Implementation of targeted interventions is needed to rectify their diabetes-related outcomes and mortality gap.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"91 ","pages":"Pages 25-36"},"PeriodicalIF":6.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial DNA copy number is significantly increased in bipolar disorder patients and is correlated with long-term lithium treatment","authors":"Anna Meloni ,&nbsp;Pasquale Paribello ,&nbsp;Marco Pinna ,&nbsp;Martina Contu ,&nbsp;Raffaella Ardau ,&nbsp;Caterina Chillotti ,&nbsp;Donatella Congiu ,&nbsp;Massimo Gennerelli ,&nbsp;Alessandra Minelli ,&nbsp;Lisa Buson ,&nbsp;Giovanni Severino ,&nbsp;Claudia Pisanu ,&nbsp;Mirko Manchia ,&nbsp;Alessio Squassina","doi":"10.1016/j.euroneuro.2024.10.012","DOIUrl":"10.1016/j.euroneuro.2024.10.012","url":null,"abstract":"<div><div>Mitochondrial dysfunctions have been reported in bipolar disorder (BD), but their role in the etiopathogenesis of BD as well as their implications in modulating response to pharmacological treatments with psychotropic medications have been scarcely explored. Mitochondrial DNA copy number (mtDNA-cn) has been linked to mitochondria functioning, and, despite some degree of inconsistence, previous findings showed that BD patients present significant differences in mtDNA-cn compared to healthy controls. Here we measured mtDNA-cn in a sample of 89 patients with BD and 78 healthy controls (HC). Patients in the BD sample were treated either with lithium (<em>n</em> = 47) and characterized as responders (<em>n</em> = 22) or non-responders (<em>n</em> = 25), or with other mood stabilizers (<em>n</em> = 42). BD patients had larger mtDNA-cn compared to HC (adjusted model: F₂=9.832; <em>p</em> = 0.000095; contribution of diagnosis F₁= 10.798; <em>p</em> = 0.001). When the BD sample was stratified for treatment exposure, mtDNA-cn was lower in patients treated with lithium compared to those treated with other mood stabilizers (adjusted model: F₄=23.770, <em>p</em> = 7.0929E-13; contribution of treatment: F₁=54.300, <em>p</em> = 1.55E-10). Moreover mtDNA-cn was higher in patients treated with other mood stabilizers compared to controls and Li-treated BD patients (F₃=28.125, <em>p</em> = 1.36E-14; contribution of groups F₂=36.156, <em>p</em> = 1.25E-13). Finally, there was no difference in mtDNA-cn levels in lithium responders compared to non-responders and neither between the two diagnostic groups (BD type 1 and 2). Our findings suggest that BD may be associated with mitochondrial dysfunctions, and that exposure to lithium but not to other mood stabilizers may restore these abnormalities, though this does not appear correlated with the clinical efficacy of lithium.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"91 ","pages":"Pages 37-44"},"PeriodicalIF":6.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis use and psychosis: evidence and new clinical features of a new epidemic","authors":"Giovanni Martinotti ,&nbsp;Marta Di Forti","doi":"10.1016/j.euroneuro.2024.11.007","DOIUrl":"10.1016/j.euroneuro.2024.11.007","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"91 ","pages":"Pages 45-46"},"PeriodicalIF":6.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}