Mycobacterium - Research and Development最新文献

Introductory Chapter: Scientific Research on Mycobacteria and the Absence of Evaluation Processes 导论:分枝杆菌的科学研究和评价方法的缺失

Mycobacterium - Research and Development Pub Date : 2018-06-20 DOI: 10.5772/intechopen.76831

Wellman Ribón

引用次数: 0

Overview of Non Tuberculosis Mycobacterial Lung Diseases 非结核分枝杆菌肺病综述

Mycobacterium - Research and Development Pub Date : 2018-06-20 DOI: 10.5772/intechopen.73542

Overview o.N.T.M.L. Diseases

引用次数: 0

Conventional and Molecular Diagnosis of Drug-Sensitive and Drug-Resistant Pulmonary Tuberculosis 药敏和耐药肺结核的常规和分子诊断

Mycobacterium - Research and Development Pub Date : 2018-06-20 DOI: 10.5772/INTECHOPEN.75004

Y. Martínez-Martínez, Herminia GuadalupeMartínez-Rodríguez, S. Said-Fernández

引用次数: 1

Mycobacterium as Polycyclic Aromatic Hydrocarbons (PAHs) Degrader 分枝杆菌作为多环芳烃(PAHs)的降解剂

Mycobacterium - Research and Development Pub Date : 2018-06-20 DOI: 10.5772/INTECHOPEN.73546

Dushyant Dudhagara, B. Dave

引用次数: 11

Mycobacterium tuberculosis: Macrophage Takeover and Modulation of Innate Effector Responses 结核分枝杆菌:巨噬细胞接管和先天效应反应的调节

Mycobacterium - Research and Development Pub Date : 2018-06-20 DOI: 10.5772/INTECHOPEN.75003

K. H. Bhat, Imtiyaz Yaseen

{"title":"Mycobacterium tuberculosis: Macrophage Takeover and Modulation of Innate Effector Responses","authors":"K. H. Bhat, Imtiyaz Yaseen","doi":"10.5772/INTECHOPEN.75003","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.75003","url":null,"abstract":"Macrophages mediate the first line of defense in the host against various intracellular path- ogens. They are armed with several immune-effector mechanisms to detect and combat pathogens. However, intracellular pathogens have developed strategies to overcome the macrophage protective immune responses and colonize inside the macrophages. Tuberculosis (TB), both pulmonary and extrapulmonary, is an infectious disease of global concern caused by Mycobacterium tuberculosis . M . tuberculosis is a highly successful pathogen and has acquired various strategies to downregulate critical innate-effector immune responses of macrophages such as phagosome-lysosome fusion, antigen presentation, autophagy, and inhibition of reactive oxygen (ROI) and reactive nitrogen (RNI) species to ensure its longer survival inside the macrophages. In addition to these, the bacilli also modulate Tcell immune response which can help the bacilli to survive inside the host for a long time. In this chapter, we focus to describe important macrophage innate defense mechanisms and the signaling that can influence Tcell adaptive response and the strategies adopted by the bacilli to exploit these signaling cascades to favor its replication and persistence inside the macrophages for establishing a productive infection. by macrophage surveillance their safe which in designing suitable interventions against","PeriodicalId":120491,"journal":{"name":"Mycobacterium - Research and Development","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114401220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Mosaic Structure as the Main Feature of Mycobacterium bovis BCG Genomes 镶嵌结构是牛分枝杆菌BCG基因组的主要特征

Mycobacterium - Research and Development Pub Date : 2018-06-20 DOI: 10.5772/INTECHOPEN.75005

Voronina Olga Lvovna, Aksenova Ekaterina Ivanovna, KundaMarina Sergeevna, Ryzhova Natalia Nikolaevna, Semenov AndreyNikolaevich, Sharapova Natalia Eugenievna, Gintsburg AlexandrLeonidovich

{"title":"Mosaic Structure as the Main Feature of Mycobacterium bovis BCG Genomes","authors":"Voronina Olga Lvovna, Aksenova Ekaterina Ivanovna, KundaMarina Sergeevna, Ryzhova Natalia Nikolaevna, Semenov AndreyNikolaevich, Sharapova Natalia Eugenievna, Gintsburg AlexandrLeonidovich","doi":"10.5772/INTECHOPEN.75005","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.75005","url":null,"abstract":"Background: The genome stability of attenuated live BCG vaccine preventing the acute forms of childhood tuberculosis is an important aspect of vaccine production. The pur pose of our study was a whole genome comparative analysis of BCG sub-strains and identification of potential triggers of sub-strains’ transition. Results: Genomes of three BCG Russia seed lots (1963, 1982, 2006 years) have been sequenced, and the stability of vaccine sub-strain genomes has been confirmed. A com parative genome analysis of nine Mycobacterium bovis BCG and three M. bovis strains revealed their specific genome features associated with prophage profiles. A number of prophage-coded homologs to Caudovirales ORFs were common to all BCG genomes. Prophage profiles of BCG Tice and BCG Montreal genomes were unique and coded homologs to herpes viruses ORFs. The data of phylogenetic analysis of BCG sub-strain groups based on whole genome sequences and genome restriction maps were in con - gruence with prophage profiles. The only fragmentary similarity of specific prophage sequences of BCG Tice, BCG Montreal, and BCG Russia 368 in pair-wise alignments was observed, suggesting the impact of prophages on mosaic structure of genomes. Conclusions: The whole genome sequencing approach is essential for genomes with mosaic structure, harboring numerous prophage sequences. Tools for prophage search are effective instruments in this analysis.","PeriodicalId":120491,"journal":{"name":"Mycobacterium - Research and Development","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125419362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clients’ Perception of Quality of Multidrug-Resistant Tuberculosis Treatment and Care in Resource-Limited Setting: Experience from Nigeria 在资源有限的环境下，客户对耐多药结核病治疗和护理质量的感知:来自尼日利亚的经验

Mycobacterium - Research and Development Pub Date : 2018-06-20 DOI: 10.5772/INTECHOPEN.76001

O. Oladimeji, D. Adeyinka, LehlogonoloMakola, K. H. Mitonga, E. Udoh, B. Ushie, K. Oladimeji, J. Chikovore, M. Mabaso, A. Adeleke, OsmanEltayeb, Oluwatoyin J. Kuye, G. Mustapha, Olusoji MayowaIge, J. N. Mbatha, J. Creswell, J. Tsoka-Gwegweni, L. Lawson, E. Igumbor

{"title":"Clients’ Perception of Quality of Multidrug-Resistant Tuberculosis Treatment and Care in Resource-Limited Setting: Experience from Nigeria","authors":"O. Oladimeji, D. Adeyinka, LehlogonoloMakola, K. H. Mitonga, E. Udoh, B. Ushie, K. Oladimeji, J. Chikovore, M. Mabaso, A. Adeleke, OsmanEltayeb, Oluwatoyin J. Kuye, G. Mustapha, Olusoji MayowaIge, J. N. Mbatha, J. Creswell, J. Tsoka-Gwegweni, L. Lawson, E. Igumbor","doi":"10.5772/INTECHOPEN.76001","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.76001","url":null,"abstract":"Additional information is available at the end of the chapter Abstract Background: Quality care is essential to the well-being and survival of people with multidrug-resistant tuberculosis (MDR-TB). The aim of this study is to explore how MDR- TB patients, who were voluntarily hospitalized, perceived care and treatment strategy and to assess the influence of psychosocial factors on their perception of care and treatment strategy in Nigeria. Methods: The study enrolled 98 MDR-TB patients on voluntary confinement in four MDR-TB hospitals in Nigeria. Patients ’ perceptions of quality of care and treatment strategy were evaluated with 28-item and 6-item instru- ments, respectively. Bivariate analysis was used to test for an association and multivariate analysis for factors that might contribute to the perceived quality of care. Results: Seventy-eight per cent (78%) of the participating patients perceived the quality of care to be good. Patients with better psychosocial well-being had five times higher odds to report good quality of care. Conclusion: The majority of MDR-TB patients perceived the quality of inpatient care to be good in Nigerian hospitals; however, their psychological health influenced their perception significantly. Health care providers need to improve treatment strategies to encourage acceptance of care as poor perception to health care service delivery may deter treatment completion and also cause relapse among clients on treatment.","PeriodicalId":120491,"journal":{"name":"Mycobacterium - Research and Development","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127429681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Web Resources on Tuberculosis: Information, Research, and Data Analysis 关于结核病的网络资源:信息、研究和数据分析

Mycobacterium - Research and Development Pub Date : 2018-03-02 DOI: 10.5772/INTECHOPEN.73549

Edson Machado, C. Cerdeira, A. B. Miranda, M. Catanho

引用次数: 1

Patients and Health System-Related Factors Impacting on Tuberculosis Program Implementation in Resource-Constrained Settings: Experience from Multi-TB Facilities in Oyo State, South-West of Nigeria 在资源有限的环境中，患者和卫生系统相关因素影响结核病规划的实施:来自尼日利亚西南部奥约州多结核病设施的经验

Mycobacterium - Research and Development Pub Date : 2018-02-23 DOI: 10.5772/INTECHOPEN.73583

O. Oladimeji, J. Tsoka-Gwegweni, L. Mlangeni, L. Makola, Olusegun Awolaran

{"title":"Patients and Health System-Related Factors Impacting on Tuberculosis Program Implementation in Resource-Constrained Settings: Experience from Multi-TB Facilities in Oyo State, South-West of Nigeria","authors":"O. Oladimeji, J. Tsoka-Gwegweni, L. Mlangeni, L. Makola, Olusegun Awolaran","doi":"10.5772/INTECHOPEN.73583","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.73583","url":null,"abstract":"Background : Tuberculosis (TB) is one of the most prevalent human infections and is the second leading cause of deaths from infectious diseases worldwide, and Nigeria is the fourth among the 22 high-burden countries in the world for tuberculosis even though the exact burden of TB in Nigeria is not known. Methods : The study used exploratory cross-sectional design. A multistage stratified ran - dom sampling technique was used to select 680 participants from 16 DOTS facilities in one state in Nigeria. Results : The results show that 59.25% (410) of individuals believed that the quality of access to care was excellent, 78.44% (542) of individuals believed that the appearance of the healthcare facility they attended was excellent, 75.40% (518) of individuals believed that there were many people accessing healthcare facilities and 82.33% (559) reported that they waited less than 30 minutes at a healthcare facility. Conclusions : Providing good was generally satisfactory. Findings from this study are relevant for policy formation and strategic implementation for TB control program in resource-limited settings. its association with HIV), health literacy (TB-related knowledge and education) and sociocultural (gender roles and status in the family) factors, whereas provider-/system-level barriers include provider’s degree of suspicion for TB, the number and types of providers seen before TB diagnosis, provider adherence to national TB program guidelines and patient satisfaction with TB services [2, 6, 7]. Due to these challenges, a comprehensive understand-ing of barriers is needed in order to provide insight into TB service programs, research and policy. It is against this background that this study was designed to determine individual and provider’s barriers and delays that limit access and adherence to TB services.","PeriodicalId":120491,"journal":{"name":"Mycobacterium - Research and Development","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122587556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Physiology of Mycobacterium tuberculosis in the Context of Drug Resistance: A System Biology Perspective 耐药性背景下结核分枝杆菌的生理学:系统生物学视角

Mycobacterium - Research and Development Pub Date : 2017-12-20 DOI: 10.5772/INTECHOPEN.69594

L. Nieto, C. Mehaffy, K. Dobos

引用次数: 7