ACS Chemical Biology最新文献_第5页

Molecular Glue and Phosphorylation-Dependent 14-3-3 Recruitment to p53 with an Engineered Interaction Cassette 分子胶和磷酸化依赖性14-3-3募集p53与工程相互作用盒。

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-08-21 DOI: 10.1021/acschembio.6c00482

Diana C. Muñoz-Lasso, Yan Ni, Glenn Weber, Federica Eduati, Roderick L. Beijersbergen, Christian Ottmann, Luc Brunsveld

{"title":"Molecular Glue and Phosphorylation-Dependent 14-3-3 Recruitment to p53 with an Engineered Interaction Cassette","authors":"Diana C. Muñoz-Lasso, Yan Ni, Glenn Weber, Federica Eduati, Roderick L. Beijersbergen, Christian Ottmann, Luc Brunsveld","doi":"10.1021/acschembio.6c00482","DOIUrl":"10.1021/acschembio.6c00482","url":null,"abstract":"The tumor suppressor p53 is regulated by phosphorylation-dependent protein–protein interactions, including via binding to 14-3-3 adaptor proteins, which can tune p53 activity. Molecular glue (MG)-induced stabilization of 14-3-3/client interactions offers an attractive strategy to probe such networks, but cellular engagement is often constrained by context-dependent phosphorylation and interaction occupancy. Here, we engineered phosphorylation- and MG-dependent 14-3-3 interaction cassettes (IC1 and IC2) and fused them to p53 to promote recruitment of endogenous 14-3-3 proteins in human cells. Biochemical characterization establishes high-affinity binding of the phosphorylated cassettes to 14-3-3 and enhanced in vitro stabilization by the 14-3-3 molecular glue 3′-deacetylated fusicoccin-A (FC-A). In HEK293T cells, Flag–p53–IC1 and Flag–p53–IC2 co-immunoprecipitated native 14-3-3 proteins. Mutation of the cassette’s phospho-accepting serine to alanine abolished binding, confirming phosphorylation dependent recruitment. Transcriptomic profiling of transiently transfected cells reveals cassette-dependent remodeling of a p53-associated gene expression landscape. Together, these results establish a modular, MG- and phosphorylation-dependent platform for engaging 14-3-3 in a p53 context and for evaluating how chemical stabilization translates from biochemical interaction control to cellular pathway-level readouts.","PeriodicalId":11,"journal":{"name":"ACS Chemical Biology","volume":"21 9","pages":"2369–2383"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Substrate Specificities of Dermatan Sulfate Epimerase 1 (DS-epi1) and 4-O-sulfotransferase (DS 4-OST) Using Synthetic Oligosaccharide Substrates 利用合成低聚糖底物研究皮肤硫酸酯epimase 1 （DS-epi1）和4- o -硫转移酶（DS- 4-OST）的底物特异性

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-08-31 DOI: 10.1021/acschembio.6c00533

Yongmei Xu, Yi-Chi Wang, Eduardo Stancanelli, Haoran Wang, Jianxiang Zhang, Emil Tykesson, Anders Malmström, Jian Liu

{"title":"Investigation of the Substrate Specificities of Dermatan Sulfate Epimerase 1 (DS-epi1) and 4-O-sulfotransferase (DS 4-OST) Using Synthetic Oligosaccharide Substrates","authors":"Yongmei Xu, Yi-Chi Wang, Eduardo Stancanelli, Haoran Wang, Jianxiang Zhang, Emil Tykesson, Anders Malmström, Jian Liu","doi":"10.1021/acschembio.6c00533","DOIUrl":"10.1021/acschembio.6c00533","url":null,"abstract":"Dermatan sulfate epimerase 1 (DS-epi1, DSE) and dermatan sulfate 4-O-sulfotransferase (DS 4-OST, CHST14) are critical enzymes involved in the biosynthesis of dermatan sulfate. In this study, structurally homogeneous chondroitin oligosaccharide substrates were used to investigate the substrate specificity of each individual enzyme, as well as their combined actions. The structures of the enzyme-modified oligosaccharides were confirmed by high-resolution mass spectrometry (MS) and NMR or determined by LC–MS-based sequencing analysis. Our results demonstrate that DS-epi1 catalyzes the reversible conversion between glucuronic acid (GlcA) and iduronic acid (IdoA), with GlcA being the predominant product once the reaction reaches equilibrium. DS 4-OST selectively sulfates the 4-hydroxyl group of N-acetylgalactosamine (GalNAc) residues that are linked to the reducing end of an IdoA unit (–IdoA–GalNAc–). Furthermore, DS-epi1 and DS 4-OST act in a concerted and ordered manner to generate clustered –IdoA–GalNAc4S– domains. During the reaction, the enzyme mixture initiates modifications at the non-reducing end of the saccharide chain and proceeds toward the reducing end consecutively. These findings provide new insights into the regulatory mechanisms governing dermatan sulfate biosynthesis and demonstrate the feasibility of synthesizing structurally defined dermatan sulfate oligosaccharides.","PeriodicalId":11,"journal":{"name":"ACS Chemical Biology","volume":"21 9","pages":"2415–2426"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Chemigenetic Ca2+ Indicator Based on a Red Fluorescent Protein and a Synthetic Chelator 基于红色荧光蛋白和合成螯合剂的化学Ca2+指示剂。

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-09-03 DOI: 10.1021/acschembio.6c00209

Shosei Imai, Wenchao Zhu, Robert E. Campbell, Takuya Terai

{"title":"A Chemigenetic Ca2+ Indicator Based on a Red Fluorescent Protein and a Synthetic Chelator","authors":"Shosei Imai, Wenchao Zhu, Robert E. Campbell, Takuya Terai","doi":"10.1021/acschembio.6c00209","DOIUrl":"10.1021/acschembio.6c00209","url":null,"abstract":"Fluorescent indicators are indispensable imaging tools for visualizing the spatiotemporal dynamics of biological processes. Red fluorescent indicators are in particularly high demand because they offer compatibility with existing green fluorescent indicators or optogenetic tools, and longer wavelength fluorescence has inherent advantages for biological applications. We previously described a chemigenetic indicator design that combines a green fluorescent protein and a synthetic chelator in an effort to combine the advantages of conventional protein-based biosensors and synthetic chemosensors. We now demonstrate that this chemigenetic design can be extended to red fluorescent proteins. Through screening of variants with a range of chromophore–chelator orientations, followed by directed evolution, we developed a red fluorescent calcium ion (Ca2+) indicator with 5.4-fold fluorescence intensity change when going from 0 to 39 μM Ca2+ with purified proteins. Although the functionality of the current version is lost when expressed in mammalian cells and the selectivity is low, these results establish this chemigenetic design as a strategy that can be extended to other fluorescent protein color variants.","PeriodicalId":11,"journal":{"name":"ACS Chemical Biology","volume":"21 9","pages":"2112–2118"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploiting Acquired Drug Resistance in Pancreatic Cancer through Selective Covalent Targeting of MAP2K4/7 通过选择性共价靶向MAP2K4/7开发胰腺癌获得性耐药

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-09-06 DOI: 10.1021/acschembio.6c00580

Gina M. Connors, Thao D. Pham, Jeffrey H. Becker, Aria A. Argus, Kenkichi Baba, Takayoshi Kinoshita, Hidayatullah G. Munshi, Karl A. Scheidt

引用次数: 0

Evaluation of HDAC8 as a Druggable Target in STAG2-Mutant Ewing Sarcoma HDAC8在stag2突变型Ewing肉瘤中作为可药物靶点的评价

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-08-26 DOI: 10.1021/acschembio.6c00345

Olasunkanmi Olaoye, Yuan Xiong, Cory D. Rillahan, Biniam Adane, Giulia DiGiovanni, Kenneth N. Ross, Gabriela Alexe, Briana Howard, Nadia Kirmani, Radosław P. Nowak, Katherine A. Donovan, Eric S. Fischer, Kimberly Stegmaier

{"title":"Evaluation of HDAC8 as a Druggable Target in STAG2-Mutant Ewing Sarcoma","authors":"Olasunkanmi Olaoye, Yuan Xiong, Cory D. Rillahan, Biniam Adane, Giulia DiGiovanni, Kenneth N. Ross, Gabriela Alexe, Briana Howard, Nadia Kirmani, Radosław P. Nowak, Katherine A. Donovan, Eric S. Fischer, Kimberly Stegmaier","doi":"10.1021/acschembio.6c00345","DOIUrl":"10.1021/acschembio.6c00345","url":null,"abstract":"Ewing sarcoma is an aggressive pediatric cancer for which no targeted therapies have been approved. This disease is driven by EWSR1::ETS family fusions that, like most fusion transcription factors, have proven difficult to target directly. Here, we focus on identifying actionable dependencies within the high-risk STAG2-mutant (STAG2-mut) disease subtype of Ewing sarcoma. In STAG2-mut Ewing sarcoma, STAG1 knockout is synthetically lethal but is not readily druggable. Using the Cancer Dependency Map (DepMap), we identify histone deacetylase 8 (HDAC8) as an enriched vulnerability in this molecular context. CRISPR validation and a newly developed HDAC8 degrader, XY-09-36, confirm this selective dependency and suggest increased reliance on HDAC8-mediated cohesin regulation when STAG2 is lost. These findings establish HDAC8 as a context-dependent, pharmacologically accessible vulnerability and outline a framework for discovering rational targets in tumor subtypes where primary drivers are intrinsically hard to drug.","PeriodicalId":11,"journal":{"name":"ACS Chemical Biology","volume":"21 9","pages":"2188–2199"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allosteric Inhibition of TrkB Activation as Related to Neuroblastoma by Triazole Bridged Compounds 三唑桥接化合物对神经母细胞瘤相关TrkB活化的变构抑制

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-08-13 DOI: 10.1021/acschembio.6c00423

Samuel V. Rasmussen, Shefali Chauhan, Emma Lashyro, Xiaolei Lian, John M. Maris, Alvin Farrel, Robert C. Doebele, Tyuji Hoshino, Charles Keller

{"title":"Allosteric Inhibition of TrkB Activation as Related to Neuroblastoma by Triazole Bridged Compounds","authors":"Samuel V. Rasmussen, Shefali Chauhan, Emma Lashyro, Xiaolei Lian, John M. Maris, Alvin Farrel, Robert C. Doebele, Tyuji Hoshino, Charles Keller","doi":"10.1021/acschembio.6c00423","DOIUrl":"https://doi.org/10.1021/acschembio.6c00423","url":null,"abstract":"TrkB (NTRK2) overexpression in neuroblastoma is reported to be associated with poor prognostic features, including MYCN amplification and advanced tumor stages. In this study, TrkB expression in available cell lines was characterized, and allosteric inhibitors of ligand-activated TrkB were designed, characterized, and tested. The designed compounds commonly bear a triazole group at their center, which bridges three aromatic components. Based on the chemical design, 25 compounds were synthesized for the cell-based assay to examine the neuroblastoma cell growth inhibition. Several cell lines were used in the assay based on TrkB expression levels. TrkB non-enhanced and TrkA overexpressing cell cultures were also tested for comparison. Many of the synthesized compounds suppressed the phosphorylation of the TrkB (cytoplasmic side) induced by brain-derived neurotrophic factor (BDNF) binding to the extracellular domain of TrkB. Several compounds showed effective suppression of phosphorylation to a similar degree as larotrectinib, an approved TrkB inhibitor targeting the cytoplasmic tyrosine kinase domain. The compounds’ potency to suppress neuroblastoma cell growth was evaluated using a basal high TrkB-expressing culture. Select compounds showed strong cell growth suppression, with 50% inhibitory activities below 30 nM. Two potent compounds were also tested to determine their inhibitory activities on other cell lines. Cell growth inhibition was observed for three cell cultures, but moderate for one. Neither the approved TrkB inhibitor, larotrectinib, nor our allosteric compounds could completely inhibit the growth of all neuroblastoma cell lines natively expressing TrkB.","PeriodicalId":11,"journal":{"name":"ACS Chemical Biology","volume":"21 9","pages":"2263–2274"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148985217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Biosynthetic Pathway for the Hybrid NRPS-NIS Siderophore Nocardichelin Contains NcdG, a Succinylase that Cleaves the Hydroxamate Bond of the Acylcadaverine Intermediate nrpps - nis铁载体Nocardichelin的生物合成途径含有NcdG，一种琥珀酰化酶，可切割酰基尸胺中间体的羟酸键

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-08-13 DOI: 10.1021/acschembio.6c00490

Mercedes B. Fisk, Collin E. Merrick, Timothy A. Wencewicz, Andrew M. Gulick

{"title":"The Biosynthetic Pathway for the Hybrid NRPS-NIS Siderophore Nocardichelin Contains NcdG, a Succinylase that Cleaves the Hydroxamate Bond of the Acylcadaverine Intermediate","authors":"Mercedes B. Fisk, Collin E. Merrick, Timothy A. Wencewicz, Andrew M. Gulick","doi":"10.1021/acschembio.6c00490","DOIUrl":"https://doi.org/10.1021/acschembio.6c00490","url":null,"abstract":"Bacteria produce natural products for multiple activities including cell signaling, competition, and virulence. Another important role is nutrient acquisition, which is carried out by a diverse pool of iron-sequestering molecules called siderophores. Siderophores can be produced by nonribosomal peptide synthetases (NRPSs), NRPS-independent siderophore (NIS) synthetases, or both pathways, as shown in the biosynthesis of the recently described hybrid siderophore nocardichelin. Nocardichelin and the hydroxamate siderophore desferrioxamine B both contain N-hydroxy-N-succinylcadaverine (HSC) and N-hydroxy-N-acylcadaverine (HRC) biosynthetic intermediates. Some desferrioxamine pathways contain DesG, an N-terminal nucleophile (Ntn) hydrolase, that has been proposed to hydrolyze HSC to create N-hydroxycadaverine and succinate, which may help to modulate levels of the two building blocks, HSC and HRC. The biosynthetic gene cluster of nocardichelin also harbors an Ntn hydrolase and homologue of DesG. To explore the biochemical function of NcdG and its role in nocardichelin biosynthesis, we examined its structure and function. We demonstrate that NcdG cleaves the hydroxamate bond of HSC and HSC dimers and also determine the structure of NcdG, an acyl hydroxamate-cleaving Ntn hydrolase.","PeriodicalId":11,"journal":{"name":"ACS Chemical Biology","volume":"21 9","pages":"2347–2355"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148985256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isotopic Tracing of [13C6]scyllo-Inositol Uncovers Its Incorporation into Phosphatidylinositols in Immortalized Mammalian Cells [13C6]scyllo-肌醇的同位素示踪揭示了其在永生化哺乳动物细胞中与磷脂酰肌醇的结合。

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-08-26 DOI: 10.1021/acschembio.6c00409

Meike M. Amma, Laxmikanth Kollipara, Tobias Dürr-Mayer, Josefin Streeck, Peter Schmieder, Adolfo Saiardi, Henning J. Jessen, Sven Heiles, Dorothea Fiedler

{"title":"Isotopic Tracing of [13C6]scyllo-Inositol Uncovers Its Incorporation into Phosphatidylinositols in Immortalized Mammalian Cells","authors":"Meike M. Amma, Laxmikanth Kollipara, Tobias Dürr-Mayer, Josefin Streeck, Peter Schmieder, Adolfo Saiardi, Henning J. Jessen, Sven Heiles, Dorothea Fiedler","doi":"10.1021/acschembio.6c00409","DOIUrl":"10.1021/acschembio.6c00409","url":null,"abstract":"Inositols are a family of cyclic sugar alcohols comprising nine stereoisomers. myo-Inositol is the most abundant isomer found in humans and has been studied most extensively. It plays an important role in osmoregulation and is incorporated into membrane-anchored phosphatidylinositols. scyllo-Inositol is the second most abundant inositol isomer in the human brain, and aberrant concentrations are associated with various diseases; however, its biological functions remain unclear. Here, the development and application of [13C6]scyllo-inositol as an isotopic tracer to study its metabolism are reported. A concise and robust synthetic route was established to obtain [13C6]scyllo-inositol from [13C6]myo-inositol in good yield. The uptake of [13C6]scyllo-inositol at concentrations used in clinical trials and the responses of endogenous inositol isomers were measured in multiple immortalized mammalian cell lines by hydrophilic liquid interaction (HILIC)-MS/MS. [13C6]scyllo-Inositol proved to be a versatile isotopic tracer when coupled with mass spectrometry (MS)-based lipidomics and 2D nuclear magnetic resonance (NMR) experiments. These experiments provide evidence that scyllo-inositol is incorporated into phosphatidylinositols in different immortalized mammalian cell lines and suggest a previously underappreciated role of scyllo-inositol. Future research utilizing [13C6]scyllo-inositol can elucidate scyllo-inositol metabolism and its role in physiological and diseased states.","PeriodicalId":11,"journal":{"name":"ACS Chemical Biology","volume":"21 9","pages":"2232–2243"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurosteroids Inhibit RORγ and Induce Major Rearrangement of Its Activation Motif 神经类固醇抑制RORγ并诱导其激活基序重排

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-08-13 DOI: 10.1021/acschembio.6c00373

Úrsula López-García, Minh Sai, Xiu Ge, Emily C. Hank, Thomas Wein, Julian A. Marschner, Vasily Morozov, Daniel Merk

引用次数: 0

Discovery and Characterization of Inhibitors of Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5): Targeting the UFMylation Pathway in Cancer and Neurodegenerative Diseases 泛素样修饰物激活酶5 （UBA5）抑制剂的发现和表征：靶向肿瘤和神经退行性疾病的ufmy化途径

IF 3.6 2区生物学

ACS Chemical Biology Pub Date : 2026-09-18 Epub Date: 2026-08-17 DOI: 10.1021/acschembio.6c00369

Vigyasa Singh, Yuansong Wan, Zhisong Gao, Tahsin Reaz Ahmed, Si-Yu Wang, Ke Chen, Subodh Kumar Samrat, Zhong Li, Subhash Sinha, Li Gan, Hongmin Li

{"title":"Discovery and Characterization of Inhibitors of Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5): Targeting the UFMylation Pathway in Cancer and Neurodegenerative Diseases","authors":"Vigyasa Singh, Yuansong Wan, Zhisong Gao, Tahsin Reaz Ahmed, Si-Yu Wang, Ke Chen, Subodh Kumar Samrat, Zhong Li, Subhash Sinha, Li Gan, Hongmin Li","doi":"10.1021/acschembio.6c00369","DOIUrl":"10.1021/acschembio.6c00369","url":null,"abstract":"UBA5 is the E1 enzyme that initiates UFMylation, a ubiquitin-like modification implicated in proteostasis, neurodegeneration, and cancer. Here, we report a chemical biology approach to interrogate UBA5 function through small-molecule inhibition. We developed a robust high-throughput screening assay based on AMP-GloTM and screened a library of blood–brain barrier-permeable compounds, identifying five inhibitors spanning three distinct scaffolds with low-micromolar potency. Orthogonal biochemical and gel-based assays confirmed that these compounds directly inhibit UBA5-mediated UFM1 activation and conjugation, with selectivity over other E1 enzymes, including UBA1. In cells, these compounds suppressed endogenous UFMylation without significantly affecting global polyubiquitination, supporting pathway and target engagement. Together, these studies establish UBA5 as a tractable enzymatic target and provide first-in-class chemical tools to probe UFMylation. Given the emerging role of UFMylation in disease, these inhibitors offer a foundation for developing therapeutics targeting proteostasis pathways.","PeriodicalId":11,"journal":{"name":"ACS Chemical Biology","volume":"21 9","pages":"2200–2215"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0