European journal of anatomy最新文献_第8页

Gross congenital abnormalities induced by leflunomide in mice embryos 来氟米特在小鼠胚胎中引起的严重先天性异常

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/wnei1659

K. Pandey, Nishtha K. Singh, A. Nayak, C. Mohanty

{"title":"Gross congenital abnormalities induced by leflunomide in mice embryos","authors":"K. Pandey, Nishtha K. Singh, A. Nayak, C. Mohanty","doi":"10.52083/wnei1659","DOIUrl":"https://doi.org/10.52083/wnei1659","url":null,"abstract":"Leflunomide is an antirheumatic drug commonly used by females, as this disease is common in females and there are chances of pregnancy while taking this medication in initial months of pregnancy this commonly prescribed drug lacks studies related to its teratogenic potential. Present study was conducted to know about its teratogenicity in mice embryos. Pregnant mice were exposed to Leflunomide by oral route on gestational days 6 to 11 either as single dose in one of the gestational days or continuous doses. The embryos were collected on day 19 of gestation, were measured and examined for external anomalies. Findings suggested that Leflunomide was embryo lethal when given as continuous dose as there were 100% resorption of embryos. In the single dose group, maximum resorptions were found when was given in early pregnancy. Other anomalies included malrotated limbs, open eyes, kinking of tails, defect in anterior abdominal wall and visceroptosis and anencephaly. these anomalies were noted in embryos exposed to leflunomide only on gestational days 7 and 8. The above findings suggest that leflunomide interferes with embryonic growth It also interferes with neural tube closure leading to anencephaly. Findings of open eyes and kinking tails suggest that the drug may affect epithelial and mesodermal growth. Leflunomide perhaps interferes with the lateral folding of the embryo leading to defect in the anterior abdominal wall and visceroptosis. The present study concludes that Leflunomide is teratogenic and embryolethal in mice and should be avoided in human pregnancy.","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81142249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomy of the buccal fat pad for structures at risk during bichatectomy 双颊切除术中口腔脂肪垫结构的解剖分析

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/nsqz9800

A. Moreno-Salinas, J. Treviño-Gonzalez, C. Casas-Murillo, K. Aguilar-Morales, R. Pinales-Razo, Miguel De La Parra-Marquez, Rodrigo E Elizondo-Omaña, S. Guzmán-López, A. Quiroga-Garza

{"title":"Anatomy of the buccal fat pad for structures at risk during bichatectomy","authors":"A. Moreno-Salinas, J. Treviño-Gonzalez, C. Casas-Murillo, K. Aguilar-Morales, R. Pinales-Razo, Miguel De La Parra-Marquez, Rodrigo E Elizondo-Omaña, S. Guzmán-López, A. Quiroga-Garza","doi":"10.52083/nsqz9800","DOIUrl":"https://doi.org/10.52083/nsqz9800","url":null,"abstract":"The buccal fat pad (BFP), is an adipose tissue located in the cheek, with complex morphology. Oral bichatectomy is a frequent aesthetic procedure with possible complications. Our objective was to determine the volume and its relationship with the upper 2nd molar and the facial artery (FA). A cross-sectional, observational study was performed. Computed tomography was used to obtain 3D images to determine volume, length, and width. Distances from the 2nd molar to each extension, and the nearest distance to the FA were measured. A total of 106 BFP (70 male) were included. The mean age was 51±21. The mean volume, length, and width were 13.8±5.4 ml, 72.9±10.7 mm, and 21.4±5.6 mm, respectively. The BFP extends mainly cephalically and caudally from the second molar, reaching upto 8.5 cm and 32 ml. The mean distance between the second molar and FA was 12.9 mm, but as close as 3 mm. The FA had a mean distance of 2.1mm to the nearest BFP extension, with 42.5% in intimate contact, and another 9.4% crossing the center of the masseter extension. There were no statistically significant differences between sexes. The BFP has a dynamic shape with highly variable size and volume. The FA is often at risk of damage during procedures due to proximity","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73540309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring low formaldehyde exposure values in the dissection hall after embalming human body donors with ethanol-based fixation methods 用乙醇基固定法测定捐献者尸体防腐后解剖大厅的低甲醛暴露值

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/cyoj3969

Anke Schnapper-Isl, Frank Klose, A. Schmiedl

{"title":"Measuring low formaldehyde exposure values in the dissection hall after embalming human body donors with ethanol-based fixation methods","authors":"Anke Schnapper-Isl, Frank Klose, A. Schmiedl","doi":"10.52083/cyoj3969","DOIUrl":"https://doi.org/10.52083/cyoj3969","url":null,"abstract":"The dissection course plays a central role in teaching anatomy and body donors are also needed in clinical-anatomical courses. In order to reduce formaldehyde exposure of students, participants and staff during these courses, we employed fixation solutions with low formaldehyde content. In this study, we present two ethanol-based protocols, and elucidate their suitability for the dissection process and compliance with occupational exposure limits for formaldehyde and other hazardous substances. Body donors were fixed according to an ethanol- based fixation protocol for the dissection course or an ethanol-glycerin-based fixation protocol for specialist training courses. The quality of fixation was determined during the dissection process. Exposure to hazardous substances (formaldehyde, ethanol, 2-phenoxyethanol) was measured in a regular dissection course setting at different locations (room-related and person-related measurements), and exposure indices were calculated. The quality of fixation of both methods was good and fulfilled all requirements of the student dissection course and the specialist training courses, respectively. Exposure to all hazardous substances remained well below the exposure limits. Room-related air concentration measurements were 0.073/0.058 mg/m³ (2016/2017) for formaldehyde and 65/107 mg/m³ (2016/2017) for ethanol. Person-related measurements amounted to 0.107-0.229 mg/m³ for formaldehyde and 268- 388 mg/m³ for ethanol. Room-related and person- related concentrations of 2-phenoxyethanol remained below the detection limit. The ethanol-based embalming protocols presented here offer a good alternative for the different applications. The protocols are discussed regarding current regulations and further measures to reduce formaldehyde exposure.","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77699723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bibliometric and visualized analysis of global research on technology in anatomy education from 1987 to 2021 1987 - 2021年全球解剖学教育技术研究的文献计量与可视化分析

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/hnny3374

Y. E. Kundakcı, E. Atay

{"title":"Bibliometric and visualized analysis of global research on technology in anatomy education from 1987 to 2021","authors":"Y. E. Kundakcı, E. Atay","doi":"10.52083/hnny3374","DOIUrl":"https://doi.org/10.52083/hnny3374","url":null,"abstract":"While anatomy has been taught by means of traditional methods for centuries, today anatomy education methods are developing with various digital educational resources. Therefore, determining the trends of publications on the use of technology in anatomy education can provide a roadmap for future studies on this topic. This study aims to conduct a bibliometric analysis of the documents about technology in anatomy education. Using the bibliometric analysis method, 437 documents between 1987 and 2021 were included in the study. Publications in journals indexed in Web of Science were reviewed in terms of the country, journal, citation, year, author, keywords, co-authorship, co-occurrence, and co-citation. The H-index value of the publications was 47, and the total number of citations was 8501. The publications highlight an exponential increase in the last few years, as well as the prominence of a particular journal and countries such as the USA, England or Australia. Wilson TD was the most prolific author in the field. According to the co-occurrence analysis, it is observed that the terms “gross anatomy education”, and “medical education” are frequently used by the authors. In the last few years, 3D printing, virtual reality, augmented reality and social media were selected in anatomy education. This study identified the main research hotspots related to the use of technology in anatomy education. The findings can also help provide new directions and ideas for future research.","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80243870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Deep femoral artery branching by MDCT in a Turkish population and its potential clinical implications 土耳其人群的MDCT股深动脉分支及其潜在的临床意义

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/xsan1528

A. Keleş, Mustafa YILMAZ, C. Kadıyoran, D. A. Saygın

{"title":"Deep femoral artery branching by MDCT in a Turkish population and its potential clinical implications","authors":"A. Keleş, Mustafa YILMAZ, C. Kadıyoran, D. A. Saygın","doi":"10.52083/xsan1528","DOIUrl":"https://doi.org/10.52083/xsan1528","url":null,"abstract":"The deep femoral artery and its branches are vital for the arterial circulation of the lower extremity. The aim of the current study is to obtain morphometric and morphological data on the deep femoral artery and its branches and to investigate their clinical importance in the Turkish population. Morphometric measurements of the deep femoral artery and femoral artery were performed. The diameters of the femoral artery and deep femoral artery were measured in the axial plane. Classification was made according to the size of these diameters. A morphological classification was obtained by examining the variations of the deep femoral artery branches. The distance from the origin of the deep femoral artery to the midpoint of the inguinal ligament was 39.56 ± 8.52 mm, and the distances from the origin of the lateral circumflex femoral artery to the medial circumflex femoral artery were 17.15 ± 4.79 mm and 12.52 ± 4.58 mm, respectively. The study results show that there was a significant difference between genders in terms of the diameters measured. In the classification made by using the diameters, Type D (39%) had the highest rate, whereas Type C had the lowest rate (7.3%). According to the morphological classification, Type I (52.1%) was the most common in all individuals, and Type V and Type VII (2.3%) were the least common. Our study includes both morphometric and morphological information about the femoral artery and deep femoral artery of the Turkish population. We consider that the current study will be useful for cardiologists, interventional radiologists, orthopedists, and regional surgeons in clinical practice.","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80556162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital cervical teratoma – an amalgamation of embryology with clinical findings 先天性宫颈畸胎瘤-胚胎学与临床表现的融合

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/dhmy7841

Fariha Sabeen

{"title":"Congenital cervical teratoma – an amalgamation of embryology with clinical findings","authors":"Fariha Sabeen","doi":"10.52083/dhmy7841","DOIUrl":"https://doi.org/10.52083/dhmy7841","url":null,"abstract":"Teratoma means “A malformed body part of a monster” in Greek. A cervical teratoma is a very rare congenital tumor in the neck. These tumors tend to be large, disfiguring masses – partly solid and partly fluid. They make it impossible for a newborn to breathe upon birth. Knowledge of basic embryology of the brachial apparatus is necessary to understand neck malformations and congenital abnormalities. Here, a recent observation of this exceptional case is described. A pregnant woman, gravida 2, presented with pain abdomen in the 37th week of gestation. A male, living baby was delivered by caesarean section. A well-defined mass was present in the anterior neck region. A diagnosis of giant congenital cervical teratoma with airway compromise was made. The baby was intubated but could not survive. The objective of this study is the significance of a thorough knowledge of anatomy and embryology to prevent any late diagnosis or misdiagnosis. This report aims to create awareness about embryological development of a fetus to enhance the clinical recognition of this rare disorder, to highlight their occurrence in our locale, and to reiterate the associated management challenges in resource-limited settings. The present case highlights the importance of regular antenatal checkups, with timely ultrasounds, so that such congenital defects can be diagnosed prenatally and their management can be planned accordingly.","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78964933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examination of the cross-sectional area of the carpal tunnel on fetal cadavers 胎儿尸体腕管截面积的检查

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/bzok4444

Mehtap Kondak, Merve Celep, Mehmet Haluk Uluutku3

{"title":"Examination of the cross-sectional area of the carpal tunnel on fetal cadavers","authors":"Mehtap Kondak, Merve Celep, Mehmet Haluk Uluutku3","doi":"10.52083/bzok4444","DOIUrl":"https://doi.org/10.52083/bzok4444","url":null,"abstract":"This study aimed to determine the anatomical features of the carpal tunnel (CT) in fetal cadavers and understand the role of etiology in the development of carpal tunnel syndrome (CTS). Seventy hand-wrist regions (35 right, 35 left) of 35 fetal cadavers (24 females; 11 males) that were not exposed to environmental factors and handedness were examined. The contents and cross-sectional area (CSA) of the CT were measured using ImageJ ©. The CSA consisting of the flexor tendons and median nerve (MN) in the CT were calculated as a percentage. The results showed that the area covered by the MN and flexor tendons in the CT was significantly smaller in female fetuses (P<0.05). There was no significant difference in other ratios between male and female fetuses (P>0.05). There was no significant difference in the ratios regarding the CT and contents between the right and left-hand sides (P>0.05). It was concluded that the difference in CT anatomy may help explain the variations in the prevalence of CTS among genders. The lack of a difference between the right- and left-hand sides supports the theory that repetitive hand activities, hand dominance, and functional factors play a key role in the development of CTS by causing morphological changes in the CT, MN, and flexor tendons. In our opinion, the examination of CTs that have not been exposed to any environmental effects may provide guidance in understanding the effect of anatomical and morphometric features on the etiology of CTS.","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77062666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variations in corpus and ramus measurements based on gonial angles in adult complete dentate mandibles 成人完整齿状下颌骨骨角的体支测量变化

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/awym4087

Ken Hiratsuka, S. Osato

{"title":"Variations in corpus and ramus measurements based on gonial angles in adult complete dentate mandibles","authors":"Ken Hiratsuka, S. Osato","doi":"10.52083/awym4087","DOIUrl":"https://doi.org/10.52083/awym4087","url":null,"abstract":"This study aimed to reveal differences in the mandibular corpus and ramus measurements, volume (VOM), and gross weight of the mandible (GWOM) between the low and high gonial angles (L-GA and H-GA, respectively) in adult mandibles, and to evaluate the correlations between GAs and the measurement variables. Twenty-nine dried adult human complete dentate mandibles (L-GA ≤ 120°: 13 mandibles; H-GA: 125° ≥ GA: 16 mandibles) were measured using a lateral radiograph image-processing system, digital Vernier calipers, and an electric balance. The total length of the mandible (TLOM), corpus length (mental foramen– gonion [MeF’-Go’], mental foramen–mandibular foramen [MeF’-MaF’], and mandibular foramen–gonion [MaF’-Go’]), inter-ramus (bicondylar, bicoronion, and bigonion) widths (BiCoW, BiCorW, and BiGoW), GA width (GAW), condylar perpendicular height (CPH), the VOM, and GWOM were measured. Data were assessed using the exact binomial test, Mann–Whitney U test and Pearson’s correlation coefficient test. The MeF’- Go’ and MaF’-Go’, three inter-ramus widths, GAW, CPH, VOM, and GWOM in the L-GA group were significantly larger than those in the H-GA group. Significant negative correlations were found between GA size and multiple variables other than TLOM and BiCorW. Therefore, GA size was closely related to the enlarged morphometric dimensions of both the GA and the mandibular ramus in the posterior region of the mandibular corpus, as well as the volume and weight of the mandible, but it was not related to TLOM. These results indicate that the evaluation of GA size is useful for strategic dental treatment.","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78705852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lawsonia inermis and paraphenylenediamine exerts an insidious effect on the epidermal, renal, and hepatic tissue with repeated application: a histological and morphometrical study 刺槐和对苯二胺对表皮、肾和肝组织有潜在的影响，反复使用:组织学和形态计量学研究

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/hyka4571

Samuel E Jen, Maimuna A Adam, S. Garba, M. Attah, N. Dibal

{"title":"Lawsonia inermis and paraphenylenediamine exerts an insidious effect on the epidermal, renal, and hepatic tissue with repeated application: a histological and morphometrical study","authors":"Samuel E Jen, Maimuna A Adam, S. Garba, M. Attah, N. Dibal","doi":"10.52083/hyka4571","DOIUrl":"https://doi.org/10.52083/hyka4571","url":null,"abstract":"Ground leaves of Lawsonia inermis (LI) made into a paste has been used from the Bronze Age as cosmetic application. Para-Phenylenediamine (PPD) is an organic compound that is added to LI to increase its aesthetic appearance and longevity. Addition of PPD increases the possibility of allergic contact dermatitis from LI tattoo combinations, and may be absorbed through the skin, affecting body organs. The current study was conducted to determine the effect of this mixture on the histology of skin, liver and kidney tissue. Thirty albino rats were grouped into five groups. The treatment protocol included a control group (I), application of LI paste alone for a period of two weeks (II), and four weeks (III), and a combination of LI and PPD for two weeks (IV), and four weeks (V). All rats in each group had an area on the lumbar region shaved and marked, and the paste was applied to this region. The rats were sacrificed after the experimental period and the tissues of interest removed for further histological and morphometric analysis. Application of LI alone caused no observable histological changes, however, in combination with PPD, LI caused thinning of the epidermis, reduction in the quantity of collagen fibers in the dermis, distorted the arrangement of hepatocytes, caused infiltration of inflammatory cells into the liver tissue and distortion in the arrangement of renal tubular epithelial cells. The longer the exposure to LI and PPD, the more alteration to the normal histology of tissues.","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75099683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term supplementation with young coconut juice help prevent bone loss of orchidectomized rats by increasing connectivity density, percentage bone volume and osteoblast-/osteocyte-(ERα-/ ERβ-) immunoreactive cells of the L5 vertebra and femur 长期补充椰汁可以通过增加L5椎体和股骨的连接密度、骨体积百分比和成骨细胞/骨细胞(ERα-/ ERβ-)免疫反应细胞来预防兰花切除大鼠的骨质流失

IF 0.3

European journal of anatomy Pub Date : 2023-07-01 DOI: 10.52083/cjwj5539

Asma Asae, A. Hutapea, Jirawat Saetan, N. Radenahmad

{"title":"Long-term supplementation with young coconut juice help prevent bone loss of orchidectomized rats by increasing connectivity density, percentage bone volume and osteoblast-/osteocyte-(ERα-/ ERβ-) immunoreactive cells of the L5 vertebra and femur","authors":"Asma Asae, A. Hutapea, Jirawat Saetan, N. Radenahmad","doi":"10.52083/cjwj5539","DOIUrl":"https://doi.org/10.52083/cjwj5539","url":null,"abstract":"Adult male rats were orchidectomized (ORX) and treated with 17β-estradiol or young coconut juice (YCJ) for ten weeks. Their femur and L5 vertebra were dissected, and the percentage of bone volume was measured using a Micro-CT scan. Immunohistochemistry was used to detect ERα and ERβ to determine if the osteoporotic protective effects of YCJ were due to the attachment of the YCJ active components(s) to estrogen receptors. It was found that both ERα and ERβ were found in osteocytes and osteoblasts, but not osteoclasts. Compared to normal rats, the percentage of bone volume and number of osteoblast- and osteocyte- reactive cells of both femur and L5 were significantly reduced in ORX rats. Those numbers in the ORX rats were restored to normal by injecting estradiol benzoate or by feeding YCJ to the rats, which was not dose-related. Significant correlations were detected between osteoblast-/osteocyte- (ERα-/ERβ)-reactive cells vs. serum E2 level. The optimal dose of this study was 10 mL/kg BW/ day for ERα-of both osteoblasts and osteocytes and 40 mL/kg BW/day for ERβ-of both osteoblasts and osteocytes. The results suggest that YCJ may be as efficient as estradiol benzoate in attenuating osteoporosis, probably by being a selective estrogen receptor moderator.","PeriodicalId":11978,"journal":{"name":"European journal of anatomy","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74067879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0