European Heart Journal Open最新文献

{"title":"Left atrial appendage strain predicts subclinical atrial fibrillation in embolic strokes of undetermined source.","authors":"Jørg Saberniak,&nbsp;Loreta Skrebelyte-Strøm,&nbsp;Eivind Bjørkan Orstad,&nbsp;Janne Mykland Hilde,&nbsp;Magnar Gangås Solberg,&nbsp;Ole Morten Rønning,&nbsp;Harald Kjekshus,&nbsp;Kjetil Steine","doi":"10.1093/ehjopen/oead039","DOIUrl":"https://doi.org/10.1093/ehjopen/oead039","url":null,"abstract":"<p><strong>Aims: </strong>Left atrial (LA) strain is promising in prediction of clinical atrial fibrillation (AF) in stroke patients. However, prediction of subclinical AF is critical in patients with embolic strokes of undetermined source (ESUS). The aim of this prospective study was to investigate novel LA and left atrial appendage (LAA) strain markers in prediction of subclinical AF in ESUS patients.</p><p><strong>Methods and results: </strong>A total of 185 patients with ESUS, mean age 68 ± 13years, 33% female, without diagnosed AF, were included. LAA and LA function by conventional echocardiographic parameters and reservoir strain (Sr), conduit strain (Scd), contraction strain (Sct), and mechanical dispersion (MD) of Sr were assessed with transoesophageal and transthoracic echocardiography. Subclinical AF was detected by insertable cardiac monitors during follow-up. LAA strain was impaired in 60 (32%) patients with subclinical AF compared to those with sinus rhythm: LAA-Sr, 19.2 ± 4.5% vs. 25.6 ± 6.5% (<i>P</i> < 0.001); LAA-Scd, -11.0 ± 3.1% vs. -14.4 ± 4.5% (<i>P</i> < 0.001); and LAA-Sct, -7.9 ± 4.0% vs. -11.2 ± 4% (<i>P</i> < 0.001), respectively, while LAA-MD was increased, 34 ± 24 ms vs. 26 ± 20 ms (<i>P</i> = 0.02). However, there was no significant difference in phasic LA strain or LA-MD. By ROC analyses, LAA-Sr was highly significant in prediction of subclinical AF and showed the best AUC of 0.80 (95% CI 0.73-0.87) with a sensitivity of 80% and a specificity of 73% (<i>P</i> < 0.001). LAA-Sr and LAA-MD were both independent and incremental markers of subclinical AF in ESUS patients.</p><p><strong>Conclusion: </strong>LAA function by strain and mechanical dispersion predicted subclinical AF in ESUS patients. These novel echocardiographic markers may improve risk stratification in ESUS patients.</p>","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead039"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/b7/oead039.PMC10171229.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9467649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: The association between sodium intake and coronary and carotid atherosclerosis in the general Swedish population.","authors":"","doi":"10.1093/ehjopen/oead062","DOIUrl":"https://doi.org/10.1093/ehjopen/oead062","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/ehjopen/oead024.][This corrects the article DOI: 10.1093/ehjopen/oead024.].</p>","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead062"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/5e/oead062.PMC10273188.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9660971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the link between Gilbert's syndrome and atherosclerotic cardiovascular disease: insights from a subpopulation-based analysis of over one million individuals.","authors":"Uri Kartoun,&nbsp;Akl C Fahed,&nbsp;Shinwan Kany,&nbsp;Pulkit Singh,&nbsp;Shaan Khurshid,&nbsp;Aniruddh P Patel,&nbsp;Puneet Batra,&nbsp;Anthony Philippakis,&nbsp;Amit V Khera,&nbsp;Steven A Lubitz,&nbsp;Patrick T Ellinor,&nbsp;Vibha Anand,&nbsp;Kenney Ng","doi":"10.1093/ehjopen/oead059","DOIUrl":"https://doi.org/10.1093/ehjopen/oead059","url":null,"abstract":"Center for Computational Health, IBM Research, 314 Main St., Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA; Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA; and Verve Therapeutics, Boston, MA, USA","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead059"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/89/77/oead059.PMC10291878.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9781801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Septal radioablation therapy for patients with hypertrophic obstructive cardiomyopathy: first-in-human study.","authors":"Xuping Li,&nbsp;Zhaowei Zhu,&nbsp;Jun Liu,&nbsp;Yawen Gao,&nbsp;Yichao Xiao,&nbsp;Zhenfei Fang,&nbsp;Qiming Liu,&nbsp;Xianling Liu,&nbsp;Chunhong Hu,&nbsp;Fang Ma,&nbsp;Mu Zeng,&nbsp;Zhi Liu,&nbsp;Lin Hu,&nbsp;Na Liu,&nbsp;Fan Xiang,&nbsp;Xinqun Hu,&nbsp;Lihong Huang,&nbsp;Shenghua Zhou","doi":"10.1093/ehjopen/oead052","DOIUrl":"https://doi.org/10.1093/ehjopen/oead052","url":null,"abstract":"<p><strong>Aims: </strong>There is still no non-invasive septal reduction therapy for patients with hypertrophic obstructive cardiomyopathy (HOCM). This study aimed to investigate the feasibility, safety, and efficacy of stereotactic body radiotherapy (SBRT) in patients with drug-refractory symptomatic HOCM.</p><p><strong>Methods and results: </strong>The radiation target of ventricular septum was determined by multiple anatomical imaging. Stereotactic body radiotherapy was performed with standard techniques. Patients were treated with a single fraction of 25 Gy, followed up at 1, 3, 6, and 12 months by clinical visit. Five patients were enrolled and completed the 12 months follow-up. The mean radioablation time was 21.6 min, and the mean target volume was 10.5 cm³. All five patients survived and showed improvements in symptoms after SBRT. At 12 months post-SBRT, the echocardiography-derived left ventricular outflow tract gradient decreased from 88 mmHg (range, 63-105) to 52 mmHg (range, 36-66) at rest and from 101 mmHg (range, 72-121) to 74 mmHg (range, 65-100) after Valsalva. The end-diastolic thickness of the targeted septum reduced from 23.7 mm (range, 20.3-29) to 22.4 mm (range, 19.7-26.5); 6 min walking distance increased from 190.4 m (range, 50-370) to 412.0 m (range, 320-480). All patients presented with new fibrosis in the irradiated septum area. No radiation-related complications were observed during SBRT and up to 12 months post procedure.</p><p><strong>Conclusion: </strong>The current study suggests that SBRT might be a feasible radioablation therapeutic option for patients with drug-refractory symptomatic HOCM.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04686487.</p>","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead052"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/37/oead052.PMC10371052.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9878491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial reservoir strain predicts ischaemic stroke after coronary artery bypass grafting independent of postoperative atrial fibrillation.","authors":"Frederikke Vyff,&nbsp;Niklas Dyrby Johansen,&nbsp;Flemming J Olsen,&nbsp;Lisa S Duus,&nbsp;Søren Lindberg,&nbsp;Thomas Fritz-Hansen,&nbsp;Sune Pedersen,&nbsp;Allan Iversen,&nbsp;Søren Galatius,&nbsp;Rasmus Møgelvang,&nbsp;Tor Biering-Sørensen","doi":"10.1093/ehjopen/oead045","DOIUrl":"https://doi.org/10.1093/ehjopen/oead045","url":null,"abstract":"<p><strong>Aims: </strong>Measures of left atrial (LA) function are known to predict both ischaemic stroke and atrial fibrillation in specific patient groups. The aim of this study was to investigate the value of LA reservoir strain for predicting ischaemic stroke in patients undergoing coronary artery bypass grafting (CABG) and investigate whether the presence of postoperative atrial fibrillation (POAF) modified this relationship.</p><p><strong>Methods and results: </strong>Patients undergoing isolated CABG were included. The primary endpoint was ischaemic stroke. The association between LA reservoir strain and ischaemic stroke was investigated in uni- and multivariable Cox proportional hazards regression models including adjustment for POAF.We included 542 patients (mean age 67.3±8.9 years, 16.4% female). During a median follow-up period of 3.9 years, 21 patients (3.9%) experienced an ischaemic stroke. In total, 96 patients (17.7%) developed POAF during the index hospitalization. In a multivariable-adjusted Cox proportional hazards regression model, LA reservoir strain was significantly associated with the development of ischaemic stroke [HR (hazard ratio) 1.09 (95% CI 1.02-1.17) per 1% decrease, <i>P</i> = 0.011]. The presence of POAF did not modify this association (<i>p</i> for interaction = 0.07). The predictive value of the LA reservoir strain persisted in multiple sensitivity analyses including restricting the analysis to patients with normal left atrial volumes (LAV<34 ml/m²), patients without POAF, patients without prior stroke, and when excluding patients who developed atrial fibrillation at any time during follow-up.</p><p><strong>Conclusion: </strong>LA reservoir strain was independently associated with ischaemic stroke in CABG patients. The predictive value of LA reservoir strain was unaffected by the presence of POAF. Prospective studies are warranted to validate the potential usefulness of LA reservoir strain to predict postoperative ischaemic stroke in the setting of CABG.</p>","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead045"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/66/oead045.PMC10220504.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9900245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Takotsubo syndrome and cardiogenic shock: Authors' response.","authors":"Francesco Santoro,&nbsp;Iván J Núñez Gil,&nbsp;Thomas Stiermaier,&nbsp;Ingo Eitel,&nbsp;Luca Arcari,&nbsp;Natale Daniele Brunetti","doi":"10.1093/ehjopen/oead054","DOIUrl":"https://doi.org/10.1093/ehjopen/oead054","url":null,"abstract":"Department of Medical and Surgical Sciences, University of Foggia, viale Pinto 1, Foggia 71122, Italy; Interventional, Cardiology, Cardiovascular Institute, Hospital Clínico Universitario San Carlos, Madrid, Spain; Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Spain; University Heart Center Lübeck, Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine) and German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany; Institute of Cardiology, Madre Giuseppina Vannini Hospital, Rome, Italy; and Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University, Rome, Italy","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead054"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/f1/oead054.PMC10243835.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9955058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical implication of intra-aortic balloon pumping in patients with Takotsubo syndrome and cardiogenic shock.","authors":"Teruhiko Imamura","doi":"10.1093/ehjopen/oead050","DOIUrl":"https://doi.org/10.1093/ehjopen/oead050","url":null,"abstract":"Commentary on Santoro et al. , Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syn- drome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry. Eur Heart J Open 2023;3:oead003.","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead050"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9955061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New approaches to reduce recurrent PCI: to angioplasty and beyond!","authors":"Pierre Sabouret,&nbsp;Stéphane Manzo-Silberman,&nbsp;Mirvat Alasnag,&nbsp;Marinos Fysekidis,&nbsp;Martha Gulati,&nbsp;Giuseppe Galati,&nbsp;Luigi Spadafora,&nbsp;Maciej Banach,&nbsp;Giuseppe Biondi-Zoccai,&nbsp;Deepak L Bhatt","doi":"10.1093/ehjopen/oead049","DOIUrl":"https://doi.org/10.1093/ehjopen/oead049","url":null,"abstract":"Heart Institute, ACTION Study Group-CHU Pitié-Salpétrière Paris, 47-83 Boulevard de l’Hôpital, 75005 Paris, France; Collège National des Cardiologues Français (CNCF), 13 rue Niepce, 75014 Paris, France; Cardiac Center, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia; Department of endocrinology, Avicenne Hospital, AP-HP, 125, rue de Stalingrad, 93000 Bobigny, France; Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, USA; Heart Failure Unit, Division of Cardiology, Department of Cardiothoracic and Vascular, San Raffaele Hospital, Scientific Institute (IRCCS), Via Olgettina 60, 20132 Milan, Italy; Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy; Department of Preventive Cardiology and Lipidology, Medical University of Lodz and Polish Mother’s Memorial Hospital Research Institute, Lodz, Poland; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; Mediterranea Cardiocentro, Napoli, Italy; and Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY, USA","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead049"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/9f/oead049.PMC10233093.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9578618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis.","authors":"Hiroki Usuku,&nbsp;Eiichiro Yamamoto,&nbsp;Daisuke Sueta,&nbsp;Momoko Noguchi,&nbsp;Tomohiro Fujisaki,&nbsp;Koichi Egashira,&nbsp;Fumi Oike,&nbsp;Koichiro Fujisue,&nbsp;Shinsuke Hanatani,&nbsp;Yuichiro Arima,&nbsp;Seiji Takashio,&nbsp;Yawara Kawano,&nbsp;Seitaro Oda,&nbsp;Hiroaki Kawano,&nbsp;Kenichi Matsushita,&nbsp;Mitsuharu Ueda,&nbsp;Hirotaka Matsui,&nbsp;Masao Matsuoka,&nbsp;Kenichi Tsujita","doi":"10.1093/ehjopen/oead048","DOIUrl":"https://doi.org/10.1093/ehjopen/oead048","url":null,"abstract":"<p><strong>Aims: </strong>Left ventricular (LV) global longitudinal strain (GLS) (LV-GLS) is a strong and independent predictor of outcomes in patients with immunoglobulin light-chain (AL) cardiac amyloidosis. This study was performed to investigate whether right ventricular (RV) GLS (RV-GLS) provides prognostic information in patients with AL amyloidosis.</p><p><strong>Methods and results: </strong>Among 74 patients who were diagnosed with AL cardiac amyloidosis at Kumamoto University Hospital from December 2005 to December 2022, 65 patients who had enough information for two-dimensional speckle tracking imaging and did not receive chemotherapy before the diagnosis of cardiac amyloidosis were retrospectively analysed. During a median follow-up of 359 days, 29 deaths occurred. In two-dimensional echocardiographic findings, LV-GLS, left atrium reservoir strain (LASr), and RV-GLS were significantly lower in the all-cause death group than in the survival group (LV-GLS: 8.9 ± 4.2 vs. 11.7 ± 3.9, <i>P</i> < 0.01; LASr: 9.06 ± 7.28 vs. 14.09 ± 8.32, <i>P</i> < 0.05; RV-GLS: 12.0 ± 5.1 vs. 16.8 ± 4.0, <i>P</i> < 0.01). Multivariable Cox proportional hazard analysis showed RV-GLS was significantly and independently associated with all-cause death in patients with AL cardiac amyloidosis (hazard ratio 0.85; 95% confidence interval, 0.77-0.94; <i>P</i> < 0.01). Receiver operating characteristic analysis showed that the area under the curve of RV-GLS for all-cause death was 0.774 and that the best cut-off value of RV-GLS was 14.5% (sensitivity, 75%; specificity, 72%). In the Kaplan-Meier analysis, patients with AL cardiac amyloidosis who had low RV-GLS (<14.5%) had a significantly higher probability of all-cause death (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>RV-GLS has prognostic value in patients with AL cardiac amyloidosis and provides greater prognostic power than LV-GLS and LASr.</p>","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead048"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/f6/oead048.PMC10196102.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9503341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of ST-segment depression during atrial fibrillation rhythm for subsequent heart failure events.","authors":"Tetsuma Kawaji,&nbsp;Yasuhiro Hamatani,&nbsp;Masashi Kato,&nbsp;Takafumi Yokomatsu,&nbsp;Shinji Miki,&nbsp;Mitsuru Abe,&nbsp;Masaharu Akao","doi":"10.1093/ehjopen/oead060","DOIUrl":"https://doi.org/10.1093/ehjopen/oead060","url":null,"abstract":"<p><strong>Aims: </strong>The clinical significance of ST-segment depression during atrial fibrillation (AF) rhythm has not been fully evaluated. The aim of the present study was to explore the association of ST-segment depression during AF rhythm with subsequent heart failure (HF) events.</p><p><strong>Methods and results: </strong>The study enrolled 2718 AF patients whose baseline electrocardiography (ECG) was available from a Japanese community-based prospective survey. We assessed the association of ST-segment depression in baseline ECG during AF rhythm with clinical outcomes. The primary ednpoint was a composite HF endpoint: cardiac death or hospitalization due to HF. The prevalence of ST-segment depression was 25.4% (upsloping 6.6%, horizontal 18.8%, downsloping 10.1%). Patients with ST-segment depression were older and had more comorbidities than those without. During the median follow-up of 6.0 years, the incidence rate of the composite HF endpoint was significantly higher in patients with ST-segment depression than those without (5.3% vs. 3.6% per patient-year, log-rank <i>P</i> < 0.01). The higher risk was present in horizontal or downsloping ST-segment depression, but not in upsloping one. By multivariable analysis, ST-segment depression was an independent predictor for the composite HF endpoint (hazard ratio 1.23, 95% confidence interval 1.03-1.49, <i>P</i> = 0.03). In addition, ST-segment depression at anterior leads, unlike inferior or lateral leads, was not associated with higher risk for the composite HF endpoint.</p><p><strong>Conclusion: </strong>ST-segment depression during AF rhythm was associated with subsequent HF risk; however, the association was affected by type and distribution of ST-segment depression.</p>","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":"3 3","pages":"oead060"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/c9/oead060.PMC10287539.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9713869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}