Nanomaterials eJournal最新文献_第3页

Thermally Activated Plastic Deformation Behavior of Nano Oxide Dispersion Strengthened Fe-18Cr Steel: Experiments and Analysis 纳米氧化物弥散强化Fe-18Cr钢的热活化塑性变形行为:实验与分析

Nanomaterials eJournal Pub Date : 2019-01-10 DOI: 10.2139/ssrn.3313268

R. Jarugula, S. Raman, G. Sundararajan

{"title":"Thermally Activated Plastic Deformation Behavior of Nano Oxide Dispersion Strengthened Fe-18Cr Steel: Experiments and Analysis","authors":"R. Jarugula, S. Raman, G. Sundararajan","doi":"10.2139/ssrn.3313268","DOIUrl":"https://doi.org/10.2139/ssrn.3313268","url":null,"abstract":"Abstract The objective of the present work is to investigate the ultra-high temperature (1273–1473 K) plastic deformation behavior of a nano oxide dispersion strengthened Fe-18Cr ferritic steel (n-ODS-18Cr steel) over a range of strain rates (10−2 to 10 s−1). The flow (true) stress-true strain behavior of this steel, reported for the first time, has been utilized to obtain the flow stress as a function of temperature and strain rate. From the above data, the strain rate sensitivity parameter (m) and also the activation volume have been obtained as a function of temperature (1273–1473 K). It is then demonstrated that the flow stress values obtained in the present steel over the temperature range 1273–1473 K is due to a single dominant strengthening mechanism, i.e. Orowan dispersion strengthening. Hence, the predictions of the theoretical models which assume Orowan strengthening as the dominant mechanism can be compared with the experimental flow stress data. Such a comparison indicates that the model due to Rosler and Arzt predicts the experimental data very well while the prediction of the model due to Brandes, Kovarik, Miller, Daehn and Mills is satisfactory. It is also shown that the experimentally obtained activation volume is consistent with the dislocation detachment model.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124680996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Fusion DEMO sCO 2 Layout Design with Battery Farm 融合演示sCO 2布局设计与电池农场

Nanomaterials eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3933568

J. Syblik, S. Entler, L. Vesely, J. Štěpánek, Václav Dostál

{"title":"Fusion DEMO sCO 2 Layout Design with Battery Farm","authors":"J. Syblik, S. Entler, L. Vesely, J. Štěpánek, Václav Dostál","doi":"10.2139/ssrn.3933568","DOIUrl":"https://doi.org/10.2139/ssrn.3933568","url":null,"abstract":"Nuclear fusion is a promising low-carbon and low-emission source of energy. The first fusion power plant is the European Union's demonstration fusion power plant DEMO. One of the key attributes that influences the whole DEMO design is the power plant pulse operation. Due to the power fluctuations and instability of the power source, there may be a significant impact on the power grid, turbine, etc. Therefore, a power conversion system based on a supercritical CO2 capable of operating in two nominal power levels is proposed. The system operates in nominal parameters during the entire power cycle without the need for thermal power pulses balancing. Unlike other designs, instead of connecting the energy storage system directly to the primary circuit, this article proposes a layout with energy storage behind the generator. Power pulses are balanced using a battery farm, compensating the fluctuations in the gross power and power plant self-consumption. Power conversion system is based on a sCO2 Brayton simple cycle with regeneration and includes technology for nominal operation at two levels of thermal power. Optimization of the proposed layout shows lower thermodynamic net efficiency of 24 % in comparison with other applications such as nuclear or coal power plants.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125081333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intrinsic Toughness/Brittleness of Nanoporous Ag: Depending on Network Connectivity and Micro-Cracks 纳米多孔银的固有韧性/脆性:基于网络连通性和微裂纹

Nanomaterials eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3458130

Chaoyang Wang, Shengli Zhu, Yanqin Liang, Z. Cui, C. Qin, A. Inoue

{"title":"Intrinsic Toughness/Brittleness of Nanoporous Ag: Depending on Network Connectivity and Micro-Cracks","authors":"Chaoyang Wang, Shengli Zhu, Yanqin Liang, Z. Cui, C. Qin, A. Inoue","doi":"10.2139/ssrn.3458130","DOIUrl":"https://doi.org/10.2139/ssrn.3458130","url":null,"abstract":"The effective engineering applications of nanoporous metals (NPMs) require uniform ligaments network, specifically crack-free and ductile monolithic bodies. Here we investigate the effects of ligament-network connectivity and micro-cracks on the mechanical properties of nanoporous Ag (np Ag). The well-interconnected np Ag metal exhibits higher tensile strength, nanohardness and Vickers hardness than those for the ill-interconnected np Ag metal. The quality of the network connectivity dominates the strength and hardness of the np Ag. The ductility/brittleness is determined by the micro-crack in np Ag. The crack-free np Ag exhibits good ductile behavior. When micro-cracks are introduced, the np Ag becomes brittle. The np Ag with many micro-cracks is easily crushed because the cracks nucleate from the inherent micro-cracks and quickly propagate along the concentrated stress. The low values of volume shrinkage rate (V<sub>sr</sub>) and surface diffusivity (D<sub>s</sub>) effectively suppress the crack initiation and propagation of as-formed np Ag. These results provide useful insights to synthesize more flexible and crack-free NPM materials for effective use in diverse engineering applications.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122743954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heating Loss Mechanism in β-NaFeO 2 Nanoparticles for Cancer Treatment Under Alternating Field 交变电场下β-NaFeO 2纳米颗粒治疗肿瘤的热损失机理

Nanomaterials eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3793925

Sarbjit Singh, A. Tovstolytkin, Gurmeet Singh

引用次数: 0

Characterization by FTIR and Ampicillin Release in Collagen-Polyurethane Hydrogels Coupled with Metal-Organic Frameworks FTIR表征及氨苄西林在金属有机骨架偶联的胶原-聚氨酯水凝胶中的释放

Nanomaterials eJournal Pub Date : 1900-01-01 DOI: 10.38177/ajast.2020.4214

Nadia J. Amaya-Chantaca

{"title":"Characterization by FTIR and Ampicillin Release in Collagen-Polyurethane Hydrogels Coupled with Metal-Organic Frameworks","authors":"Nadia J. Amaya-Chantaca","doi":"10.38177/ajast.2020.4214","DOIUrl":"https://doi.org/10.38177/ajast.2020.4214","url":null,"abstract":"In this work, the capacity of encapsulation and subsequent release of the drug ampicillin was evaluated, for this, two different hydrogels were made by the microemulsion method, having different crosslinking agent based on polyurethane: P(IPDI) and P(HDI), the metal-organic framework (MOF) that was used inside the two composite hydrogels was MIL-53, which is a derivative of the hydrothermal synthesis of terephthalic acid and Al (III) ions. Characterization tests were carried out on the hydrogels, the FTIR sprectra were obtained to evaluate the encapsulation of the drug and the quantification by UV-Vis spectrophotometry to monitor the mass of ampicillin released in the two systems studied. Hydrogels based on C-P(HDI)-MIL53 show higher intermolecular interactions with encapsulated ampicillin, observed by the variation in the intensities of the FTIR signals related to the -NH, -OH, amide I and II bonds that make up the systems; in addition this type of hydrogel also exhibits a higher release of ampicillin than C-P(IPDI)-MIL53 hydrogel. These hydrogels can be studied as 3D culture systems or materials for wound healing, thus avoiding the formation of bacterial infections.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123569283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytarabine Nanotherapeutics with Increased Stability and Enhanced Lymphoma Uptake for Tailored Highly Effective Therapy of Mantle Cell Lymphoma 阿糖胞苷纳米治疗剂增加稳定性和增强淋巴瘤摄取，用于套细胞淋巴瘤的定制高效治疗

Nanomaterials eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3684928

R. Pola, E. Pokorná, P. Vockova, E. Böhmová, M. Pechar, J. Karolová, J. Pankrác, L. Šefc, M. Trněný, T. Etrych, P. Klener

{"title":"Cytarabine Nanotherapeutics with Increased Stability and Enhanced Lymphoma Uptake for Tailored Highly Effective Therapy of Mantle Cell Lymphoma","authors":"R. Pola, E. Pokorná, P. Vockova, E. Böhmová, M. Pechar, J. Karolová, J. Pankrác, L. Šefc, M. Trněný, T. Etrych, P. Klener","doi":"10.2139/ssrn.3684928","DOIUrl":"https://doi.org/10.2139/ssrn.3684928","url":null,"abstract":"Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma (B-NHL) with chronically relapsing clinical course. Implementation of cytarabine (araC) into induction and salvage regimen became standard of care for majority of MCL patients. In this study, tailored N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer nanotherapeutics containing covalently bound araC (araC co-polymers) were designed, synthesized and evaluated for their anti-lymphoma efficacy in vivo using a panel of six patient-derived lymphoma xenografts (PDX) derived from newly diagnosed and relapsed / refractory (R/R) MCL. While free araC led to temporary inhibition of growth of MCL tumors, araC co-polymers induced long-term disappearance of the engrafted lymphomas with no observed toxicity even in the case of PDX models derived from patients, who relapsed after high-dose araC-based treatments. The results provide sound preclinical rationale for the use of HPMA-based araC co-polymers in induction, salvage or palliative therapy of MCL patients.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116880372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-Delivery of NIR-II Semiconducting Polymer and pH-Sensitive Doxorubicin-Conjugated Prodrug for Photothermal/Chemotherapy NIR-II半导体聚合物与ph敏感的阿霉素偶联前药在光热/化疗中的共同递送

Nanomaterials eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3854487

Dongsheng Yu, Yazhou Wang, Jifeng Chen, Shuang Liu, Shaohui Deng, Chengbo Liu, I. McCulloch, W. Yue, Du Cheng

{"title":"Co-Delivery of NIR-II Semiconducting Polymer and pH-Sensitive Doxorubicin-Conjugated Prodrug for Photothermal/Chemotherapy","authors":"Dongsheng Yu, Yazhou Wang, Jifeng Chen, Shuang Liu, Shaohui Deng, Chengbo Liu, I. McCulloch, W. Yue, Du Cheng","doi":"10.2139/ssrn.3854487","DOIUrl":"https://doi.org/10.2139/ssrn.3854487","url":null,"abstract":"Semiconducting polymer (SP) is a promising photothermal agent in antitumor application, but co-delivery of NIR-II SPs with chemotherapeutic drug remains a challenge. Here, SPs was firstly improved via backbone and alky side chain engineering, and afterward SPs and pH-sensitive prodrug copolymer PEG-PAsp(BzA- co -DIP- co -DOX) assembled into a nanoparticle PADD@SPs for photoacoustic (PA)-imaging guided combination of photothermal therapy and chemotherapy. SPs-encapsulated nanoparticles PADD@SPs exhibited a high photothermal conversion efficiency of ~48% at a relatively low power level of NIR irradiation (0.3 W/cm 2 for 5 min). DOX was rapidly released from nanoparticles in response to acidic environment within lysosome. PA and fluorescence imaging confirmed that photothermal therapy effectively drove DOX penetration inside tumor tissue, killing tumor cells survived from hyperthermia. The synergistic effect of SPs-based photothermal therapy and DOX-induced chemotherapy was verified in vivo. Overall, co-delivery of the SP and DOX using pH-sensitive nanoparticles represents a feasible strategy for photothermal therapy with potentially synergistic drug effects.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126319958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Myelination of Dorsal Root Ganglia Neurons Cocultured with Schwann Cells in a Three-Dimensional Tissue-Engineered Model 背根神经节神经元与雪旺细胞共培养的三维组织工程模型中的髓鞘形成

Nanomaterials eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3640708

Sahar Shahidi, M. Janmaleki, S. Riaz, A. S. Nezhad, Naweed Seyed

{"title":"Myelination of Dorsal Root Ganglia Neurons Cocultured with Schwann Cells in a Three-Dimensional Tissue-Engineered Model","authors":"Sahar Shahidi, M. Janmaleki, S. Riaz, A. S. Nezhad, Naweed Seyed","doi":"10.2139/ssrn.3640708","DOIUrl":"https://doi.org/10.2139/ssrn.3640708","url":null,"abstract":"Investigating axonal myelination by Schwann cells (SCs) in three-dimensional (3D) tissue constructs is crucial to understand mechanisms underlying demyelination and remyelination, helping to gain insights into incurable disorders like neurodegenerative diseases. The existing 3D tissue models have shown a limited performance to permit visualization of direct between SCs and individual axons. In this study, a biocompatible gelatin-based hydrogel, gelatin methacrylate (GelMA), was refined and optimized to achieve the biocompatibility, porosity, mechanical stability, and degradability needed to provide high cell viability for dorsal root ganglia (DRG) neurons and SCs and to enable their long-term culture needed for myelination studies. The results of cell viability, neurite elongation, SC function and maturation, SC-axon interaction, and myelination were compared to the two other commonly used substrates, namely collagen and Poly-D Lysine (PDL). The tuned GelMA constructs enhanced single axon generation (unlike collagen) and promoted the interaction of DRG neurons and SCs (unlike PDL). Further adjusting the hydrogel properties to achieve two distinct ranges of relatively small and large pores supported SCs to extend their processes freely and enable physical contact with and wrapping around their corresponding axons. Staining the cells with myelin basic protein (MBA) and myelin-associated glycoprotein (MAG) revealed the myelination process on GelMA hydrogels. Moreover, the engineered porosity enhanced DRGs and SCs attachments and flexibility of movement across the substrate. Finally, various cellular mechanisms related to the superiority of GelMA properties for myelination studies were discussed. This engineered GelMA 3D structure can be further used to model demyelination in neurodegenerative diseases and study effect of various drug compounds on myelin regeneration.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128316489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization, Crystallographic Structure, Theoretical Studies, and in Vitro Cytotoxicity Assessment of Two Gd(III), Ce(IV) Complexes of Pyridine-2,6-Dicarboxylic Acid 吡啶-2,6-二羧酸两种Gd(III)， Ce(IV)配合物的合成、表征、晶体结构、理论研究及体外细胞毒性评价

Nanomaterials eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3898510

Mina Zohrevani, S. Abdolmaleki, M. Ghadermazi, Yasin Gholiee, A. Aliabadi, Elham Motieiyan, M. Hakimi, D. Marabello

{"title":"Synthesis, Characterization, Crystallographic Structure, Theoretical Studies, and in Vitro Cytotoxicity Assessment of Two Gd(III), Ce(IV) Complexes of Pyridine-2,6-Dicarboxylic Acid","authors":"Mina Zohrevani, S. Abdolmaleki, M. Ghadermazi, Yasin Gholiee, A. Aliabadi, Elham Motieiyan, M. Hakimi, D. Marabello","doi":"10.2139/ssrn.3898510","DOIUrl":"https://doi.org/10.2139/ssrn.3898510","url":null,"abstract":"This paper reports the synthesis of two complexes through one-pot reactions of pyridine-2,6-dicarboxylic acid (pydcH2), phenanthroline, and 2-aminopyridine, with Gd(NO3)3.6H2O and Ce (NO3)3.6H2O metal salts. The new coordination complexes C1 and C2 have been identified by spectroscopic methods. The complexes were characterized by X-ray crystallography. The nature of metal-ligand interactions was studied theoretically using NBO and EDA-NOCV analyses. The results showed that the contribution of electrostatic interactions in both complexes is considerably larger than orbital. However, the contribution of orbital interactions in [CeL3]2–, is more than that in [GdL3]3– (28.8% vs. 21.8%). In following, the cytotoxic effect of synthetic complexes was investigated in vitro using oxaliplatin as a standard against three cancer cell lines including human breast cancer (MCF7), human colon adenocarcinoma (HT29), and human lymphocyte (HL60). The most significant inhibition activity was observed by both C1 (IC50=80.7 μM, Viability inhibition=83.41%) and C2 (IC50=98.3 μM, Viability inhibition=77.19%) toward the MCF7 cell line.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128183256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluid Interfaces with Physiological Relevance 与生理相关的流体界面

Nanomaterials eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3818060

Pascal Bertsch, J. Bergfreund, E. Windhab, P. Fischer

{"title":"Fluid Interfaces with Physiological Relevance","authors":"Pascal Bertsch, J. Bergfreund, E. Windhab, P. Fischer","doi":"10.2139/ssrn.3818060","DOIUrl":"https://doi.org/10.2139/ssrn.3818060","url":null,"abstract":"Fluid interfaces, i.e. the boundary layer of two fluids or a fluid and a gas, play a vital role in physiological processes as diverse as visual perception, oral health and taste, lipid metabolism, and pulmonary breathing. These fluid interfaces exhibit a complex composition, structure, and rheology tailored to their individual physiological functions. Advances in interfacial thin film techniques have facilitated the analysis of such complex interfaces under physiologically relevant conditions. This allowed new insights on the origin of their physiological functionality, how deviations may cause disease, and has revealed new therapy strategies. Furthermore, the interactions of physiological fluid interfaces with exogenous substances is crucial for understanding certain disorders and exploiting drug delivery routes to or across fluid interfaces. Here, we provide an overview on fluid interfaces with physiological relevance, namely tear films, interfacial aspects of saliva, lipid droplet digestion and storage in the cell, and the functioning of lung surfactant. We elucidate their structure-function relationship, discuss diseases associated with interfacial composition, and describe therapies and drug delivery approaches targeted at fluid interfaces.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123019597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0