European journal of anaesthesiology. Supplement最新文献_第6页

Clinical pharmacology and rationale of analgesic combinations. 镇痛药联合用药的临床药理学及基本原理。

European journal of anaesthesiology. Supplement Pub Date : 2003-01-01

J Desmeules, V Rollason, V Piguet, P Dayer

{"title":"Clinical pharmacology and rationale of analgesic combinations.","authors":"J Desmeules, V Rollason, V Piguet, P Dayer","doi":"","DOIUrl":"","url":null,"abstract":"Background and objective: Oral fixed drug combination analgesics have potential advantages over monotherapy, but these can only be attained through careful design.Results: The main reasons for developing combination analgesics are to gain efficacy and to reduce toxicity. Analgesic combinations interact pharmacokinetically, or pharmacodynamically, or both, in positive or negative terms. The t(max) value for both enantiomers of tramadol occur two hours following administration, and that for the active, (+)-M1 metabolite occurs after three hours. Thus, pairing tramadol with acetaminophen, a rapid-onset analgesic, represents a pharmacokinetically rational combination. Analgesic combinations should satisfy two important pharmacodynamic criteria: the components of the combination should display additive or synergistic analgesia; and this interaction should allow lower doses of each substance to be used in combination, resulting in an improved safety profile. Clinical studies of the pharmacodynamic between oral tramadol and acetaminophen in third molar extraction and cold pressor models have provided evidence that this combination provides better efficacy than either individual component of the combination.Conclusions: In summary, combination analgesics can play a valuable role in pain management. However, dubious combinations (directed against the same targets or with unwanted interactions) and 'old fashioned' fixed-dose multiple analgesic agent combinations should be avoided. Fixed-dose combination analgesics are of value only when they have been developed according to rational pharmacokinetic and pharmacodynamic criteria, and when claims for their benefits have been supported by evidence-based data and well-designed clinical studies.","PeriodicalId":11873,"journal":{"name":"European journal of anaesthesiology. Supplement","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22417345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Euroanaesthesia 2003. Abstracts of the joint meeting of the European Society of Anaesthesiologists and European Academy of Anaesthesiology, Confederation of European National Societies of Anaesthesiology, and Association of Anaesthetists of Great Britain & Ireland. May 31-June 3, 2003. Glasgow, Scotland. Euroanaesthesia 2003。欧洲麻醉师学会和欧洲麻醉学学会、欧洲国家麻醉学学会联合会和大不列颠及爱尔兰麻醉师协会联合会议摘要。2003年5月31日至6月3日格拉斯哥,苏格兰。

European journal of anaesthesiology. Supplement Pub Date : 2003-01-01

引用次数: 0

Epidemiology of analgesic use: a gender perspective. 镇痛药使用的流行病学:性别视角。

European journal of anaesthesiology. Supplement Pub Date : 2002-01-01 DOI: 10.1097/00003643-200219261-00003

D Isacson, K Bingefors

{"title":"Epidemiology of analgesic use: a gender perspective.","authors":"D Isacson, K Bingefors","doi":"10.1097/00003643-200219261-00003","DOIUrl":"https://doi.org/10.1097/00003643-200219261-00003","url":null,"abstract":"Background and objective: Women consistently report significantly more frequent analgesic use in epidemiological studies. The aim of this study was to analyse the influence of medical and non-medical factors on the difference in use of analgesics between women and men from a population perspective.Methods: Cross-sectional survey. Postal questionnaires were sent to a random sample of the general population in the country of Uppland, Sweden (5404 answered the questionnaire, response rate: 68%).Results: 34.8% of the women and 21.4% of the men had used analgesics during the two week recall period (Odds Ratio = 1.96). Social structure, social status, marital status, educational level, economic situation, lifestyle, attitudes toward drugs, medication knowledge and self-care orientation were of minor importance for the difference in use between women and men. Difference in prevalence of various types of pain and ache and the degree of pain experienced were the most influential factors affecting the difference in use. However, when all factors were analysed there remained a substantial difference in use between women and men (OR = 1.39, CI (95%) 1.20 to 1.60).Conclusions: In the population, women use analgesics much more frequently than men. Consequently women may be at greater risk for adverse effects and dependency. Some of the gender difference is explained by the greater frequency of pain conditions among women, but a significant difference in use still remains to be explained.","PeriodicalId":11873,"journal":{"name":"European journal of anaesthesiology. Supplement","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00003643-200219261-00003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22182223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 94

Sex differences in analgesic responses: evidence from experimental pain models. 镇痛反应的性别差异:来自实验疼痛模型的证据。

European journal of anaesthesiology. Supplement Pub Date : 2002-01-01 DOI: 10.1097/00003643-200219261-00004

R B Fillingim

{"title":"Sex differences in analgesic responses: evidence from experimental pain models.","authors":"R B Fillingim","doi":"10.1097/00003643-200219261-00004","DOIUrl":"https://doi.org/10.1097/00003643-200219261-00004","url":null,"abstract":"Background and objective: Sex-related influences on the experience of pain have received considerable empirical attention. Women are at greater risk for several forms of clinical pain and exhibit greater perceptual responses to experimental pain. In recent years, investigators have turned their attention to the influence of sex-related factors on analgesic responses. The purpose of this review is to examine the literature on sex differences in analgesic responses, emphasizing findings from experimental studies.Methods: First, important methodological issues in laboratory pain research are presented, and sex differences in responses to experimentally-induced pain are briefly addressed. Next, previous data from non-human animal research and human experimental and clinical research related to sex differences in analgesia are discussed. Also, preliminary results are presented from an ongoing study in our laboratory examining analgesic responses in women and men.Results and conclusions: Both previous research and preliminary findings from our laboratory suggests that opioids produce greater analgesic responses in women than men. Potential mechanisms underlying sex differences in analgesia are proposed, and important directions for future research are suggested.","PeriodicalId":11873,"journal":{"name":"European journal of anaesthesiology. Supplement","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00003643-200219261-00004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22182224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Sex differences and analgesics. 性别差异与镇痛药。

European journal of anaesthesiology. Supplement Pub Date : 2002-01-01 DOI: 10.1097/00003643-200219261-00001

A Holdcroft

引用次数: 9

COX-2-selective inhibition: a new advance in pain management. Chairman's introduction. cox -2选择性抑制:疼痛管理的新进展。主席的介绍。

European journal of anaesthesiology. Supplement Pub Date : 2002-01-01

K Korttila

引用次数: 0

COX-2-selective inhibitors: clinical relevance in surgical and acute pain. cox -2选择性抑制剂:在外科和急性疼痛中的临床意义。

European journal of anaesthesiology. Supplement Pub Date : 2002-01-01 DOI: 10.1097/00003643-200219251-00003

D J Rowbotham