Eurasian heart journal最新文献

{"title":"EURASIAN ASSOCIATION OF CARDIOLOGY (EAC) GUIDELINES FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES IN PATIENTS WITH DIABETES AND PREDIABETES (2021)","authors":"I. Chazova, M. Shestakova, Y. Zhernakova, N. Blinova, T. Markova, N. Mazurina, M. Ezhov, S. Tereshchenko, I. Zhirov, A. L. Komarov, O. Mironova, Y. Yuricheva, O. Y. Suhareva, O. Kislyak, A. Mkrtumyan, V. Podzolkov, V. Azizov, P. A. Zelveyan, E. A. Grigorenko, Z. Y. Rahimov, A. Sarybaev, S. D. Kasymova, A. Narzullaeva","doi":"10.38109/2225-1685-2021-2-6-61","DOIUrl":"https://doi.org/10.38109/2225-1685-2021-2-6-61","url":null,"abstract":"The EAC Guidelines represent the views of the EAC, and were produced after careful consideration of the scientific and medical knowledge, and the evidence available at the time of their publication. The EAC is not responsible in the event of any contradiction, discrepancy, and/or ambiguity between the EAC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthcare or therapeutic strategies. Health professionals are encouraged to take the EAC Guidelines fully into account when exercising their clinical judgment, as well as in the determination and the implementation of preventive, diagnostic, or therapeutic medical strategies; however, the EAC Guidelines do not override, in any way whatsoever, the individual responsibility of health professionals to make appropriate and accurate decisions in consideration of each patient’s health condition and in consultation with that patient and, where appropriate and/or necessary, the patient’s caregiver. Nor do the EAC Guidelines exempt health professionals from taking into full and careful consideration the relevant official updated recommendations or guidelines issued by the competent public health authorities, in order to manage each patient’s case in light of the scientifically accepted data pursuant to their respective ethical and professional obligations. It is also the health professional’s responsibility to verify the applicable rules and regulations relating to drugs and medical devices at the time of prescription.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90768498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARRHYTHMIC PHENOTYPE OF NON-COMPACTION CARDIOMYOPATHY","authors":"S. Komissarova, N. Chakova, N. M. Rinejskaya, T. Dolmatovich, S. Niyazova","doi":"10.38109/2225-1685-2021-2-62-69","DOIUrl":"https://doi.org/10.38109/2225-1685-2021-2-62-69","url":null,"abstract":"Сведения об авторах: Комиссарова Светлана Михайловна, ведущий научный сотрудник лаборатории хронической сердечной недостаточности РНПЦ «Кардиология», доктор мед. наук, доцент, ORCID: https://orcid.org/0000-0001-9917-5932 Чакова Наталья Николаевна, ведущий научный сотрудник лаборатории генетики животных ГНУ «Институт генетики и цитологии НАН Беларуси», ORCID: https://orcid.org/0000-0003-4721-9109 Долматович Татьяна Владимировна, ведущий научный сотрудник лаборатории генетики животных ГНУ «Институт генетики и цитологии НАН Беларуси», ORCID: https://orcid.org/0000-0001-7562-131X Ниязова Светлана Сергеевна, младший научный сотрудник лаборатории генетики животных ГНУ «Институт генетики и цитологии НАН Беларуси», ORCID: https://orcid.org/0000-0002-3566-7644 *Автор, ответственный за переписку: Ринейская Надежда Михайловна, младший научный сотрудник лаборатории хронической сердечной недостаточности РНПЦ «Кардиология», 220036, Минск, ул. Р.Люксембург 110Б, РНПЦ “Кардиология”, тел.+375(29)340-87-88, e-mail: nadya.rin@ gmail.com, ORCID: https://orcid.org/0000-0002-1986-1367 ГЕНЕТИЧЕСКИЕ ПРИЧИНЫ АРИТМИЧЕСКОГО ФЕНОТИПА НЕКОМПАКТНОЙ КАРДИОМИОПАТИИ","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89098591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METABOLOMIC APPROACHES IN STUDYING OF CARDIOVASCULAR DISEASES","authors":"A. A. Аbdullaev, G. J. Аbdullaeva, Kh. F. Usupova","doi":"10.38109/2225-1685-2021-1-106-117","DOIUrl":"https://doi.org/10.38109/2225-1685-2021-1-106-117","url":null,"abstract":"Modern scientific approaches give clinicians an advantage in using additional tools and methods for assisting in clinical assessment and expanding their capabilities for classifying patients according to risk factors for cardiovascular complications. Biomarkers are a simple tool that allows to identify and classify people with different risk degree, quickly and accurately diagnose the condition of the disease, effectively predict and control treatment. Therefore, the identification and study of biomarkers is a serious and promising approach to understanding and treating cardiovascular diseases (CVD). Among a wide range of biomarkers, the genetic and metabolic markers is of high importance. Cardio-metabolomics is a new direction in cardiovascular science that allows researchers to study changes in metabolome and metabolic networks in diseases of the cardiovascular system in order to better understand their pathophysiological mechanism. Thus, the study of metabolome can provide important information about the pathogenesis of CVDs, as well as offer the possibility of identifying new CVD biomarkers.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89100563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EURASIAN ASSOCIATION OF CARDIOLOGY (EAC) GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION (2020)","authors":"I. Chazova, T. Martynyuk, Z. Valieva, V. Azizov, R. Akchurin, A. Ansheles, O. Vasiltseva, T. Veselova, A. Galyavich, S. Gorbachevsky, N. Danilov, A. Edemskiy, P. A. Zelveyan, I. Lazareva, Y. Matchin, K. Mershin, M. Mukarov, S. Nakonechnikov, M. Saidova, A. Sarybaev, Sergienko Vb, O. Stukalova, E. Filippov, A. Chernyavsky, M. A. Chernyavsky, S. Shalaev, A. A. Shmalts","doi":"10.38109/2225-1685-2021-1-6-43","DOIUrl":"https://doi.org/10.38109/2225-1685-2021-1-6-43","url":null,"abstract":"Disclaimer The EAC Guidelines represent the views of the EAC, and were produced after careful consideration of the scientific and medical knowledge, and the evidence available at the time of their publication. The EAC is not responsible in the event of any contradiction, discrepancy, and/or ambiguity between the EAC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthcare or therapeutic strategies. Health professionals are encouraged to take the EAC Guidelines fully into account when exercising their clinical judgment, as well as in the determination and the implementation of preventive, diagnostic, or therapeutic medical strategies; however, the EAC Guidelines do not override, in any way whatsoever, the individual responsibility of health professionals to make appropriate and accurate decisions in consideration of each patient’s health condition and in consultation with that patient and, where appropriate and/or necessary, the patient’s caregiver. Nor do the EAC Guidelines exempt health professionals from taking into full and careful consideration the relevant official updated recommendations or guidelines issued by the competent public health authorities, in order to manage each patient’s case in light of the scientifically accepted data pursuant to their respective ethical and professional obligations. It is also the health professional’s responsibility to verify the applicable rules and regulations relating to drugs and medical devices at the time of prescription.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89534498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIOLOGICAL ASPECTS OF THE PERIOPERATIVE MANAGEMENT OF PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION FOR PULMONARY THROMBOENDARTERECTOMY","authors":"D. D. Tsyrenov, R. Akchurin, K. Mershin, E. A. Tabakyan, E. Vlasova, V. V. Gazizоv, S. Kurbanov, I. Starostin","doi":"10.38109/2225-1685-2020-3-94-104","DOIUrl":"https://doi.org/10.38109/2225-1685-2020-3-94-104","url":null,"abstract":"Aim. To analyze the factors associated with a poor outcome of pulmonary thromboendarterectomy (PTE) and complications of the hospital postoperative period; on the basis of this analysis to optimize preoperative preparation and therapeutic support of the operation. Materials and methods. The study included 47 patients with operable CTEPH, who underwent PTE in the Department of cardiovascular surgery of the national medical research center of cardiology from 2010 to 2018. Patients were observed during the intrahospital period, all were evaluated for clinical, instrumental, hemodynamic, and laboratory parameters. Diagnosis and treatment of complications, assessment of the relationship of factors associated with the development of these pathological conditions were carried out. Results. A comprehensive assessment of the parameters revealed that age over 50 years, the presence of proven antiphospholipid syndrome (AFS) were independently associated with a higher frequency of adverse surgical outcomes and in-hospital complications. Older age and a history of smoking were independently associated with a greater likelihood of developing reperfusion pulmonary edema. The probability of developing transient neurological complications is independently associated with a long duration of deep hypothermic circulatory arrest (DHCA), an increased level of D-dimer. A greater age and longer duration of ventilation are independently associated with the likelihood of developing acute kidney injury (AKI). A higher level of antithrombin III and the presence of AFS were independently associated with the likelihood of developing prolonged ventilation. Conclusion. When selecting candidates for surgery, in addition to the generally accepted clinical and instrumental parameters, it is necessary to take into account a history of Smoking, an increase in d-dimer, and the presence of AFS. Patients with this pathology need a more thorough risk assessment, correction of target levels of activated partial thromboplastin time (aPTT), activated clotting time (ACT) due to their falsely inflated indicators, and further development of standards for perioperative support. The main principle of cardiological support of the operation is the earliest possible diagnosis of all known perioperative complications and the rapid start of their treatment, which ensures the stabilization of the patient’s condition in 85% of cases in the hospital period. In the postoperative period, an early transition from ventilator to independent breathing is indicated for the prevention of associated complications, including AKI.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76431666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INACTIVATION OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM. WHICH CLASS OF ANTIHYPERTENSIVE MEDICINE PRODUCTS TO PREFER?","authors":"СИСТЕМЫ. Какой Класс, Препаратов Предпочесть, S. V. Stolov","doi":"10.38109/2225-1685-2020-4-64-78","DOIUrl":"https://doi.org/10.38109/2225-1685-2020-4-64-78","url":null,"abstract":"Сведения об авторе: Столов Сергей Валентинович, д.м.н., заведующий кафедрой терапии, МСЭ и реабилитации No1 ФГБУ ДПО «Санкт-Петербургский институт усовершенствования врачей-экспертов» Минтруда России, Санкт-Петербург; профессор кафедры терапии и ревматологии им. Э.Э. Эйхвальда ФГБУ ВО «Северо-Западный государственный медицинский университет», e-mail: sv100lov@gmail.com; sergey.stolov@szgmu.ru, ORCID: 00000002-3431-1224 ИНАКТИВАЦИЯ РЕНИН-АНГИОТЕНЗИН-АЛЬДОСТЕРОНОВОЙ СИСТЕМЫ. КАКОЙ КЛАСС ПРЕПАРАТОВ ПРЕДПОЧЕСТЬ?","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76766485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ORTHOSTATIC HYPOTENSIVE REACTIONS IN ELDERLY AND SENILE PATIENTS WITH ARTERIAL HYPERTENSION","authors":"I. Atyunina, E. Oshchepkova, A. Rogoza","doi":"10.38109/2225-1685-2020-4-52-63","DOIUrl":"https://doi.org/10.38109/2225-1685-2020-4-52-63","url":null,"abstract":"Сведения об авторах: *Автор, ответственный за связь с редакцией: Атюнина Ирина Валентиновна, мл. науч. сотрудник лаборатории мониторинга снижения смертности от ССЗ научно-организационного отдела ФГБУ «НМИЦ кардиологии» Минздрава России, atyunina_i@mail.ru, 121552, Москва, ул. 3-я Черепковская, д. 15 а; ORCID: 0000-0002-7771-172X Ощепкова Елена Владимировна, д-р мед. наук, профессор, главный научный сотрудник отдела гипертонии ФГБУ «НМИЦ кардиологии» Минздрава России; ORCID: 0000-0003-4534-9890 Рогоза Анатолий Николаевич, д-р биол. наук, профессор, руководитель отдела новых методов диагностики, ФГБУ «НМИЦ кардиологии» Минздрава России; ORCID: 0000-0002-0543-3089 ОРТОСТАТИЧЕСКИЕ ГИПОТЕНЗИВНЫЕ РЕАКЦИИ У БОЛЬНЫХ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА С АРТЕРИАЛЬНОЙ ГИПЕРТОНИЕЙ","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86773057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MARKERS OF RISK FACTORS FOR CARDIOVASCULAR DISEASE","authors":"N. Bashirov","doi":"10.38109/2225-1685-2020-3-78-84","DOIUrl":"https://doi.org/10.38109/2225-1685-2020-3-78-84","url":null,"abstract":"Objective: To study the role of risk factors for cardiovascular diseases to optimize their pathogenetic diagnosis.Material and research methods. At the initial stage of clinical trials, all participants (n = 200) were questioned with age-sex characteristics and the main risk factors for cardiovascular diseases (alcohol abuse, smoking, obesity, stress). Biochemical and clinical studies were carried out in two groups of patients, 15 people in each group (the first main group - in addition to bad habits, there is an obesity factor, the second control group - bad habits are detected, but in the absence of obesity) as part of preventive medical examinations.The results of research. When studying psychosocial risk factors for the development of diseases of the cardiovascular system, a higher prevalence rate was noted for men in depression indicators - 26.3% of cases, and in the group of female patients the results were almost 2.5 times lower and amounted to only 15.0%. in both groups of healthy individuals, a low level of the frequency of occurrence of overweight and obesity was observed, compared with the main group, which were diagnosed in 28.6% of cases in the male half of the subjects, and among the representatives of the opposite sex, the indicator was 24.0%. The proportion of obese women in the main and control groups was higher than men by almost 1.5 times. Against the background of obesity and the presence of signs of non-alcoholic fatty degeneration of the liver, in comparison with patients with normal body weight, certain violations were detected in the form of a higher level in the blood of the liver enzyme ALAT - 35.2 ± 1.57 U / L and 21.3 ± 0 95 U / L, respectively, in the first main group and in the second control group.Conclusions. Thus, it was found that the cause of cardiovascular diseases, in particular, cardiac automatism disorders, stroke, myocardial infarction due to metabolic and psychoemotional disorders are overweight and obesity, which worsen the prognosis of CVD, creating the prerequisites for the development of complications.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73029887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CONTRAST-INDUCED NEPHROPATHY IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE AND 1-YEAR PROGNOSIS","authors":"O. Mironov, O. Sivakova, V. Fomin","doi":"10.38109/2225-1685-2020-3-100-105","DOIUrl":"https://doi.org/10.38109/2225-1685-2020-3-100-105","url":null,"abstract":"Aim.The aim of our study was to assess the prevalence of contrast-induced nephropathy (CIN) in patients with chronic coronary artery disease (CAD) and its 1-year prognostic significance.Materials and methods.462 patients with chronic CAD and indications to the interventions with intraarterial contrast media administration were included in the study. We conducted a prospective open cohort study (ClinicalTrials.gov NCT04014153). The primary endpoint was the development of CIN. The secondary endpoints were total mortality, cardiovascular mortality, myocardial infarction, stroke, gastrointestinal bleeding, acute decompensation of heart failure, coronary artery bypass grafting, repeat percutaneous coronary intervention.Results.28 patients (6%) developed CIN. The rate of CIN in female patients was twice higher, than in males (9,29% vs. 4,66%). There was a trend towards less cases of CIN in patients without obesity (5,88% vs. 6,22%). CIN developed more frequently in patients with anemia (8,9% и 5,7%, р=0,3649, ОR 1,633,95% CI 0,6507-4,239). There was a trend to higher incidence of CIN in people with hyperuricemia (8% vs. 5,95%, р=0,6575, ОR 1,375,95% CI 0,3055-5,808). The rate of CIN in patients with diabetes mellitus was 2% higher, then without one. People, who suffered from myocardial infarction after 1 year of follow up, had the highest rate of CIN (26,7%), as well as patients with other major cardiovascular complications (18,1%). The rate of repeat percutaneous coronary interventions was 9,5%, the rate of acute decompensation of heart failure was 7%.Conclusion.The prevalence of CIN in patients with chronic CAD was 6%. After 1 year of follow up the rate of CIN was higher in patients who had myocardial infarction, repeat percutaneous coronary interventions and acute decompensation of heart failure.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84847806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL CASE OF NON-COMPACTION CARDIOMYOPATHY IN A PATIENT WITH PKP2 GENE MUTATION","authors":"S. Komissarova, N. Rineiskaya, N. Chakova, S. Niyazova, T. Dolmatovich","doi":"10.38109/2225-1685-2020-3-106-111","DOIUrl":"https://doi.org/10.38109/2225-1685-2020-3-106-111","url":null,"abstract":"The features of the clinical course of non-compaction cardiomyopathy, its prognosis and even its diagnosis are still the subject of discussion. The variety of phenotypes of this disease and genetic heterogeneity dictates the need for detailed clinical and molecular genetic examination of patients with this pathology. The article presents a clinical observation of a patient with a dilated phenotype of left ventricular non-compaction, progression of chronic heart failure, as well as the presence of ventricular rhythm and conduction disorders that required the implantation of cardiac resynchronization therapydefibrillator (CRT-D). The patient was found to have a missense mutation c. 1892A>G (p.Tyr631Cys, rs1060501183) in PKP2 gene in a heterozygous state. The issues of differential diagnostics with arrhythmogenic right ventricular cardiomyopathy and treatment strategies for the disease were discussed.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79815728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}