Eurasian Journal of Medicine and Oncology最新文献

{"title":"Epigenetic Code for Cell Fate During Development and Disease in Human","authors":"Selcen Çelik Uzuner","doi":"10.14744/ejmo.2023.42324","DOIUrl":"https://doi.org/10.14744/ejmo.2023.42324","url":null,"abstract":"DOI: 10.14744/ejmo.2023.42324 EJMO 2023;7(2):95–102","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75009065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between ABO Blood Group and Hashimoto Thyroiditis","authors":"","doi":"10.14744/ejmo.2023.49922","DOIUrl":"https://doi.org/10.14744/ejmo.2023.49922","url":null,"abstract":"in","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135103365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interval Comparison of Zoledronic Acid Treatment in Patients with Metastatic Bone Disease, Is 4-Weekly or 12-Weekly More Effective?: A Systematic Review and Meta-analysis","authors":"I Gede Eka Wiratnaya","doi":"10.14744/ejmo.2023.34433","DOIUrl":"https://doi.org/10.14744/ejmo.2023.34433","url":null,"abstract":"Objectives: The aim of bisphosphonate treatment in patients with metastatic bone disease is to prevent metastatic skeletal morbidity and prevent cancer treatment-induced skeletal damage. The classical recommendation of Zoledronic acid treatment is to be given indefinitely as intravenous infusion every 3 to 4 weeks until patients' health deteriorates. Data on zoledronic acid's long-term effectiveness and safety are insufficient, and some recent literatures start to consider 12-weekly administration as a reasonable alternative in order to minimize the adverse effects. Methods: A systematic search was conducted based on PRISMA guideline to identify relevant studies through PubMed, Google Scholar, and Cochrane database. A total of 5 studies (2867 patients) were included, divided into outcome analysis, processed using Review Manager 5.3. Results: The search of electronic databases yielded a total of 299 entries. Five studies were included in the qualitative and quantitative synthesis following the steps of identifying, screening, determining eligibility, eliminating duplicates, and excluding studies. Out of a total of 2.867 patients, 1.427 received ZA for 12 weeks and 1.440 received ZA for 4 weeks, making up the total number of patients included in this meta-analysis. Each trial had a comparable one-year follow-up duration after ZA was given. We discovered that the incidence of adverse effects varied significantly between the two groups. In contrast, there is no statistically significant difference in the rates of SRE, ONJ, renal dysfunction, or death between the two groups. Conclusion: Our systematic review and meta-analysis reveals that 12-week intervals of zoledronic acid is as effective as the standard 4-week interval in terms of skeletal related event, jaw osteonecrosis, renal dysfunction, and mortality rate. However, the standard 4-week intervals led to higher rate of adverse effects.","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135103468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypofractionated Versus Hyperfractionated Versus Conventionally Fractionated Thoracic Radiotherapy in Limited-Stage Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis","authors":"S. Lin, C. Ren, Jun Chen, Tingting Liu, J. Dang","doi":"10.14744/ejmo.2023.44908","DOIUrl":"https://doi.org/10.14744/ejmo.2023.44908","url":null,"abstract":"DOI: 10.14744/ejmo.2023.44908 EJMO 2023;7(2):120–134 Systematic Meta Analysis Cite This Article: Lin S, Ren C, Chen J, Liu T, Dang J. Hypofractionated Versus Hyperfractionated Versus Conventionally Fractionated Thoracic Radiotherapy in Limited-Stage Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. EJMO 2023;7(2):120–134.","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84968247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Deubiquitinating Enzyme USP1 is Auto-Ubiquitinated and Destabilized by ML323 in Colorectal Cancer Cells","authors":"Yili Yang","doi":"10.14744/ejmo.2023.46574","DOIUrl":"https://doi.org/10.14744/ejmo.2023.46574","url":null,"abstract":". Objectives: Our previous study indicated that USP1 inhibitor ML323 downregulated USP1 in colorectal cancer (CRC) cells, but the specific mechanism was still unknown. Methods: CRC cells were lysed for immunoblotting to detect protein expressions. Quantitative real-time PCR was performed to examine mRNA levels. Cycloheximide chase assays were carried out to evaluate the half-life of USP1. Co-immunoprecipitation was used to analyze the polyubiquitination of USP1. Results: USP1 protein stability was enhanced by the proteasome inhibitor MG132 in CRC cells. The wild-type USP1 was upregulated by MG132, but not its catalytic mutant. Additionally, the polyubiquitination of USP1 was enhanced by MG132 as well, which indicated USP1 was degraded through the ubiquitin-proteasome pathway. Meanwhile, we confirmed ML323 downregulated USP1 expression in CRC cells, and cycloheximide chase assay also revealed ML323 reduced USP1 protein stability. Further results showed ML323-induced USP1 downregulation and destabilization were abolished by MG132. Moreover, USP1 protein destabilization was not reversed by the caspase inhibitor Z-VAD, which further suggested ML323-induced USP1 downregulation was not dependent on the effects of cell death in CRC cells. Conclusion: Our results showed USP1 was auto-ubiquitinated, and ML323 destabilized USP1 through the ubiquitin-proteasome pathway in CRC cells, providing a theoretical basis for anti-CRC drugs’ development targeting USP1.","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81215446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Autophagy in Myocardial Ischemia and Reperfusion","authors":"Xueli Guo","doi":"10.14744/ejmo.2023.53477","DOIUrl":"https://doi.org/10.14744/ejmo.2023.53477","url":null,"abstract":"hypoxia and low levels of oxidative stress, [6, 7] can promote cell survival. But excessively activated autophagy can cause cell death. [8, 9] Therefore, autophagy is considered a therapeutic target for ischemic heart disease, but the specific mechanism is still clear. [10, 11] In recent years, the role of autophagy in MI/RI has been paid more and more attention. This paper will review the role of autophagy in MI/RI.","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79002054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linked Color Imaging and Color Analytic Model Based on Pixel Brightness for Diagnosing H. Pylori Infection in Gastric Antrum","authors":"Yang Xu","doi":"10.14744/ejmo.2023.33713","DOIUrl":"https://doi.org/10.14744/ejmo.2023.33713","url":null,"abstract":"Objectives: Linked color imaging (LCI) helps to differentiate minor mucosal changes, which can be objectively judged by red–green–blue pixel brightness. However, whether this color analytic model based on pixel brightness can be applied to diagnose Helicobacter pylori infection remains unknown. Methods: Consecutive adult patients with indications and underwent esophagogastroduodenoscopy for the 1 st time were enrolled in the training (n=166) and validation (n=79) set. Demographic and clinical characteristics were recorded. Target region in gastric antrum was pictured before biopsy for rapid urea test, and pixel brightness was calculated by MATLAB software. Results: In training set, 25 patients had H. pylori infection. Pixel brightness for R and B in patients with H. pylori infection was greatly higher than those in patients without H. pylori infection (R: 210.203±27.233 vs. 196.401±29.018, p=0.043; B: 127.621±26.112 vs. 125.334±27.812, p=0.025). At the cut off of R = 210 and B = 127, the specificity and sensitivity were 0.696 and 0.701. In validation set, 10 patients had H. pylori infection and the findings were consistent with those in training set. Conclusion: Color analytic model based on pixel brightness under LCI was useful in diagnosing H. pylori infection in gastric antrum.","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75701223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Higher Prevalence of Anemia among Diabetic Patients with Desirable Lipid Profile: A Retrospective Analysis","authors":"Y. Roosta","doi":"10.14744/ejmo.2023.98984","DOIUrl":"https://doi.org/10.14744/ejmo.2023.98984","url":null,"abstract":",","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78425427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic Enzymes Elevation and Emergency Setting: Pancreatitis or Not Pancreatitis? That is the Question","authors":"M. Barone","doi":"10.14744/ejmo.2023.75981","DOIUrl":"https://doi.org/10.14744/ejmo.2023.75981","url":null,"abstract":"Dear Editor, Notwithstanding often no clinically evident acute pancreatitis findings are found, a serum pancreatic enzyme elevation is found in up to 80% of critically ill patients.[1] In an emergency setting, in fact, the diagnosis of acute pancreatitis can be misleading due to various reasons, hence concomitant patients’ clinical conditions (e.g. hemodynamic instability, mechanical ventilation) and the establishment of rapidly evolving physiopathological mechanisms. Does an enzyme increase justify the diagnosis of pancreatitis? Actually no. Although a three-time greater titer than upper limits represents one of the recognized diagnostic criteria, findings of hyperamylasemia and/or hyperlipasemia could lead to several interpretations, such as the evolution of severe acute pancreatitis, as defined by the Atlanta criteria, pancreatic complications in patients admitted for other pathologies or a mere biochemical increase in the absence of clinical-radiological signs attributable to pancreatic inflammation. Furthermore, the enzymatic titer does not represent a prognostic factor or an index of progression to a necrotic or haemorrhagic state. Although, a diagnosis of acute pancreatitis at onset can established on the basis of an enzymatic increase supported by suggestive clinical findings, the enzymatic dosage cannot be considered predictive of progression, as in case of the C-reactive protein. Furthermore, in the early stages of the disease, the extensive use of diagnostic radiologic investigations (<96 hours) has no role.[2] As reported by Weaver et al.,[3] in a retrospective analysis including 192 emergency patients, 36.45% had hyperamylasemia but none met clinical or radiological criteria for acute pancreatitis. Furthermore, only 9.4% in this cohort was attributable to an increase in the pancreatic serum isoform. The authors therefore concluded by recommending caution in the dosage and interpretation of the titers of serum amylase in critically ill patients. If on the one hand these evidences represent an explicit recommendation for a prompt and exhaustive nosological classification of hyperamylasemia that could mislead to an erroneous diagnosis, on the other they suggest the need for a critical review of the diagnostic criteria of acute pancreatitis where laboratory findings as far as clinical and radiological findings could lead to a reduced diagnostic power in critically ill patients. Mirko Barone,1 Massimo Ippoliti,1 Felice Mucilli1,2","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84220902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Efficacy and Safety of Camrelizumab-Based Treatment for Refractory or Metastatic Oesophageal Squamous Cell Carcinoma","authors":"Yuan Yuan","doi":"10.14744/ejmo.2023.42506","DOIUrl":"https://doi.org/10.14744/ejmo.2023.42506","url":null,"abstract":"Objectives: To evaluate the shortterm efficacy and safety of camrelizumab in combination with apatinib for refractory or metastatic oesophageal squamous cell carcinoma","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135103869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}