Environmental Epigenetics最新文献_第6页

Differential susceptibility to endocrine disruptor-induced epimutagenesis. 对内分泌干扰物诱导的突变的不同易感性。

IF 4.8

Environmental Epigenetics Pub Date : 2020-12-08 eCollection Date: 2020-01-01 DOI: 10.1093/eep/dvaa016

Jake D Lehle, John R McCarrey

{"title":"Differential susceptibility to endocrine disruptor-induced epimutagenesis.","authors":"Jake D Lehle, John R McCarrey","doi":"10.1093/eep/dvaa016","DOIUrl":"10.1093/eep/dvaa016","url":null,"abstract":"There is now considerable evidence indicating the potential for endocrine disrupting chemicals to alter the epigenome and for subsets of these epigenomic changes or \"epimutations\" to be heritably transmitted to offspring in subsequent generations. While there have been many studies indicating how exposure to endocrine disrupting chemicals can disrupt various organs associated with the body's endocrine systems, there is relatively limited information regarding the relative susceptibility of different specific organs, tissues, or cell types to endocrine disrupting chemical-induced epimutagenesis. Here we review available information about different organs, tissues, cell types, and/or cell lines which have been shown to be susceptible to specific endocrine disrupting chemical-induced epimutations. In addition, we discuss possible mechanisms that may be involved, or impacted by this tissue- or cell type-specific, differential susceptibility to different endocrine disrupting chemicals. Finally, we summarize available information indicating that certain periods of development display elevated susceptibility to endocrine disrupting chemical exposure and we describe how this may affect the extent to which germline epimutations can be transmitted inter- or transgenerationally. We conclude that cell type-specific differential susceptibility to endocrine disrupting chemical-induced epimutagenesis is likely to directly impact the extent to, or manner in, which endocrine disrupting chemical exposure initially induces epigenetic changes to DNA methylation and/or histone modifications, and how these endocrine disrupting chemical-induced epimutations can then subsequently impact gene expression, potentially leading to the development of heritable disease states.","PeriodicalId":11774,"journal":{"name":"Environmental Epigenetics","volume":"6 1","pages":"dvaa016"},"PeriodicalIF":4.8,"publicationDate":"2020-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/03/dvaa016.PMC7722801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38716578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Communicating science: epigenetics in the spotlight. 交流科学:聚光灯下的表观遗传学。

IF 3.8

Environmental Epigenetics Pub Date : 2020-11-18 eCollection Date: 2020-01-01 DOI: 10.1093/eep/dvaa015

Stephanie O M Dyke, Catherine A Ennis, Yann Joly, Jörn Walter, Reiner Siebert, Tomi Pastinen

{"title":"Communicating science: epigenetics in the spotlight.","authors":"Stephanie O M Dyke, Catherine A Ennis, Yann Joly, Jörn Walter, Reiner Siebert, Tomi Pastinen","doi":"10.1093/eep/dvaa015","DOIUrl":"https://doi.org/10.1093/eep/dvaa015","url":null,"abstract":"Given the public interest in epigenetic science, this study aimed to better understand media representations of epigenetics in national newspaper coverage in various regions in North America, Europe, and Asia. Content analysis was used to study media messages about epigenetics, their policy focus, and the balance of the reporting. We identified several recurring themes in the news reports, including policy messages relating to individual and societal responsibilities. We also found shortcomings in the media's portrayal of epigenetic science, and sought to identify potential causes by considering the underlying scientific evidence that the media reported on. A case study analysis showed that the results of epigenetic studies were often overstated in academic research publications due to common experimental limitations. We suggest that defining standardized criteria with which to evaluate epigenetic studies could help to overcome some of the challenges inherent in translating complex epigenetic research findings for non-technical audiences, and present a Press Kit template that researchers can adapt and use to aid in the development of accurate and balanced press releases.","PeriodicalId":11774,"journal":{"name":"Environmental Epigenetics","volume":"6 1","pages":"dvaa015"},"PeriodicalIF":3.8,"publicationDate":"2020-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38642804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Impact of mothers' early life exposure to low or high folate on progeny outcome and DNA methylation patterns. 母亲早期生活暴露于低或高叶酸对后代结局和DNA甲基化模式的影响

IF 3.8

Environmental Epigenetics Pub Date : 2020-11-18 eCollection Date: 2020-01-01 DOI: 10.1093/eep/dvaa018

Lundi Ly, Donovan Chan, Mylène Landry, Camille Angle, Josée Martel, Jacquetta Trasler

{"title":"Impact of mothers' early life exposure to low or high folate on progeny outcome and DNA methylation patterns.","authors":"Lundi Ly, Donovan Chan, Mylène Landry, Camille Angle, Josée Martel, Jacquetta Trasler","doi":"10.1093/eep/dvaa018","DOIUrl":"https://doi.org/10.1093/eep/dvaa018","url":null,"abstract":"The dynamic patterning of DNA and histone methylation during oocyte development presents a potentially susceptible time for epigenetic disruption due to early life environmental exposure of future mothers. We investigated whether maternal exposure to folic acid deficient and supplemented diets starting in utero could affect oocytes and cause adverse developmental and epigenetic effects in next generation progeny. Female BALB/c mice (F0) were placed on one of four amino acid defined diets for 4 weeks before pregnancy and throughout gestation and lactation: folic acid control (rodent recommended daily intake; Ctrl), 7-fold folic acid deficient, 10-fold folic acid supplemented or 20-fold folic acid supplemented diets. F1 female pups were weaned onto Ctrl diets, mated to produce the F2 generation and the F2 offspring were examined at E18.5 for developmental and epigenetic abnormalities. Resorption rates were increased and litter sizes decreased amongst F2 E18.5-day litters in the 20-fold folic acid supplemented group. Increases in abnormal embryo outcomes were observed in all three folic acid deficient and supplemented groups. Subtle genome-wide DNA methylation alterations were found in the placentas and brains of F2 offspring in the 7-fold folic acid deficient , 10-fold folic acid supplemented and 20-fold folic acid supplemented groups; in contrast, global and imprinted gene methylation were not affected. The findings show that early life female environmental exposures to both low and high folate prior to oocyte maturation can compromise oocyte quality, adversely affecting offspring of the next generation, in part by altering DNA methylation patterns.","PeriodicalId":11774,"journal":{"name":"Environmental Epigenetics","volume":"6 1","pages":"dvaa018"},"PeriodicalIF":3.8,"publicationDate":"2020-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/eep/dvaa018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38642805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Linker histone H1.5 is an underestimated factor in differentiation and carcinogenesis. 连接蛋白H1.5在分化和癌变中是一个被低估的因素。

IF 3.8

Environmental Epigenetics Pub Date : 2020-10-03 eCollection Date: 2020-01-01 DOI: 10.1093/eep/dvaa013

Marthe Behrends, Olivia Engmann

{"title":"Linker histone H1.5 is an underestimated factor in differentiation and carcinogenesis.","authors":"Marthe Behrends, Olivia Engmann","doi":"10.1093/eep/dvaa013","DOIUrl":"https://doi.org/10.1093/eep/dvaa013","url":null,"abstract":"Human histone H1.5, in mice called H1b, belongs to the family of linker histones (H1), which are key players in chromatin organization. These proteins sit on top of nucleosomes, in part to stabilize them, and recruit core histone modifying enzymes. Through subtype-specific deposition patterns and numerous post-translational modifications, they fine-tune gene expression and chromatin architecture, and help to control cell fate and homeostasis. However, even though it is increasingly implicated in mammalian development, H1.5 has not received as much research attention as its relatives. Recent studies have focused on its prognostic value in cancer patients and its contribution to tumorigenesis through specific molecular mechanisms. However, many functions of H1.5 are still poorly understood. In this review, we will summarize what is currently known about H1.5 and its function in cell differentiation and carcinogenesis. We will suggest key experiments that are required to understand the molecular network, in which H1.5 is embedded. These experiments will advance our understanding of the epigenetic reprogramming occurring in developmental and carcinogenic processes.","PeriodicalId":11774,"journal":{"name":"Environmental Epigenetics","volume":"6 1","pages":"dvaa013"},"PeriodicalIF":3.8,"publicationDate":"2020-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/eep/dvaa013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38729659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Evolution of anticipatory effects mediated by epigenetic changes 表观遗传变化介导的预期效应的进化

IF 3.8

Environmental Epigenetics Pub Date : 2020-10-02 DOI: 10.1093/eep/dvac007

Ilkka Kronholm

引用次数: 5

TCDD-induced multi- and transgenerational changes in the methylome of male zebrafish gonads. TCDD诱导的雄性斑马鱼性腺甲基组的多代和跨代变化

IF 3.8

Environmental Epigenetics Pub Date : 2020-09-27 eCollection Date: 2020-01-01 DOI: 10.1093/eep/dvaa010

Camille Akemann, Danielle N Meyer, Katherine Gurdziel, Tracie R Baker

{"title":"TCDD-induced multi- and transgenerational changes in the methylome of male zebrafish gonads.","authors":"Camille Akemann, Danielle N Meyer, Katherine Gurdziel, Tracie R Baker","doi":"10.1093/eep/dvaa010","DOIUrl":"10.1093/eep/dvaa010","url":null,"abstract":"The legacy endocrine disrupting chemical and aryl hydrocarbon receptor agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is produced as a byproduct of industrial processes and causes adverse health effects ranging from skin irritation to cancer. TCDD endpoints are also observed in subsequent, unexposed generations; however, the mechanisms of these multi- and transgenerational effects are unknown. We hypothesized an epigenetic mechanism, specifically DNA methylation for the transgenerational, male-mediated reproductive effects of developmental TCDD exposure. Using whole genome bisulfite sequencing, we evaluated DNA methylation changes in three generations of zebrafish, the first of which was exposed to TCDD during sexual development at 50 ppt for 1 h at both 3- and 7-week post-fertilization. We discovered that TCDD induces multi- and transgenerational methylomic changes in testicular tissue from zebrafish with decreased reproductive capacity, but most significantly in the indirectly exposed F1 generation. In comparing differentially methylated genes to concurrent transcriptomic changes, we identified several genes and pathways through which transgenerational effects of low level TCDD exposure are likely inherited. These include significant differential methylation of genes involved in reproduction, endocrine function, xenobiotic metabolism, and epigenetic processing. Notably, a number of histone modification genes were both differentially methylated and expressed in all generations, and many differentially methylated genes overlapped between multiple generations. Collectively, our results suggest that DNA methylation is a promising mechanism to explain male-mediated transgenerational reproductive effects of TCDD exposure in zebrafish, and these effects are likely inherited through integration of multiple epigenetic pathways.","PeriodicalId":11774,"journal":{"name":"Environmental Epigenetics","volume":"6 1","pages":"dvaa010"},"PeriodicalIF":3.8,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/90/dvaa010.PMC7660120.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38729658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational exposure to particulate air pollution exacerbates the growth phenotypes induced by preconception paternal alcohol use: a multiplex model of exposure. 妊娠期暴露于颗粒空气污染加剧了由孕前父亲饮酒引起的生长表型:多重暴露模型。

IF 3.8

Environmental Epigenetics Pub Date : 2020-09-27 eCollection Date: 2020-01-01 DOI: 10.1093/eep/dvaa011

Toriq A Mustapha, Richard C Chang, Dennis Garcia-Rhodes, Drew Pendleton, Natalie M Johnson, Michael C Golding

{"title":"Gestational exposure to particulate air pollution exacerbates the growth phenotypes induced by preconception paternal alcohol use: a multiplex model of exposure.","authors":"Toriq A Mustapha, Richard C Chang, Dennis Garcia-Rhodes, Drew Pendleton, Natalie M Johnson, Michael C Golding","doi":"10.1093/eep/dvaa011","DOIUrl":"https://doi.org/10.1093/eep/dvaa011","url":null,"abstract":"It is now clear that parental histories of drug use, toxicant exposure, and social stress all have a significant influence on the health and development of the next generation. However, the ability of epigenetic parental life memories to interact with subsequent gestational exposures and cumulatively modify the developmental trajectory of the offspring remains an unexplored perspective in toxicology. Studies from our laboratory have identified male-specific postnatal growth restriction in a mouse model of chronic, preconception paternal alcohol exposure. The goal of the current study was to determine if paternal alcohol use, before conception, could modify the susceptibility of the offspring to a completely separate exposure encountered by the mother during pregnancy. In independent experiments, we previously identified altered developmental programming and increased markers of severe asthma induced by gestational exposure to particulate air pollution. In this study, male mice were exposed to either the control or alcohol preconception treatments, then mated to naive females, which we subsequently exposed to an ultrafine mixture of particulate matter via inhalation. Individually, neither preconception paternal drinking nor gestational exposures to particulate air pollution impacted the postnatal growth of female offspring. However, when both exposures were combined, females displayed a 30% reduction in weight gain. Unexpectedly, this exposure paradigm resulted in a dramatic postnatal increase in litter loss due to maternal cannibalism, which prevented additional measures of offspring health. These preliminary studies provide evidence of a complex interplay between preconception life history and intrauterine environmental factors in the control of postnatal growth.","PeriodicalId":11774,"journal":{"name":"Environmental Epigenetics","volume":"6 1","pages":"dvaa011"},"PeriodicalIF":3.8,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/eep/dvaa011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38729657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

General anesthesia, germ cells and the missing heritability of autism: an urgent need for research. 全身麻醉、生殖细胞和自闭症遗传性的缺失：研究的迫切需要。

IF 4.8

Environmental Epigenetics Pub Date : 2020-07-18 eCollection Date: 2020-01-01 DOI: 10.1093/eep/dvaa007

Jill Escher, La Donna Ford

引用次数: 0

Transgenerational epigenetic reprogramming of early embryos: a mechanistic model. 早期胚胎的跨代表观遗传重编程:一个机制模型。

IF 3.8

Environmental Epigenetics Pub Date : 2020-07-18 eCollection Date: 2020-01-01 DOI: 10.1093/eep/dvaa009

Corrado Spadafora

{"title":"Transgenerational epigenetic reprogramming of early embryos: a mechanistic model.","authors":"Corrado Spadafora","doi":"10.1093/eep/dvaa009","DOIUrl":"https://doi.org/10.1093/eep/dvaa009","url":null,"abstract":"The notion that epigenetic information can be transmitted across generations is supported by mounting waves of data, but the underlying mechanisms remain elusive. Here, a model is proposed which combines different lines of experimental evidence. First, it has been shown that somatic tissues exposed to stressing stimuli release circulating RNA-containing extracellular vesicles; second, epididymal spermatozoa can take up, internalize and deliver the RNA-containing extracellular vesicles to oocytes at fertilization; third, early embryos can process RNA-based information. These elements constitute the building blocks upon which the model is built. The model proposes that a continuous stream of epigenetic information flows from parental somatic tissues to the developing embryos. The flow can cross the Weismann barrier, is mediated by circulating vesicles and epididymal spermatozoa, and has the potential to generate epigenetic traits that are then stably acquired in the offspring. In a broader perspective, it emerges that a natural 'assembly line' operates continuously, aiming at passing the parental epigenetic blueprint in growing embryos.","PeriodicalId":11774,"journal":{"name":"Environmental Epigenetics","volume":"6 1","pages":"dvaa009"},"PeriodicalIF":3.8,"publicationDate":"2020-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/eep/dvaa009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38185354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

DNA methylation reprogramming in medaka fish, a promising animal model for environmental epigenetics research. 环境表观遗传学研究中有前景的动物模型——medaka鱼的DNA甲基化重编程。

IF 3.8

Environmental Epigenetics Pub Date : 2020-07-07 eCollection Date: 2020-01-01 DOI: 10.1093/eep/dvaa008

Xuegeng Wang, Ramji K Bhandari

引用次数: 16