Electronic Physician最新文献

{"title":"Sequential Therapy versus Standard Triple Therapy for Helicobacter Pylori Eradication in Iran: a double-blind, randomized, placebo-controlled trial","authors":"Seyed Hamid Moosavi, H. Mahboobi, H. Dadvand","doi":"10.19082/7378","DOIUrl":"https://doi.org/10.19082/7378","url":null,"abstract":"Background and aim: Currently, different regimens are used for Helicobacter pylori eradication. The aim of this study is to compare the efficacy and safety of sequential and standard triple therapy for Helicobacter pylori eradication in Bandar Abbas in 2018. Methods: This randomized controlled trial was done on 150 patients in Bandar Abbas in 2018. Patients were randomly assigned into two groups either to receive standard triple therapy or sequential therapy for Helicobacter pylori eradication. Patients were followed for helicobacter eradication, minor and major side effects and drug intolerance. Data were analyzed using SPSS 23.0 software. Results: Two groups were similar in baseline characteristics. Helicobacter pylori eradication was reported in 70 (90.9 %) in the sequential and 54 (74 %) in the standard triple therapy group (p=0.006). Minor side effects were reported in 20 (26 %) in the sequential and 36 (49.3 %) in the standard triple therapy (p=0.003). Major side effects (p=0.142) and drug intolerance (p=0.480) were similar in both groups. Conclusion: Sequential therapy is more effective and has lower rate of minor complications in eradication of Helicobacter pylori. Trial registration: The protocol of study was registered at the Iranian Registry of Clinical Trials (IRCT) with ID number of IRCT20180131038581N2. Funding: Hormozgan University of Medical Sciences, thesis number: 93-95/231","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49641761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Development of Bullous Pemphigoid in a Known Case of Psoriasis Vulgaris: a case report","authors":"Yousef Abuhaimed, Alaa Salem Alshamsy, Sarah Albreiki, Khalid Saleh Alkarawi","doi":"10.19082/7386","DOIUrl":"https://doi.org/10.19082/7386","url":null,"abstract":"Introduction: The development of Bullous pemphigoid (BP) in a patient with Psoriasis vulgaris (PV) is rare, as Bullous pemphigoid affects a different age group and its cause is not related to psoriasis. The cause of coexistence between the two diseases is still not clear and requires more reporting and review. Case Presentation: Here, we report a case of a 55-year-old woman with a 22-year history of Psoriasis vulgaris who developed itching and blisters to all four limbs around the scaly plaques of PV. Biopsy of the lesion revealed sub-epidermal bullae and an eosinophilic inflammatory infiltrate. Immunofluorescence microscopy showed linear C3 deposition at the basement membrane zone, and the condition was diagnosed as Bullous pemphigoid. Treatment in such conditions varies among reported cases, and includes methotrexate, cyclosporine, dapsone, azathioprine, and others. In this case, methotrexate was suggested but because patient could not tolerate the course of methotrexate she was started on a combination therapy of cyclosporine 100 mg PO twice daily and tetracycline PO 500 mg PO Q 6 hourly. Both conditions showed significant improvement within 4 weeks. Take-away lesson: As the cause of the concurrence is still unclear, the correct management for such cases still vary. The case report highlighted our experience to benefit dermatologists and physicians, with one therapeutic regimen that can benefit patients who cannot tolerate methotrexate due to its side effects.","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44713320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Mindfulness-based Stress Reduction in Hemodialysis Patients with Anxiety and Depression: a randomized, double-blind, parallel-group trial","authors":"Mostafa Haghshenas, Fatemeh Assarian, A. Omidi, Mohammadreza Razaghof, H. Rahimi","doi":"10.19082/7370","DOIUrl":"https://doi.org/10.19082/7370","url":null,"abstract":"Background: Diseases with a chronic and debilitating nature, such as chronic kidney disease, are frequently associated with psychiatric disorders like anxiety and depression. Objective: To assess the efficacy of mindfulness-based stress reduction (MBSR) on anxiety and depression in hemodialysis patients. Methods: In this randomized clinical trial, fifty hemodialysis patients were selected from two dialysis centers of Kashan city in Iran in 2016. The patients had desired cognitive status based on MMSE (Mini Mental Status Examination) and clinical interview, and were randomly allocated into the intervention and control groups. The intervention group (n=25) received a Mindfulness-Based Stress Reduction (MBSR) program in addition to the health education program in eight sessions, whereas the control group (n=25) received only the health education program. To measure the anxiety and depression score before and after study, the Hospital Anxiety and Depression Scale were used. Data were analyzed by SPSS version 11.5, using Analysis of Covariance (ANCOVA), t-test, Chi-square, Mann-Whitney U, and Fisher exact test. Results: The mean age of intervention and control groups were 46.86±11.66 and 46.26±11.71 respectively. The mean duration of illness was 2.47±1.78 and 2.62±1.32 in intervention and control groups respectively. There were no significant differences between the two groups regarding age, sex, education level and job. Depression and anxiety were reduced in the intervention group compared with the control group (p=0.0001). Conclusions: The MBSR program may reduce anxiety and depression in hemodialysis patients. Funding: This study was financially supported by the Deputy of Research, Kashan University of Medical Sciences, Kashan, Iran (Ref: 9436). Clinical Trial Registration: The protocol of study was registered at the Iranian Registry of Clinical Trials (IRCT) with ID number of IRCT2015081723652N1.","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47095337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitude towards basic life support among primary health care physicians in Taif, Saudi Arabia, in 2018: a regression analysis","authors":"M. Albaqami, Hani Abozaid","doi":"10.19082/7415","DOIUrl":"https://doi.org/10.19082/7415","url":null,"abstract":"","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45741008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genistein elicits its anticancer effects through up-regulation of E-Cadherin in Acute Lymphoblastic Leukemia (ALL) cells: an in vitro experimental study","authors":"Vahideh Namordizadeh, K. Malekzadeh, S. Ebrahimi","doi":"10.19082/7391","DOIUrl":"https://doi.org/10.19082/7391","url":null,"abstract":"","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48068946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxicity and radiosensitizing effect of wogonin, an extract from Scutellaria litwinowii, in head and neck squamous cell carcinoma line HN5","authors":"Z. Asli, Mahnaz Nourbakhsh, S. Mousavi, Solmaz Pourgonabadi, A. Fanipakdel","doi":"10.19082/7355","DOIUrl":"https://doi.org/10.19082/7355","url":null,"abstract":"Background: Radiotherapy is one of the most prominent techniques used in cancer therapy. However, efforts for finding new effective radiosensitizers in improvement of radiotherapy efficacy have been continued yet. Wogonin is a natural flavonoid from Scutellaria litwinowii with known cytotoxic effects in some cancer cells. Objective: To determine the potential of radiosensitizer effects of wogonin in a head and neck cancer cell line (HN5). Methods: This study was carried out in Omid Hospital and Herbal Medicine Research Center (Mashhad, Iran). HN5 cells were cultured in DMEM medium and incubated with different concentrations of wogonin (25-500 μg/ml) and were exposed to (2-10 Gray [Gy]) γ-rays. Cell viability was quantified by MTT assay in wogonin cytotoxicity assay after 24, 48 and 72 hours and in coincident radiation and wogonin therapy after 72 hours. Data were analyzed by performing one-way ANOVA in SPSS (V.16). P-value ≤ 0.05 was considered significant. Results: Wogonin decreased cell viability in HN5 cells as a timeand concentration-dependent manner. Wogonin could also enhance radiation-induced toxicity. For instance, while cell viability percentage in separate administration of wogonin (100 μM) and radiation (2 Gy) was significantly decreased to 53.98±2.76 and 74.97±1.05 respectively (p<0.001), wogonin 100 μM concurrent with 2 Gy radiation decreased the percentage of cell viability to 33.29±1.76 (p<0.001). Conclusion: Concurrent use of wogonin and radiation increased radiation sensitivity and cell death in HN5 cells. Therefore, wogonin is a good radiosensitizer candidate for more study.","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45285566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic metastasis from colorectal cancer, seven procedures and five recurrences, when to stop? A Case report","authors":"M. Alharthi, A. Alzahrani, Shaikhah A-Jumaiah, Mohammed S. Alqahtani","doi":"10.19082/7364","DOIUrl":"https://doi.org/10.19082/7364","url":null,"abstract":"Introduction: Colorectal cancer commonly metastasizes to the liver. Patients treated by metastasectomy gain a longer overall survival and progression-free survival than those patients treated by radiofrequency ablation. Case presentation: This paper reports the case of a 58-year-old male who presented with constipation, bleeding per rectum and weight loss. Colonoscopy showed rectosigmoid mass, and an MRI of the abdomen and pelvis revealed that there was a circumferential polypoidal rectal soft tissue mass involving the upper half of the rectum extending approximately 8 cm in the longitudinal length to the retro-sigmoid junction and 9 cm from the anal verge. It showed local extension to the mesorectal fat with significant invasion to the mesorectal fascia anteriorly. The lesion did not extend to the scrotum, prostate or urinary bladder. Multiple mesorectal lymph node and multiple foci lesions were seen in the liver, suggesting metastasis. The patient was staged as T3N2M1. After that, lower anterior resection with diversion ileostomy and intraoperative radiofrequency ablation of segment IVa and resection of IVb segment was done. From 2013 to 2017 the patient had multiple procedures: right hepatectomy, resection of segment II and IVA, alcohol ablation of segment II, microwave ablation through US guided for segment II and wedge resection in segment IV respectively. Six weeks later, the patient was looking well with normal liver function tests. Resection offers the greatest possibility of cure for patients with liver-isolated colorectal cancers, with 5-year survival rates of 25-58%. Take-away lesson: The overall clinical importance of this case report is to show how repeated liver resection improves the quality of life.","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68387033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between clusters of anxiety and psychosomatic disorder with lifestyle habits in children and adolescents: the CASPIAN-V study","authors":"S. Daniali, Roya Riahi, Majzoubeh Taheri, Tahereh Aminaei, R. Heshmat, M. Qorbani, R. Kelishadi","doi":"10.19082/7314","DOIUrl":"https://doi.org/10.19082/7314","url":null,"abstract":"Background: Anxiety and psychosomatic disorders are the most common mental health problems among children and adolescents. Such disorders could have negative effects on lifestyle habits. Objective: To examines the clustering of anxiety and psychosomatic disorders in Iranian children and adolescents, and its association with their lifestyles. Methods: This cross-sectional survey was conducted as the fifth survey of a national school-based program in Iran in 2015. Participants were 14,400 students, aged 7 to 18 years old, who were selected by a multi-stage cluster random sampling method, from 30 provinces across the country. Data were obtained from a World Health Organization–Global Student Health Survey questionnaire (WHO-GSHS). A two-step cluster analysis was performed and clusters of anxiety and psychosomatic disorder were identified. The logistic regression model was applied to predict the association between identified clusters and lifestyle variables including dietary habits, sedentary behavior, and sleep duration. The reference category of this model was considered as clusters including students with low anxiety and low psychosomatic disorder symptoms. In order to determine the relation between demographic characteristics and other variables with lifestyle habits in identified clusters, one-way analysis of variance (ANOVA) and Pearson Chi-square tests were used. Analyses were performed in SPSS v 18 (PASW Statistics for Windows). The statistical significance level was set at p<0.05. Results: The mean (SD) of the age of the participants was 12.29 (3.15). The prevalence of high anxiety with recurrent mental disorders was 20.4%. This group of students had a higher frequency of sadness than other students did (43.8% vs. 25.8%, p<0.001). They had a higher frequency of prolonged screen time (>2 hr/day) (OR: 2.00, 95% CI: 1.79 2.24), skipping breakfast (OR: 1.83; 95% CI:1.59-2.11), as well as daily consumption of Electronic physician Page 7315 candy (OR: 1.15; 95% CI: 1.001-1.31), salty snacks (OR: 1.81, 95% CI: 1.52-2.16), and soft drinks (OR: 6.68, 95% CI: 4.86-9.18). Moreover, they had a lower frequency of consuming fruits/vegetables (OR: 0.79, 95% CI: 0.69-0.88) and milk (OR: 0.76, 95% CI: 0.69-0.84) than their counterparts. Conclusion: This study showed that risk of unhealthy lifestyle behaviors in children and adolescents with high anxiety and psychosomatic disorders higher than others, should be considered in health promoting programs.","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43989173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of lifestyle training on serum lipids of children and adolescents with dyslipidemia: a quasi-experimental study","authors":"A. Yaghoobi, F. Taheri, Marjan Farzad, T. Kazemi","doi":"10.19082/7348","DOIUrl":"https://doi.org/10.19082/7348","url":null,"abstract":"Background: Dyslipidemia is one of the most important risk factors for cardiovascular diseases. It can cause a rise in the incidence of these diseases in adulthood. Lifestyle modification is a determinant factor for incidence, prognosis and complications of cardiovascular diseases. Objective: The aim of the study was to evaluate the effect of lifestyle modification on serum lipids of children and adolescents with dyslipidemia. Methods: This quasi-experimental study (before and after design) was conducted on all dyslipidemia children and adolescents with dyslipidemia referred to the cardiovascular diseases research center of Birjand University of Medical Sciences (Iran) in 2015. Participants underwent 6 sessions of training, appropriate to their age, including fat definition and healthy lifestyle. Before the study and 6 months after trainings, in the same circumstances, subjects were examined for level of blood lipids and blood pressure. Data were analyzed using paired-samples ttest, Pearson correlation coefficient, and independent-samples t-test. P-value of less than 0.05 was considered statistically significant. Results: This study was performed on 50 children with dyslipidemia, of whom 52% were female and 48% were male. The mean age of participants was 12.77±1.84 years. The study showed a significant difference between the mean of cholesterol (p<0.001) and LDL (p=0.008) before and after the study. Comparing the changes made in the mean of variables such as FBS, Cholesterol, TG, HDL and LDL as a result of gender-based lifestyle modification, no significant difference between the two sexes was seen (p>0.05). Pearson correlation coefficient showed no significant relationship between the mean of these variables in children as a result of lifestyle modification and their age (p>0.05). Conclusion: Lifestyle modification relying on exercise and physical activity, nutrition and sufficient sleep and rest can be effective as a non-pharmacological supplement in reducing blood lipids and dyslipidemia. Lifestyle modification training is essential for both children and their parents after diagnosis of dyslipidemia as a part of the Therapeutic plan.","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48383666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of digital device usage and its related health effects on elementary and middle school students: an instrument development and regression analysis","authors":"Abdullah Alamri, N. Alhibshi, Majed Alnefaie, Wejdan S Alzhrani, Adel Almaymuni, Mahmoum Mosli","doi":"10.19082/7333","DOIUrl":"https://doi.org/10.19082/7333","url":null,"abstract":"Background: The use of digital devices has increased tremendously during recent years in Saudi Arabia. Many concerns were raised about the safety of this technology. Objective: To develop an instrument for determining the pattern of use of digital devices, and to investigate the link between the use of digital devices and visual symptoms among students of general education schools. Methods: This cross-sectional study was carried out from the beginning of April 2017 to the end of September 2017 among students of general education schools in the Western region of Saudi Arabia. The study sample included 475 randomly selected participants. A self-administered questionnaire was used for data collection. The questionnaire had two parts: the first part was about personal information of the study participants, while the second part was about the pattern of use of digital devices, associated visual complaints after use, and recommendations to decrease visual health hazards. IBM-SPSS version 22 was used to conduct the statistical analysis. Logistic regression analysis was used to examine associations with visual and muscular complaints; odds ratios with 95% confidence intervals were generated. Chi square goodness-of-fit test was used to compare categorical variable frequencies across different groups. A p-value of < 0.05 was considered statistically significant. Results: A total of 475 students completed the questionnaire. Nearly half the respondents were males aged more than 19 years old (p<0.001). Most respondents attended secondary schools (p<0.001). Most users experienced neck or shoulder pain (n=305, 64.2%, p<0.001), followed by headaches (n=301, 63.4%, p<0.001), and visual disturbances (n = 275, 57.9%, p=0.001). The majority of students used cellular phones or tablets (n=389, 83.8%). Half the respondents spent more than 4 hours daily using digital devices (p<0.001) and had 2 or more devices. Most students agreed that decreasing the duration of usage (n=217, 45.7%) and scheduling hours (n=214, 45.1%) are the best solutions to decrease the health hazards of digital devices. Logistic regression analysis identified female gender (OR: 2.8, 95% CI: 1.6-4.8, p<0.001) and exposure to digital devices for more than 2 hours per day (OR: 2.9, 95% CI: 1.4-6.3, p=0.006) as significant predictors of symptoms. Conclusion: A significant proportion of school students were aware that prolonged use of digital devices is associated with visual and muscular complaints. Females and individuals spending more than 2 hours a day using these devices are more prone to visual and muscular complaints. Decreasing the hours of usage is necessary to avoid digital device-related health risks.","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47002394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}