Drug Safety - Case Reports最新文献

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Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series 他汀类药物治疗期间的情绪、性格和行为改变:一个病例系列
Drug Safety - Case Reports Pub Date : 2015-12-29 DOI: 10.1007/s40800-015-0024-2
S. Cham, H. J. Koslik, B. Golomb
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引用次数: 50
Post-Menopausal Vaginal Hemorrhage Related to the Use of a Hop-Containing Phytotherapeutic Product 绝经后阴道出血与使用含有啤酒花的植物治疗产品有关
Drug Safety - Case Reports Pub Date : 2015-12-01 DOI: 10.1007/S40800-015-0016-2
F. Hunsel, S. Koppel, E. Puijenbroek
{"title":"Post-Menopausal Vaginal Hemorrhage Related to the Use of a Hop-Containing Phytotherapeutic Product","authors":"F. Hunsel, S. Koppel, E. Puijenbroek","doi":"10.1007/S40800-015-0016-2","DOIUrl":"https://doi.org/10.1007/S40800-015-0016-2","url":null,"abstract":"","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89544467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Enoxaparin-Induced Liver Injury: Case Report and Review of the Literature and FDA Adverse Event Reporting System (FAERS). 依诺肝素诱发的肝损伤:病例报告、文献综述和 FDA 不良事件报告系统 (FAERS)。
Drug Safety - Case Reports Pub Date : 2015-12-01 DOI: 10.1007/s40800-015-0018-0
Katherine J Hahn, Shannon J Morales, James H Lewis
{"title":"Enoxaparin-Induced Liver Injury: Case Report and Review of the Literature and FDA Adverse Event Reporting System (FAERS).","authors":"Katherine J Hahn, Shannon J Morales, James H Lewis","doi":"10.1007/s40800-015-0018-0","DOIUrl":"10.1007/s40800-015-0018-0","url":null,"abstract":"<p><p>Anticoagulants are a well known cause of drug-induced liver injury (DILI). We recently encountered a 45-year-old male who developed DILI during treatment with enoxaparin, a low-molecular-weight heparin (LMWH), for dural venous thrombosis. The man received enoxaparin 80 mg subcutaneously, twice daily. After 4 days, the patient was asymptomatic but he developed liver aminotransferase elevations: AST 340 U/L and ALT 579 U/L. Investigation revealed an R ratio of 19.9 by day 5 and a Roussel Uclaf Causality Assessment Method score of 10, giving a high probable likelihood that enoxaparin was the cause of hepatic injury. Enoxaparin was discontinued on day 7, and 1 week later AST and ALT had decreased to 61 and 273 U/L, respectively. This case prompted a literature search and a review of the FDA Adverse Event Reporting System (FAERS) database for the range of hepatic adverse events (HAEs) associated with this class. A MEDLINE/PubMed search was conducted using DILI terms and cross-referenced with the anticoagulant classes. A Freedom of Information Act (FOIA) request was also made to identify adverse events (AEs) associated with enoxaparin in FAERS. Case type, severity of outcome, and demographic information were analyzed. Five publications have reported DILI with enoxaparin. Trial data found elevations in ALT >3 times the upper limit of normal (ULN) for unfractionated heparins (UFH) and LMWH in 8 and 4-13 % of subjects, respectively. However, liver injury in all cases was mild, self-limited, and asymptomatic. Our FOIA request yielded 8336 adverse events related to enoxaparin over a 14-year period (Jan 2000-Sept 2014). Specific HAEs were found in 4 % of reports, but all were described with other serious adverse events. The reported outcomes of hospitalization (75 %), death (17 %), and life-threatening medical events (5 %) were likely due to other related serious adverse events such as hemorrhage (28 %) and thrombocytopenia (11 %). We conclude that LMWH-related liver injury is uncommon and reversible. The mechanism of liver injury is not known, although an idiosyncratic effect is postulated. Although the FAERS database lists hepatic injury in 4 % of all enoxaparin-related AEs, it appears that serious outcomes are related to non-hepatic events.</p>","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88440675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accidental Overdose of Oral Cyclosporine in Haematopoietic Stem Cell Transplantation: A Case Report and Literature Review 造血干细胞移植中意外过量口服环孢素一例报告及文献复习
Drug Safety - Case Reports Pub Date : 2015-12-01 DOI: 10.1007/s40800-015-0023-3
A. Tafazoli
{"title":"Accidental Overdose of Oral Cyclosporine in Haematopoietic Stem Cell Transplantation: A Case Report and Literature Review","authors":"A. Tafazoli","doi":"10.1007/s40800-015-0023-3","DOIUrl":"https://doi.org/10.1007/s40800-015-0023-3","url":null,"abstract":"","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74280634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Status Epilepticus and Delirium Associated with Ertapenem in a Very Elderly Patient with Chronic Kidney Disease and Silent Ischaemic Cerebrovascular Disease 厄他培南治疗老年慢性肾病和无症状缺血性脑血管病患者的癫痫持续状态和谵妄
Drug Safety - Case Reports Pub Date : 2015-11-23 DOI: 10.1007/s40800-015-0021-5
Huimin Lin, S. Chew
{"title":"Status Epilepticus and Delirium Associated with Ertapenem in a Very Elderly Patient with Chronic Kidney Disease and Silent Ischaemic Cerebrovascular Disease","authors":"Huimin Lin, S. Chew","doi":"10.1007/s40800-015-0021-5","DOIUrl":"https://doi.org/10.1007/s40800-015-0021-5","url":null,"abstract":"","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83042460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Colchicine-Induced Acute Neuromyopathy in a Patient Using Concomitant Fluconazole: Case Report and Literature Review 合用氟康唑致秋水仙碱急性神经肌病1例报告及文献复习
Drug Safety - Case Reports Pub Date : 2015-11-05 DOI: 10.1007/s40800-015-0020-6
Yi-Chia Su, Chih-Chien Wu
{"title":"Colchicine-Induced Acute Neuromyopathy in a Patient Using Concomitant Fluconazole: Case Report and Literature Review","authors":"Yi-Chia Su, Chih-Chien Wu","doi":"10.1007/s40800-015-0020-6","DOIUrl":"https://doi.org/10.1007/s40800-015-0020-6","url":null,"abstract":"","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86144687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
A Suspected Case of Efavirenz-Induced Stevens–Johnson Syndrome 一例疑似依非韦伦诱发的史蒂文斯-约翰逊综合征
Drug Safety - Case Reports Pub Date : 2015-09-24 DOI: 10.1007/s40800-015-0019-z
Sabyasachi Paik, Agnik Pal, S. Sen, Netai Pramanick, S. Tripathi
{"title":"A Suspected Case of Efavirenz-Induced Stevens–Johnson Syndrome","authors":"Sabyasachi Paik, Agnik Pal, S. Sen, Netai Pramanick, S. Tripathi","doi":"10.1007/s40800-015-0019-z","DOIUrl":"https://doi.org/10.1007/s40800-015-0019-z","url":null,"abstract":"","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74258441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
High-Dose Verapamil in Episodic and Chronic Cluster Headaches and Cardiac Adverse Events: Is It as Safe as We Think? 大剂量维拉帕米治疗阵发性和慢性丛集性头痛和心脏不良事件:它像我们想象的那样安全吗?
Drug Safety - Case Reports Pub Date : 2015-08-28 DOI: 10.1007/s40800-015-0015-3
J. Alexandre, X. Humbert, M. Sassier, P. Milliez, A. Coquerel, S. Fédrizzi
{"title":"High-Dose Verapamil in Episodic and Chronic Cluster Headaches and Cardiac Adverse Events: Is It as Safe as We Think?","authors":"J. Alexandre, X. Humbert, M. Sassier, P. Milliez, A. Coquerel, S. Fédrizzi","doi":"10.1007/s40800-015-0015-3","DOIUrl":"https://doi.org/10.1007/s40800-015-0015-3","url":null,"abstract":"","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74173444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Citalopram-Induced Long QT Syndrome and the Mammalian Dive Reflex 西酞普兰诱发的长QT综合征与哺乳动物潜水反射
Drug Safety - Case Reports Pub Date : 2015-08-01 DOI: 10.1007/s40800-015-0013-5
F. Vincenzi, P. Lunetta
{"title":"Citalopram-Induced Long QT Syndrome and the Mammalian Dive Reflex","authors":"F. Vincenzi, P. Lunetta","doi":"10.1007/s40800-015-0013-5","DOIUrl":"https://doi.org/10.1007/s40800-015-0013-5","url":null,"abstract":"","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72883165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Postoperative Bleeding After Administration of a Single Dose of Rivaroxaban to a Patient Receiving Antiretroviral Therapy 接受抗逆转录病毒治疗的患者单剂量利伐沙班术后出血
Drug Safety - Case Reports Pub Date : 2015-08-01 DOI: 10.1007/s40800-015-0014-4
C. Corallo, Louise Grannell, Huyen A Tran
{"title":"Postoperative Bleeding After Administration of a Single Dose of Rivaroxaban to a Patient Receiving Antiretroviral Therapy","authors":"C. Corallo, Louise Grannell, Huyen A Tran","doi":"10.1007/s40800-015-0014-4","DOIUrl":"https://doi.org/10.1007/s40800-015-0014-4","url":null,"abstract":"","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79148343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 56
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