Drug Safety - Case Reports最新文献_第5页

Hazardous Drug Diversion of Valproate from a General Practitioner to his Patient's Dog. 一名全科医生将丙戊酸钠转用于病人的狗身上，造成危险。

Drug Safety - Case Reports Pub Date : 2017-12-01 DOI: 10.1007/s40800-017-0050-3

Pierre-Marie Morice, Joachim Alexandre, Alexandre Cesbron, Marion Sassier, Sophie Fedrizzi, Xavier Humbert

引用次数: 0

Urticarial Reaction to Ustekinumab During the Treatment of Plaque Psoriasis in a Hepatitis C-Positive Patient. 在丙型肝炎阳性患者治疗斑块型银屑病期间，Ustekinumab的荨麻疹反应。

Drug Safety - Case Reports Pub Date : 2017-12-01 DOI: 10.1007/s40800-017-0051-2

Christopher H Chu, Charles Davis

{"title":"Urticarial Reaction to Ustekinumab During the Treatment of Plaque Psoriasis in a Hepatitis C-Positive Patient.","authors":"Christopher H Chu, Charles Davis","doi":"10.1007/s40800-017-0051-2","DOIUrl":"https://doi.org/10.1007/s40800-017-0051-2","url":null,"abstract":"A 62-year-old white woman with a history of hepatitis C and type 2 diabetes mellitus developed urticaria during treatment with ustekinumab for plaque psoriasis. The patient received two 45-mg ustekinumab injections in her first 2 months and then one 45-mg injection every 3 months for her psoriasis. After 10 months, she developed a round red rash on her skin diffusely on her body. She also complained of joint pain in her hands. Rheumatology became involved, and investigations revealed that her antinuclear antibody titer was negative, but her rheumatoid factor, erythrocyte sedimentation rate, and liver function enzymes were elevated. She was diagnosed with urticaria, and ustekinumab was discontinued. A Naranjo assessment score of 6 was obtained, indicating a probable relationship between the patient's urticaria and her use of ustekinumab. Ustekinumab was subsequently discontinued, and the patient received a course of Harvoni® (Gilead Sciences, Inc., Forest City, California, United States) (ledispasvir/sofosbuvir) with clearance of the hepatitis C virus. The patient is currently receiving another biologic agent, ixekizumab, and reports no complaints, including that of urticaria.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"4 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-017-0051-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35142165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Psychomotor Agitation Following Treatment with Hydroxychloroquine. 羟氯喹治疗后精神运动性躁动。

Drug Safety - Case Reports Pub Date : 2017-12-01 DOI: 10.1007/s40800-017-0048-x

Ciro Manzo, Pietro Gareri, Alberto Castagna

{"title":"Psychomotor Agitation Following Treatment with Hydroxychloroquine.","authors":"Ciro Manzo, Pietro Gareri, Alberto Castagna","doi":"10.1007/s40800-017-0048-x","DOIUrl":"https://doi.org/10.1007/s40800-017-0048-x","url":null,"abstract":"We describe the case of an elderly woman with elderly-onset rheumatoid arthritis, where the use of 4 mg/kg/day of hydroxychloroquine (HCQ) was followed by the onset of psychomotor agitation with marked physical and verbal violence towards her partner, including throwing objects at her partner. No disturbance in sleep and no anxiety, nervousness, or irritability had emerged before the onset of her psychomotor agitation. The disappearance of agitation following targeted pharmacologic intervention and HCQ interruption, its re-onset after reintroduction of the drug, and the high score (9) of Naranjo's algorithm are surely linked to the existence of a causal relationship between HCQ and psychomotor agitation. HCQ may produce undesirable effects on the central nervous system, mainly irritability, nervousness, emotional changes, and nightmares. To the best of our knowledge, there are only a few case reports of psychosis due to HCQ. No favoring condition such as pharmacokinetic interactions or a personal and family psychiatric history was present in our patient. The neuropsychiatric manifestations we observed could be considered a bizarre-type adverse drug reaction linked to an individual's hypersensitivity.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"4 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-017-0048-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34780973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Reversible Hypokalemia and Bartter-Like Syndrome during Prolonged Systemic Therapy with Colistimethate Sodium in an Adult Patient. 1例成人患者长时间全身治疗时的可逆性低钾血症和巴特样综合征。

Drug Safety - Case Reports Pub Date : 2017-12-01 DOI: 10.1007/s40800-017-0052-1

Tarek Kamal Eldin, Grazia Tosone, Alfredo Capuano, Raffaele Orlando

引用次数: 5

Atypical Fracture of the Sternum After Long-Term Alendronate Plus Cholecalciferol Treatment: A Case Report. 长期阿仑膦酸钠加胆骨化醇治疗后发生非典型胸骨骨折1例。

Drug Safety - Case Reports Pub Date : 2017-12-01 DOI: 10.1007/s40800-017-0046-z

Luis H Martín Arias, Pilar García Ortega, María Sáinz Gil, Ester Navarro García, Carlos Treceño Lobato, Virginia Delgado Armas

{"title":"Atypical Fracture of the Sternum After Long-Term Alendronate Plus Cholecalciferol Treatment: A Case Report.","authors":"Luis H Martín Arias, Pilar García Ortega, María Sáinz Gil, Ester Navarro García, Carlos Treceño Lobato, Virginia Delgado Armas","doi":"10.1007/s40800-017-0046-z","DOIUrl":"https://doi.org/10.1007/s40800-017-0046-z","url":null,"abstract":"A 55-year-old woman developed an atraumatic sternum fracture during treatment with alendronate for osteoporosis. The woman received alendronate 70 mg in combination with cholecalciferol 5600 IU once weekly, as well as nonsteroidal anti-inflammatory drugs. After 4 years of treatment, following a dorsal flexion with no direct thoracic trauma, the patient suffered a fracture of the sternum, with an X-ray revealing sternal body fracture. This fracture was seen to be transverse, noncomminuted and without displacement. Magnetic resonance imaging was carried out to rule out the presence of either a pathological fracture or a fracture resulting from osteoporotic fragility, and showed a triple sternal fracture involving the body, as well as the upper and lower manubrium of the sternum. This fracture presented the features of an atypical femur fracture, except for the location. The alendronate and cholecalciferol combination was discontinued and denosumab was prescribed. After the withdrawal of alendronate, the patient showed clinical improvement, with a decrease in pain, and is currently having routine checkups. The causality algorithm of the Spanish Pharmacovigilance System shows a score of 5, indicating a possible relationship between the patient's sternum fracture and her use of the suspect drug (Naranjo scale 6 = probable).","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"4 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-017-0046-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34772907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle Injury After Intramuscular Administration of Diclofenac: A Case Report Supported by Magnetic Resonance Imaging. 双氯芬酸肌注后肌肉损伤:1例磁共振成像支持。

Drug Safety - Case Reports Pub Date : 2017-12-01 DOI: 10.1007/s40800-017-0049-9

Mareike Probst, Jens-Peter Kühn, Christiane Modeß, Eberhard Scheuch, Anne Seidlitz, Norbert Hosten, Werner Siegmund, Werner Weitschies

{"title":"Muscle Injury After Intramuscular Administration of Diclofenac: A Case Report Supported by Magnetic Resonance Imaging.","authors":"Mareike Probst, Jens-Peter Kühn, Christiane Modeß, Eberhard Scheuch, Anne Seidlitz, Norbert Hosten, Werner Siegmund, Werner Weitschies","doi":"10.1007/s40800-017-0049-9","DOIUrl":"https://doi.org/10.1007/s40800-017-0049-9","url":null,"abstract":"Intramuscular injection of diclofenac is still frequently practiced, although there is ample evidence that the risk of local tissue intolerability is highly underestimated. The aim of this study was to evaluate local toxicity in a patient using magnetic resonance imaging. A patient who gave written informed consent received a medically indicated intramuscular administration of diclofenac 75 mg/2 mL. Simultaneously with magnetic resonance imaging of the depot, a clinical-chemical evaluation and quantification of diclofenac in plasma was performed. A manifold enhancement of the T2-weighted magnetic resonance signal was observed in a muscle area of approximately 60 mL volume, with maximum signal intensity 30 min after injection, the time of maximum diclofenac plasma exposure. Plasma creatine kinase activity was elevated approximately sixfold within 8 h and normalized within 1 week, whereas the magnetic resonance enhancement disappeared within 5 weeks. Interestingly, the patient did not complain about any clinical symptoms at the injection site. Asymptomatic tissue injury after intramuscular injection of diclofenac, caused by intramuscular dosing, can be reliably evaluated by magnetic resonance imaging and should be applied early during the development of parenteral dosage forms. Clinical Trials Registration Number: BB130/16 (Ethics Committee of the University Medicine Greifswald).","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"4 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-017-0049-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34855791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Salicylate Intoxication in an Infant: A Case Report. 婴儿水杨酸中毒1例报告。

Drug Safety - Case Reports Pub Date : 2017-11-27 DOI: 10.1007/s40800-017-0065-9

Rita Espírito Santo, Sara Vaz, Filipa Jalles, Leonor Boto, Francisco Abecasis

引用次数: 3

Are Hypomanic/Manic Episodes "Induced by" or "Associated with" Quetiapine Initiation? 轻躁狂/躁狂发作是由喹硫平引发的还是与喹硫平相关的?

Drug Safety - Case Reports Pub Date : 2017-11-25 DOI: 10.1007/s40800-017-0063-y

Rami Bou Khalil

引用次数: 0

Acknowledgement to Referees 致推荐人的确认函

Drug Safety - Case Reports Pub Date : 2017-11-25 DOI: 10.1007/s40800-017-0064-x

S. Albayrak, Neslihan Takmaz, A. Ciravoğlu, D. Celikdemir, Derya Adıgüzel, Doğan Altuner, Ebru Esendemirli, Emel Yarimoglu, Engin Ayvaz, Gökay Özerim, Gökçe Özdemir, G. E. Tosun, İlker Kahraman, Jan Jonker, Janusz Reichel, K. Çalıyurt, Michael Haase, Okan Tuna, Øyvind Ihlen, Ömer Baybars Tek, Ömür Özmen, Özge Can, S. Idowu, Yunus Emre Özer, Z. Toprak

引用次数: 0

Tachon Syndrome: Rare Side Effect of Articular Injections of Corticosteroids. A Report of Two Cases. 速子综合征:关节注射皮质类固醇的罕见副作用。两例报告

Drug Safety - Case Reports Pub Date : 2017-11-24 DOI: 10.1007/s40800-017-0062-z

Sonia Rekik, Soumaya Boussaid, Hedia Ben Abla, Ilhem Cheour, Med Ben Amor, Med Elleuch

{"title":"Tachon Syndrome: Rare Side Effect of Articular Injections of Corticosteroids. A Report of Two Cases.","authors":"Sonia Rekik, Soumaya Boussaid, Hedia Ben Abla, Ilhem Cheour, Med Ben Amor, Med Elleuch","doi":"10.1007/s40800-017-0062-z","DOIUrl":"https://doi.org/10.1007/s40800-017-0062-z","url":null,"abstract":"Epidural or intra-articular injections of corticosteroids are an option for the treatment of several pain conditions but are not without adverse effects. Here, we discuss a rare systemic side effect of this therapy: Tachon syndrome. We report two cases, a 64-year-old woman and a 43-year-old man, who presented with Tachon syndrome after receiving, respectively, a shoulder and a lumbar injection of cortivazol 3.75 mg/1.5 ml suspension for injection in pre-filled syringes. The indication for this therapy was, respectively, tendinopathy of the supraspinatus and a mechanical L5 lumbosciatica. A few minutes after receiving the injection, patients experienced acute low back pain, chest tightness, facial erythema and profuse sweating. All vital and biologic parameters were normal. In the first case, improvement was spontaneous and all symptoms resolved in 20 min. The second patient remained under observation and received an intravenous 'physiological' infusion. Both patients recovered fully and returned home. A causal relationship between the corticosteroid injections and the patients' symptoms was very likely because of the acute clinical presentation and the rapid improvement in the patients' conditions and that no further signs indicating other serious complications developed.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"4 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2017-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-017-0062-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35640583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6