Diving and hyperbaric medicine最新文献

{"title":"Hyperbaric oxygen therapy for acute idiopathic sudden sensorineural hearing loss; a systematic review with meta-analysis.","authors":"Annemarie Newth, Matthias Perleth, Susannah Sherlock, Lorena Romero, Michael H Bennett","doi":"10.28920/dhm55.4.398-406","DOIUrl":"10.28920/dhm55.4.398-406","url":null,"abstract":"<p><strong>Introduction: </strong>Idiopathic sudden sensorineural hearing loss (ISSHL) is hearing loss of unknown cause with greater than 30 dB loss over 72 hours or less across three consecutive frequencies. Hyperbaric oxygen therapy (HBOT) is a widely accepted treatment for this condition. HBOT protocols and outcomes measured vary between studies.</p><p><strong>Methods: </strong>To update a systematic review with meta-analysis of relevant randomised trials to both quantify and estimate the quality of evidence to support or refute the use of HBOT for ISSHL. We followed the Cochrane Handbook for Systematic Reviews of Interventions methodology. We conducted a focussed search of the following databases - AMED, BIOSIS Previews, CENTRAL, CINAHL, Embase, Emcare, Global Health, Medline, Scopus and Web of Science. There were no language or publication status restrictions. The updated search covered 1 April 2012 to 22 February 2023. A total of 148 papers were found with 24 randomised and pseudo-randomised studies identified of which seven contributed to the final analysis. Studies using usual treatment (steroids) plus HBOT or no treatment plus HBOT were included. The ROBB 2 tool for risk of bias and the GRADE tool for certainty of evidence were utilised.</p><p><strong>Results: </strong>Data pooling was hampered by variation in reporting of changes in pure tone average across these studies. Pooled analysis from five studies suggested the chance of improvement following HBOT and steroids was greater than after steroids alone (RR 1.6, 95% CI 1.3 to 2.0). Pooled data from four trials suggested a greater mean improvement following HBOT (mean difference 15.6 dB, 95% CI 1.5-29.8).</p><p><strong>Conclusions: </strong>There is moderate evidence that HBOT improves hearing when applied up to 30 days after the onset of ISSHL. HBOT in combination with steroids (oral or intra-tympanic) can be justified as a routine treatment. Future trials should address optimal dose and timing of HBOT and ensure outcomes enable pooling of data in future reviews, as well as addressing some measure of the functional significance of any improvement.</p>","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"398-406"},"PeriodicalIF":1.3,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of reporting in hyperbaric medicine clinical trials: a cross-sectional study.","authors":"Yeonjung Yoo, Angélique Cléroux, Neal W Pollock, Sylvain Boet","doi":"10.28920/dhm55.4.352-368","DOIUrl":"10.28920/dhm55.4.352-368","url":null,"abstract":"<p><strong>Introduction: </strong>Research in hyperbaric oxygen (HBO) medicine is growing, but the quality of HBO studies is variable. Low study quality may compromise evidence-based decision-making and clinical translation.</p><p><strong>Methods: </strong>This cross-sectional study examined the adherence of 50 randomly selected HBO clinical trials (25 randomised controlled trials [RCTs] and 25 observational studies) to relevant core reporting guidelines: consolidated standards of reporting trials (CONSORT), non-pharmacologic treatments (NPT), and strengthening the reporting of observational studies in epidemiology (STROBE). Studies published in peer-reviewed journals between January 2018 and May 2023 and indexed on PubMed were analysed. Reporting quality was classified as 'excellent' (> 85% of guideline items adequately reported), 'good' (50-85%), or 'poor' (< 50%).</p><p><strong>Results: </strong>The sample represented 29% of RCTs and 16% of observational studies for the timeframe assessed. No study was rated as 'excellent' for completeness, 28 (56%) were rated as 'good', and 22 (44%) as 'poor'. In RCTs, only one study (4%) adequately reported protocol adherence and eight studies (32%) reported blinding procedures. The NPT checklist showed that key items, including care provider adherence (0 studies) and participant adherence (one study; 4%), were frequently not reported. For observational studies, basic design elements were adequately reported, but with significant gaps in bias management (nine studies; 36%) and missing data handling (13 studies; 52%). Only six studies (12%) mentioned the use of reporting guidelines.</p><p><strong>Conclusions: </strong>Our results showed that quality of reporting of HBO studies is suboptimal. These findings highlight the need for increased awareness and implementation of reporting guidelines, as well as the potential development of HBO-specific guidelines.</p>","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"352-368"},"PeriodicalIF":1.3,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decompression illness in breath-hold divers: insights from an online survey.","authors":"Elaine Yu, Nicole Lin, Peter Lindholm","doi":"10.28920/dhm55.4.384-390","DOIUrl":"10.28920/dhm55.4.384-390","url":null,"abstract":"<p><strong>Introduction: </strong>Breath-hold divers can surface with neurological symptoms consistent with nitrogen buildup in tissues or gas entry into the arterial circulation, collectively termed decompression illness (DCI). While DCI has historically been attributed to diving with compressed air, breath-hold divers have reported similar syndromes. The causes, diagnosis, and management of DCI in breath-hold divers is poorly understood.</p><p><strong>Methods: </strong>We developed an online survey that queried breath-hold divers on the symptoms they experienced during decompression illness events and the medical management of each event.</p><p><strong>Results: </strong>A total of 36 (31 M, 5 F) breath-hold divers filled out the survey. A majority identified as recreational freedivers, competitive freedivers, and/or spearfishers with an average age of 45 years and 18 years of breath-hold diving experience. Of those surveyed, 33 (92%) held a certification from an accredited training agency. A total of 18 (50%) reported experiencing DCI, with 21 DCI incidents reported by 13 individuals from 1999-2024. Sixteen (76%) of DCI incidents occurred during training, with an average depth of 83.4 m and average speed of 1.0 m∙s-1. Thirteen (62%) percent of DCI incidents occurred while diving to depths shallower than a previous personal best. The most common symptoms were weakness, numbness, slurred speech, and fatigue. The most common treatment modalities were surface oxygen, in-water recompression, and hyperbaric oxygen therapy. Sixteen divers (76%) had partial or complete resolution of their symptoms. The top cited contributors to the DCI incidents were depth, short surface interval between dives, and pulmonary barotrauma.</p><p><strong>Conclusions: </strong>Breath-hold divers can experience DCI even when diving within their limits. The most cited contributors to DCI were depth, short surface interval between dives, and pulmonary barotrauma. Most divers' symptoms resolved after treatment with surface oxygen, in-water recompression, and/or hyperbaric oxygen therapy.</p>","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"384-390"},"PeriodicalIF":1.3,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Power under pressure' - defibrillation during hyperbaric oxygen therapy: a scoping review.","authors":"Sophia Nöhl, Christian Burisch, Daniel Gödde, Timur Sellmann","doi":"10.28920/dhm55.4.407-418","DOIUrl":"10.28920/dhm55.4.407-418","url":null,"abstract":"<p><strong>Introduction: </strong>Although defibrillation is the standard treatment for cardiac arrest with shockable rhythms, its safety during hyperbaric oxygen therapy (HBOT) remains uncertain, as the oxygen-enriched atmosphere and increased ambient pressure could, in case of sparking, increase fire and explosion risk. As established guidelines are lacking, this scoping review synthesizes the current knowledge, addressing the unique challenges that arise in this special environment.</p><p><strong>Methods: </strong>A systematic literature search was conducted in CINAHL, Cochrane Library, EMBASE and PubMed. Two authors independently screened titles and abstracts, with a third author resolving discrepancies. Duplicate records were removed after initial screening. Full-text screening was also performed independently by two authors. Manual data extraction focused on actual defibrillation during HBOT, including outcomes, safety concerns, recommendations and further helpful information.</p><p><strong>Results: </strong>The search initially identified 10,348 publications, ten of which were included. Screening of reference lists yielded another 23 publications, resulting in 33 finally included publications. Of these, four publications presented five patient cases of actual defibrillation during HBOT, while the remaining publications provided additional information on the topic.</p><p><strong>Conclusions: </strong>Findings highlight a lack of standardised guidelines and limited empirical data, necessitating cautious consideration of defibrillation during HBOT. Safety protocols, including oxygen level and equipment specifications, vary between monoplace and multiplace hyperbaric chambers, influencing the feasibility of in-chamber defibrillation. There is strong consensus that defibrillation is strictly contraindicated inside monoplace chambers, while in multiplace chambers, risks and benefits must be assessed individually. While defibrillation during HBOT is rare, ensuring its safety remains of paramount importance. Future research should focus on refining safety protocols and establishing guidelines to optimise patient outcomes during HBOT-associated emergencies.</p>","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"407-418"},"PeriodicalIF":1.3,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blurred vision after diving, what's your diagnosis?","authors":"Jean-Eric Blatteau, Romain Roffi, Bernard Valero","doi":"10.28920/dhm55.4.434-435","DOIUrl":"10.28920/dhm55.4.434-435","url":null,"abstract":"","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"434-435"},"PeriodicalIF":1.3,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of airway protection tools: an international survey on the use of mouthpiece retaining straps in closed-circuit rebreather diving.","authors":"Emmanuel Gouin, Emmanuel Dugrenot, Rachel M Lance, Thierry Michot, Laura Marroni, Frauke Tillmans","doi":"10.28920/dhm55.4.369-375","DOIUrl":"10.28920/dhm55.4.369-375","url":null,"abstract":"<p><strong>Introduction: </strong>Rebreather diving carries a high fatality rate (estimated 1.8-3.8 deaths per 100,000 dives), yet its popularity is growing. Among 54 French military divers who lost consciousness underwater, none died when using a mouthpiece retaining strap (MRS) in a team diving setup. Despite this, MRS use remains limited among recreational divers for whom drowning is a major cause of death. This study assessed knowledge, perceptions, and training regarding MRS use within the rebreather diving community.</p><p><strong>Methods: </strong>An international online survey targeting certified rebreather divers was disseminated via social media. The survey gathered demographic information, diving experience, MRS usage, and details on related training.</p><p><strong>Results: </strong>A total of 563 responses were collected. Of these, 133 (23.6%) were instructors, and 210 (37.3%) had received MRS training. On a 0 to 100 scale, divers trained on MRS use rated MRS importance higher (median score: 74 [IQR 33-90]) than divers with no MRS training (median: 49 [IQR 16-67]). Barriers to MRS adoption included negative past experiences, poor training, misuse, and concerns about complications during bailout procedures.</p><p><strong>Conclusions: </strong>While not widely adopted among recreational divers, the MRS is supported by strong safety data. Formal training significantly improves its perceived value and acceptance. Greater involvement from manufacturers, training agencies, and instructors is essential to promote education and encourage MRS adoption as a key safety measure in rebreather diving.</p>","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"369-375"},"PeriodicalIF":1.1,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12823153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional outcome and quality of life after iatrogenic cerebral air embolism treated with hyperbaric oxygen: a prospective cohort study.","authors":"Raoul A Fakkert, Lisa van Beers, Nina C Weber, Benedikt Preckel, Robert A van Hulst, Robert P Weenink","doi":"10.28920/dhm55.4.330-337","DOIUrl":"10.28920/dhm55.4.330-337","url":null,"abstract":"<p><strong>Introduction: </strong>Iatrogenic cerebral air embolism (CAE) is an uncommon, potentially fatal condition characterised by accidental introduction of air into the circulation during invasive procedures. Prompt recognition and treatment with hyperbaric oxygen therapy (HBOT) are required. Data on long-term functional outcome and specifically quality of life (QoL) in patients experiencing CAE are limited.</p><p><strong>Methods: </strong>This prospective, single-centre, observational cohort study examined patients with iatrogenic CAE who were treated with HBOT. Patient characteristics, clinical severity scores and treatment details were recorded. The primary outcomes of the study were the Glasgow Outcome Scale (GOS) score at discharge and six months, and QoL measured by the World Health Organization quality of life brief version at six months.</p><p><strong>Results: </strong>A total of 22 patients were included, with 14 patients (64%) having arterial CAE, five (23%) retrograde venous CAE, and the remaining three having either both (n = 1) or unknown (n = 2) forms of CAE. Median time-to-HBOT was seven hours [IQR 5-10]. The overall mortality rate was 23% (n = 5), eight of 22 patients achieving full recovery (GOS 5) at six months, and another six patients having moderate disability (GOS 4) at six months. Nine of 17 survivors (53%) reported a decline in QoL compared to their pre-incident status. Outcome in patients with retrograde venous CAE seemed to be better, and outcome in patients with CAE following neuroangiographic procedures for stroke or subarachnoid haemorrhage seemed to be worse, compared to the remainder of patients.</p><p><strong>Conclusions: </strong>Iatrogenic CAE is associated with substantial morbidity and mortality, with only a third of patients in our cohort achieving good functional recovery. Over half of survivors in this cohort self-reported reduced QoL as compared to their situation before the CAE incident.</p>","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"330-337"},"PeriodicalIF":1.1,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12823156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence of cardiac arrest requiring defibrillation and defibrillation protocols in Australasian hyperbaric units.","authors":"Anja G Beilharz, Neil Banham, Ian Gawthrope","doi":"10.28920/dhm55.4.338-342","DOIUrl":"10.28920/dhm55.4.338-342","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiac arrest (CA) during hyperbaric oxygen treatment (HBOT) is exceedingly rare with only a few cases reported. It is unknown if in-chamber defibrillation of a patient has been performed in Australasia. In-chamber defibrillation is potentially dangerous with the risk of fire in an oxygen-rich environment. Australasian Standards prohibit the use of currently available defibrillators licensed for in-chamber use, as they contain lithium batteries. This study aimed to investigate how CA is managed in Australasian hyperbaric medicine units (HMUs) and to establish if there is a need to develop standardised protocols.</p><p><strong>Methods: </strong>A 10-part SurveyMonkey® questionnaire sent to all 15 Australasian HMUs. Questions aimed to ascertain if there were cases where defibrillation during HBOT was indicated and if it was performed. We asked about emergency treatment protocols, defibrillation capabilities and if regular training drills were conducted. We asked if colleagues felt the need to have a uniform treatment protocol across Australasia and invited them to share their emergency protocols.</p><p><strong>Results: </strong>Fourteen responses (93.3%) were received. No clinical cases of in-chamber CA or defibrillation were reported. Examples of emergency treatment protocols were provided by two respondents. Six respondents (43%) stated that regular emergency training drills for CA are performed in their HMU. Eleven respondents (79%) favoured standardised treatment protocols; however, comments suggested that this might be unachievable.</p><p><strong>Conclusions: </strong>CA requiring defibrillation in the hyperbaric medicine context is rare and has not been performed in Australasia. Most HMUs have protocols in place, but they are not universally practiced regularly.</p>","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"338-342"},"PeriodicalIF":1.3,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric oxygen treatment and pulmonary air-containing lesions.","authors":"Osman Türkmen, Recep Özkan, Kübra Özgök Kangal, Merve Dur İnce, Yakup Arslan","doi":"10.28920/dhm55.4.343-351","DOIUrl":"10.28920/dhm55.4.343-351","url":null,"abstract":"<p><strong>Introduction: </strong>Pulmonary barotrauma is a rare but serious complication of hyperbaric oxygen treatment. Pulmonary air-containing lesions may predispose pulmonary barotrauma by causing air trapping during changes in environmental pressure. This study aimed to investigate whether pulmonary air-containing lesions cause pulmonary barotrauma during hyperbaric oxygen treatment.</p><p><strong>Methods: </strong>This study retrospectively analysed data from individuals who presented to the Undersea and Hyperbaric Medicine Clinic at Gülhane Training and Research Hospital, Health Sciences University, between 2017 and 2022. The relationship between presence of pulmonary air-containing lesions on computed tomography and pulmonary barotrauma was evaluated.</p><p><strong>Results: </strong>Gas containing lesions were not associated with an increased risk of pulmonary barotrauma. The incidence of pneumothorax during hyperbaric oxygen was extremely low (0.0059% per session, 0.15% per patient).</p><p><strong>Conclusions: </strong>Pulmonary air-containing lesions, including bullae, were not associated with an increased risk under standard hyperbaric oxygen treatment protocols. Routine chest computed tomography screening is not warranted due to the low complication rate. Nevertheless, clinical evaluation and informed consent are essential, particularly for patients with underlying lung disease. Further studies are needed to improve risk assessment.</p>","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"343-351"},"PeriodicalIF":1.3,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel use of hyperbaric oxygen treatment for treatment-resistant disseminated Saksenaea and Fusarium in a patient on extracorporeal membrane oxygenation (ECMO): a case report.","authors":"Bridget Devaney, Joseph Mathew, Scott Ferris, Lloyd Roberts, Christopher Covelli, Judit Orosz, Vinodh Bhagyalakshmi Nanjayya, Andrew Fuller, Ian Millar","doi":"10.28920/dhm55.4.309-314","DOIUrl":"10.28920/dhm55.4.309-314","url":null,"abstract":"<p><p>Filamentous soil moulds such as Saksenaea and Fusarium are angioinvasive fungi responsible for severe disseminated infections. Saksenaea causes zygomycosis, with disseminated cases having over ninety percent mortality. Fusarium, a hyphomycetes mould, can also cause disseminated infections in immunocompromised individuals, with high mortality. We describe the case of a normally healthy 20-year-old male who survived major traumatic injuries resulting from an aviation incident. He subsequently developed disseminated cutaneous zygomycetes (Saksenaea) and Fusarium infection with associated immunosuppression, multiorgan dysfunction and sepsis. Treatment strategies included repeated and extensive surgical debridement (inferior orbital region to carotid sheath in the neck, to a depth of buccal mucosa and zygomatic bone in the cheek), antifungal agents including intravenous (IV) liposomal amphotericin B and voriconazole, and IV immunoglobulin and granulocyte colony stimulating factor. Despite maximal medical and surgical treatment, disease control was not achieved. After multi-specialty consensus that current management had failed to control the disease process, hyperbaric oxygen treatment (HBOT) was added to standard therapy on an experimental basis based on several case reports, pathophysiological rationale, and institutional experience with angioinvasive Mucor. The patient was on venovenous extracorporeal membrane oxygenation for all HBOT sessions; details are reported separately. Thirteen treatment sessions (243 kPa [2.4 atmospheres absolute], 95 min) were successfully delivered. Local and systemic disease control was achieved within several days of commencing HBOT, and after a prolonged period of rehabilitation and reconstruction, the patient was discharged home. We conclude that HBOT may have an important role in the management of angioinvasive fungal disease.</p>","PeriodicalId":11296,"journal":{"name":"Diving and hyperbaric medicine","volume":"55 4","pages":"309-314"},"PeriodicalIF":1.1,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12823155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}