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Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion Model 探讨PAK抑制在三维胰腺癌侵袭模型中的作用
Cells 2023 Pub Date : 2023-04-14 DOI: 10.3390/blsf2023021032
Marianne Best, D. Sarker, C. Wells
{"title":"Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion Model","authors":"Marianne Best, D. Sarker, C. Wells","doi":"10.3390/blsf2023021032","DOIUrl":"https://doi.org/10.3390/blsf2023021032","url":null,"abstract":": Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer, with over half of patients presenting with metastatic PDAC at diagnosis. Most patients receive conventional chemotherapy which invariably faces resistance, and a key facilitator in this is the PDAC stroma which acts as a functional mediator of disease progression through bilateral crosstalk between stromal cells and cancer cells. ‘Migrastatics’ are a new drug class which target cell migration pathway effector proteins to attenuate cancer cell invasion. Improvement in PDAC treatment strategy is well-overdue and migrastatics as adjuvant therapy is one avenue gaining traction. The p21-activated kinase (PAK) family is frequently overexpressed and/or amplified in PDAC where it regulates cytoskeletal actin contractility as well as transcription. Pre-clinical PAK inhibitors have shown reduced PDAC cell invasion in vitro, yet it is unknown how the PDAC stromal cells would respond to a PAK inhibitor and how this could consequently affect PDAC invasion. My PhD project investigates the Pancreatic stellate cell response to PAK inhibition.","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133418217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Pluripotent Stem Cells from Diabetic and Nondiabetics Improve Retinal Pathology in Diabetic Mice 来自糖尿病和非糖尿病的人多能干细胞改善糖尿病小鼠的视网膜病理
Cells 2023 Pub Date : 2023-04-14 DOI: 10.3390/blsf2023021033
C. Gil, D. Chakraborty, Cristiano P. Vieira, Nutan Prasain, S. L. Calzi, Seth D Fortmann, Ping Hu, Kimihiko Banno, Mohamed Jamal, Chao Huang, Micheli S. Sielski, Yang Lin, Xinxin Huang, Mariana Dupont, J. Floyd, R. Prasad, A. L. Longhini, Trevor J McGill, H-M Chung, M. Murphy, D. Kotton, M. Boulton, M. Yoder, M. Grant
{"title":"Human Pluripotent Stem Cells from Diabetic and Nondiabetics Improve Retinal Pathology in Diabetic Mice","authors":"C. Gil, D. Chakraborty, Cristiano P. Vieira, Nutan Prasain, S. L. Calzi, Seth D Fortmann, Ping Hu, Kimihiko Banno, Mohamed Jamal, Chao Huang, Micheli S. Sielski, Yang Lin, Xinxin Huang, Mariana Dupont, J. Floyd, R. Prasad, A. L. Longhini, Trevor J McGill, H-M Chung, M. Murphy, D. Kotton, M. Boulton, M. Yoder, M. Grant","doi":"10.3390/blsf2023021033","DOIUrl":"https://doi.org/10.3390/blsf2023021033","url":null,"abstract":"","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116362152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probiotic Engineering: Resolving How Fermentable Sugars Affect Aggregation, Adhesion, and Aggression in Lactobacillaceae 益生菌工程:解决可发酵糖如何影响乳酸杆菌科的聚集、粘附和侵袭
Cells 2023 Pub Date : 2023-04-04 DOI: 10.3390/blsf2023021031
R. Suissa, M. Meijler, O. Koren, Ilana Kolodkin-Gal
{"title":"Probiotic Engineering: Resolving How Fermentable Sugars Affect Aggregation, Adhesion, and Aggression in Lactobacillaceae","authors":"R. Suissa, M. Meijler, O. Koren, Ilana Kolodkin-Gal","doi":"10.3390/blsf2023021031","DOIUrl":"https://doi.org/10.3390/blsf2023021031","url":null,"abstract":": Lactobacillaceae are Gram-positive and lactic acid-positive (LAB) bacteria that frequently serve as probiotics. LAB strains vary in their responses to different carbohydrates as free-living and biofilm communities. We previously found that fermentable sugars triggered an altered carrying capacity with strain specificity during planktonic growth, calling for adding a buffering system during the formulation of probiotics. In addition, a heterogeneous response to fermentable sugars was manifested in microbial aggregation (measured by image-stream flow cytometry), colony development, and attachment to mucin. Of all the probiotic strains, L. rhamnosus GG (LGG), a prevalent probiotic species, manifested an enhanced survival of self-imposed acid stress, consistent with the enhanced cell wall modulation observed by transmitting electron microscopy and proteomic analysis. A comprehensive proteomic and metabolomic study revealed that the formation of biofilms and aggregation capacity is a specific response to glucose independent of self-imposed acid stress. In contrast, the increased competitiveness and aggression of LGG and other LAB strains towards enteric pathogens were a synergistic outcome of a change in organic acid production, glucose-dependent bacteriocin production, and fermentation-specific volatile production. Our improved resolution into the cellular circuits (metabolome, proteome, and volatilome) of probiotic strains and their interactions can lead to developing novel therapeutic approaches to combat GI tract infections.","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124881739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of Extrasynaptic Glutamatergic Signaling by Polysialylated NCAM in Health and Disease 多唾液化的NCAM在健康和疾病中调节突触外谷氨酸能信号
Cells 2023 Pub Date : 2023-04-03 DOI: 10.3390/blsf2023021030
A. Dityatev
{"title":"Regulation of Extrasynaptic Glutamatergic Signaling by Polysialylated NCAM in Health and Disease","authors":"A. Dityatev","doi":"10.3390/blsf2023021030","DOIUrl":"https://doi.org/10.3390/blsf2023021030","url":null,"abstract":": The neural cell adhesion molecule NCAM is known to mediate cell–to–cell and cell–to– extracellular matrix (ECM) adhesion via homophilic and heterophilic interactions. During brain development, NCAM and the associated glycan, polysialic acid (polySia), play important roles in cell migration proliferation, neurite outgrowth and fasciculation, and synaptogenesis. In the adult rodent brain, NCAM regulates synaptic plasticity, learning, and memory. Dysregulated cortical expression of NCAM and polySia has been reported in Alzheimer’s disease and schizophrenia. Our data demonstrate i) the importance of polySia–NCAM in the balancing of signaling through synaptic/extrasynaptic NMDA receptors and ii) the therapeutic value of short defined-length polySia fragments to restrain GluN2B-mediated signaling in several animal models of neurological and psychiatric diseases.","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126345293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Rab11 Family Controls Signalling to the Cytoskeleton for Cell Migration and Invasion Rab11家族控制细胞迁移和侵袭的细胞骨架信号传导
Cells 2023 Pub Date : 2023-03-27 DOI: 10.3390/blsf2023021029
P. Caswell, Jakub Gemperle, Chloe Flett, B. Wilson
{"title":"The Rab11 Family Controls Signalling to the Cytoskeleton for Cell Migration and Invasion","authors":"P. Caswell, Jakub Gemperle, Chloe Flett, B. Wilson","doi":"10.3390/blsf2023021029","DOIUrl":"https://doi.org/10.3390/blsf2023021029","url":null,"abstract":"","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122154579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Hyperhomocysteinemia Disturbs the Brain Development and Maturation in Offspring 母体高同型半胱氨酸血症扰乱后代大脑发育和成熟
Cells 2023 Pub Date : 2023-03-27 DOI: 10.3390/blsf2023021028
D. Vasilev, A. D. Shcherbitskaia, N. Tumanova, Yu. P. Milyutina, A. A. Kovalenko, N. Dubrovskaya, A. Mikhel, Daria B. Inozemtseva, I. V. Zalozniaia, A. Arutjunyan
{"title":"Maternal Hyperhomocysteinemia Disturbs the Brain Development and Maturation in Offspring","authors":"D. Vasilev, A. D. Shcherbitskaia, N. Tumanova, Yu. P. Milyutina, A. A. Kovalenko, N. Dubrovskaya, A. Mikhel, Daria B. Inozemtseva, I. V. Zalozniaia, A. Arutjunyan","doi":"10.3390/blsf2023021028","DOIUrl":"https://doi.org/10.3390/blsf2023021028","url":null,"abstract":"","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130625242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin (IL)-11 Is Involved in the Functional Liaison between Breast Tumor Cells and the Surrounding Stroma 白介素(IL)-11参与乳腺肿瘤细胞与周围基质的功能联系
Cells 2023 Pub Date : 2023-03-27 DOI: 10.3390/blsf2023021023
M. Talia, F. Cirillo, D. Scordamaglia, M. Santolla, A. Spinelli, Salvatore De Rosis, L. Muglia, Azzurra Zicarelli, Anna Maria Miglietta, M. Maggiolini, R. Lappano
{"title":"Interleukin (IL)-11 Is Involved in the Functional Liaison between Breast Tumor Cells and the Surrounding Stroma","authors":"M. Talia, F. Cirillo, D. Scordamaglia, M. Santolla, A. Spinelli, Salvatore De Rosis, L. Muglia, Azzurra Zicarelli, Anna Maria Miglietta, M. Maggiolini, R. Lappano","doi":"10.3390/blsf2023021023","DOIUrl":"https://doi.org/10.3390/blsf2023021023","url":null,"abstract":"","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114355804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of Retinoic Acid Receptor Signaling Pathway via All-Trans Retinoic Acid in Merkel Cell Carcinoma Cells 全反式维甲酸对Merkel细胞癌细胞中视黄酸受体信号通路的调节
Cells 2023 Pub Date : 2023-03-24 DOI: 10.3390/blsf2023021027
J. Rotondo, C. Mazziotta, G. Morciano, C. Cervellera, Giada Badiale, Giulia Tonnini, G. Di Mauro, P. Pinton, A. Touzé, P. Gaboriaud, M. Tognon, F. Martini
{"title":"Modulation of Retinoic Acid Receptor Signaling Pathway via All-Trans Retinoic Acid in Merkel Cell Carcinoma Cells","authors":"J. Rotondo, C. Mazziotta, G. Morciano, C. Cervellera, Giada Badiale, Giulia Tonnini, G. Di Mauro, P. Pinton, A. Touzé, P. Gaboriaud, M. Tognon, F. Martini","doi":"10.3390/blsf2023021027","DOIUrl":"https://doi.org/10.3390/blsf2023021027","url":null,"abstract":"","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114733015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Insights on Signaling Pathways Deregulated in LAP1-Deficient Cells: A Proteomics Study 蛋白质组学研究:lap1缺陷细胞信号通路失调的新见解
Cells 2023 Pub Date : 2023-03-24 DOI: 10.3390/blsf2023021025
Cátia D. Pereira, Guadalupe Espadas, F. Martins, A. Bertrand, Laurent Servais, E. Sabidó, O. A. B. da Cruz e Silva, S. Rebelo
{"title":"New Insights on Signaling Pathways Deregulated in LAP1-Deficient Cells: A Proteomics Study","authors":"Cátia D. Pereira, Guadalupe Espadas, F. Martins, A. Bertrand, Laurent Servais, E. Sabidó, O. A. B. da Cruz e Silva, S. Rebelo","doi":"10.3390/blsf2023021025","DOIUrl":"https://doi.org/10.3390/blsf2023021025","url":null,"abstract":"","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129720623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impaired Nuclear and Mitochondrial Cross-Talk Might Alter mtDNA Epigenetic Regulation in Maternally Inherited Diabetes- and Deafness-Affected Patients 细胞核和线粒体串扰受损可能改变母系遗传性糖尿病和耳聋患者mtDNA表观遗传调控
Cells 2023 Pub Date : 2023-03-24 DOI: 10.3390/blsf2023021026
L. Donato, C. Scimone, S. Alibrandi, M. Vadala', M. Castellucci, Domenico Mordà, C. Rinaldi, R. D’Angelo, A. Sidoti
{"title":"Impaired Nuclear and Mitochondrial Cross-Talk Might Alter mtDNA Epigenetic Regulation in Maternally Inherited Diabetes- and Deafness-Affected Patients","authors":"L. Donato, C. Scimone, S. Alibrandi, M. Vadala', M. Castellucci, Domenico Mordà, C. Rinaldi, R. D’Angelo, A. Sidoti","doi":"10.3390/blsf2023021026","DOIUrl":"https://doi.org/10.3390/blsf2023021026","url":null,"abstract":"","PeriodicalId":112836,"journal":{"name":"Cells 2023","volume":"21 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120925420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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