Disease Markers最新文献

{"title":"Retracted: Keloid Core Factor CTRP3 Overexpression Significantly Controlled TGF-<i>β</i>1-Induced Propagation and Migration in Keloid Fibroblasts.","authors":"Disease Markers","doi":"10.1155/2023/9842457","DOIUrl":"https://doi.org/10.1155/2023/9842457","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2023/9638322.].</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"9842457"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10700904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Relationship between Changes in Blood Glucose and Blood Lipid Levels and the Risk of Thyroid Cancer in Patients with Type 2 Diabetes Mellitus.","authors":"Disease Markers","doi":"10.1155/2023/9890238","DOIUrl":"https://doi.org/10.1155/2023/9890238","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2023/4814328.].</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"9890238"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10700886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: The Use of Cytotoxic Drugs as First Line Chemotherapy for EGFR (+) Nonsquamous NSCLC: A Network Meta-Analysis.","authors":"Disease Markers","doi":"10.1155/2023/9841863","DOIUrl":"https://doi.org/10.1155/2023/9841863","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2023/5272125.].</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"9841863"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Hypertension and Its Consequences Are the Main Predictors of Embolic Stroke of Undetermined Source.","authors":"Alexander B Berdalin, Daria D Namestnikova, Elvira A Cherkashova, Denis A Golovin, Ilya L Gubskiy, Vladimir G Lelyuk","doi":"10.1155/2023/3469755","DOIUrl":"https://doi.org/10.1155/2023/3469755","url":null,"abstract":"<p><strong>Methods: </strong>We performed a hospital-based prospective cohort study with 1,317 enrolled participants. We compared patients and healthy volunteers according to the main demographic, anthropometric parameters, stroke risk factors, comorbidities, and data of clinical and instrumental examination. In order to balance the study and the control groups for age and sex, the propensity score matching was performed. In order to generate the overall predictive model, a multivariate analysis was performed using the binary logistic regression method.</p><p><strong>Results: </strong>The following predictors of ESUS were identified in current study: arterial hypertension (AH); increased heart rate and pulmonary arterial systolic pressure (PASP); the presence of conduction disturbance; the enlargement of left, right atrium, and left ventricle end-systolic length; increased intima-media thickness (IMT) in right and left common carotid artery (CCA); lowered Montreal Cognitive Assessment (MoСA) cognitive scale score; the presence of subcortical microbleeds; central brain atrophy; the larger size of third ventricle; and the higher medial temporal lobe atrophy (MTA) score. The following risk factors were included in the final predictive model: the presence of AH (<i>p</i> < 0.0005; OR = 12.98 (95% CI: 4.53-37.21)) and PASP (<i>p</i>=0.018; OR = 1.13 (95% CI: 1.02-1.25)) and male sex (<i>p</i>=0.046; OR = 2.771 (95% CI: 1.017-7.555)). The Nagelkerke's pseudo-R-squared value was 0.404 and the significance of the Hosmer-Lemeshow test was 0.733, which indicate the goodness of the final logistic regression model.</p><p><strong>Conclusions: </strong>We propose that AH and its consequences are the main predictors of ESUS. The results of this study emphasize the importance of AH control for primary and secondary prevention of ESUS.</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"3469755"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of Metabolite Biomarkers to Predict the Efficacy of Dupilumab Treatment for Atopic Dermatitis.","authors":"Shoko Miyamoto, Yasutomo Imai, Masako Matsutani, Makoto Nagai, Kiyofumi Yamanishi, Nobuo Kanazawa, Shin Nishiumi","doi":"10.1155/2023/9013756","DOIUrl":"10.1155/2023/9013756","url":null,"abstract":"<p><p>Dupilumab (DUP) is the first biological agent used treating atopic dermatitis (AD). Notwithstanding its high cost, the type of patient group for which the drug is effective remains unclear. In this retrospective study, we aimed to identify novel and reliable biomarkers which can be measured before DUP administration and to predict the efficacy of DUP. Serum samples from 19 patients with AD treated with DUP were analysed by metabolome analysis using gas chromatography-mass spectrometry. Total 148 metabolites were detected, and the relative values of the metabolites were compared between the patient group that achieved 75% improvement in Eczema Area and Severity Index 16 weeks after administration of DUP (high responders: HR; <i>n</i> = 11) and that did not (low responders: LR; <i>n</i> = 8). The HR and LR groups had significant differences in the relative values of the eight metabolites (lactic acid, alanine, glyceric acid, fumaric acid, nonanoic acid, ribose, sorbitol, and ornithine), with ribose emerging as the best. Furthermore, we evaluated the serum concentrations of ribose and found that ribose may be a useful metabolite biomarker for predicting the efficacy of DUP in AD.</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"9013756"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Neurotransmitters and Electrophysiological Changes Might Work as Biomarkers for Diagnosing Affective Disorders.","authors":"Disease Markers","doi":"10.1155/2023/9792838","DOIUrl":"10.1155/2023/9792838","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2021/9116502.].</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"9792838"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis of Assessment of Total Oxidative Stress and Total Antioxidant Capacity in Patients with Periodontitis.","authors":"Khadijah Mohideen, Krithika Chandrasekaran, Harsha Veeraraghavan, Shahul Hameed Faizee, Safal Dhungel, Snehashish Ghosh","doi":"10.1155/2023/9949047","DOIUrl":"10.1155/2023/9949047","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is intricately linked to oxidative stress-antioxidant (redox) imbalance. The antioxidant system scavenges the oxygen free radicals in biological fluids in patients with periodontitis. However, little is still known about the free radicals mediated oxidative stress and reductive ability of the antioxidant system. Thus, the present meta-analysis aims to quantitatively review the literature that assessed the oxidative stress marker total oxidative stress (TOS) and total antioxidant capacity (TAC) in various biological fluids of patients with periodontitis. <i>Methodology</i>. Electronic databases were searched for studies that assessed TOS and TAC levels in various biological samples of patients with periodontitis.</p><p><strong>Results: </strong>From the 1,812 articles identified, 1,754 were excluded based on title and abstract screening due to irrelevance to the topic of interest. A full-text assessment of the remaining 58 articles led to the selection of 42 articles that satisfied the inclusion criteria. Of these, only 24 studies had consistent data for quantitative analysis. The periodontitis group displayed significantly elevated TOS levels (<i>p</i> < 0.05) in serum, gingival crevicular fluid (GCF), and saliva samples in the studies evaluated. In contrast, the periodontitis group exhibited significantly attenuated TAC levels (<i>p</i> < 0.01) compared to healthy controls in plasma, serum, and GCF samples of the studies evaluated, which was insignificant in salivary samples (<i>p</i>=0.433). At the same time, the periodontitis group displayed insignificantly elevated TAC levels after periodontal therapy (<i>p</i>=0.130).</p><p><strong>Conclusions: </strong>The present meta-analysis showed significantly higher TOS and lower TAC in periodontitis, reflecting the elevated oxidative stress level than the control group. <i>Clinical Relevance</i>. Scientific rationale for the study: The imbalance between oxidants and antioxidants (oxidative stress (OS)) plays a critical role in the onset and progression of periodontitis; the assessment of the relationship between OS-related biomarkers in regional samples and systemic samples of patients with periodontitis helps us to evaluate the periodontal disease progression. The OS biomarker levels can be used to assess periodontal disease and therapeutic efficacy.</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"9949047"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Bioinformatics Analysis Identifies <i>ASCL1</i> as the Key Transcription Factor in Hepatocellular Carcinoma Progression.","authors":"Disease Markers","doi":"10.1155/2023/9894804","DOIUrl":"10.1155/2023/9894804","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2023/3560340.].</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"9894804"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54228199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the Role of Galectin-3 as a Diagnostic and Prognostic Biomarker of Atrial Fibrillation.","authors":"Yasmin Mohtasham Kia,&nbsp;Alessandro Cannavo,&nbsp;Pegah Bahiraie,&nbsp;Sanam Alilou,&nbsp;Behrad Saeedian,&nbsp;Nastaran Babajani,&nbsp;Elina Ghondaghsaz,&nbsp;Amirmohammad Khalaji,&nbsp;Amir Hossein Behnoush","doi":"10.1155/2023/2097012","DOIUrl":"10.1155/2023/2097012","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is an irregular atrial activity and the most prevalent type of arrhythmia. Although AF is easily diagnosed with an electrocardiogram, there is a keen interest in identifying an easy-to-dose biomarker that can predict the prognosis of AF and its recurrence. Galectin-3 (Gal-3) is a beta-galactoside binding protein from the lectin family with pro-fibrotic and -inflammatory effects and a pivotal role in a variety of biological processes, cell proliferation, and differentiation; therefore, it is implicated in the pathogenesis of many cardiovascular (e.g., heart failure (HF)) and noncardiovascular diseases. However, its specificity and sensitivity as a potential marker in AF patients remain debated and controversial. This article comprehensively reviewed the evidence regarding the interplay between Gal-3 and patients with AF. Clinical implications of measuring Gal-3 in AF patients for diagnosis and prognosis are mentioned. Moreover, the role of Gal-3 as a potential biomarker for the management of AF recurrence is investigated. The association of Gal-3 and AF in special populations (coronary artery disease, HF, metabolic syndrome, chronic kidney disease, and diabetes mellitus) has been explored in this review. Overall, although further studies are needed to enlighten the role of Gal-3 in the diagnosis and treatment of AF, our study demonstrated the high potential of this molecule to be used and focused on by researchers and clinicians.</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"2097012"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41233192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis of Prognostic Gene Expression, Tumor Microenvironment, and Tumor-Infiltrating Immune Cells in Ovarian Cancer.","authors":"Qing Li,&nbsp;Zongjing Yang,&nbsp;Xingqing Ling,&nbsp;Junming Ye,&nbsp;Jiaying Wu,&nbsp;Yu Wang,&nbsp;Chun Yao,&nbsp;Jinghui Zheng","doi":"10.1155/2023/9672158","DOIUrl":"10.1155/2023/9672158","url":null,"abstract":"<p><strong>Objective: </strong>Tumor microenvironment (TME) research can provide a crucial direction for the innovation and continuous improvement of novel biologic therapies for cancer. This study examined the relationship between the TME, expression profiles of the tumor-infiltrating immune cell, and prognostic gene expression in ovarian cancer (OC).</p><p><strong>Materials and methods: </strong>Screening of CD3E, CD3G, CD2, CD3D, CCL19, and IL2RG was performed using the bioinformatics methods.</p><p><strong>Results: </strong>All six genes were found to participate in immune-related molecular mechanisms and could regulate the expression of tumor-infiltrating cells. A Kaplan-Meier survival analysis results demonstrated a strong association between overall survival and all gene expressions in patients with OC. CIBERSORT analysis results showed that the expression level of all genes was positively correlated with <i>γδ</i> T cell proportions.</p><p><strong>Conclusion: </strong>Therefore, in the OC microenvironment, CD3E, CD3G, CD2, CD3D, CCL19, and IL2RG can be potential immunotherapy targets and prognostic markers.</p>","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":"2023 ","pages":"9672158"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41233191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}