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Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten最新文献

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[Studies of pure human pancreatic juice]. [纯人类胰液的研究]。
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01
H Weber, W Dummler, S Liebe
{"title":"[Studies of pure human pancreatic juice].","authors":"H Weber,&nbsp;W Dummler,&nbsp;S Liebe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The test-combination from Fa. Boehringer Mannheim GmbH for measuring citric acid present in foodstuffs is also suitable for use in human pancreatic juice. Accuracy, within-run and between-day imprecision are satisfactory. The detection limit of the method is at least 10 mumol citrate/l pancreatic juice. The limit can be reduced when exact additions of citrate are given to the pancreatic juice and then evaluated using regression analysis. The presence of Ca-ions and possibly also trypsin in the material to be tested does not interfere with the reaction. It is, however, necessary to remove proteins from the sample. Deproteinization can be performed either by ultrafiltration or with perchloric acid.</p>","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"47 5","pages":"252-60"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14559329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical relevance of the determination of TSH-binding inhibitory immunoglobulins (TBII) in patients with immunogenic hyperthyroidism in methimazole therapy]. [甲巯咪唑治疗免疫原性甲亢患者tsh结合抑制性免疫球蛋白(TBII)测定的临床意义]。
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01
H J Heberling, B Bierwolf, E Kuhlmann, T Klugmann, P Dietel, S Fischer
{"title":"[Clinical relevance of the determination of TSH-binding inhibitory immunoglobulins (TBII) in patients with immunogenic hyperthyroidism in methimazole therapy].","authors":"H J Heberling,&nbsp;B Bierwolf,&nbsp;E Kuhlmann,&nbsp;T Klugmann,&nbsp;P Dietel,&nbsp;S Fischer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 38 patients with immunogenic hyperthyroidism a follow-up was performed to estimate the value of TBII before, during and after methimazole therapy. Before therapy increased TBII were detectable in 37 patients (94.4%). After 12 months methimazole therapy 25 patients had TSH-receptor antibodies (66%) within the normal range. In 13 patients positive antibody titres were found. In most cases persistence of increased TBII-values during drug treatment was an indicator of the persistence of active hyperthyroidism (10 of 13 patients). In the rule a disappearance of TBII-activity was combined with a functional remission (22 of 25 patients). Prolonged demonstration of TBII-activity in conjunction with persistence of hyperthyroidism should lead to ablative measures. In contrast to this medical therapy should be finished in patients with immunological and functional remission. Though in the further follow-up a recurrence of the immunological base of the disease with a functional and clinical relapse is possible.</p>","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"47 6","pages":"331-6"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14032126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Alimentary iodine deficiency in East Germany and its reflection in thyroid parameters following the initiation of struma prevention]. [东德的食源性碘缺乏症及其在甲状腺参数中的反映]。
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01
K Bauch
{"title":"[Alimentary iodine deficiency in East Germany and its reflection in thyroid parameters following the initiation of struma prevention].","authors":"K Bauch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>By regional and countrywide studies carried out in the past 10 years the occurrence of endemic goitre and iodine deficiency (ID) of grade II has been demonstrated in 1981. In 1983 till 1985 an iodized salt (25 mg KI/kg) was offered mainly in the southern counties of the G.D.R. This measure has been followed by the production of 84% of the whole paket salt iodized with stable potassium iodate (32 mg KIO3/kg) since July 1985 and delivered in all the G.D.R. Nevertheless, in the end of 1985 the persistence of iodine deficiency of grade II has yet to be stated by low renal iodine excretion, low iodine content of milk and human milk post partum. The reference values of TT3 (0.84-3.76 nmol/l) and TT4 (41.8-137.3 nmol/l) assessed in 1985 for the G.D.R. are to be interpreted before the background of an iodine deficiency of grade II.</p>","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"47 6","pages":"341-6"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14572098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of various liver diseases on the activity of 2 subtypes of cytochrome P-450]. [各种肝脏疾病对细胞色素P-450 2亚型活性的影响]
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01
A Balogh, H J Simon, M Reinhardt, F K Splinter, A Traeger
{"title":"[Effect of various liver diseases on the activity of 2 subtypes of cytochrome P-450].","authors":"A Balogh,&nbsp;H J Simon,&nbsp;M Reinhardt,&nbsp;F K Splinter,&nbsp;A Traeger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The elimination of caffeine from the plasma and the elimination of metamizol-metabolites in urine were determined in 37 patients with different liver diseases. In severe liver diseases the demethylation of caffeine as well as the metabolism of metamizol is significantly reduced. The extent of reduced elimination capacity depends on the severity of the disease rather than on the type of disease. In patients with liver cirrhosis the determination of synthesis capacity and of humoral activity (s. tab. I) is suitable to evaluate the capacity of the cytochrome P-450 system. In noncirrhotic diseases only the activity of liver disease (tab. I.) determines the extent of reduced biotransformation capacity. Beside biotransformation-phase I, the acetylation--phase II biotransformation--also appears to be reduced.</p>","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"47 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14703871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of primary biliary cirrhosis (PBC) specific mitochondrial determinants by immunoblotting. 原发性胆汁性肝硬化(PBC)特异性线粒体决定因素的免疫印迹表征。
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01 DOI: 10.1016/s0168-8278(85)80243-9
M. Manns, G. Gerken, C. Trautwein, M. Meuer, T. Porally, H. Dienes, K. Meyer zum Büschenfelde
{"title":"Characterization of primary biliary cirrhosis (PBC) specific mitochondrial determinants by immunoblotting.","authors":"M. Manns, G. Gerken, C. Trautwein, M. Meuer, T. Porally, H. Dienes, K. Meyer zum Büschenfelde","doi":"10.1016/s0168-8278(85)80243-9","DOIUrl":"https://doi.org/10.1016/s0168-8278(85)80243-9","url":null,"abstract":"","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"10 26 1","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86417953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
[The splendor and misery of Whipple's disease]. [惠普尔病的辉煌与痛苦]。
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01
H J Klugmann, B Wohlgemuth, E Kupsch
{"title":"[The splendor and misery of Whipple's disease].","authors":"H J Klugmann,&nbsp;B Wohlgemuth,&nbsp;E Kupsch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>On the basis of two cases diagnosed by ourselves, and a review of literature the problematic Whipple's disease is demonstrated. The treatment of this rare disease is very successful but it is too seldom included in the differential diagnosis of arthralgia and malabsorption. Therefore fatal false diagnosis results very often.</p>","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"47 6","pages":"280-9"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13599032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathogenesis of hyperoxalurias and calcium oxalate calculi in intestinal diseases]. [肠道疾病中高尿酸和草酸钙结石的发病机制]
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01
G Müller, W Schütte, T Möller
{"title":"[Pathogenesis of hyperoxalurias and calcium oxalate calculi in intestinal diseases].","authors":"G Müller,&nbsp;W Schütte,&nbsp;T Möller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hyperoxaluria and calcium oxalate lithiasis have a multifactorial genesis in bowel diseases. The augmented synthesis of oxalic acid in the liver is of minor importance. A diminished bacterial degradation is to asses up to day only hardly. The increasing absorption is of highest importance by deficient production of calcium oxalate in the intestinal tract and by increasing permeability of colonic mucosa above all in steatorrhoea or in patients with augmented calcium absorption. The crystallization of calcium oxalate in the urine is promoted by shortage of vitamin A, citrate, zinc or magnesium.</p>","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"47 3","pages":"105-12"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14438893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Histologic and cell kinetic findings in stomach ulcer of different healing times]. [不同愈合时间胃溃疡的组织学和细胞动力学表现]。
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01
E Zinsser, G Machnik, K H Stiller
{"title":"[Histologic and cell kinetic findings in stomach ulcer of different healing times].","authors":"E Zinsser,&nbsp;G Machnik,&nbsp;K H Stiller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The 3-month healing rate in gastric ulcer patients treated on an outpatient basis and with no H2 blockers is only some 40%. In order to be able to improve therapy at an early stage, prognosis-relevant parameters were searched for also among histological findings. The semiquantitatively evaluated morphological parameters from 62 gastric ulcer patients of a case control study were subjected to a computerized multivariate analysis. Accordingly, at the stage of healing of gastric ulcer, the features 'complete intestinal metaplasia' and 'incomplete intestinal metaplasia' separate with the aid of a non-elementary discriminant function between healing in an appropriate period (3 months) and delayed healing. Histoautoradiographic in vitro examinations of 50 gastric ulcer cases reveal that the mucous membrane around an ulcer healing with delay has a significantly higher cell labeling rate than the gastric mucosa of control persons. The influence of a reflux of bile from the duodenum is discussed, as there is no correlation with the degree of chronic gastritis.</p>","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"47 5","pages":"197-206"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14559325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of primary biliary cirrhosis (PBC) specific mitochondrial determinants by immunoblotting. 原发性胆汁性肝硬化(PBC)特异性线粒体决定因素的免疫印迹表征。
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01
M Manns, G Gerken, C Trautwein, M Meuer, T Porally, H P Dienes, K H Meyer zum Büschenfelde
{"title":"Characterization of primary biliary cirrhosis (PBC) specific mitochondrial determinants by immunoblotting.","authors":"M Manns,&nbsp;G Gerken,&nbsp;C Trautwein,&nbsp;M Meuer,&nbsp;T Porally,&nbsp;H P Dienes,&nbsp;K H Meyer zum Büschenfelde","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antimitochondrial antibodies (AMA) are detected in up to 100% of patients with primary biliary cirrhosis (PBC); subtypes of AMA are disease specific. Sera from 21 patients with PBC and from 50 patients with various hepatic and non-hepatic diseases were tested for AMA by indirect immunofluorescence, radioimmunoassay for PBC-specific subtype anti M2 and characterized by western blot analysis and agarose-IEF-immunoblotting. Sera from patients with PBC reacted with up to 7 different mitochondrial polypeptides on western blots, mol. wt. 24,000-62,000 dalton. Sera from 50 patients with various hepatic and non-hepatic diseases did not react with these polypeptides. Sera with other AMA subtypes were included in this study (anti M1, anti M3, and anti M5). These mitochondrial polypeptides were associated with inner mitochondrial membranes (mitoplasts). Sonification led to a solubilization of several mitochondrial polypeptides (p 62, p 48, p 40, p 24). On agarose-IEF-immunoblotting sera from patients with PBC and 3 sera from patients with AMA positive cholestatic CAH but no other sera reacted with a protein band at pI 4.0; seven PBC sera reacted in addition with a protein band at pI 4.4. Western blot and agarose-IEF-immunoblotting are sensitive and specific tools to identify and characterize mitochondrial target antigens in PBC. Furthermore these techniques allow to study the clinical relevance of the heterogeneity of AMA in cholestatic liver disease.</p>","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"47 2","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13587841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[ST elevation in the initial phase of myocardial infarct--a sequela of acute coronary occlusion of an expression of neurohumorally-induced metabolic processes?]. 【心肌梗死初期ST段抬高——急性冠状动脉闭塞引起的神经体液诱导代谢过程表达的后遗症?】
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten Pub Date : 1987-01-01
G Jentsch, B Kottwitz
{"title":"[ST elevation in the initial phase of myocardial infarct--a sequela of acute coronary occlusion of an expression of neurohumorally-induced metabolic processes?].","authors":"G Jentsch,&nbsp;B Kottwitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The artificial coronary artery occlusion results immediately in ST-segment elevation (ST-E), therefore the ST-E in acute myocardial infarction is considered to be the result of acute coronary occlusion. But in the early phase of myocardial infarction a significant correlation between ST-E and occlusion of the coronary artery does not exist. The early ST-E seems to be predominantly the consequence of sympathico-adrenergic induced metabolic processes in the ischemic myocardium. The beta receptor blockade during the first 90 minutes after the onset of infarction decreased the ST-E by 73 +/- 6% within one hour. Treatment with beta receptor blockers in the acute phase in all patients with first anterior wall infarcts accompanied with ST-E leads to a favorable prognosis. Early ST-E can therefore be considered as a sign of sympathico-adrenergic induced changes in myocardial metabolism. Thus the beta receptor blockade in the acute phase (of anterior wall infarctions) seems to be therapeutically indicated.</p>","PeriodicalId":11189,"journal":{"name":"Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten","volume":"47 6","pages":"347-60"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14032127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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