Current opinion in rheumatology最新文献_第8页

Introduction, Vasculitis 2023. 导论，血管炎2023。

IF 5.1 2区医学

Current opinion in rheumatology Pub Date : 2024-01-01 Epub Date: 2023-11-30 DOI: 10.1097/BOR.0000000000000984

Hasan Yazici, Yusuf Yazici

引用次数: 0

Pregnancies in women with antineutrophil cytoplasmatic antibody associated vasculitis. 抗中性粒细胞细胞质抗体相关性血管炎妇女的妊娠。

IF 5.1 2区医学

Current opinion in rheumatology Pub Date : 2024-01-01 Epub Date: 2023-09-07 DOI: 10.1097/BOR.0000000000000977

Ann-Christin Pecher, Melanie Henes, Joerg C Henes

{"title":"Pregnancies in women with antineutrophil cytoplasmatic antibody associated vasculitis.","authors":"Ann-Christin Pecher, Melanie Henes, Joerg C Henes","doi":"10.1097/BOR.0000000000000977","DOIUrl":"10.1097/BOR.0000000000000977","url":null,"abstract":"Purpose of review: Antineutrophil cytoplasmatic antibody associated vasculitis (AAV) usually manifests after age fifty, thus making it very rare during reproductive age. Although rare, AAV, particularly eosinophilic granulomatosis with polyangiitis, can manifest at a younger age. AAV can also appear for the first time during pregnancy.Recent findings: Data from pregnant patients with AAV mostly derive from case reports or retrospective studies, with an absolute number of <100 published cases. Therefore, numbers of results of pregnancy outcome vary widely.Summary: As with other chronic autoimmune diseases, patients and infants seem to be at a higher risk for preterm delivery, intrauterine growth retardation and preeclampsia. Possible treatment for AAV in pregnancy depends upon gestational age and include glucocorticosteroids, azathioprine, intravenous immunoglobulins, and in severe cases rituximab and even cyclophosphamide. Plasma exchange might be an option in selected patients. Aside from cyclophosphamide these medications can also be used during breastfeeding. Acetylsalicylic-acid 100-150 mg/day reduces the risk of preeclampsia, also in this population. Patients should be counseled prior to conception and medication that is suitable for pregnancy should be established early on. During pregnancy, we recommend close monitoring of disease activity, blood pressure and ideally to co-consult with a gynecologist in an interdisciplinary approach.","PeriodicalId":11145,"journal":{"name":"Current opinion in rheumatology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10535754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term safety of biologic and targeted synthetic disease modifying drugs in rheumatology. 风湿病学中生物制剂和靶向合成疾病调节药物的长期安全性。

IF 5.1 2区医学

Current opinion in rheumatology Pub Date : 2023-12-21 DOI: 10.1097/bor.0000000000000995

Kaia Barth, Harsimrat Gill, Namrata Singh

引用次数: 0

Cardiovascular disease in spondyloarthritis: a narrative review of risk factors and the effect of treatments. 脊柱关节炎的心血管疾病：风险因素和治疗效果综述。

IF 5.1 2区医学

Current opinion in rheumatology Pub Date : 2023-12-21 DOI: 10.1097/bor.0000000000000999

Rouhin Sen, Liron Caplan, Maria I Danila

引用次数: 0

Chimeric antigen receptor T-cell therapy in rheumatology: B-cell depletion 2.0. 风湿病学中的嵌合抗原受体 T 细胞疗法：B 细胞耗竭 2.0。

IF 5.1 2区医学

Current opinion in rheumatology Pub Date : 2023-12-18 DOI: 10.1097/bor.0000000000000994

Rohith Appalaneni, Nikhila Achanta, Chandra Mohan

引用次数: 0

Pathogenesis of vasculopathy in systemic sclerosis and its contribution to fibrosis. 系统性硬化症血管病变的发病机制及其对纤维化的影响。

IF 5.1 2区医学

Current opinion in rheumatology Pub Date : 2023-11-01 Epub Date: 2023-07-24 DOI: 10.1097/BOR.0000000000000959

Yasushi Kawaguchi, Masataka Kuwana

{"title":"Pathogenesis of vasculopathy in systemic sclerosis and its contribution to fibrosis.","authors":"Yasushi Kawaguchi, Masataka Kuwana","doi":"10.1097/BOR.0000000000000959","DOIUrl":"10.1097/BOR.0000000000000959","url":null,"abstract":"Purpose of review: In patients with systemic sclerosis (SSc), vascular manifestations precede skin and organ fibrosis. There is increasing evidence demonstrating a pathogenic link between early vascular injury and subsequent development of tissue fibrosis.Recent findings: Our knowledge of cellular and molecular mechanisms underlying a unique relationship between SSc-related vasculopathy and fibrosis has changed over the last few years. There is increasing evidence showing viral infection as a potential trigger elucidating vascular injury. Due to defective vascular repair machinery, this initial event results in endothelial cell activation and apoptosis as well as the recruitment of inflammatory/immune cells, leading to endothelial-to-mesenchymal transition. This sequential process induces destructive vasculopathy in capillaries, fibroproliferative vascular lesions in arteries, and excessive fibrosis in the surrounding tissue. A variety of molecular mechanisms and pathways involved in vascular remodeling linked to subsequent excessive fibrosis have been identified and serve as attractive therapeutic targets for SSc.Summary: Endothelial injury may play a central role in connecting three features that characterize SSc pathogenesis: vasculopathy, chronic inflammation, and fibrosis. Our understanding of the processes responsible for myofibroblast differentiation triggered by vascular injury will provide the rationale for novel targeted therapies for SSc.","PeriodicalId":11145,"journal":{"name":"Current opinion in rheumatology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10228649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Methods for objective assessment of skin involvement in systemic sclerosis. 系统性硬化症皮肤受累的客观评估方法。

IF 5.2 2区医学

Current opinion in rheumatology Pub Date : 2023-11-01 Epub Date: 2023-08-21 DOI: 10.1097/BOR.0000000000000968

Ruhani Desai, Harshdeep Chawla, Kirill Larin, Shervin Assassi

{"title":"Methods for objective assessment of skin involvement in systemic sclerosis.","authors":"Ruhani Desai, Harshdeep Chawla, Kirill Larin, Shervin Assassi","doi":"10.1097/BOR.0000000000000968","DOIUrl":"10.1097/BOR.0000000000000968","url":null,"abstract":"Purpose of review: Skin fibrosis is the most prominent disease manifestation of systemic sclerosis (SSc). Although the treatment for other SSc manifestations has expanded over the years, there is limited progress in identifying effective treatment options for SSc skin involvement. This is in part due to limitations in the utilized outcome measures for assessment of skin fibrosis. This review focuses on different emerging assessment tools for SSc skin involvement and their potential use for clinical care and multicenter trials.Recent findings: Durometer and other device-based methodologies requiring application of direct pressure to the affected skin have been studied in SSc. However, there are concerns that the required application of pressure might be a source of variability. Ultrasound-based methods have been compared with modified Rodnan Skin Score in several studies, indicating acceptable construct validity. However, few studies have examined their criterion validity by providing comparisons to skin histology. Optical coherence-based methods show promising preliminary results for simultaneous assessment of skin fibrosis and vasculopathy. Further standardization and validation (including comparison to skin histology) of these promising novel assessment tools in large, longitudinal SSc cohort studies are needed to establish them as clinically useful outcome measures with acceptable sensitivity to change.Summary: Recent advances in imaging techniques provide a promising opportunity for development of a valid and reliable assessment tool for quantification of SSc skin fibrosis, which can pave the way for approval of effective treatment options for this high burden disease manifestation.","PeriodicalId":11145,"journal":{"name":"Current opinion in rheumatology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11015902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10039281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of dietary interventions in psoriatic arthritis. 饮食干预对银屑病关节炎的影响。

IF 5.1 2区医学

Current opinion in rheumatology Pub Date : 2023-11-01 Epub Date: 2023-05-16 DOI: 10.1097/BOR.0000000000000949

Ajesh B Maharaj, Lihi Eder, Alexis Ogdie

引用次数: 0

Myopathy in systemic sclerosis. 系统性硬化症中的肌病。

IF 5.2 2区医学

Current opinion in rheumatology Pub Date : 2023-11-01 Epub Date: 2023-08-22 DOI: 10.1097/BOR.0000000000000966

Caoilfhionn M Connolly, Julie J Paik

{"title":"Myopathy in systemic sclerosis.","authors":"Caoilfhionn M Connolly, Julie J Paik","doi":"10.1097/BOR.0000000000000966","DOIUrl":"10.1097/BOR.0000000000000966","url":null,"abstract":"Purpose of review: Systemic sclerosis associated myopathy (SSc-AM) is a complex, heterogenous disease that is associated with poor outcomes. SSc-AM lacks a clear definition, and continues to be poorly recognized. The purpose of this review is to provide a contemporary overview of the clinical, serological and pathophysiologic findings in SSc-AM to guide optimal recognition and management of this challenging disease manifestation.Recent findings: There have been several advances in diagnostic techniques to facilitate characterization of SSc-AM, including muscle MRI, in which findings were correlated to distinct histopathologic categories of muscle involvement in SSc, histopathologic findings of prominent fibrosis or inflammation on biopsy, and the identification of novel autoantibodies associated with SSc-AM, which may be associated with distinct clinical phenotypes. In one of the largest studies to date, 17% of a well phenotyped SSc cohort were found to have myopathy, which was an independent risk of death, even after adjusting for potential confounders, further highlighting the importance of timely recognistion and management of SSc-AM.Summary: There is increasing recognition of the importance of SSc-AM. Novel diagnostic tools provide the opportunity for more detailed insights into pathophysiologic mechanisms, which may facilitate the development of a rigorous consensus definition of SSc-AM.","PeriodicalId":11145,"journal":{"name":"Current opinion in rheumatology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring challenges in the management and treatment of inclusion body myositis. 探索包涵体肌炎的管理和治疗中的挑战。

IF 5.2 2区医学

Current opinion in rheumatology Pub Date : 2023-11-01 Epub Date: 2023-07-25 DOI: 10.1097/BOR.0000000000000958

Michael P Skolka, Elie Naddaf

{"title":"Exploring challenges in the management and treatment of inclusion body myositis.","authors":"Michael P Skolka, Elie Naddaf","doi":"10.1097/BOR.0000000000000958","DOIUrl":"10.1097/BOR.0000000000000958","url":null,"abstract":"Purpose of review: This review provides an overview of the management and treatment landscape of inclusion body myositis (IBM), while highlighting the current challenges and future directions.Recent findings: IBM is a slowly progressive myopathy that predominantly affects patients over the age of 40, leading to increased morbidity and mortality. Unfortunately, a definitive cure for IBM remains elusive. Various clinical trials targeting inflammatory and some of the noninflammatory pathways have failed. The search for effective disease-modifying treatments faces numerous hurdles including variability in presentation, diagnostic challenges, poor understanding of pathogenesis, scarcity of disease models, a lack of validated outcome measures, and challenges related to clinical trial design. Close monitoring of swallowing and respiratory function, adapting an exercise routine, and addressing mobility issues are the mainstay of management at this time.Summary: Addressing the obstacles encountered by patients with IBM and the medical community presents a multitude of challenges. Effectively surmounting these hurdles requires embracing cutting-edge research strategies aimed at enhancing the management and treatment of IBM, while elevating the quality of life for those affected.","PeriodicalId":11145,"journal":{"name":"Current opinion in rheumatology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ad/de/corhe-35-404.PMC10552844.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41194418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0