Dermato-Endocrinology最新文献

{"title":"Stage I and II Stress Incontinence (SIC): High dosed vitamin D may improve effects of local estriol.","authors":"Claus Schulte-Uebbing,&nbsp;Siegfried Schlett,&nbsp;Doru Craiut,&nbsp;Gheorghe Bumbu","doi":"10.1080/19381980.2015.1079359","DOIUrl":"https://doi.org/10.1080/19381980.2015.1079359","url":null,"abstract":"<p><strong>Unlabelled: </strong>After the age of 55 almost every third woman suffers from conditions of the incapability to retain urine when the intra-abdominal pressure is raised by different causes. So called stress incontinence. It' s caused by a predisposition in the family, weakness of the tissue, physical strain, deficiency in the metabolism, especially an increasing local estrogen deficiency and a local and systemic vitamin D deficiency.</p><p><strong>Patients: </strong>We evaluated the data of 60 meno- and postmenopausal female patients with a stress incontinence (SIC). All had a SIC in spite of a former local estriol treatment with a treatment of OeKolp® forte (= 0.5 mg estriol/ov), 3 times a week, for 6 weeks and in spite of a regular pelvic floor exercise for 6 weeks in the morning and in the evening, according to the protocol. Thirty were in stage I SIC and 30 were in stage II SIC.</p><p><strong>Method: </strong>We evaluated vitamin-D-levels in serum of our 60 postmenopausal women. Only 20% of this group had good vitamin D-levels. The medical intervention combined estriol (0.5 mg) together with high dosed vitamin D (12.500 I.U.) locally 3 times a week for a period of 6 weeks. The patients also had the instruction to continue their daily exercises in pelvic floor (morning and evening, due to their protocol). After six weeks of treatment the vitamin D level in serum was defined and correlated to the patients condition (symptomatic of stress incontinence, protocol of micturitions, Pad-test).</p><p><strong>Results: </strong>About one-third of women from our test assigned to be now capable of retaining urine. More than one-third of our patients cleared a profit of treatment. They reported mimimum regression about 25% of volume of incontinence. Therefore more than 2-third of our women being incapable of retaining urine improved their body conditions by using a combination of locally administered etriol and high dosed vitamin D.</p><p><strong>Conclusion: </strong>Stress incontinence (being incapable of retaining urine when the intra-abdominal pressure arises) in lower and middle grade, improves their body conditions under a combination of local administered estriol and vitamin D. This small study is not representative. We need much bigger studies with much more dates and with a follow up.</p>","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"8 1","pages":"e1079359"},"PeriodicalIF":0.0,"publicationDate":"2016-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2015.1079359","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34561121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solar radiation and the incidence and mortality of leading invasive cancers in the United States.","authors":"Alan B Fleischer,&nbsp;Sarah E Fleischer","doi":"10.1080/19381980.2016.1162366","DOIUrl":"https://doi.org/10.1080/19381980.2016.1162366","url":null,"abstract":"<p><p>Invasive cancer risk is inversely related to ultraviolet light exposure. This study explores relationships between cancer and the satellite-derived sunlight energy. We obtained the North America Land Data Assimilation System (NLDAS) daily average sunlight for the continental United States from 1999-2011. US Cancer Statistics age-adjusted-incidence and mortality was also obtained from the Centers for Disease Control and Prevention (CDC). We found that cancer incidence for all invasive cancers and for 11 of 22 leading cancers significantly decreased with increased solar radiation. Cancer mortality for all invasive cancers was not significantly associated with solar radiation, but for 7 of 22 leading cancers, including cancers of the uterus, leukemias, lung, ovary, and urinary bladder, increased solar radiation predicted decreased mortality. With increasing solar radiation, increased incidence and cancer mortality was observed for liver cancer and increased incidence but not mortality was observed for cervical cancer. The current study confirms studies relating UV radiation to the incidence and mortality of a variety of cancer types. We find associations between solar radiation energy and the incidence and mortality of a number of types of cancers. </p>","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"8 1","pages":"e1162366"},"PeriodicalIF":0.0,"publicationDate":"2016-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2016.1162366","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34561124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TNF-α increases the expression and activity of vitamin D receptor in keratinocytes: role of c-Jun N-terminal kinase.","authors":"Ester Ziv,&nbsp;Ruth Koren,&nbsp;Muayad A Zahalka,&nbsp;Amiram Ravid","doi":"10.1080/19381980.2015.1137399","DOIUrl":"https://doi.org/10.1080/19381980.2015.1137399","url":null,"abstract":"<p><p>Several inflammatory mediators increase calcitriol production by epidermal keratinocytes. In turn calcitriol attenuates the keratinocyte inflammatory response. Since the effect of the in-situ generated calcitriol depends also on the sensitivity to the hormone we studied the effect of inflammatory cytokines on the response of HaCaT human keratinocytes to calcitriol by examining the expression and transcriptional activity of VDR. Treatment with TNF, but not with IL-1β or interferon γ, increased VDR protein level, while decreasing the level of its heterodimerization partner RXRα. This was associated with increased VDR mRNA levels. c-Jun N-terminal kinase, but not P38 MAPK or NFκB, was found to participate in the upregulation of VDR by TNF. The functional significance of the modulation of VDR and RXRα levels by TNF is manifested by increased induction of VDR target gene CYP24A1 by calcitriol. Calcitriol, in turn, inhibited the enhanced expression of VDR by TNF. In conclusion, the inflammatory cytokine TNF increases the response of keratinocytes to calcitriol through upregulation of its receptor VDR, which in turn is subject to negative feedback by the hormone accelerating the return of the keratinocyte vitamin D system to its basal activity. We surmise that the increased generation and sensitivity to calcitriol in keratinocytes play a role in the resolution of epidermal inflammation. </p>","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"8 1","pages":"e1137399"},"PeriodicalIF":0.0,"publicationDate":"2016-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2015.1137399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34561123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of geographical ecological studies in identifying diseases linked to UVB exposure and/or vitamin D.","authors":"William B Grant","doi":"10.1080/19381980.2015.1137400","DOIUrl":"10.1080/19381980.2015.1137400","url":null,"abstract":"<p><p>Using a variety of approaches, researchers have studied the health effects of solar ultraviolet (UV) radiation exposure and vitamin D. This review compares the contributions from geographical ecological studies with those of observational studies and clinical trials. Health outcomes discussed were based on the author's knowledge and include anaphylaxis/food allergy, atopic dermatitis and eczema, attention deficit hyperactivity disorder, autism, back pain, cancer, dental caries, diabetes mellitus type 1, hypertension, inflammatory bowel disease, lupus, mononucleosis, multiple sclerosis, Parkinson disease, pneumonia, rheumatoid arthritis, and sepsis. Important interactions have taken place between study types; sometimes ecological studies were the first to report an inverse correlation between solar UVB doses and health outcomes such as for cancer, leading to both observational studies and clinical trials. In other cases, ecological studies added to the knowledge base. Many ecological studies include other important risk-modifying factors, thereby minimizing the chance of reporting the wrong link. Laboratory studies of mechanisms generally support the role of vitamin D in the outcomes discussed. Indications exist that for some outcomes, UVB effects may be independent of vitamin D. This paper discusses the concept of the ecological fallacy, noting that it applies to all epidemiological studies. </p>","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"8 1","pages":"e1137400"},"PeriodicalIF":0.0,"publicationDate":"2016-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/48/kder-08-01-1137400.PMC4862381.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34496339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local corticosterone activation by 11β-hydroxysteroid dehydrogenase 1 in keratinocytes: the role in narrow-band UVB-induced dermatitis.","authors":"Saori Itoi-Ochi,&nbsp;Mika Terao,&nbsp;Hiroyuki Murota,&nbsp;Ichiro Katayama","doi":"10.1080/19381980.2015.1119958","DOIUrl":"https://doi.org/10.1080/19381980.2015.1119958","url":null,"abstract":"<p><p>Keratinocytes are known to synthesize cortisol through activation of the enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). To confirm the function of 11β-HSD1 in keratinocytes during inflammation in vivo, we created keratinocyte-specific-11β-HSD1 knockout mice (K5-Hsd11b1-KO mice) and analyzed the response to narrow-band ultraviolet B (NB-UVB) irradiation. Firstly, we measured the mRNA and protein levels of 11β-HSD1 following NB-UVB irradiation and found that the expression of 11β-HSD1 in keratinocytes of mouse ear skin was enhanced at 3 and 24 hours after 250 mJ/cm(2), 500 mJ/cm(2), 1 J/cm(2), and 2 J/cm(2) NB-UVB irradiation. Next, we determined that 24 hours after exposure to 1 J/cm(2) NB-UVB irradiation, the numbers of F4/80-, CD45-, and Gr-1-positive cells were increased in K5-Hsd11b1-KO mice compared to wild type (WT) mice. Furthermore, the expression of the chemokine (C-X-C-motif) ligand 1 (CXCL1) and interleukin (IL)-6 was also significantly enhanced in NB-UVB-irradiated K5-Hsd11b1-KO mice compared with WT mice. In addition, activation of nuclear factor-kappa B (NF-κB) after NB-UVB irradiation was enhanced in K5-Hsd11b1-KO mice compared to that in WT mice. Thus, NB-UVB-induced inflammation is augmented in K5-Hsd11b1-KO mice compared with WT mice. These results indicate that 11β-HSD1 may suppress NB-UVB-induced inflammation via inhibition of NF-κB activation. </p>","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"8 1","pages":"e1119958"},"PeriodicalIF":0.0,"publicationDate":"2016-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2015.1119958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34561122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated economic benefit of increasing 25-hydroxyvitamin D concentrations of Canadians to or above 100 nmol/L","authors":"W. Grant, S. Whiting, Gerry K Schwalfenberg, S. Genuis, S. Kimball","doi":"10.1080/19381980.2016.1248324","DOIUrl":"https://doi.org/10.1080/19381980.2016.1248324","url":null,"abstract":"ABSTRACT Mounting evidence from observational and clinical trials indicates that optimal vitamin D reduces the risk of many diseases. We used observational studies and recent data on 25-hydroxyvitamin D [25(OH)D] concentrations of Canadians from Cycle 3 of the Canadian Health Measures Survey to estimate the reduction in disease incidence, mortality rates, and the total economic burden (direct plus indirect) of disease if 25(OH)D concentrations of all Canadians were raised to or above 100 nmol/L. Recently, the mean 25(OH)D concentration of Canadians varied depending on age and season (51–69 nmol/L), with an overall mean of 61 nmol/L. The diseases affected by 25(OH)D concentration included cancer, cardiovascular disease, dementia, diabetes mellitus, multiple sclerosis, respiratory infections, and musculoskeletal disorders. We used 25(OH)D concentration–health outcome relations for breast cancer and cardiovascular disease and results of clinical trials with vitamin D for respiratory infections and musculoskeletal disorders to estimate the reductions in disease burden for increased 25(OH)D concentrations. If all Canadians attained 25(OH)D concentrations>100 nmol/L, the calculated reduction in annual economic burden of disease was $12.5 ± 6 billion on the basis of economic burdens for 2016 and a reduction in annual premature deaths by 23,000 (11,000–34,000) on the basis of rates for 2011. However, the effects on disease incidence, economic burden, and mortality rate would be phased in gradually over several years primarily because once a chronic disease is established, vitamin D affects its progression only modestly. Nevertheless, national policy changes are justified to improve vitamin D status of Canadians through promotion of safe sun exposure messages, vitamin D supplement use, and/or facilitation of food fortification.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88110876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risks and benefits of sun exposure 2016","authors":"D. Hoel, M. Berwick, F. D. de Gruijl, M. Holick","doi":"10.1080/19381980.2016.1248325","DOIUrl":"https://doi.org/10.1080/19381980.2016.1248325","url":null,"abstract":"ABSTRACT Public health authorities in the United States are recommending that men, women and children reduce their exposure to sunlight, based on concerns that this exposure will promote skin cancer. On the other hand, data show that increasing numbers of Americans suffer from vitamin D deficiencies and serious health problems caused by insufficient sun exposure. The body of science concerning the benefits of moderate sun exposure is growing rapidly, and is causing a different perception of sun/UV as it relates to human health. Melanoma and its relationship to sun exposure and sunburn is not adequately addressed in most of the scientific literature. Reports of favorable health outcomes related to adequate serum 25(OH)D concentration or vitamin D supplementation have been inappropriately merged, so that benefits of sun exposure other than production of vitamin D are not adequately described. This review of recent studies and their analyses consider the risks and benefits of sun exposure which indicate that insufficient sun exposure is an emerging public health problem. This review considers the studies that have shown a wide range health benefits from sun/UV exposure. These benefits include among others various types of cancer, cardiovascular disease, Alzheimer disease/dementia, myopia and macular degeneration, diabetes and multiple sclerosis. The message of sun avoidance must be changed to acceptance of non-burning sun exposure sufficient to achieve serum 25(OH)D concentration of 30 ng/mL or higher in the sunny season and the general benefits of UV exposure beyond those of vitamin D.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90621721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The disintegrin-metalloproteinases ADAM10 and ADAM17 are upregulated in cutaneous squamous cell carcinomas","authors":"S.T. Oh, A. Stark, J. Reichrath","doi":"10.1080/19381980.2016.1228499","DOIUrl":"https://doi.org/10.1080/19381980.2016.1228499","url":null,"abstract":"Sir, Cutaneous squamous cell carcinoma (CSCC) is the second most common malignant neoplasm of the human skin. The incidence of CSCC is increasing, representing a major medical and economic problem. CSCC is characterized by a marked propensity for invasion and metastatic capacity. The degree of cellular differentiation, tumor thickness, location, and other features have prognostic value. Identification of the pathogenic mechanisms for CSCC could facilitate the treatment and prevention of this cancer. There is increasing evidence that the ADAMs (a disintegrin andmetalloprotease) are differentially expressed in malignant tumors and may, therefore, participate in the pathogenesis of carcinomas. Among proteases, 2 ADAMs (ADAM10 and ADAM17) have been of special interest, due to their characteristics of releasing and activating several ligands for the epidermal growth factor receptor (EGFR)/human EGFR (HER) family of receptors. HB-EGF, important substrate of ADAM10 and 17, plays a key role in the transactivation of the EGFR by G protein-coupled receptors. Recent studies have indicated that HB-EGF gene expression is significantly elevated in variety of human cancers and its expression level is much higher than those of the other EGFR ligands. Interestingly, it was postulated that HB-EGF might promote tumor growth of CSCC. In this study, we investigated for the first time the expression and localization of ADAM10 and 17 in different histologic subtypes of CSCC, using immunohistochemical analysis. The study was approved by the ethical committee of the Catholic University of Korea (DC12TIG10010). Formalin-fixed, paraffin-embedded specimens were used. CSCC can be divided into 3 histological subtypes, according to differentiation. The following histological specimens were examined: CSCC (n D 26) [histological subtypes: well differentiated (nD12); differentiated cells are greater than 75%, moderately differentiated (n D 7); differentiated cells are 25–75%, poorly differentiated (n D 7); differentiated cells are less than 25%]. Immunohistochemical analysis was performed using specific polyclonal antibodies and a streptavidin-peroxidase technique with Dako Kit (DAKO REAL detection system alkaline phosphatase/ RED rabbit/mouse, Dako, Cat.No. K5005). The primary antibody to the C-terminus of ADAM10 was from Santa Cruz (Heidelberg, Germany), the ADAM17 antibody from eBioscience (Malden, Netherland). The antibodies were used in the following dilutions: ADAM10 (1:50), and ADAM17 (1:100). Microscopic analysis was performed by 2 independent observers (S. O. and J. R.). The degree of expression was graded semi-quantitatively as follows: ¡, negative (0%); C, focal (1–20%); CC, moderate (21–50%); and CCC, diffuse (>50 %). The ADAM 10, 17 immunoreactivity was also assessed with respect to localization (membranous, cytoplasmic and nuclear). Mann-Whitney test was performed to compare ADM10 and ADAM17 expression between normal and CSCC epidermis, respectively. Kruskal-Wallis ","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"301 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73596967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantage of soybean isoflavone as antiandrogen on acne vulgaris.","authors":"Puguh Riyanto, Prasetyowati Subchan, Rosa Lelyana","doi":"10.1080/19381980.2015.1063751","DOIUrl":"10.1080/19381980.2015.1063751","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris (AV) is the commonest skin disorder, whereas soybean isoflavone had been proved as antiandrogen that is it can inhibit the enzyme 3ß-hydroxysteroid dehydrogenase,17ß-hydroxysteroid dehydrogenase and 5α-reductase. The purpose of this study is to prove the advantage of soybean isoflavone as antiandrogen on AV.</p><p><strong>Methods: </strong>this study is a clinical study using randomized pretest-posttest control group design. This study is a study with 40 samples randomized into 2 groups, i.e. placebo group and 160 mgs of isoflavone group, the duration is 12 weeks, conducted a double-blind manner. The dependent variabel is total of AV lesion, whereas the intermediate variable is DHT that will be examined using ELISA. Defferential test and multivariate analysis were performed on dependent, independent and intermediate variables.</p><p><strong>Results: </strong>This study found that the difference in mean of total AV lesion before treatment was not significant (p: 0.099), whereas after treatment it differed significantly (p: 0.000), with significant delta difference (p: 0.000). Difference of mean DHT level before treatment was not significant (p: 0.574), whereas after treatment it differed significantly (p: 0.000), with significant delta difference (p: 0.000). Delta of DHT (p: 0.003) (r: 0.736) had significant influence on delta of total AV lesion (P < 0.05).</p><p><strong>Conclusion: </strong>This study concludes that supplementation with 160 mgs/day of soybean isoflavone can reduce total AV lesion as a result of decreased DHT level.</p>","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"7 1","pages":"e1063751"},"PeriodicalIF":0.0,"publicationDate":"2015-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/71/kder-07-01-1063751.PMC4579974.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34109232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A vitamin D analog inhibits Th2 cytokine- and TGFβ -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis.","authors":"Mika Terao,&nbsp;Lingli Yang,&nbsp;Sayaka Matsumura,&nbsp;Mizuki Yutani,&nbsp;Hiroyuki Murota,&nbsp;Ichiro Katayama","doi":"10.1080/19381980.2015.1010983","DOIUrl":"https://doi.org/10.1080/19381980.2015.1010983","url":null,"abstract":"<p><p>Scleroderma is an autoimmune disease characterized by extracellular matrix deposition and inflammation. Topical vitamin D analogs have been reported as effective treatments for scleroderma. We previously reported that a matricellular protein, periostin (POSTN), contributes to pathogenesis of scleroderma as POSTN knockout mice were resistant to bleomycin (BLM)-induced scleroderma. We investigated whether a vitamin D analog affects the expression of POSTN in dermal fibroblasts and in a BLM-induced scleroderma model. The vitamin D analog, maxacalcitol (22-oxacalcitriol [OCT]), was applied to dermal fibroblasts and POSTN expression was measured. The effect of OCT on Th2 cytokine- and TGFβ-induced POTSN and Collagen 1 α 1 (Col1A1) expression was also assessed. In vivo, OCT was administered to BLM-induced scleroderma model and outcomes were determined by dermal thickness, collagen density and POSTN expression. Treatment with OCT significantly decreased POSTN expression in dermal fibroblasts. Th2 cytokine- and TGFβ-induced expression of POSTN and Col1A1 was also suppressed by OCT. In vivo, OCT administration decreased the density of collagen bundles and POSTN expression in a BLM-induced scleroderma model. In addition to the previously reported immunosuppressive effect, the vitamin D analog OCT might be effective to treat scleroderma, in part through inhibition of Th2 cytokine- and TGFβ-induced POSTN expression. </p>","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"7 1","pages":"e1010983"},"PeriodicalIF":0.0,"publicationDate":"2015-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2015.1010983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34109234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}