Dermato-Endocrinology最新文献_第2页

Efficacy of Tofacitinib in the Treatment of Universal Alopecia Areata and Primary Sjögren Syndrome 托法替尼治疗广泛性斑秃及原发性Sjögren综合征的疗效观察

Dermato-Endocrinology Pub Date : 2023-04-21 DOI: 10.3390/dermato3020009

T. Ródenas-Herranz, Marta Cebolla-Verdugo, Carlos Llamas-Segura, R. Ruiz-Villaverde, M. T. Herranz-Marín

引用次数: 0

Congenital Atrophic Dermatofibrosarcoma Protuberans: A Case Report and Review of the Literature 先天性萎缩性皮肤纤维肉瘤隆突1例报告及文献复习

Dermato-Endocrinology Pub Date : 2023-04-16 DOI: 10.3390/dermato3020008

I. Salem, Katherine E. Bradley, Julianne A Mann, Joseph H. Shin, M. LeBoeuf, Aravindhan Sriharan

引用次数: 0

An In Vitro Pilot Study Investigating the Antineoplastic Effects of GP-2250 on Cutaneous Squamous Cell Carcinoma Cell Lines: Preliminary Results GP-2250对皮肤鳞状细胞癌细胞抗肿瘤作用的体外初步研究

Dermato-Endocrinology Pub Date : 2023-03-14 DOI: 10.3390/dermato3010007

Milan Barras, L. Schmitz, C. Braumann, W. Uhl, M. Skrygan, M. Buchholz, T. Meyer, E. Stockfleth, T. Müller, J. Becker, T. Gambichler

引用次数: 1

FDTD Simulations of Sweat Ducts and Hair at 0.45 THz 0.45太赫兹下汗腺和毛发的时域有限差分模拟

Dermato-Endocrinology Pub Date : 2023-03-02 DOI: 10.3390/dermato3010006

Zoltan Vilagosh, Negin Foroughimehr, A. Lajevardipour, A. Wood

引用次数: 2

Violaceous Lesions on the Leg: What Else Apart from Kaposi Sarcoma? Differential Diagnosis with a Narrative Review of the Literature 腿上的紫色病变:除了卡波西肉瘤还有什么?鉴别诊断与文献叙述回顾

Dermato-Endocrinology Pub Date : 2023-02-16 DOI: 10.3390/dermato3010005

A. Pileri, Gionathan Orioni, C. Zengarini, V. Grandi, B. Piraccini, V. Gaspari

{"title":"Violaceous Lesions on the Leg: What Else Apart from Kaposi Sarcoma? Differential Diagnosis with a Narrative Review of the Literature","authors":"A. Pileri, Gionathan Orioni, C. Zengarini, V. Grandi, B. Piraccini, V. Gaspari","doi":"10.3390/dermato3010005","DOIUrl":"https://doi.org/10.3390/dermato3010005","url":null,"abstract":"With this work, we aimed to review the principal benign and malignant tumors (including vascular, keratinocytic/epidermal, melanocytic, hematopoietic, and lymphoid origin), primarily affecting the leg’s skin. The lesions’ location can also help focus on a spectrum of differential diagnoses in clinical practice. All the diseases present the same clinical presentation characterized by erythematous to violaceous nodules. Despite the same clinical presentation, each disease’s prognostic outcome and therapeutic management can be somewhat different. Since clinical diagnosis may sometimes be challenging, histology and immunohistochemistry play a fundamental role in recognizing and staging these types of lesions. Molecular studies can help to determine the exact nature of lesions with no specific characteristics. Kaposi’s sarcoma is an angioproliferative neoplasm that typically occurs in the lower limbs and can enter into differential diagnosis with several other rarer skin diseases. The principal differential diagnosis concerns primary cutaneous lymphomas, of which mycosis fungoides represent the most frequent primary cutaneous T-cell lymphoma. Other rare forms include primary cutaneous B-cell lymphomas, which can be divided into indolent and aggressive forms, such as the primary cutaneous diffuse large B-cell lymphoma, leg type, and lymphomatoid papulomatosis (LyP). In the case of indolent lesions, skin-directed therapies, limited-field radiotherapy, and surgical approaches can be good options. At the same time, different management, with systemic chemotherapy and allogenic bone marrow transplant, is required with aggressive neoplasms, such as blastic plasmacytoid dendritic cell neoplasia or advanced mycosis fungoides. The dermatologist’s role can be crucial in recognizing such diseases and avoiding misdiagnosis, giving the pathologist the correct clinical information for an accurate diagnosis, and starting the suitable therapy.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83930033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rapid Melanoma Death of an Adult Male with Congenital Bathing Trunk Nevus despite Initiation of Combination Immunotherapy 一例成年男性先天性浴干痣患者在开始联合免疫治疗后迅速死亡

Dermato-Endocrinology Pub Date : 2023-02-08 DOI: 10.3390/dermato3010004

T. Gambichler, Kathrin Noldes, Yousef Arafat, M. Neid, A. Rütten, S. Boms

引用次数: 0

Merkel Cell Carcinoma in Kidney Transplant Recipients 肾移植受者的默克尔细胞癌

Dermato-Endocrinology Pub Date : 2023-01-30 DOI: 10.3390/dermato3010003

Henry H. L. Wu, Isobel Pye, R. Chinnadurai

{"title":"Merkel Cell Carcinoma in Kidney Transplant Recipients","authors":"Henry H. L. Wu, Isobel Pye, R. Chinnadurai","doi":"10.3390/dermato3010003","DOIUrl":"https://doi.org/10.3390/dermato3010003","url":null,"abstract":"Merkel cell carcinoma (MCC) is an uncommon form of skin neoplasm with poor histological differentiation and an aggressive disease process, leading to high recurrence and mortality. There are multiple risk factors in which being in an immunocompromised state is a significant factor, and the discovery of Merkel cell polyomavirus (MCPyV) since 2008 has strengthened causal associations between MCC and immunosuppression. Individuals who have undergone kidney transplantation are therefore more susceptible to having MCC, secondary to post-transplant immunosuppression which plays a vital role in reducing the risk of transplant kidney rejection. Over recent years a rise in the incidence of MCC following kidney transplantation is noted, with increased reporting of such cases. Whilst localized MCC is observed, MCC metastasis to the lymphatic system, brain, bone, liver, lung, and heart has been previously observed in patients with transplanted kidneys. Kidney metastasis is less common and has been only reported in recent years with greater frequency. The management of aggressive, metastatic MCC has historically been palliative, and prognosis is poor. Recently, the use of immune checkpoint inhibitors for metastatic MCC in multi-center phase II clinical trials have shown promising survival outcomes and have been approved for use in countries such as the United States as a first-line treatment. In this review we will explore the potential pathophysiological processes of MCC manifesting post-kidney transplantation. We will then evaluate the epidemiology of MCC within the context of kidney transplantation, before discussing the various clinical presentations, diagnostic measures, surveillance strategies, and current treatment options as well as future directions to best manage MCC in kidney transplant recipients.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82667105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis 白细胞介素33与银屑病的相关性:系统回顾和荟萃分析

Dermato-Endocrinology Pub Date : 2023-01-09 DOI: 10.3390/dermato3010002

Keshav Kc, Hua Hu, Tilak Mahatara, S. Koirala, S. Shrestha, Shiv K. Sharma, Xiangfeng Song, Zhongwei Tian

{"title":"The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis","authors":"Keshav Kc, Hua Hu, Tilak Mahatara, S. Koirala, S. Shrestha, Shiv K. Sharma, Xiangfeng Song, Zhongwei Tian","doi":"10.3390/dermato3010002","DOIUrl":"https://doi.org/10.3390/dermato3010002","url":null,"abstract":"Psoriasis is a common genetic autoimmune disorder with a global prevalence of 2–3%. The clear pathogenesis of psoriasis is not fully understood, but hyperproliferation and inflammation of the epidermis with marked infiltration of immune cells have been indicated in psoriasis with such cells producing different types of cytokines- interleukin. As such a new member of the IL-1 cytokine family, in some research, IL-33 has been linked with psoriasis showing high serum concentration of IL-33 in human psoriatic plaques compared to normal healthy skin. Despite this, the association between IL-33 and psoriasis is not clear. Herein, in this review, we aim to investigate the correlation between serum IL-33 levels and psoriasis. We conducted meta-analysis using fixed or random-effects models to calculate pooled standard mean differences. We found that the mean IL-33 serum levels were reported between 0.35 pg/mL to 586 pg/mL in the psoriatic group and 0 pg/mL to 87.7 pg/mL in the healthy control group. Out of five, four individual studies included in the analysis reported statistically significant differences in IL-33 levels, the pooled estimate (SMD = 0.340 95% CI: −0.308 to 0.988), however, did not indicate a significant relation between IL-33 and psoriasis. This analysis revealed no significant difference between serum IL-33 levels in the psoriatic population in comparison to healthy controls. This may be because we did not include any animal studies, lab-based studies, any other markers mixed together, or any other cases of diseases mixed together. However, further research is warranted to confirm the reported association as this analysis is limited by the low-quality and observational nature of the included studies.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73959311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of Knowledge and Misperceptions on Photoprotection among Brazilian Youngsters 巴西青少年对光防护知识的缺乏和误解

Dermato-Endocrinology Pub Date : 2022-12-23 DOI: 10.3390/dermato3010001

M. de Paula Corrêa, Fabrina Bolzan Martins, A. Yamamoto, Natana Batista Paiva, L. F. Silva, R. J. Souza, Mayara Motta Melo, Clarissa Santos de Carvalho Ribeiro

{"title":"Lack of Knowledge and Misperceptions on Photoprotection among Brazilian Youngsters","authors":"M. de Paula Corrêa, Fabrina Bolzan Martins, A. Yamamoto, Natana Batista Paiva, L. F. Silva, R. J. Souza, Mayara Motta Melo, Clarissa Santos de Carvalho Ribeiro","doi":"10.3390/dermato3010001","DOIUrl":"https://doi.org/10.3390/dermato3010001","url":null,"abstract":"Daily photoprotection (PhP) is essential in preventing harmful effects from solar ultraviolet radiation (UVR) exposure. For that reason, we interviewed students aged from 4 to 20 years old about their knowledge on sun exposure and PhP habits. Age, sex, family income, and skin phototype were statistically related to the proposed questions. Our results show that Brazilian youngsters do not have the habit of wearing long-sleeved clothing (<15% in summer), sunglasses (0.0%), or hats (2.1%). More than 40% had no knowledge about ultraviolet index (UVI), while another 30% misinterpreted what it is. Less than half of all students wear sunscreen when out in the sun. Despite this low PhP use-rate, more than 90% know that UVR causes skin cancers. Low income was the factor that showed the greatest number of significant relationships with respect to the lack of PhP. The findings suggest that current traditional PhP campaigns are not efficient. We propose that PhP should be part of school curricula from elementary school onwards. After all, the lack of educational programs predisposes these youngsters to an increased chance of skin diseases in the future.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73049066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pityriasis Lichenoides Chronica-like CD8-Positive Mycosis Fungoides 慢性地衣癣样cd8阳性蕈样真菌病

Dermato-Endocrinology Pub Date : 2022-10-19 DOI: 10.3390/dermato2040011

T. Gambichler, Ekaterina Heinzer, C. Hendricks, Nicole Duschner, S. Boms

引用次数: 0