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Genomics and Molecular Mechanisms of Ovarian Cancer最新文献

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Abstract AP13: GENOME-SCALE CRISPR KNOCKOUT SCREEN IDENTIFIES TIGAR AS A MODIFIER OF PARP INHIBITOR SENSITIVITY 摘要AP13:基因组级CRISPR敲除筛选鉴定TIGAR是PARP抑制剂敏感性的修饰因子
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.OVCASYMP18-AP13
Pingping Fang, Kay Minn, J. Chien
{"title":"Abstract AP13: GENOME-SCALE CRISPR KNOCKOUT SCREEN IDENTIFIES TIGAR AS A MODIFIER OF PARP INHIBITOR SENSITIVITY","authors":"Pingping Fang, Kay Minn, J. Chien","doi":"10.1158/1557-3265.OVCASYMP18-AP13","DOIUrl":"https://doi.org/10.1158/1557-3265.OVCASYMP18-AP13","url":null,"abstract":"A key challenge is to understand the mechanisms that contribute to “BRCAness” and hence sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors. Using the sensitivity to PARP inhibitor olaparib as a surrogate for “BRCAness”, we performed a CRISPR/Cas9-based genome-scale loss-of-function screen and identified TIGAR as a modifier of olaparib response. TIGAR knockdown increases the level of intracellular reactive oxygen species, induces more DNA damage after olaparib treatment, and causes “BRCAness” by downregulating BRCA1 and genes in the Fanconi anemia pathway. Further, TIGAR knockdown induces senescence, reduces spheroid tumor cell growth, and enhances the cytotoxic effect of olaparib. Finally, TIGAR is amplified in ovarian cancer and a higher expression of TIGAR is associated with poor overall survival in high-grade serous ovarian cancer. Our study shows that TIGAR knockdown causes extensive transcriptional reprogramming and enhances sensitivity to PARP inhibitor, demonstrating that TIGAR is a relevant therapeutic target for treating ovarian cancer. Citation Format: Pingping Fang, Kay Minn, Jeremy Chien. GENOME-SCALE CRISPR KNOCKOUT SCREEN IDENTIFIES TIGAR AS A MODIFIER OF PARP INHIBITOR SENSITIVITY [abstract]. In: Proceedings of the 12th Biennial Ovarian Cancer Research Symposium; Sep 13-15, 2018; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2019;25(22 Suppl):Abstract nr AP13.","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115018315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Abstract GMM-046: CCNE1 AND BRD4 EXPRESSION AND PLATINUM RESISTANCE IN HIGH-GRADE SEROUS OVARIAN CANCERS GMM-046: CCNE1和BRD4在高级别浆液性卵巢癌中的表达和铂耐药
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-gmm-046
S. Petersen, Andrew J. Wilson, D. Khabele
{"title":"Abstract GMM-046: CCNE1 AND BRD4 EXPRESSION AND PLATINUM RESISTANCE IN HIGH-GRADE SEROUS OVARIAN CANCERS","authors":"S. Petersen, Andrew J. Wilson, D. Khabele","doi":"10.1158/1557-3265.ovcasymp18-gmm-046","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-gmm-046","url":null,"abstract":"","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"90 9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123492551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract GMM-030: MODELS AND ANALYTIC TECHNIQUES OF MULLERIAN TISSUE-DERIVED ORGANOIDS 摘要GMM-030:缪勒氏组织衍生类器官的模型和分析技术
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-gmm-030
Germain C. Ho, D. Cochrane, Evan Gibbard, Kieran Campbell, B. Tessier-Cloutier, Kendall Greening, Forouh Kalantari, G. Trigo-Gonzalez, Yemin Wang, J. McAlpine, Sohrab P. Shah, D. Huntsman
{"title":"Abstract GMM-030: MODELS AND ANALYTIC TECHNIQUES OF MULLERIAN TISSUE-DERIVED ORGANOIDS","authors":"Germain C. Ho, D. Cochrane, Evan Gibbard, Kieran Campbell, B. Tessier-Cloutier, Kendall Greening, Forouh Kalantari, G. Trigo-Gonzalez, Yemin Wang, J. McAlpine, Sohrab P. Shah, D. Huntsman","doi":"10.1158/1557-3265.ovcasymp18-gmm-030","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-gmm-030","url":null,"abstract":"","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127625598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract GMM-027: DYNLL1 INHIBITS DNA END RESECTION IN BRCA1-DEFICIENT CELLS AND REGULATES PARP INHIBITOR SENSITIVITY GMM-027: DYNLL1抑制brca1缺陷细胞的DNA末端切除并调节PARP抑制剂的敏感性
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-gmm-027
Y. He, Khyati Meghani, Marie-christine Caron, Chunyu Yang, Daryl A. Ronato, J. Bian, Anchal Sharma, Jessica Miller, Niraj R. Joshi, A. Detappe, John G Doench, G. Legube, D. Root, A. D’Andrea, P. Drané, Subhojyoti De, P. Konstantinopoulos, J. Masson, Dipanjan Chowdhury
{"title":"Abstract GMM-027: DYNLL1 INHIBITS DNA END RESECTION IN BRCA1-DEFICIENT CELLS AND REGULATES PARP INHIBITOR SENSITIVITY","authors":"Y. He, Khyati Meghani, Marie-christine Caron, Chunyu Yang, Daryl A. Ronato, J. Bian, Anchal Sharma, Jessica Miller, Niraj R. Joshi, A. Detappe, John G Doench, G. Legube, D. Root, A. D’Andrea, P. Drané, Subhojyoti De, P. Konstantinopoulos, J. Masson, Dipanjan Chowdhury","doi":"10.1158/1557-3265.ovcasymp18-gmm-027","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-gmm-027","url":null,"abstract":"","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128045402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Abstract GMM-050: IDENTIFICATION OF NOVEL CHROMOSOMAL REARRANGEMENTS IN HIGH-GRADE SEROUS OVARIAN CANCER 摘要GMM-050:鉴定高级别浆液性卵巢癌中新的染色体重排
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-gmm-050
N. Sarvilinna, Barun Pradhan, Imrul Faisal, M. Tumiati, A. Alkodsi, L. Kauppi
{"title":"Abstract GMM-050: IDENTIFICATION OF NOVEL CHROMOSOMAL REARRANGEMENTS IN HIGH-GRADE SEROUS OVARIAN CANCER","authors":"N. Sarvilinna, Barun Pradhan, Imrul Faisal, M. Tumiati, A. Alkodsi, L. Kauppi","doi":"10.1158/1557-3265.ovcasymp18-gmm-050","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-gmm-050","url":null,"abstract":"","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114954892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract GMM-017: UPREGULATION OF MIR-328 CONTRIBUTES TO OVARIAN CANCER STEM CELL MAINTENANCE BY DOWNREGULATING DDB2 摘要GMM-017: MIR-328的上调通过下调DDB2参与卵巢癌干细胞的维持
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-gmm-017
A. Srivastava, T. Cui, Ananya Banerjee, Chunhua Han, Shurui Cai, Lu Liu, Dayong Wu, R. Cui, Zaibo Li, Xiaoli Zhang, Guozhen Xie, Selvendiran Karuppalyah, A. Karpf, Jinsong Liu, David Cohn, Qi-En Wang
{"title":"Abstract GMM-017: UPREGULATION OF MIR-328 CONTRIBUTES TO OVARIAN CANCER STEM CELL MAINTENANCE BY DOWNREGULATING DDB2","authors":"A. Srivastava, T. Cui, Ananya Banerjee, Chunhua Han, Shurui Cai, Lu Liu, Dayong Wu, R. Cui, Zaibo Li, Xiaoli Zhang, Guozhen Xie, Selvendiran Karuppalyah, A. Karpf, Jinsong Liu, David Cohn, Qi-En Wang","doi":"10.1158/1557-3265.ovcasymp18-gmm-017","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-gmm-017","url":null,"abstract":"","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127114737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract GMM-062: TARGETING OVARIAN CANCER STEM CELLS THROUGH THE TUMOR SUPPRESSOR DAB2IP-MEDIATED WNT SIGNALING PATHWAY 摘要GMM-062:通过肿瘤抑制因子dab2ip介导的WNT信号通路靶向卵巢癌干细胞
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-gmm-062
Xingyue Zong, Ali R. Özeş, K. Nephew
{"title":"Abstract GMM-062: TARGETING OVARIAN CANCER STEM CELLS THROUGH THE TUMOR SUPPRESSOR DAB2IP-MEDIATED WNT SIGNALING PATHWAY","authors":"Xingyue Zong, Ali R. Özeş, K. Nephew","doi":"10.1158/1557-3265.ovcasymp18-gmm-062","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-gmm-062","url":null,"abstract":"","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123142477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract GMM-031: CLINICAL PATHOLOGIC EXPRESSION OF CELL CYCLE REGULATORY COMPLEXES IN HIGH GRADE SEROUS OVARIAN CARCINOMA 摘要GMM-031:细胞周期调控复合物在高级别浆液性卵巢癌中的临床病理表达
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-gmm-031
A. Iness, L. Rubinsak, J. Chaoul, M. Dozmorov, Cora Uram-Tuculescu, Larisa Litovchick, S. Temkin
{"title":"Abstract GMM-031: CLINICAL PATHOLOGIC EXPRESSION OF CELL CYCLE REGULATORY COMPLEXES IN HIGH GRADE SEROUS OVARIAN CARCINOMA","authors":"A. Iness, L. Rubinsak, J. Chaoul, M. Dozmorov, Cora Uram-Tuculescu, Larisa Litovchick, S. Temkin","doi":"10.1158/1557-3265.ovcasymp18-gmm-031","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-gmm-031","url":null,"abstract":"","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123321438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract GMM-055: BMI1 AND RING1A ARE INVOLVED IN H2A UBIQUITINATION AT SITES OF PLATINUM-INDUCED DAMAGE 摘要GMM-055: BMI1和RING1A参与了铂诱导损伤位点的H2A泛素化
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-gmm-055
S. Sriramkumar, H. O’Hagan
{"title":"Abstract GMM-055: BMI1 AND RING1A ARE INVOLVED IN H2A UBIQUITINATION AT SITES OF PLATINUM-INDUCED DAMAGE","authors":"S. Sriramkumar, H. O’Hagan","doi":"10.1158/1557-3265.ovcasymp18-gmm-055","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-gmm-055","url":null,"abstract":"","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116757401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract GMM-056: IGF-AXIS SIGNALING DURING OVULATION IS RESPONSIBLE FOR THE STEMNESS CELL EXPANSION AND TRANSFORMATION OF FALLOPIAN TUBE FIMBRIAL EPITHELIUM 摘要GMM-056:排卵过程中igf轴信号通路与输卵管毛上皮干细胞的扩增和转化有关
Genomics and Molecular Mechanisms of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-gmm-056
T. Chu, Che-Fang Hsu, Hsuan-shun Huang
{"title":"Abstract GMM-056: IGF-AXIS SIGNALING DURING OVULATION IS RESPONSIBLE FOR THE STEMNESS CELL EXPANSION AND TRANSFORMATION OF FALLOPIAN TUBE FIMBRIAL EPITHELIUM","authors":"T. Chu, Che-Fang Hsu, Hsuan-shun Huang","doi":"10.1158/1557-3265.ovcasymp18-gmm-056","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-gmm-056","url":null,"abstract":"","PeriodicalId":111140,"journal":{"name":"Genomics and Molecular Mechanisms of Ovarian Cancer","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121096450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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