Current Opinion in Urology最新文献_第8页

Does radical cystectomy still have a role in BCG-unresponsive nonmuscle invasive bladder cancer? 根治性膀胱切除术对卡介苗无反应的非肌层浸润性膀胱癌还有作用吗？

IF 2.1 3区医学

Current Opinion in Urology Pub Date : 2024-11-01 Epub Date: 2024-08-19 DOI: 10.1097/MOU.0000000000001213

Leilei Xia, Siamak Daneshmand

{"title":"Does radical cystectomy still have a role in BCG-unresponsive nonmuscle invasive bladder cancer?","authors":"Leilei Xia, Siamak Daneshmand","doi":"10.1097/MOU.0000000000001213","DOIUrl":"10.1097/MOU.0000000000001213","url":null,"abstract":"Purpose of review: Several novel therapies approved by the Food and Drug Administration (FDA) and explosion of clinical trials have changed the landscape Bacillus Calmette-Guérin (BCG)-unresponsive nonmuscle invasive bladder cancer (NMIBC). Given the recent advancements in bladder sparing options, the role of radical cystectomy (RC) in BCG-unresponsive NMIBC remains a subject of debate.Recent findings: All three novel agents currently approved by the FDA for BCG-unresponsive NMIBC have strict indication [carcinoma in situ (CIS)], low response rate, and short response duration. Some promising new agents are awaiting results and/or FDA approval. RC still provides the best oncologic control and acceptable quality of life, and potentially represents the most cost-effective option.Summary: It is an exciting time for the urologic oncology community to see the FDA approvals of some of the novel bladder sparing therapies and expansion of ongoing clinical trials. Yet, RC should still be considered as the gold standard of BCG-unresponsive NMIBC. We also must be cautious and selective in recommending bladder sparing options for patients with BCG-unresponsive NMIBC.","PeriodicalId":11093,"journal":{"name":"Current Opinion in Urology","volume":" ","pages":"489-494"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introductions. 编辑介绍。

IF 2.1 3区医学

Current Opinion in Urology Pub Date : 2024-11-01 Epub Date: 2024-10-03 DOI: 10.1097/MOU.0000000000001219

引用次数: 0

The evolving world of the urinary microbiome. 不断演变的泌尿微生物群世界。

IF 2.1 3区医学

Current Opinion in Urology Pub Date : 2024-11-01 Epub Date: 2024-09-02 DOI: 10.1097/MOU.0000000000001222

Hrishikesh Dalvi, Nicole J De Nisco

{"title":"The evolving world of the urinary microbiome.","authors":"Hrishikesh Dalvi, Nicole J De Nisco","doi":"10.1097/MOU.0000000000001222","DOIUrl":"10.1097/MOU.0000000000001222","url":null,"abstract":"Purpose of review: The existence of urinary microbiome in healthy individuals is now widely accepted as the longstanding belief in urinary tract sterility was disproved over a decade ago. The urinary microbiome has since been implicated in multiple urologic conditions including urinary tract infection (UTI), urinary incontinence, and bladder cancer. This review relays new findings of urinary microbiome compositional changes associated with aging and UTI susceptibility.Recent findings: Recent advancements have established how the urinary microbiome changes over the lifespan. Studies finding distinct urinary microbiomes in prepubescent, reproductive age, and postmenopausal females have identified sex hormones as potential modulators of urinary microbiome composition and have identified prevalent species that may be markers of dysbiosis. Research in male children finds a cultivable urinary microbiota that varies with age or urologic history but not delivery mode. Emerging research also addresses the function of the urinary microbiota, including genetic factors associated with urinary tract colonization and interactions with uropathogens.Summary: The urinary microbiome is a promising therapeutic target for urologic disease. However, a more functional understanding is necessary for the development of microbiome-based therapies. Future research should develop accurate animal models and explore functional relationships between the urinary microbiome and the host environment.","PeriodicalId":11093,"journal":{"name":"Current Opinion in Urology","volume":" ","pages":"422-427"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative platform for muscle-invasive bladder cancer trials: designs and endpoints. 肌肉浸润性膀胱癌试验围手术期平台：设计和终点。

IF 2.5 3区医学

Current Opinion in Urology Pub Date : 2024-09-12 DOI: 10.1097/mou.0000000000001228

Ekaterina Laukhtina,Marco Moschini,Jeremy Yuen-Chun Teoh,Shahrokh F Shariat

{"title":"Perioperative platform for muscle-invasive bladder cancer trials: designs and endpoints.","authors":"Ekaterina Laukhtina,Marco Moschini,Jeremy Yuen-Chun Teoh,Shahrokh F Shariat","doi":"10.1097/mou.0000000000001228","DOIUrl":"https://doi.org/10.1097/mou.0000000000001228","url":null,"abstract":"PURPOSE OF REVIEWThis review explores the design and endpoints of perioperative platforms in clinical trials for muscle-invasive bladder cancer (MIBC).RECENT FINDINGSThe choice of clinical trial design in perioperative platforms for MIBC must align with specific research objectives to ensure robust and meaningful outcomes. Novel designs in perioperative platforms for MIBC integrate bladder-sparing approaches. Primary endpoints such as pathological complete response and disease-free survival are highlighted for their role in expediting trial results in perioperative setting. Incorporating patient-reported outcomes is important to inform healthcare decision makers about the outcomes most meaningful to patients. Given the growing body of evidence, potential biomarkers, predictive and prognostic tools should be considered and implemented when designing trials in perioperative platforms for MIBC.SUMMARYEffective perioperative platforms for MIBC trials are critical in enhancing patient outcomes. The careful selection and standardization of study designs and endpoints in the perioperative platform are essential for the successful implementation of new therapies and the advancement of personalized treatment approaches in MIBC.","PeriodicalId":11093,"journal":{"name":"Current Opinion in Urology","volume":"62 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association and risk of metabolic syndrome and kidney stone disease: outcomes from a systematic review and meta-analysis. 代谢综合征与肾结石疾病的关系和风险：系统回顾和荟萃分析的结果。

IF 2.5 3区医学

Current Opinion in Urology Pub Date : 2024-09-10 DOI: 10.1097/mou.0000000000001227

Sohani N Dassanayake,Tanguy Lafont,Bhaskar K Somani

引用次数: 0

Assessing the ripple effects of natural disasters on healthcare systems: a narrative review. 评估自然灾害对医疗保健系统的连锁反应：叙述性综述。

IF 2.1 3区医学

Current Opinion in Urology Pub Date : 2024-09-01 Epub Date: 2024-06-07 DOI: 10.1097/MOU.0000000000001193

Filippo Dagnino, Zhiyu Qian, Edoardo Beatrici

{"title":"Assessing the ripple effects of natural disasters on healthcare systems: a narrative review.","authors":"Filippo Dagnino, Zhiyu Qian, Edoardo Beatrici","doi":"10.1097/MOU.0000000000001193","DOIUrl":"10.1097/MOU.0000000000001193","url":null,"abstract":"Purpose of review: Natural disasters are on the rise, driven by shifts in climatic patterns largely attributed to human-induced climate change. This relentless march of climate change intensifies the frequency and severity of these disasters, heightening the vulnerability of communities and causing significant harm to both lives and socio-economic systems. Healthcare services are particularly strained during extreme weather events, with impacts felt not only on infrastructure but also on patient care.Recent findings: This narrative review explored the overarching impact of natural disasters on healthcare infrastructure. We delved into how these disasters impact diverse health conditions, the healthcare systems of low and middle-income countries (LMICs), the psychological toll on both clinicians and survivors, and the ramifications for end-of-life care.Summary: Natural disasters significantly impact healthcare, especially in LMICs due to their limited resources. Patients with cancer or chronic diseases struggle to access care following a natural disaster. Those in need for palliative care experience delay due to shortages in medical resources. Psychological consequences like posttraumatic stress disorder on disaster survivors and healthcare providers highlight the need for mental health support. Addressing challenges requires proactive disaster preparedness policies and urgent public policy initiatives are needed for optimal disaster response.","PeriodicalId":11093,"journal":{"name":"Current Opinion in Urology","volume":" ","pages":"371-376"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate change and its implications for kidney health. 气候变化及其对肾脏健康的影响。

IF 2.1 3区医学

Current Opinion in Urology Pub Date : 2024-09-01 Epub Date: 2024-06-12 DOI: 10.1097/MOU.0000000000001197

David S Goldfarb, Anuj A Patel

引用次数: 0

Phantom sensation in genital gender-affirming surgery: a narrative review. 生殖器性别确认手术中的幻觉：叙述性综述。

IF 2.1 3区医学

Current Opinion in Urology Pub Date : 2024-09-01 Epub Date: 2024-06-19 DOI: 10.1097/MOU.0000000000001199

Peter C Ferrin, Elliot Burghardt, Blair R Peters

{"title":"Phantom sensation in genital gender-affirming surgery: a narrative review.","authors":"Peter C Ferrin, Elliot Burghardt, Blair R Peters","doi":"10.1097/MOU.0000000000001199","DOIUrl":"10.1097/MOU.0000000000001199","url":null,"abstract":"Purpose of review: To review findings related to phantom genital sensation, emphasizing phantom sensation in the transgender and gender diverse (TGD) population. We discuss prevalence, presentation and potential implications for sensory outcomes in genital gender-affirming surgery.Recent findings: There is a high prevalence of phantom genital sensations in the TGD population. The prevalence varies by body part, approaching 50% in the most frequently reported transgender phantom - the phantom penis. Unlike genital phantoms that occur after trauma or surgery which are often painful, transgender phantoms are typically neutral and often erogenous in experience. Phantom sensation in the TGD population can be an affirming experience and important part of sexual well being and embodiment.Summary: Recent studies have begun to characterize the prevalence and presentations of phantom genital sensations in TGD people, informing our evolving understanding of the sensory experiences of the transgender and gender diverse population. Targeting integration of these centrally-mediated phantom genital sensations with the peripherally generated sensation from genital stimulation may represent one potential avenue to improve sensation and embodiment following genital gender-affirming surgical procedures. Additionally, emerging techniques in modern peripheral nerve surgery targeting phantom pain may offer potential treatment options for painful phantom sensation seen after cases of genital surgery or trauma.","PeriodicalId":11093,"journal":{"name":"Current Opinion in Urology","volume":" ","pages":"344-349"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-based diets, animal agriculture, and the connection with urological and planetary health. 植物性饮食、畜牧业以及与泌尿系统和地球健康的关系。

IF 2.1 3区医学

Current Opinion in Urology Pub Date : 2024-09-01 Epub Date: 2024-05-31 DOI: 10.1097/MOU.0000000000001191

Natasha Gupta, Michael S Leapman, Stacy Loeb

引用次数: 0

Climate change, microplastics, and male infertility. 气候变化、微塑料和男性不育症。

IF 2.1 3区医学

Current Opinion in Urology Pub Date : 2024-09-01 Epub Date: 2024-06-26 DOI: 10.1097/MOU.0000000000001201

Danesha Daniels, Alexandra Berger Eberhardt

{"title":"Climate change, microplastics, and male infertility.","authors":"Danesha Daniels, Alexandra Berger Eberhardt","doi":"10.1097/MOU.0000000000001201","DOIUrl":"10.1097/MOU.0000000000001201","url":null,"abstract":"Purpose of review: Semen quality is on the decline. While the etiology is unknown, recent literature suggests there may be a relationship between climate change, environmental toxins and male fertility. This review relays new information regarding associations between our environment and male infertility.Recent findings: Several recent studies have documented a negative association between heat stress and spermatogenesis, which suggests that climate change may be a factor in declining in sperm counts. The influence of particle pollution on spermatogenesis has also been recently investigated, with studies demonstrating a negative association. Another possible factor are microplastics, which have been posited to reduce sperm production. Recent animal studies have shown that microplastic exposure alters both adult sperm production and prenatal male genital development. The relationship between endocrine disrupting chemicals and male fertility remains an area of active study, with recent animal and human studies suggesting an association between these chemicals and male fertility.Summary: The etiology of the decline in male fertility over the past decades is yet unknown. However, changes in our environment as seen with climate change and exposure to pollutants and endocrine disrupting chemicals are proposed mechanisms for this decline. Further studies are needed to investigate this association further.","PeriodicalId":11093,"journal":{"name":"Current Opinion in Urology","volume":" ","pages":"366-370"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0