Current Issues in Pharmacy and Medical Sciences最新文献_第10页

Comparative efficacy of empagliflozin versus placebo in the treatment of type 1 diabetes mellitus: a meta-analysis of randomized controlled trials 恩格列净与安慰剂治疗1型糖尿病的比较疗效:随机对照试验的荟萃分析

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-09-01 DOI: 10.2478/cipms-2021-0024

S. Gillani, Anam Azhar, Shabaz Mohiuddin Gulam, Fithawit Bahran Gebreigziabher, H. Rathore

{"title":"Comparative efficacy of empagliflozin versus placebo in the treatment of type 1 diabetes mellitus: a meta-analysis of randomized controlled trials","authors":"S. Gillani, Anam Azhar, Shabaz Mohiuddin Gulam, Fithawit Bahran Gebreigziabher, H. Rathore","doi":"10.2478/cipms-2021-0024","DOIUrl":"https://doi.org/10.2478/cipms-2021-0024","url":null,"abstract":"Abstract The objective of this meta-analysis study was to evaluate the comparative efficacy of empagliflozin (25 mg) with placebo in the treatment and management of type 1 diabetes mellitus. This study is a meta-analysis, so an ethical statement is not required. Different databases and individual journal websites like SCOPUS, Science direct, Cochrane review library etc. were used. The articles were evaluated based on the search and eligibility criteria. A total of five RCTs were incorporated in this meta-analysis. These studies contained a total of 1058 patients, including 526 patients with placebo (or control-treated patients), and 532 patients with empagliflozin (25 mg) treated combination. The mean follow-up time ranged from 7 days to 6 months. Overall, mean reduction in placebo was -0.50% and empa-treated was -0.85%, while the pooled WMD was 3.82 995% CI 1.20 – 5.88, p=0.0001). Regarding urinary glucose excretion, that the pooled WMD was 6.67 (95% CI 4.87-10.14, p=0.001) indicated a significant increase in empa-arm compared to placebo. No heterogeneity was found (I2 – 15.03%). This meta-analysis underlined the therapeutic benefit of empagliflozin as an adjunctive therapy for patients with type 1 diabetes.","PeriodicalId":11071,"journal":{"name":"Current Issues in Pharmacy and Medical Sciences","volume":"34 1","pages":"123 - 129"},"PeriodicalIF":0.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45954152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reverse drug distribution in Poland 波兰的反向药物分销

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-09-01 DOI: 10.2478/cipms-2021-0028

Marek Stych, Beata Pawlica

引用次数: 1

Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3) 柠檬杨桃叶提取物的纳米壳聚糖包封促进ROS诱导，导致人鳞状细胞（HSC-3）凋亡

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-09-01 DOI: 10.2478/cipms-2021-0026

Sasqia Faadillah Andikoputri, K. Komariah, M. Roeslan, Dewi Ranggaini, D. Bustami

{"title":"Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)","authors":"Sasqia Faadillah Andikoputri, K. Komariah, M. Roeslan, Dewi Ranggaini, D. Bustami","doi":"10.2478/cipms-2021-0026","DOIUrl":"https://doi.org/10.2478/cipms-2021-0026","url":null,"abstract":"Abstract World-wide, Indonesia is ranked 17th in oral cancers, with deaths reaching 2.326 cases. Of the oral cancers, 90% are squamous cell carcinoma (HSC-3). Unfortunately, conventional cancer therapy still has many ill side effects. Therefore, pharmacologists have looked for natural ingredients to prevent the growth of oral cancer cells. One source is Cymbopogon citratus leaf. Research shows that the active compound of C. citratus leaf is a chemopreventive, doing so by increasing the production of re-active oxygen species (ROS) to induce apoptosis in cancer cells. The active compound of C. citratus leaf has low stability and solubility, so it is necessary to use an encapsulation matrix such as chitosan, and modify it into smaller particles to increase its effectiveness. Purpose is determining the effect of nano chitosan encapsulation of C. citratus leaf ethanol extract (NCECC) on the reactive oxygen species of HSC-3 tongue cancer cells. This study is divided into ten groups – without treatment, doxorubicin (positive control), hydrogen peroxide, nano chitosan and C. citratus leaf extract groups, and five groups of NCECC treatment – concentrations of 100%, 75%, 50%, 25%, and 12.5%, respectively. The 100% NCECC group showed the highest ROS concentration (p<0.05), compared to 75%, 50%, 25%, 12.5% NCECC groups, and the 100% NCECC was higher than the positive control group. NCECC is effective in inducing oxidative stress on HSC-3 through increased production of ROS. Moreover, the higher the encapsulation concentration given, the greater the increase in ROS production.","PeriodicalId":11071,"journal":{"name":"Current Issues in Pharmacy and Medical Sciences","volume":"34 1","pages":"134 - 137"},"PeriodicalIF":0.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46623962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause 蜂胶对去卵巢雌性大鼠绝经后模型的骨强化作用

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-09-01 DOI: 10.2478/cipms-2021-0025

Dian Ayu Juwita, A. Almahdy, Rahmad Abdillah, Fiony Syahputri

{"title":"The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause","authors":"Dian Ayu Juwita, A. Almahdy, Rahmad Abdillah, Fiony Syahputri","doi":"10.2478/cipms-2021-0025","DOIUrl":"https://doi.org/10.2478/cipms-2021-0025","url":null,"abstract":"Abstract Osteoporosis is a bone disease characterized by decreased quality and strength of bones so that it becomes porous and fracture. Propolis is known to have many pharmacological activity, including an anti-osteoporosis effect. This study aims to determine the effect of propolis administration and the effects of propolis dosage variation in preventing osteoporosis based on the strength value of femur bone impact in female white rats in the form of an ovariectomy postmenopausal model. The rats were divided into 5 groups: positive control group (subjected to ovariectomy), negative control group (not subjected to ovariectomy, and treatment groups that were subjected to ovariectomy and given propolis at a dose of 180 mg/kg BW, dose 360 mg/kg BW and dose 720 mg/kg BW. Propolis was administered orally for 30 days. Bone impact strength testing was undertaken after 30 days using an impact testing machine. Research data were analyzed via one-way ANOVA and continued with the Duncan’s Multiple Range Test. From the test results, we noted that propolis administration had an effect on the value of bone strength, with the dose of 720 mg/kg BW and 360 mg/kg BW having a significant effect, compared with others. With an increase in dose, propolis can provide an increase in the value of bone strength in rat bones.","PeriodicalId":11071,"journal":{"name":"Current Issues in Pharmacy and Medical Sciences","volume":"34 1","pages":"119 - 122"},"PeriodicalIF":0.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43808223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary iodine as an important indicator for preeclampsia: a Polish perspective 尿碘作为先兆子痫的重要指标：波兰的观点

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-09-01 DOI: 10.2478/cipms-2021-0023

K. Gajewska, M. Laskowska, A. Błażewicz

{"title":"Urinary iodine as an important indicator for preeclampsia: a Polish perspective","authors":"K. Gajewska, M. Laskowska, A. Błażewicz","doi":"10.2478/cipms-2021-0023","DOIUrl":"https://doi.org/10.2478/cipms-2021-0023","url":null,"abstract":"Abstract Preeclampsia (PE) is one of the leading causes of perinatal and maternal morbidity. Although subclinical hypothyroidism in pregnancy is one of the established risk factors for PE, the link between iodine deficiency and PE is not fully understood. The aim of our study was to assess urinary iodine concentration (UIC), serum thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) levels in Polish women with PE (PE group, n=78) compared with healthy non-pregnant women (CNP group, n=30), and healthy pregnant women (CP group, n=46). The UIC was determined by inductively coupled plasma mass spectrometry (ICP-MS). Both the mean UIC of 144.6±36.4 μg/L in the CP group and the mean of 125.8±33.6 μg/L in the PE group, respectively, were lower compared to non-pregnant women (149.8±28.8 μg/L), and the difference between the PE and CNP groups was statistically significant. TSH values were the highest in the PE group, while the lowest average level was for the CNP group. The fT3 and fT4 values in the PE group were significantly lower compared to the CNP and CP groups. Despite iodine supplementation during pregnancy, the UIC was lower compared to non-pregnant women, while in women with PE it was at a significantly lower level. To reduce the incidence of possible health complications, proper iodine supplementation and monitoring of the UIC is recommended for pregnant women suffering from PE or at risk of developing PE.","PeriodicalId":11071,"journal":{"name":"Current Issues in Pharmacy and Medical Sciences","volume":"34 1","pages":"154 - 159"},"PeriodicalIF":0.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41348264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroglossal duct cyst papillary thyroid cancer – the state of the art 甲状腺舌管囊肿乳头状甲状腺癌的最新进展

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-09-01 DOI: 10.2478/cipms-2021-0022

A. Dabrowska, J. Dudka

{"title":"Thyroglossal duct cyst papillary thyroid cancer – the state of the art","authors":"A. Dabrowska, J. Dudka","doi":"10.2478/cipms-2021-0022","DOIUrl":"https://doi.org/10.2478/cipms-2021-0022","url":null,"abstract":"Abstract Thyroglossal duct cyst is one of the most common congenital malformations in the neck area. The majority of cysts turn out to be benign tumors, however, 0.7-1.5 % of the remnants develop into carcinoma, with papillary thyroid cancer being the most frequent malignant neoplasm. The origin of the cancer has not been clearly established so far. Typically, thyroglossal duct cyst cancer is an enlarging flexible midline or slightly lateral neck mass, most often without other worrisome symptoms. The proper diagnosis can be difficult due to the rare prevalence of thyroglossal duct cyst papillary thyroid carcinoma, as well as a lack of strongly typical features distinguishing benign and malignant lesions before surgery. Thus, diagnosis is usually made postoperatively just after histopathological examination of a resected cyst. However, there are diagnostic procedures that should be considered before the surgery that may be helpful in making a proper diagnosis. These include fine-needle aspiration biopsy, computed tomography or magnetic resonance imaging. Moreover, there are some characteristics revealed through clinical and ultrasound examination that may suggest the presence of such cancer. While the Sistrunk procedure is often considered adequate, currently, there is no clear consensus about concurrent thyroidectomy or radioiodine therapy. In the article, we sum up the preoperative suggestive factors of cancer, as well as the proposed indications that can be helpful in deciding on the extent of surgery and further management.","PeriodicalId":11071,"journal":{"name":"Current Issues in Pharmacy and Medical Sciences","volume":"34 1","pages":"160 - 163"},"PeriodicalIF":0.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41982090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of antibacterial and antifungal properties of selected mouthwashes: in vitro studies 选定漱口水的抗菌和抗真菌性能评价：体外研究

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-09-01 DOI: 10.2478/cipms-2021-0029

Ewa Olejnik, Anna Biernasiuk, A. Malm, Jolanta Szymanska

{"title":"Evaluation of antibacterial and antifungal properties of selected mouthwashes: in vitro studies","authors":"Ewa Olejnik, Anna Biernasiuk, A. Malm, Jolanta Szymanska","doi":"10.2478/cipms-2021-0029","DOIUrl":"https://doi.org/10.2478/cipms-2021-0029","url":null,"abstract":"Abstract Introduction. Mouthwashes should include antimicrobial compounds to inhibit microorganism multiplication, thus the formation and development of dental plaque. Aim. The aim of the study was to evaluate the antibacterial and antifungal effectiveness of mouthwashes depending on their active ingredients. Material and methods. In the study, the effect of antibacterial and antifungal properties of mouthwashes on reference bacterial and yeast-like fungi strains was examined. The first type of the assessed mouthwashes contained only sodium fluoride or sodium fluoride and amine fluoride as active ingredients, while the second type contained sodium fluoride and cetylpyridinium chloride. In the study, a well diffusion method was used to test microorganisms constituting natural or pathogenic microflora of oral mucosa. The used reference microorganisms came from the ATCC: L. acidophilus ATCC 4356, Lactobacillus rhamnosus ATCC 53103, S. mutans ATCC 25175, and Candida yeasts: C. albicans ATCC 2091, C. albicans ATCC 10231, Candida parapsilosis ATCC 22019, Candida glabrata ATCC 90030, Candida krusei ATCC 14243. Results. The mouthwashes containing sodium fluoride and cetylpyridinium chloride showed an inhibitory effect against a greater number of reference strains used in the study than did mouthwashes that contained only sodium fluoride (or sodium fluoride and amine fluoride) as active ingredients. Against the four reference strains of Candida genus, the mouthwashes with an inorganic and organic fluoride compound showed no or minimum inhibitory effect or were much less effective than the mouthwashes that also contained cetylpyridinium chloride. Conclusion. Mouthwashes containing multiple ingredients with different antimicrobial mechanisms show synergistic action against the bacterial and fungal microflora responsible for the accumulation of dental plague.","PeriodicalId":11071,"journal":{"name":"Current Issues in Pharmacy and Medical Sciences","volume":"34 1","pages":"164 - 168"},"PeriodicalIF":0.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48711649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Casirivimab and imdevimab as investigational monoclonal antibodies for COVID-19 patients – review of the literature 卡西维单抗和依德维单抗作为COVID-19患者的实验性单克隆抗体-文献综述

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-09-01 DOI: 10.2478/cipms-2021-0030

G. Ręka, Angelika Pawlak, P. Machowiec, Marcela Maksymowicz, Halina Piecewicz-Szczęsna

{"title":"Casirivimab and imdevimab as investigational monoclonal antibodies for COVID-19 patients – review of the literature","authors":"G. Ręka, Angelika Pawlak, P. Machowiec, Marcela Maksymowicz, Halina Piecewicz-Szczęsna","doi":"10.2478/cipms-2021-0030","DOIUrl":"https://doi.org/10.2478/cipms-2021-0030","url":null,"abstract":"Abstract Casirivimab and imdevimab (REGN-COV-2) are investigational monoclonal antibodies approved in November 2020 by the Food and Drug Administration for emergency use in mild and moderate COVID-19. These two noncompeting human IgG1 monoclonal antibodies can target the receptor-binding domain of the spike protein of SARSCoV-2, prevent its entry into human cells, and reduce viral load. The antibodies can be administered intravenously for mild-to-moderate COVID-19 patients who do not require hospitalization and supplemental oxygen. The purpose of the study is to review the latest available data on COVID-19 treatment using casirivimab and imdevimab. According to recent preclinical studies, the antibody cocktail presents optimal antiviral strength and has the potential to minimize the chances of the virus escaping. It was shown in animal studies that the cocktail reduces the pathological consequences caused by viruses, decreases the number of viruses in the respiratory system, and reduces lung titers and pneumonia symptoms. Casirivimab and imdevimab as a cocktail also prevents the rapid appearance of treatment-resistant mutants. In the clinical trial, REGN-COV-2 decreased viral load, particularly in patients with a non-initiated immune response (serum antibody-negative) and with high viral load at baseline. The adverse effects were comparable in the combined REGN-COV2 dose groups (2.4 g and 8.0 g), as well as in the placebo group. The cocktail caused few and mainly low-grade toxic effects. Casirivimab and imdevimab seem to be effective and safe antiviral therapy for nonhospitalized patients with COVID-19. Further observations and research are extremely necessary to assess the efficacy, security and indications in a wider group of patients.","PeriodicalId":11071,"journal":{"name":"Current Issues in Pharmacy and Medical Sciences","volume":"34 1","pages":"138 - 141"},"PeriodicalIF":0.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43837691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of excipients influence on rheological behaviour of hydrogels with dimethindene maleate and dexpanthenol: conditions of controlled shear rate 赋形剂对马来酸二甲丁和膨胀醇水凝胶流变性能影响的研究:控制剪切速率的条件

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-06-01 DOI: 10.2478/cipms-2021-0017

Tetiana V. Popova, H. Kukhtenko, I. Gladukh, Oleksandr S. Kukhtenko, Anzhela B. Olkhovska

{"title":"Investigation of excipients influence on rheological behaviour of hydrogels with dimethindene maleate and dexpanthenol: conditions of controlled shear rate","authors":"Tetiana V. Popova, H. Kukhtenko, I. Gladukh, Oleksandr S. Kukhtenko, Anzhela B. Olkhovska","doi":"10.2478/cipms-2021-0017","DOIUrl":"https://doi.org/10.2478/cipms-2021-0017","url":null,"abstract":"Abstract Every year, the number of cases of hypersensitivity to insect bites increases. Thus, particular attention needs to be paid to the treatment of insect allergy in children, as scratching the bites can complicate the healing process and lead to infection. Therefore, a topical issue for modern medicine and pharmacy is the development of a gel of combined anti-allergic, reparative and anti-inflammatory action for the treatment of local manifestations of allergic skin reactions. Rheological studies are one of the stages of pharmaceutical development of soft dosage forms. In this study, we perform rheological studies of hydrogels containing 0.1% dimethindene maleate and 3.0% dexpanthenol made on different carriers of dispersed structures: Carbopol™ Polymers carbomer Ultrez 10 NF, Hydroxypropyl methylcellulose (HPMC) of brand Metolose SR-90SH-100000SR, Ziboxan F200 xanthan gum. The rheological studies were undertaken using a rheometer in controlled shear rate mode CSR. Basic structural and mechanical indices of the dispersed systems were determined. These included: yield stress, structural viscosity, viscosity at infinite shear rate, the hysteresis loop area. Moreover, dynamic liquefaction coefficients have been calculated. Based on the rheological studies of hydrogels containing 0.1% dimethindene maleate and 3.0% dexpanthenol prepared with various carriers, the use of 1.8% and 2.0% HPMC hydrogels, 2.0% and 2.5% xanthan gum hydrogels, 0.5% and 0.75% carbomer gels is recommended for further biopharmaceutical studies. The application of one of these formulations as the final composition, provides adhesion and will not complicate the scaling-up of the process.","PeriodicalId":11071,"journal":{"name":"Current Issues in Pharmacy and Medical Sciences","volume":"34 1","pages":"105 - 113"},"PeriodicalIF":0.3,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43538518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Influence of chromium (III), cobalt (II) and their mixtures on cell metabolic activity 铬(III)、钴(II)及其混合物对细胞代谢活性的影响

IF 0.3

Current Issues in Pharmacy and Medical Sciences Pub Date : 2021-06-01 DOI: 10.2478/cipms-2021-0019

Katarzyna Czarnek, A. Siwicki

{"title":"Influence of chromium (III), cobalt (II) and their mixtures on cell metabolic activity","authors":"Katarzyna Czarnek, A. Siwicki","doi":"10.2478/cipms-2021-0019","DOIUrl":"https://doi.org/10.2478/cipms-2021-0019","url":null,"abstract":"Abstract Chromium (III) and cobalt (II) are necessary elements required for the proper functioning of the organism, but their excess can cause toxic effects. They are the basic components of implants and are also commonly used in medicine as components of dietary supplements, vitamin and mineral products and energy drinks. The aim of this study was to investigate the effect of cobalt (II) and chromium (III) and their combination on BJ cells. In the study, BJ cells were exposed to CoCl2 or CrCl3 at concentrations ranging from 100 to 1400 µM, and the cytotoxicity of chromium (III) and cobalt (II) and their mixtures was assessed by MTT reduction, LDH release and NRU assays. The outcome of this work reveals the cytotoxic effects of chromium (III) and cobalt (II) and their mixtures on BJ cells. In the cytotoxicity assays, at low concentrations of CoCl2 and CrCl3, stimulation of cell proliferation was observed. In higher concentrations, the cell viability decreased for the tested line in all the assays. During the simultaneous incubation of fibroblasts with 200 µM of CrCl3 and 1000 µM of CoCl2, antagonism was observed: chromium (III) at the concentration of 200 µM induced protection from cobalt (II) toxicity; in the case of interaction of chromium chloride at 1000 µm and cobalt chloride at 200 µM, the protective effect of CrCl3 on CoCl2 was not observed. In the latter case, synergism between these elements was noted. Our work indicates that cobalt (II) and chromium (III) show cytotoxic properties. These metals have a destructive effect on the cell membrane, lysosomes and mitochondria, which leads to disorders of cell metabolism.","PeriodicalId":11071,"journal":{"name":"Current Issues in Pharmacy and Medical Sciences","volume":"34 1","pages":"87 - 93"},"PeriodicalIF":0.3,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45143631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2