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The Role of OX40-OX40L Axis in the Pathogenesis of Atopic Dermatitis. OX40-OX40L 轴在特应性皮炎发病机制中的作用
IF 5.2 3区 医学
Dermatitis Pub Date : 2024-05-03 DOI: 10.1089/derm.2024.0058
Natale Schettini, Lucrezia Pacetti, Monica Corazza, Alessandro Borghi
{"title":"The Role of OX40-OX40L Axis in the Pathogenesis of Atopic Dermatitis.","authors":"Natale Schettini, Lucrezia Pacetti, Monica Corazza, Alessandro Borghi","doi":"10.1089/derm.2024.0058","DOIUrl":"https://doi.org/10.1089/derm.2024.0058","url":null,"abstract":"<u><b><i/></b></u>OX40 is a co-stimulatory immune checkpoint molecule that promotes the activation and the effector function of T lymphocytes through interaction with its ligand (OX40L) on antigen-presenting cells. OX40-OX40L axis plays a crucial role in Th1 and Th2 cell expansion, particularly during the late phases or long-lasting response. Atopic dermatitis is characterized by an immune dysregulation of Th2 activity and by an overproduction of proinflammatory cytokines such as interleukin (IL)-4 and IL-13. Other molecules involved in its pathogenesis include thymic stromal lymphopoietin, IL-33, and IL-25, which contribute to the promotion of OX40L expression on dendritic cells. Lesional skin in atopic dermatitis exhibits a higher level of OX40L+-presenting cells compared with other dermatologic diseases or normal skin. Recent clinical trials using antagonizing anti-OX40 or anti-OX40L antibodies have shown symptom improvement and cutaneous manifestation alleviation in patients with atopic dermatitis. These findings suggest the relevance of the OX40-OX40L axis in atopic dermatitis pathogenesis.","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":"7 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patch Test Results Among Older Adults: A Retrospective Analysis of the North American Contact Dermatitis® Group Data (2009-2020). 老年人的斑贴测试结果:北美接触性皮炎®小组数据的回顾性分析(2009-2020 年)。
IF 4 3区 医学
Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-08-17 DOI: 10.1089/derm.2023.0130
JiaDe Yu, Hadley Johnson, Joel G DeKoven, Erin M Warshaw, James S Taylor, Donald V Belsito, Brandon L Adler, Jonathan I Silverberg, Amber R Atwater, Margo J Reeder, Nina Botto, Marie-Claude Houle, Christen M Mowad, Melanie D Pratt, Cory A Dunnick
{"title":"Patch Test Results Among Older Adults: A Retrospective Analysis of the North American Contact Dermatitis® Group Data (2009-2020).","authors":"JiaDe Yu, Hadley Johnson, Joel G DeKoven, Erin M Warshaw, James S Taylor, Donald V Belsito, Brandon L Adler, Jonathan I Silverberg, Amber R Atwater, Margo J Reeder, Nina Botto, Marie-Claude Houle, Christen M Mowad, Melanie D Pratt, Cory A Dunnick","doi":"10.1089/derm.2023.0130","DOIUrl":"10.1089/derm.2023.0130","url":null,"abstract":"<p><p><u><b><i>Background:</i></b></u> Allergic contact Dermatitis® (ACD) in older adults (OA) represents a significant health burden, but few studies examine the prevalence and characteristics of contact allergy and ACD in this population. <u><b><i>Objective:</i></b></u> To compare positive and clinically relevant patch test results in OA versus younger adults (YA) and children. <u><b><i>Methods:</i></b></u> Retrospective analysis of patch test results obtained in OA (≥65 years), YA (19-64 years), and children (≤18 years) by the North American Contact Dermatitis® Group, 2009 to 2020. <u><b><i>Results:</i></b></u> Of 28,177 patients patch tested, 5366 (19.0%) were OA. OA were more likely to have a final primary diagnosis of ACD as compared with YA (50.8% vs 49.2%, <i>P</i> = 0.035) and children (44.6%, <i>P</i> < 0.0001). The primary site of Dermatitis® also differed by age group, with OA having a higher proportion of Dermatitis® affecting the trunk, scalp, anogenital region, and \"under clothing,\" and a lower proportion of Dermatitis® affecting the face, lips, and feet. <u><b><i>Limitations:</i></b></u> Retrospective design, lack of follow-up, and referral population. <u><b><i>Conclusion:</i></b></u> OA were as likely and were statistically even more likely to have a final primary diagnosis of ACD compared with YA and children. Anatomic site of Dermatitis® also differed by age group. This underscores the need for patch testing in OA when ACD is suspected.</p>","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":" ","pages":"235-241"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10011693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Janus Kinase Inhibition in the Treatment of Prurigo Nodularis. Janus 激酶抑制剂治疗结节性瘙痒症
IF 4 3区 医学
Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-08-24 DOI: 10.1089/derm.2023.0036
Sheiva Fakhraie, Raj Chovatiya
{"title":"Janus Kinase Inhibition in the Treatment of Prurigo Nodularis.","authors":"Sheiva Fakhraie, Raj Chovatiya","doi":"10.1089/derm.2023.0036","DOIUrl":"10.1089/derm.2023.0036","url":null,"abstract":"","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":" ","pages":"299-300"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Association Between Atopic Dermatitis® and Alopecia Areata: A Systematic Review and Meta-Analysis. 特应性皮炎®与脱发之间的双侧关联:系统回顾和元分析。
IF 4 3区 医学
Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-07-20 DOI: 10.1089/derm.2023.0114
Rong Sun, Deqi Kong
{"title":"Bilateral Association Between Atopic Dermatitis® and Alopecia Areata: A Systematic Review and Meta-Analysis.","authors":"Rong Sun, Deqi Kong","doi":"10.1089/derm.2023.0114","DOIUrl":"10.1089/derm.2023.0114","url":null,"abstract":"<p><p><u><b><i></i></b></u> This systematic review and meta-analysis aimed to explore the association between atopic Dermatitis® (AD) and alopecia areata (AA). A comprehensive search was conducted in PubMed, Embase, Cochrane, and Web of Science from the inception of each database to November 10, 2022 for relevant studies. As there is a potential bilateral association between the 2 diseases, we assessed the prevalence/incidence of AA in patients with AD and the prevalence/incidence of AD in patients with AA. A total of 29 studies involving 11,233,448 participants were included in this analysis. AA was the exposure factor in 23 studies, AD in 7 studies, and both in 1 study. The meta-analysis revealed that the prevalence of AD was 11.2% (7.7%-15.1%) in patients with AA, and the prevalence of AA was 3.2% (95% confidence interval [CI]: 0.0%-11.5%) in patients with AD. The incidence of AD in AA patients was found to vary with age (<i>P</i> = 0.07). Based on 7 studies, there was a significant association between AD and AA when AA was the exposure factor [odds ratio, OR, = 4.537 (95% CI: 2.409-8.544)]; based on 10 studies, there was also a significant association between AD and AA when AD was the exposure factor [OR = 2.643 (95% CI: 1.737-3.995)]. In conclusion, this meta-analysis demonstrated the 2-way association between AD and AA, providing a clinical reference for disease prevention and control.</p>","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":" ","pages":"208-218"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9842931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Economic Costs and Implications of Occupational Skin Disease, 2011-2020. 2011-2020 年职业性皮肤病的经济成本和影响。
IF 4 3区 医学
Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-09-05 DOI: 10.1089/derm.2023.0203
Aneesh Agarwal, Annie Chang, Nicholas Gulati
{"title":"Economic Costs and Implications of Occupational Skin Disease, 2011-2020.","authors":"Aneesh Agarwal, Annie Chang, Nicholas Gulati","doi":"10.1089/derm.2023.0203","DOIUrl":"10.1089/derm.2023.0203","url":null,"abstract":"","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":" ","pages":"300-301"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10515640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No Causal Association Between Genetic Markers of Smoking Behaviors and Genetic Markers of Atopic Dermatitis®: Evidence From a Mendelian Randomization Study. 吸烟行为遗传标记与特应性皮炎遗传标记之间没有因果关系:孟德尔随机研究的证据
IF 4 3区 医学
Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-08-16 DOI: 10.1089/derm.2023.0080
Yangjian Xiao, Shengbo Huang, Zhiyu Hong, Deyou Tan
{"title":"No Causal Association Between Genetic Markers of Smoking Behaviors and Genetic Markers of Atopic Dermatitis®: Evidence From a Mendelian Randomization Study.","authors":"Yangjian Xiao, Shengbo Huang, Zhiyu Hong, Deyou Tan","doi":"10.1089/derm.2023.0080","DOIUrl":"10.1089/derm.2023.0080","url":null,"abstract":"","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":" ","pages":"312-313"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10010755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granulomatous Rosacea-Like Reaction During Dupilumab Treatment. Dupilumab治疗期间的酒糟鼻样肉芽肿反应。
IF 4 3区 医学
Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-07-11 DOI: 10.1089/derm.2023.0126
Francesca Falcinelli, Laura Lazzeri, Noemi La Francesca, Ester Sorrentino, Martina Dragotto, Vittoria Cioppa, Pietro Rubegni, Filomena Russo
{"title":"Granulomatous Rosacea-<i>Like</i> Reaction During Dupilumab Treatment.","authors":"Francesca Falcinelli, Laura Lazzeri, Noemi La Francesca, Ester Sorrentino, Martina Dragotto, Vittoria Cioppa, Pietro Rubegni, Filomena Russo","doi":"10.1089/derm.2023.0126","DOIUrl":"10.1089/derm.2023.0126","url":null,"abstract":"","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":" ","pages":"308-310"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allergic Contact Dermatitis®: A Bibliometric Analysis. 过敏性接触性皮炎®:文献计量分析。
IF 4 3区 医学
Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-08-09 DOI: 10.1089/derm.2023.0147
Medha Rao, Shreya Deoghare, JiaDe Yu
{"title":"Allergic Contact Dermatitis®: A Bibliometric Analysis.","authors":"Medha Rao, Shreya Deoghare, JiaDe Yu","doi":"10.1089/derm.2023.0147","DOIUrl":"10.1089/derm.2023.0147","url":null,"abstract":"","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":" ","pages":"303-305"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10372442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herpes Zoster Infection in Atopic Patients Undergoing Upadacitinib: Practical Suggestions on Vaccination and Management. 接受阿达帕替尼治疗的特应性患者中的带状疱疹感染:关于疫苗接种和管理的实用建议。
IF 4 3区 医学
Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-07-11 DOI: 10.1089/derm.2023.0088
Michela Ortoncelli, Luca Mastorino, Federica Gelato, Irene Richiardi, Giovanni Cavaliere, Pietro Quaglino, Simone Ribero
{"title":"Herpes Zoster Infection in Atopic Patients Undergoing Upadacitinib: Practical Suggestions on Vaccination and Management.","authors":"Michela Ortoncelli, Luca Mastorino, Federica Gelato, Irene Richiardi, Giovanni Cavaliere, Pietro Quaglino, Simone Ribero","doi":"10.1089/derm.2023.0088","DOIUrl":"10.1089/derm.2023.0088","url":null,"abstract":"","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":" ","pages":"305-307"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9822822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First Short-Term Effectiveness and Security Data of Tralokinumab in Severe Atopic Dermatitis® in Real Clinical Practice. Tralokinumab 治疗严重特应性皮炎® 在实际临床实践中的首个短期有效性和安全性数据。
IF 4 3区 医学
Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-05-02 DOI: 10.1089/derm.2023.0030
Rubén García Castro, Felipe Heras Mendaza, Diana Inmaculada Santiago Sánchez-Mateos, María Carmen Fariña Sabrís, Inmaculada Alcaraz León
{"title":"First Short-Term Effectiveness and Security Data of Tralokinumab in Severe Atopic Dermatitis® in Real Clinical Practice.","authors":"Rubén García Castro, Felipe Heras Mendaza, Diana Inmaculada Santiago Sánchez-Mateos, María Carmen Fariña Sabrís, Inmaculada Alcaraz León","doi":"10.1089/derm.2023.0030","DOIUrl":"10.1089/derm.2023.0030","url":null,"abstract":"","PeriodicalId":11047,"journal":{"name":"Dermatitis","volume":" ","pages":"301-303"},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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