Current Organocatalysis最新文献_第5页

Review on the Synthesis of Bio-Active Spiro-Fused Heterocyclic Molecules 生物活性螺融合杂环分子的合成研究进展

IF 1.1

Current Organocatalysis Pub Date : 2023-02-24 DOI: 10.2174/2213337210666230224114001

Subhash Banerjee, Geetika Patel, Ashok R. Patel, S. Kheti, Parimal Kumar Sao, Gargee Rathore

{"title":"Review on the Synthesis of Bio-Active Spiro-Fused Heterocyclic Molecules","authors":"Subhash Banerjee, Geetika Patel, Ashok R. Patel, S. Kheti, Parimal Kumar Sao, Gargee Rathore","doi":"10.2174/2213337210666230224114001","DOIUrl":"https://doi.org/10.2174/2213337210666230224114001","url":null,"abstract":"\u0000\u0000The spiro entity and heterocyclic scaffolds are decorated with a variety of biological and pharmaceutical properties. Therefore, the fusion of spiro compounds with individual moieties. Thus, the designing and expansion of the methods for the synthesis of various spiro-fused heterocyclic scaffolds are significantly important for synthetic organic chemistry.\u0000\u0000\u0000\u0000A variety of spiro-fused heterocyclic scaffolds are synthesized through different strategies and methods, such as one-pot multi-components synthesis, and multi-step methods via different organic reactions.\u0000\u0000\u0000\u0000The wide range of the applications and their interesting biological and medicinal properties encouraged the interest of the researchers to design and construct advanced strategies and methodologies for synthesizing novel spiro-fused heterocyclic molecules which resulted in the publication of numerous research papers and review articles in the literature. In this review article, we have access to the various schemes for the synthesis of different spiro-fused heterocyclic molecules and their biological importance.\u0000","PeriodicalId":10945,"journal":{"name":"Current Organocatalysis","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44512288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recent advances in polymer-supported proline-derived catalysts for asymmetric reactions 不对称反应中聚合物负载脯氨酸衍生催化剂的研究进展

IF 1.1

Current Organocatalysis Pub Date : 2023-02-24 DOI: 10.2174/2213337210666230224115814

S. Anas, Shajahan Rubina, Sarang Rithwik, Ramakrishnan Roopak

引用次数: 0

A Greener Synthetic Approach to Tetrazoles via Multicomponent Reactions 绿色合成四氮唑的多组分反应方法

IF 1.1

Current Organocatalysis Pub Date : 2023-02-22 DOI: 10.2174/2213337210666230222093637

D. Ray

{"title":"A Greener Synthetic Approach to Tetrazoles via Multicomponent Reactions","authors":"D. Ray","doi":"10.2174/2213337210666230222093637","DOIUrl":"https://doi.org/10.2174/2213337210666230222093637","url":null,"abstract":"\u0000\u0000The synthesis of heterocyclic compounds has drawn considerable attention in the scientific community due to their existence in the majority of medicinal & pharmaceutically important compounds as well as natural products. Among them, the remarkable existence of tetrazoles has been realized in several commercially available drugs. In this regard, various synthetic protocols to access tetrazoles have been developed to address the efficiency and environmental impacts in terms of minimization of the steps, elevating yields, and conducting environmentally benign and sustainable chemistry. The management and detrimental environmental impact of waste has been recognised as a consistent concern, along with the costs associated with its disposal. Among various approaches to minimise unwanted materials from a process, one of the best alternatives is to perform a reaction in the absence of excess chemical reagents and catalysts. Other options include the reactions affected by the application of heat, light, sound, or electrolysis. The multicomponent reactions (MCR) display a unique approach establishing a step forward toward clean, step and atom-economical chemical synthesis. Most of them utilize the required substrates, eliminating the stoichiometric use of reagents, reducing the possibility of forming unwanted side products. The present review displays the concepts of MCR in the synthesis and functionalization of tetrazole, which contributes to green and sustainable chemistry.\u0000","PeriodicalId":10945,"journal":{"name":"Current Organocatalysis","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48529939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Organocatalytic C-H Bond Functionalizations for the Synthesis of Heterocycles 杂环化合物合成中C-H键功能化的有机催化

IF 1.1

Current Organocatalysis Pub Date : 2023-02-13 DOI: 10.2174/2213337210666230213120833

Biswajit Panda

{"title":"Organocatalytic C-H Bond Functionalizations for the Synthesis of Heterocycles","authors":"Biswajit Panda","doi":"10.2174/2213337210666230213120833","DOIUrl":"https://doi.org/10.2174/2213337210666230213120833","url":null,"abstract":"\u0000\u0000Organocatalysis is an important and rapidly growing area for the synthesis of various organic molecules. Because of the inherent non-metal properties, mild reaction conditions, and broad functional group tolerance, the use of small organic compounds encoding and converting another organic component has developed into a remarkable process. C–H activation reactions, on the other hand, have already emerged as a powerful strategy for forming C–C and C–X (X= N, O, S) bonds. Combining organocatalysis and C-H bond functionalization is highly rational as two coexisting and rapidly growing research fields in modern synthetic chemistry, and the cooperative strength along this consistent has proven to be a successful way of making C-H bond functionalization much more feasible, reliable, and specific. At the same time, the synthesis of heterocyclic compounds is an important field in organic chemistry due to the vast application of heterocycles in pharmaceuticals, polymers, and material science. This mini-review describes the recent developments in the synthesis of heterocyclic compounds through the alliance of organocatalysis and C-H bond functionalizations.\u0000","PeriodicalId":10945,"journal":{"name":"Current Organocatalysis","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47624712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greener Approaches towards 1,4–Benzothiazine Synthesis: Recent Updates and Outlook 1,4 -苯并噻嗪合成的绿色途径:最新进展和展望

IF 1.1

Current Organocatalysis Pub Date : 2023-02-13 DOI: 10.2174/2213337210666230213144211

B. Basu, Suchandra Bhattacharya

引用次数: 1

Greener Approaches for Synthesis of Bioactive Thiadiazole Scaffolds 生物活性噻二唑支架的绿色合成方法

IF 1.1

Current Organocatalysis Pub Date : 2023-02-10 DOI: 10.2174/2213337210666230210142303

B. Sahoo, B. Banik, A. Tiwari, V. Tiwari, Manojkumar Mahapatra

{"title":"Greener Approaches for Synthesis of Bioactive Thiadiazole Scaffolds","authors":"B. Sahoo, B. Banik, A. Tiwari, V. Tiwari, Manojkumar Mahapatra","doi":"10.2174/2213337210666230210142303","DOIUrl":"https://doi.org/10.2174/2213337210666230210142303","url":null,"abstract":"\u0000\u0000Thiadiazole is a paradigm of five membered heterocyclic compound that contains two nitrogens and one sulphur as heteroatoms with molecular formula C2H2N2S. Thiadiazole is mainly present in four isomeric forms such as 1,2,3-thiadiazole, 1,2,4-thiadiazole, 1,2,5-thiadiazole and 1,3,4-thiadiazole. Out of these isomers, 1,3,4-thiadiazole has attracted remarkable attention in the field of medicinal chemistry. Some of the drugs containing 1,3,4-thiadiazole moiety are used clinically and are available in the market including Sulphamethizole (Antibacterial), Acetazolamide (Diuretic), Azetepa (Antineoplastic), Cefazolin (Antibiotic), Megazol (Antiprotozoal), Atibeprone (anti-depressant). Several greener approaches are applied for the synthesis of thiadiazole scaffolds including microwave irradiation, ultrasonic irradiation, grinding, ball milling technique, etc. These methods are eco-friendly, nonhazardous, reproducible, and economical approach. Based on these Green chemistry approaches, thiadiazole derivatives are synthesized from thiosemicarbazide. The functionalization of these heterocyclic compounds generates thiadiazole derivatives with diverse chemical structures. This review covers green synthesis, biological potentials, and structure activity relationship study of thiadiazole analogs.\u0000","PeriodicalId":10945,"journal":{"name":"Current Organocatalysis","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42496323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface 前言

IF 1.1

Current Organocatalysis Pub Date : 2023-02-01 DOI: 10.2174/221333721001230407084917

B. Banik

引用次数: 0

Meet the Editorial Board Member 与编辑委员会成员见面

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Current Organocatalysis Pub Date : 2023-02-01 DOI: 10.2174/221333721001230407085314

G. Brahmachari

引用次数: 0

A Simple and Modified One Pot Conversion of Carboxylic Acid to Ketone 一种简单改进的羧酸一锅法合成酮

IF 1.1

Current Organocatalysis Pub Date : 2022-12-23 DOI: 10.2174/2213337210666221223145319

Samaresh Jana, Debasis Sahoo, S. Sahoo

{"title":"A Simple and Modified One Pot Conversion of Carboxylic Acid to Ketone","authors":"Samaresh Jana, Debasis Sahoo, S. Sahoo","doi":"10.2174/2213337210666221223145319","DOIUrl":"https://doi.org/10.2174/2213337210666221223145319","url":null,"abstract":"\u0000\u0000Ketone is one of the important functional groups in synthetic chemistry. For this reason, organic chemists focused on the synthesis of ketone starting from various functionalities since nineties. One of the method deals with the conversion of carboxylic acids to ketones in a one pot manner. We have recently reported a one pot transformation of carboxylic acid to ketone using TsCl or MsCl as an activator of carboxylc acid. In our previous reports, two equivalents of organometallic reagent have been used which may not be useful in medicinal chemistry. In this report, we have developed an alternative process for the transformation where only one equivalent of organometallic reagent has been employed.\u0000\u0000\u0000\u0000In present scenario, we are interested to develop a process for the transformation of carboxylic acid to ketone using one equivalent of an organometallic reagent.\u0000\u0000\u0000\u0000A carboxylic acid reacted with tosyl chloride in the presence of a sodium hydride to form a mixed anhydride. Here, the acidic proton was removed from the reaction mixture as hydrogen gas. This mixed anhydride was then treated with one equivalent of an organomagnesium reagent at ̶̵ 30 °C to obtain the desired ketone.\u0000\u0000\u0000\u0000Following the optimum conditions, a few commercially available carboxylic acids were treated with TsCl, followed by the treatment of phenyl magnesium and methyl magnesium bromide to obtain phenyl and methyl ketones, respectively, in good to excellent yields.\u0000\u0000\u0000\u0000A simple and modified one pot method for the conversion of carboxylic acids to ketone has been reported. In this developed process, one equivalent of the organomagnesium reagent has been used to obtain the desired ketone under the optimized reaction conditions.\u0000","PeriodicalId":10945,"journal":{"name":"Current Organocatalysis","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43710465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-Assisted, [Bmim]PF6-Catalyzed Synthesis of Benzoxazoles under Solvent-free Conditions 微波辅助[Bmim] pf6无溶剂催化合成苯并恶唑

IF 1.1

Current Organocatalysis Pub Date : 2022-12-14 DOI: 10.2174/2213337210666221214121957

D. Duc

引用次数: 0