Current Research in Chemistry最新文献_第2页

Synthesis, Characterization, Biological Activity of 4-Oxo-imidazolidin-2-thione Derivatives 4-氧基咪唑烷-2-硫酮衍生物的合成、表征及生物活性研究

Current Research in Chemistry Pub Date : 2017-01-01 DOI: 10.3923/CRC.2017.1.13

Amal Mahmoud Yo

引用次数: 2

Synthesis and spectral study of N,N-diethyl-2-methyl-1-tosylpyrrolidine-2-carboxamide and functionalized sulfonamide scaffolds. N,N-二乙基-2-甲基-1-酰基吡咯烷-2-羧酰胺及功能化磺酰胺支架的合成与光谱研究。

Current Research in Chemistry Pub Date : 2016-06-15 DOI: 10.3923/CRC.2016.10.20

O. Ajani, J. D. Udonne, C. Ehi-Eromosele, J. Olugbuyiro, D. Aderohunmu, C. O. Ajanaku, O. Audu

{"title":"Synthesis and spectral study of N,N-diethyl-2-methyl-1-tosylpyrrolidine-2-carboxamide and functionalized sulfonamide scaffolds.","authors":"O. Ajani, J. D. Udonne, C. Ehi-Eromosele, J. Olugbuyiro, D. Aderohunmu, C. O. Ajanaku, O. Audu","doi":"10.3923/CRC.2016.10.20","DOIUrl":"https://doi.org/10.3923/CRC.2016.10.20","url":null,"abstract":"Background and Objective: Sulfonamides are known to represent a class of medicinally important compounds and chemical \u0000intermediates, which are extensively used in drug development. The aim of this present study is to synthesize a series of \u0000arylsulfonamide-based dialkylated amide motifs. Materials and Methods: In this study, the design and development of arylsulfonamide \u0000pharmacophore bearing N,N-diethyl substituted amide moieties 2a-k was achieved in improved yields using non-conventional amidation \u0000of p-tolylsulfonamide precursors 1a-k. The structures of the compounds were substantiated based on the results of elemental analysis \u0000and spectroscopic data namely, FT-IR, 1H-NMR, 13C-NMR and mass spectra. Results: The series of targeted compounds were synthesized \u0000in good to excellent yields and subsequently purified by column chromatography where necessary. Conclusion: The synthesis of \u0000arylsulfonamide-based dialkylated amide motifs was successfully achieved. These compounds may serve as versatile intermediates that \u0000pave ways toward achieving diverse bioactive heterocyclic compounds for future drug discovery and development.","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78658217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrocoagulation of Azo-2-Naphthol Dye Using Aluminium Electrodes: Effect of Solvent and Kinetics of Adsorption 铝电极电混凝偶氮-2-萘酚染料:溶剂的影响及吸附动力学

Current Research in Chemistry Pub Date : 2015-02-01 DOI: 10.3923/CRC.2015.34.43

V. Mkpenie, O. Abakedi

引用次数: 5

Synthesis, Characterization and Antibacterial Susceptibility of some Benzenesulfonyl and N-Acetylsulfanilyl Derivatives of Methyl α-D-Glucopyranoside 甲基α- d - glucopyrano苷类苯磺酰基和n -乙酰磺酰基衍生物的合成、表征及抗菌敏感性

Current Research in Chemistry Pub Date : 2015-02-01 DOI: 10.3923/CRC.2015.21.33

S. Kawsar, S. Uddin, S. Nishat, M. A. Manchur, Y. Ozeki

{"title":"Synthesis, Characterization and Antibacterial Susceptibility of some Benzenesulfonyl and N-Acetylsulfanilyl Derivatives of Methyl α-D-Glucopyranoside","authors":"S. Kawsar, S. Uddin, S. Nishat, M. A. Manchur, Y. Ozeki","doi":"10.3923/CRC.2015.21.33","DOIUrl":"https://doi.org/10.3923/CRC.2015.21.33","url":null,"abstract":"A novel regioselective benzenesulphonylation and N-acetylsulfanilylation series of methyl α-D-glucopyranoside derivative (1) has been carried out by direct method and afforded the 6-O-benzenesulfonyl derivative (2) and 6-O-N-acetylsulfanilyl derivative (7) in an excellent yields. In order to obtain newer products, the 6-O-glucopyranoside derivative was further transformed to a series of 2,3,4-tri-O-acyl derivatives (3-6 and 8-11) containing a wide variety of functionalities in a single molecular framework. The structures of the newly synthesized compounds were elucidated with the aid of FTIR, H-NMR spectroscopy and elemental analysis. All the synthesized compounds were also tested for their antibacterial activity against some human pathogenic bacterial microorganisms. For comparative studies, antibacterial activity of standard antibiotics, ampicillin was also carried out against these microorganisms. The study revealed that the acylated products exhibit moderate to good antimicrobial activities. It was interesting to observe that the selected compounds were more sensitive against gram-negative bacteria than that of the gram-positive bacterial strains. We carried out the antibacterial activities of the tested chemicals in vitro. In vivo screening studies of the tested compounds showing promising results will be the subject of our future investigation.","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79965020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Phytochemical and Ethnomedicinal Uses of Family Gentianaceae 龙胆科植物化学和民族医药用途

Current Research in Chemistry Pub Date : 2015-02-01 DOI: 10.3923/CRC.2015.44.52

D. Chandra, G. Kohli, K. Prasad, G. Bisht, Vinay Deep Punetha, K. S. Khetwal, Manoj Kumar Devrani, H. Pandey

引用次数: 22

GC-MS Determination of Bioactive Components of Napoleona imperalis P. Beauv 气相色谱-质谱联用法测定帝王拿破仑的生物活性成分

Current Research in Chemistry Pub Date : 2015-01-01 DOI: 10.3923/CRC.2015.9.13

C. Chukwu, O. C. Okafor, F. Nwabue, J. Afiukwa, A. Uwakwe

引用次数: 1

Synthesis of Some New Hydroquinoline and Pyrimido[4,5-b] Quinoline Derivatives 新型对苯二酚和嘧啶[4,5-b]喹啉衍生物的合成

Current Research in Chemistry Pub Date : 2015-01-01 DOI: 10.3923/CRC.2015.14.20

A. Ghoneim, M. Assy

{"title":"Synthesis of Some New Hydroquinoline and Pyrimido[4,5-b] Quinoline Derivatives","authors":"A. Ghoneim, M. Assy","doi":"10.3923/CRC.2015.14.20","DOIUrl":"https://doi.org/10.3923/CRC.2015.14.20","url":null,"abstract":"A new series of hydroquinolines derivatives (1, 2) have been achieved by the cyclo condensation of 2 (4-methoxybenzylidenemalonitrile), aniline and dimedone in the presence of piperidene. Cyclization of 5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-2-(phenylamino) quinoline-3-carbonitrile (2) sulphuric acid at room temperature afforded 7,8-dihydro-4-(4methoxyphenyl)-7,7-dimethylquinolin-5(6H)-one[2,3-b]2,3-dihydroquinolin-4 (1H)-one (3). Several substituted pyrimido[4,5-b]quinoline derivatives (4, 5, 6 and 7) were synthesized from 2-amino-1,4,5,6,7,8-hexahydro-4-(4-methoxphenyl)-7,7,-dimethyl-5-oxo-1-phenylquinoline-3carbonitrile (1) via cyclization with thiourea, chloroacetyl chloride, phenyl isothiocynate and formamide, respectively. The condensation of dimedone, with 4-methoxybenzylidene malononitrile in the presence of trimethylamine afforded 11-amino-3,4,8,9-tetrahydro-12-(4-methoxyphenyl)3,3,8,8-tetramethyl-2H-chromeno[2,3-b]quinoline-1, 10(7H,12H)-dione (8) but in ammonium acetate afforded 7,8-dihydro-4-(4-methoxyphenyl)-7,7-dimethylquinolin-5(1H,4H,6H)-one[2,3-b]4-amino-7,8dihydro-7,7-dimethylquinolin-5(6H)-one (9). The structures of the synthesized compounds were elucidated by elemental analyses and spectral data.","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90767000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Chemical Compositions of Medicinal Mangrove Species Acanthus ilicifolius, Excoecaria agallocha, Rhizophora apiculata and Rhizophora mucronata 红树药用物种刺槐、大褐刺槐、尖根刺槐和细根刺槐的化学成分

Current Research in Chemistry Pub Date : 2015-01-01 DOI: 10.3923/CRC.2015.1.8

K. Satyavani, S. Gurudeeban, V. Manigandan, E. Rajamanick, T. Ramanathan

引用次数: 24

Synthesis of Novel Mannich Bases of Pioglitazone 新型吡格列酮曼尼希碱的合成

Current Research in Chemistry Pub Date : 2014-01-01 DOI: 10.3923/CRC.2014.10.15

Ramit Kapoor, R. Arora, Ravinesh Mishra, Manu Arora, Pooja Mittal

引用次数: 2

Synthesis and Application of Disazo Dyes Derived from 2-amino-5-mercapto-1,3, 4-thiadiazole and 2-chloroaniline on Acrylic Fabric and Nylon 66 Fabric 2-氨基-5-巯基- 1,3,4 -噻二唑和2-氯苯胺双偶氮染料在腈纶和尼龙66织物上的合成及应用

Current Research in Chemistry Pub Date : 2014-01-01 DOI: 10.3923/CRC.2014.1.9

J. Otutu, E. M. Efurhievwe, S. U. Ameru

引用次数: 2